CN103495037A - Traditional Chinese medicine for treating chronic gastritis and peptic ulcer disease caused by helicobacter pylori infection - Google Patents
Traditional Chinese medicine for treating chronic gastritis and peptic ulcer disease caused by helicobacter pylori infection Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine for treating chronic gastritis and a peptic ulcer disease caused by helicobacter pylori infection. The traditional Chinese medicine is composed of the following raw materials, by weight, 10-15 parts of mangnolia officinalis, 15-20 parts of astragalus, 25-30 parts of salvia miltiorrhiza, 25-30 parts of dandelion, 15-20 parts of oldenlandia diffusa, 10-25 parts of tangerine peels, 10-15 parts of white paeony roots, 10-15 parts of radix angelicae, 10-15 parts of rhizoma atractylodis, 15-20 parts of rhizoma bletillae and 25-30 parts of cuttle bones. The traditional Chinese medicine is reasonable in composition, obvious in treatment effect, good in improvement effect on gastric mucosa observed under an endoscope, obvious in improvement effect on stomach pathology change, high in eradication rate of stomach helicobacter pylori, free of obvious toxic and side effect and adverse reaction, good in treatment compliance and capable of effectively treating helicobacter pylori and stomach diseases related to the same.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula, is a kind of Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease for the treatment of specifically.
Background technology
Found helicobacter pylori (Helicobacter pylori from nineteen eighty-two Australia scholar's Barry Marshall and Luo Bin Warren, be called for short Hp), and proved that this antibacterial infects stomach and can cause gastritis, gastric ulcer and duodenal ulcer, and, since gastric cancer and primary malignant lymphoma in close relations, gastroenterologist is studied the eradication therapy of Hp with regard to starting both at home and abroad.Inquire into and eradicate the Hp therapeutic scheme, as curing the chronic gastritis relevant to Hp, the fundamental way of peptic ulcer disease.At present the first-line treatment scheme of global eradication Hp is mainly that proton pump inhibitor adds clarithromycin and adds amoxicillin or proton pump inhibitor and add clarithromycin and add metronidazole.Along with going deep into of research, medicine and the prescription of eradicating Hp also had to new discovery, clinical efficacy also increases.But also reflected that some problems, distinct issues are that Hp constantly rises to clarithromycin and antibiotic drug resistance, make it the fastbacteria pearl and be on the increase simultaneously, external study on large sample demonstration, its drug resistance incidence rate is 3.0-19.3%; The side reaction of medicine increases, and especially under gastrointestinal pessimal stimulation and digestive tract power, degradation allows patient agonize; Consumption cost is higher, and the compliance of patient's drug administration is reduced; Curative effect is difficult to maintain; The eradication rate of Hp is difficult to further raising, these are all the difficult points that Hp research is eradicated in puzzlement, series of problems urgently to be resolved hurrily, therefore, seek effectively to solve the method for clinical faced difficulties and can improve curative effect, the medicine that reduces side effect is very important.
Modern Study on etiology shows, Hp is a kind of gram-negative bacteria of S-shaped or arc-shaped bend, parasitize specifically below the mucous wall of gastric mucosa, surface epithelial cell, not yet find except the gastric epithelial cell surface of mucous epithelium surface and duodenum and esophagus that at present there is this antibacterial parasitism at other positions.Visible, Hp can infect the epithelial cell in stomach, the specific host that stomach is Hp specifically.The report of Nanfang Hospital of No.1 Military Medical Univ., Hp is by discharging a series of media and the effect of body immune system being produced to inflammation, gastric mucosal cell propagation is increased, also easily cause the damage of DNA and the danger that aneuploid appears in increase simultaneously, further form multiple carcinogenicly or cause the consolidation material, therefore think that it is the main startup factor of chronic gastritis to atrophic gastritis, intestinal epithelial metaplasia, atypical hyperplasia and gastric cancer development that Hp infects.All research shows that Hp infects and the Hp toxin changes to stomach lining inflammation, precancerosis in the development of gastric cancer and plays Main Function.
It is a worldwide problem that Hp infects, and China belongs to the high country that infects, and general population's infection rate is at 50-80%.571 people in IMS Dui Yige township, Henan have carried out the gastroscope generaI investigation, and Hp infection rate male is 72%, the women be 63%, 15-20 year young group be 53.6%, adult group is 76%, normal gastric mucosa is 6.6%, chronic gastritis is 93%.Beijing Medical University carries out the gastroscopy biopsy to Mouping County, shandong Province the High Risk For Gastric Cancer area 347 routine asymptomatic patients, and the Hp recall rate is 52.5%.The Hp infection rate age 20-29 year group be 45.7%, 30-39 year group be 63%, be stabilized in 60% left and right with age growth, at >=70 years old, be 78.9%, be described early the age of China population Hp infection rate, infect contain green grass or young crops, in, old age.Infect the clinical manifestation of associated gastritis, Peptic Ulcers according to Hp, differential diagnosis in tcm surely belongs to the category of gastric abscess, noisy, syndrome of feeling fullness and distension in the upper abdomen.Making a general survey of Chinese medicine the Pathogenesis Theory of above-mentioned disease is set forth, be mainly that weakness of the spleen and stomach, mechanism of qi mistake are smooth, or the irritability criminal is contrary, gallbladder loses and secretes clearly, or eating and drinking without temperance, cold warm not normal, or qi depression to blood stasis, stomach-Yin virtual loss etc., but still lacks the understanding to the evil malicious damage of diseases caused by exogenous pathogenic factor stomach mansion.
Chinese medicine has rich experience in treatment such as gastric abscess, painful abdominal mass, noisy disease, when determining the Therapeutic Principle, it is also different people, different views, or overweight taste, or duty in liver and gall, or pay attention to the cold-evil, or control damp and hot, or distinguish that gas distinguishes blood, or pay attention to treatment, or emphasize diet etc., good clinical guidance is arranged.But along with medical science applied development with to the in-depth of etiology and pathogenesis, be familiar with, this antibacterial of Hp infects the gastropathy caused, and more scholar more payes attention to formulating the Therapeutic Principle for the cause of disease.The Chinese medicine of clinical treatment chronic gastritis has much at present, and treatment also obtains certain curative effect.
Summary of the invention
Technical problem to be solved by this invention is in order to overcome above-mentioned the deficiencies in the prior art, provides a kind of component reasonable, and cost is low, and instant effect has no side effect, and is applicable to treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease.
The technical scheme that above-mentioned technical problem to be solved by this invention adopts is: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, it adopts Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae is raw material, it is characterized in that its raw material forms and weight proportion is: Cortex Magnoliae Officinalis 10-15, Radix Astragali 15-20, Radix Salviae Miltiorrhizae 25-30, Herba Taraxaci 25-30, Herba Hedyotidis Diffusae 15-20, Pericarpium Citri Reticulatae 10-25, Radix Paeoniae Alba 10-15, Radix Angelicae Dahuricae 10-15, Rhizoma Atractylodis Macrocephalae 10-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Os Sepiae 25-30.
By " standard of Chinese pharmacopoeia promulgation in 2000 is selected said medicine in proportion, decontamination, and earth sieves.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate is standing, removes sediment, and concentrated thick paste is standby; Just remaining Herba Taraxaci 1/2 amount again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is standby that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder are stirred with blender, drying and sterilizing, powder patent medicine is loose, more capable sterilization packaging.
Usage and dosage: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Therapeutic effect: 90 routine patients, after the course for the treatment of, the helicobacter pylori clearance rate is 84.44%.Through the tcm symptom curative effect relatively, treatment group tcm symptom treatment total effective rate is 95.56%, obviously is better than 82.22% of matched group, has significant difference (P<0.01); Treatment group traditional Chinese medical science individual event symptom curative effect obviously is better than matched group, and except gastric abscess curative effect zero difference (P>0.05), other symptom curative effects all have significant difference, (P<0.01); Treatment group and matched group TCM symptom score relatively, have significant difference (P<0.05); Treatment group and matched group individual event symptom integral relatively, have significant difference (P<0.05); Treatment group scope curative effect is 84.44%, and matched group is 74.44%, two group relatively significant difference, (P<0.05); Two groups of pathology curative effect comparison treatment groups obviously are better than matched group, and except the atrophy zero difference (P ﹥ 0.05), other all have significant difference (P ﹤ 0.01); Treatment group helicobacter pylori clearance rate is 84.44%, and matched group is 74.44%, two group relatively significant difference, (P<0.05).
The present invention adopts traditional pure Chinese medicine, take powder as dosage form, and boiled water is taken after mixing it with water, and can effectively treat helicobacter pylori infections and cause the diseases such as chronic gastritis and peptic ulcer disease.The drug matching reasonable recipe of selecting, therapeutic effect is remarkable.The Endoscopic Observation gastric mucosa improves effective, and the stomach pathological change is improved obviously, high to the eradication rate of helicobacter pylori, without significantly toxic and side effects and untoward reaction, and low price, the treatment compliance is good.Can effectively treat helicobacter pylori and treatment gastritis correlated to Helicobacter pylori.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
The present invention is a kind of Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease for the treatment of, it adopts Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae is raw material, it is characterized in that its raw material forms and weight proportion is: Cortex Magnoliae Officinalis 10-15, Radix Astragali 15-20, Radix Salviae Miltiorrhizae 25-30, Herba Taraxaci 25-30, Herba Hedyotidis Diffusae 15-20, Pericarpium Citri Reticulatae 10-25, Radix Paeoniae Alba 10-15, Radix Angelicae Dahuricae 10-15, Rhizoma Atractylodis Macrocephalae 10-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Os Sepiae 25-30.
By " standard of Chinese pharmacopoeia promulgation in 2000 is selected said medicine in proportion, decontamination, and earth sieves.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate is standing, removes sediment, and concentrated thick paste is standby; Just remaining Herba Taraxaci 1/2 amount again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is standby that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder are stirred with blender, drying and sterilizing, powder patent medicine is loose, more capable sterilization packaging.
The raw material weight proportioning of the best of the present invention is: Cortex Magnoliae Officinalis 12, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 30, Herba Hedyotidis Diffusae 15, Pericarpium Citri Reticulatae 10, the Radix Paeoniae Alba 15, the Radix Angelicae Dahuricae 15, the Rhizoma Atractylodis Macrocephalae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 30.
The characteristic of disease that Hp infects is diseases caused by exogenous pathogenic factor epidemic disease poison, and sick position is at taste, close with liver and gall; Its pathomechanism is evil malicious invasion, pents up in stomach, injures the stomach film, reach for a long time in the liver spleen, and blood stasis due to qi deficiency, stasis of blood heat-transformation of a specified duration, stagnant heat is obstructed, and the stomach film loses supports, and the rotten one-tenth of film is rotten, even cancerate.Chinese medicine thinks, taste are the exterior and the interior each other, and for using, The spleen is in charge of sending up essential substances, transporting and transforming nutrients from foodstuff is precise and tiny be its merit mutually, and the stomach being liable to sending digested food downward, the digesting food of being received are its use, and the taste lifting is suitable, receiving normally, to complete digesting and assimilating of diet.If taste lifting imbalance, receiving dereliction of duty, all diseases are by life.Liver and gall are also the exterior and the interior, refinforce each other, and liver controlling conveyance and dispersion, auxiliary taste QI movement being in harmonious way; Gallbladder is secreted clear juice, helps taste to receive digesting and absorbing the essence of foodstuff.If hepato-biliary function is not normal, reach taste and living disease.As " the Plain Questions jade very will be discussed greatly " mentions when touching upon gastric abscess: " the nether world sky of fainting, wind is excessive to be won, the sick gastral cavilty of the people is taken care and is ached ", illustrating that gastric abscess and wood gas win partially, the liver stomach is become estranged relevant.If damp-heat accumulation had both hindered the lifting of taste, affect the catharsis of liver and gall, the visible belch acid regurgitation of its disease, epigastric upset, created adapt circumstance for exopathogen infects and grows again; Blood stasis due to qi deficiency stomach mansion mistake is supported, and the deficiency of vital energy stomach is moving unable, the visible swollen lack of appetite of gastral cavity, and blood stasis stomach network is not smooth, and the stomach film loses foster, visible gastralgia; Cloudy impairment of body fluid loses stomach mistake and makes moist, and in addition damp and hot causing harm, the stomach film is hindered infections by life.As " Su Wen ﹒ comments pyretography ", say: " institute of heresy gathers, and its gas must be empty ", deficiency of qi and yin has caused the aggressive factor of Hp to strengthen, and the defensive factor of stomach film weakens, and causes evil poison invasion, pents up in stomach, crouches and does not go for a long time.Therefore Hp cause a disease to belong to exopathogen by outer invasion, parasitize specifically below the mucous wall of gastric mucosa surface epithelial cell.Its sick position is at the stomach mansion, and target position is at the stomach film; Make gastric mucosa injury by its detoxifying function, destroyed the barrier action of gastric mucosa, make the unbalance by aggressive factor and defensive factor of mucosa, thereby be inflamed reaction or ulcer, intestinalization is given birth to and cancerate etc.Its Track character has excitation, gradual, repeatability, and the characteristic of pyretic toxicity is still arranged.Visible impaired gastric mucosa hyperemia, edema under gastroscope, ooze out and even mucosal pallor, coarse injustice, mucosal atrophy, meet damp-heat accumulation, QI and blood is impaired, blood stasis due to qi deficiency, and thanks to, the stomach film loses foster pathological state to cloudy impairment of body fluid.The present invention has established the evil poison of removing summer-heat, and QI and blood regulating, repair and hinder infections, cuts anti-Therapeutic Principle of cancerating.The evil poison of removing summer-heat-Hp infects, place Fu Weifu, and non-removing summer-heat can not eliminating evil poison; The reparation of QI and blood regulating-stomach film, depend on moistening of QI and blood foster.If gas can not moisten, blood can not be supported, and certainly will make defensive enginery weaken, therefore answer QI and blood regulating to improve environment in the stomach mansion, improves the anti-evil ability in stomach mansion, reaches eliminating evil purpose; The invasive that infections-Hp infects is hindered in reparation, has caused inflammation and the ulcer of gastric mucosa, by eliminating pathogenic factor for supporting vital QI, further repairs and hinders infections, effectively protects the stomach film, thereby eliminates symptom, reaches the purpose of the eliminating evil disease that heals; Cutting anti-cancerate-modern study proves: Hp infects the pathological change that causes gastric mucosa, makes that gastric mucosa occurs that inflammatory, atrophy, intestinalization are given birth to, becomes before cancer, even canceration, so, in eradicating the Hp treatment, tackle in time the generation become before cancer, plays Truncation.This Therapeutic Principle determines, to eradicate that Hp infects and treatment Gastritis, gastric ulcer significant.
Cortex Magnoliae Officinalis of the present invention has effect and the antiulcer effect of excited gastrointestinal motility, and anti-inflammatory and antalgic, antineoplastic action are arranged; The Radix Astragali has the oxygen-derived free radicals of removing and suppresses lipid peroxidation, anti-inflammatory and antalgic and antitumaous effect; Radix Salviae Miltiorrhizae has anti-inflammatory effect, by remarkable inhibition Agarose Microdroflet Assay, prevents that lysosomal enzyme, oxidative metabolism product etc. from too much discharging, and alleviates tissue injury, to control inflammation development; And there is gastric acid inhibitory and anti-ulcer effect, main by suppressing stomach H+, the K+-ATP enzymatic activity realizes; Herba Taraxaci can anti-inflammation, reduces endotoxic activity, and gastric acid secretion inhibiting, alleviate gastric mucosa damage, and the incidence rate of ulcer and ulcer index are obviously descended.Herba Hedyotidis Diffusae has and strengthens immunity, improves leukocytic phagocytic function in human blood, strengthens the specific killing activity to tumor cell, and, to the phagocytic function of tumor cell, also has in addition protective effect and antioxidation to the damage gastric mucosa.Above-mentioned inrigorating qi and promoting blood circulation antidote can effectively prevent and reverse gastric mucosa atrophy, promotes gastric mucosal blood flow, increases gastrointestinal peristalsis, thereby repairs gastric mucosa, and the prevention gastric mucosa atrophy, block and reverse its precancerous lesion.
Radix Astragali invigorating the spleen and replenishing QI in formula, to help the transporting of spleen, being received of stomach; Rhizoma Atractylodis Macrocephalae invigorating the spleen to clear away damp pathogen, spleen is strong and be beneficial to removing dampness, wet except and help spleen invigorating; The Cortex Magnoliae Officinalis alleviating distention in middle-JIAO is except full, and Compendium of Material Medica is drawn Lee east wall cloud: " Cortex Magnoliae Officinalis is bitter can the therapeutic method to keep the adverse QI flowing downwards, therefore let out real fullly, temperature can QI invigorating, therefore can wet dissipation full ", the Pericarpium Citri Reticulatae stomach invigorating of regulating the flow of vital energy, two medicines and the Rhizoma Atractylodis Macrocephalae, Radix Astragali phase 5, make it QI invigorating and not stagnant gas, circulation of qi promoting and do not consume gas.Herba Taraxaci, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, with hot and suffocating in clearing stomach, separate the stomach poison of being possessed, and " book on Chinese herbal medicine is newly organized " said: Herba Taraxaci is for rushing down the medicine of stomach-fire, and its gas is very flat, and soil is not damaged in pathogenic fire purging, and fire moves back and gastric qi is spontaneous, and Herba Taraxaci has to relieve inflammation or internal heat and protects the effect of stomach as seen.Radix Paeoniae Alba easing the affected liver to relieve pain, Radix Angelicae Dahuricae removing dampness pain relieving, the kind slow liver stomach of two medicines is anxious, and increases the machine fallen.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling and the pain of subsiding a swelling, Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding and detumescence and promoting granulation, two medicines one are lived and one are held back, and the nourishing the stomach film, hinder infections again, with Cortex Magnoliae Officinalis, the Radix Astragali mutually 5, QI and blood conditioning, stomach mansion granulation promoting.Get Os Sepiae simply, be intended to relieving gastric hyperacidity to alleviate stomachache.Make a general survey of full side, Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae are monarch drug, with the evil poison of removing summer-heat, QI and blood regulating; Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae are ministerial drug, with the principal drug assistance strengthening vital QI to eliminate pathogenic factors, and easing the affected liver spleen invigorating, relieving spasm to stop pain; Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae are adjuvant drug, with the anti-promoting flow of QI and blood of the property of convergence too, with the merit of granulation promoting antacid, help and repair the stomach film and hinder infections.Also substantially identical with the treatment viewpoint of anti-inflammation, gastric acid inhibitory, protection gastric mucosa at elimination Hp and the relevant gastropathy for the treatment of to doctor trained in Western medicine.
Usage and dosage: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.
Efficacy assessment standard: with reference to " Chinese digestive endoscopy magazine " " the endoscopic classification grade scale of chronic gastritis and tentative suggestion for the treatment of ".
The evaluation of tcm symptom total effects:
(1) produce effects: clinical symptom disappearance.
(2) effective: clinical symptoms obviously alleviates 3.
(3) invalid: clinical symptoms is not improved.
The tcm symptom efficacy evaluation:
The scope efficacy evaluation:
(1) produce effects: the positive sign of scope mucosa directly perceived disappears or alleviates II level above (containing the II level).
(2) effective: the positive sign of scope mucosa directly perceived alleviates the I level.
(3) invalid: scope mucosa sign directly perceived is without alleviating and increasing the weight of.
The pathology efficacy evaluation:
(1) produce effects: the atrophy of pathologic finding body of gland, intestinalization are given birth to and dysplasia disappears or alleviate II level above (containing the II level).
(2) effective: atrophy, intestinalization are given birth to and dysplasia alleviates the I level.
(3) invalid: atrophy, intestinalization are given birth to and dysplasia alleviates not as good as the I level or increases the weight of.
The helicobacter pylori eradication evaluation:
With gastric mucosa tissue section microscopy, or carbon 14 urea breath experiments are all negative, are assessed as helicobacter pylori infections and turn out cloudy.
Usage of the present invention and the course for the treatment of: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Therapeutic effect: 90 routine patients, after the course for the treatment of, the helicobacter pylori clearance rate is 84.44%.Treatment group tcm symptom treatment total effective rate is 95.56%, obviously is better than 82.22% of matched group, has significant difference (P<0.01); Treatment group traditional Chinese medical science individual event symptom curative effect obviously is better than matched group, and except gastric abscess curative effect zero difference (P>0.05), other symptom curative effects all have significant difference, (P<0.01); Treatment group and matched group TCM symptom score relatively, have significant difference (P<0.05); Treatment group and matched group individual event symptom integral relatively, have significant difference (P<0.05); Treatment group scope curative effect is 84.44%, and matched group is 74.44%, two group relatively significant difference, (P<0.05); Two groups of pathology curative effect comparison treatment groups obviously are better than matched group, and except the atrophy zero difference (P ﹥ 0.05), other all have significant difference (P ﹤ 0.01); Treatment group helicobacter pylori clearance rate is 84.44%, and matched group is 74.44%, two group relatively significant difference, (P<0.05).
Embodiment 1: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, take raw material by following weight proportion: Cortex Magnoliae Officinalis 12, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 30, Herba Hedyotidis Diffusae 15, Pericarpium Citri Reticulatae 10, the Radix Paeoniae Alba 15, the Radix Angelicae Dahuricae 15, the Rhizoma Atractylodis Macrocephalae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 30.Decontamination, earth sieves.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate is standing, removes sediment, and concentrated thick paste is standby; Just remaining Herba Taraxaci 1/2 amount again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is standby that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder are stirred with blender, drying and sterilizing, powder patent medicine is loose, more capable sterilization packaging.
The method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Case one is permitted certain, the man, and 38 years old, individuality, people from Weihai City examines in October, 2011.
Suffer from gastric abscess more than 4 years, once, in certain hospital's row gastroscopy, be diagnosed as chronic superficial gastritis, pathological diagnosis is that stomach lining inflammation is partly accompanied the life of glandular epithelium intestinalization, Helicobacter pylori.Give antibiotic and protection gastric mucosa Drug therapy first quarter moon,, once with the other drug treatment, the state of an illness is not felt any better, symptom while examining yet: gastric abscess (+++), feeling of fullness (++), poor appetite (++), belch (++), noisy (++).The gastroscope finding: gastric mucosa hyperemia, erosion, have little hemorrhagic focus, examines as chronic superficial gastritis.Pathological diagnosis: the gastric antrum chronic inflammation, part glandular epithelium intestinalization is given birth to, and the body of stomach subregion is moderate atypical hyperplasia, helicobacter pylori (+).Three large routines and liver, kidney function test normal range.
Observation of curative effect: take medicine and within one week, feel gastric abscess and obviously alleviate, take medicine after symptom substantially disappear.
Embodiment 2: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, take raw material by following weight proportion: Cortex Magnoliae Officinalis 10, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 25, Herba Hedyotidis Diffusae 20, Pericarpium Citri Reticulatae 25, the Radix Paeoniae Alba 10, the Radix Angelicae Dahuricae 10, the Rhizoma Atractylodis Macrocephalae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Os Sepiae 25.Decontamination, earth sieves.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate is standing, removes sediment, and concentrated thick paste is standby; Just remaining Herba Taraxaci 1/2 amount again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is standby that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder are stirred with blender, drying and sterilizing, powder patent medicine is loose, more capable sterilization packaging.
The method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Case two flood so-and-so, the man, 52 years old, the peasant, the Huancui District people of Weihai City examines in May, 2011.
Suffer from gastric abscess more than 6 years, once, in certain hospital's row gastroscopy, be diagnosed as chronic atrophic gastritis, pathological diagnosis is chronic atrophic gastritis, Helicobacter pylori.Be interrupted and take antibiotic and protection gastric mucosa Drug therapy, also once took the Chinese medicine decoction treatment, Relapse rate outbreak, symptom while examining: gastric abscess (++), feeling of fullness (+++), poor appetite (+++), belch (+), noisy (++).The gastroscope finding: the coarse injustice of gastric mucosa mucosa has more the lamellar erosion as seen, examines as chronic atrophic gastritis.Pathological diagnosis: chronic atrophic gastritis, part glandular epithelium intestinal hypertrophy, a little body of gland is arranged closely, helicobacter pylori (+).Three large routines and liver, kidney function test normal range.
Treatment: give the present embodiment medicine, three times on the one, take continuously 21 days, once, the pungent irritable food that waits of avoiding cold and uncooked food, and enjoining if any irritated and other untoward reaction, examine at once in further consultation weekly.Taking medicine checked after January.
Observation of curative effect: take medicine and within one week, feel gastric abscess and obviously alleviate, take medicine after symptom substantially disappear.
Embodiment 3:: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, take raw material by following weight proportion: Cortex Magnoliae Officinalis 12, the Radix Astragali 18, Radix Salviae Miltiorrhizae 27, Herba Taraxaci 28, Herba Hedyotidis Diffusae 19, Pericarpium Citri Reticulatae 15, the Radix Paeoniae Alba 14, the Radix Angelicae Dahuricae 14, the Rhizoma Atractylodis Macrocephalae 14, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 26.Decontamination, earth sieves.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate is standing, removes sediment, and concentrated thick paste is standby; Just remaining Herba Taraxaci 1/2 amount again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is standby that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder are stirred with blender, drying and sterilizing, powder patent medicine is loose, more capable sterilization packaging.
The method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.
Case three Zou so-and-so, the man, 49 years old, individuality, the flourish urban human in Weihai City is examined in March, 2009.
Suffer from gastric abscess more than 7 years, once, in certain hospital's row gastroscopy, be diagnosed as chronic atrophic gastritis, pathological diagnosis is that stomach lining inflammation is partly accompanied the life of glandular epithelium intestinalization, Helicobacter pylori.Be interrupted and take antibiotic and protection gastric mucosa Drug therapy, also once took the Chinese medicine decoction treatment, Relapse rate outbreak, symptom while examining: gastric abscess (++), feeling of fullness (++), poor appetite (+++), belch (+), noisy (++).The gastroscope finding: the coarse injustice of gastric mucosa mucosa has more the lamellar erosion as seen, is dispersed in petechia, examines as chronic atrophic gastritis.Pathological diagnosis: the gastric antrum chronic inflammation, part glandular epithelium intestinalization is given birth to, helicobacter pylori (+).Three large routines and liver, kidney function test normal range.
Treatment: give the present embodiment medicine, three times on the one, take continuously 21 days, once, the pungent irritable food that waits of avoiding cold and uncooked food, and enjoining if any irritated and other untoward reaction, examine at once in further consultation weekly.Taking medicine checked after January.
Observation of curative effect: take medicine and within one week, feel gastric abscess and obviously alleviate, take medicine after symptom substantially disappear.
Embodiment 4: a kind ofly treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease, take raw material by following weight proportion: Cortex Magnoliae Officinalis 14, the Radix Astragali 16, Radix Salviae Miltiorrhizae 26, Herba Taraxaci 25, Herba Hedyotidis Diffusae 18, Pericarpium Citri Reticulatae 22, the Radix Paeoniae Alba 12, the Radix Angelicae Dahuricae 12, the Rhizoma Atractylodis Macrocephalae 12, Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Os Sepiae 28.Decontamination, earth sieves.Then by above-mentioned Herba Taraxaci 1/2 amount, Radix Salviae Miltiorrhizae 1/2 amount, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting in water 2 times, merging filtrate is standing, removes sediment, and concentrated thick paste is standby; Just remaining Herba Taraxaci 1/2 amount again, Radix Salviae Miltiorrhizae 1/2 amount, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, it is standby that cuttlefish bone meal is broken into coarse powder; Above-mentioned gained thick paste and gained coarse powder are stirred with blender, drying and sterilizing, powder patent medicine is loose, more capable sterilization packaging.
The method consumption: every day three times, each 6g, half an hour, boiled water was taken after mixing it with water after meal.It within three weeks, is a course for the treatment of.2 to 3 courses for the treatment of of continuous use.After one course for the treatment of, the helicobacter pylori clearance rate is 84.44%.Through the tcm symptom curative effect relatively, treatment group tcm symptom treatment total effective rate is 95.56%.
Claims (2)
1. treat the Chinese medicine that helicobacter pylori infections causes chronic gastritis and peptic ulcer disease for one kind, it adopts Cortex Magnoliae Officinalis, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae is raw material, it is characterized in that its raw material forms and weight proportion is: Cortex Magnoliae Officinalis 10-15, Radix Astragali 15-20, Radix Salviae Miltiorrhizae 25-30, Herba Taraxaci 25-30, Herba Hedyotidis Diffusae 15-20, Pericarpium Citri Reticulatae 10-25, Radix Paeoniae Alba 10-15, Radix Angelicae Dahuricae 10-15, Rhizoma Atractylodis Macrocephalae 10-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Os Sepiae 25-30.
2. treatment helicobacter pylori infections according to claim 1 causes the Chinese medicine of chronic gastritis and peptic ulcer disease, it is characterized in that the raw material weight proportioning is: Cortex Magnoliae Officinalis 12, the Radix Astragali 15, Radix Salviae Miltiorrhizae 30, Herba Taraxaci 30, Herba Hedyotidis Diffusae 15, Pericarpium Citri Reticulatae 10, the Radix Paeoniae Alba 15, the Radix Angelicae Dahuricae 15, the Rhizoma Atractylodis Macrocephalae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Os Sepiae 30.
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| CN104352965A (en) * | 2014-10-15 | 2015-02-18 | 刘昌海 | Compound consolidant for treating helicobacter pylori and peptic ulcer |
| CN105168847A (en) * | 2015-09-01 | 2015-12-23 | 江淑芬 | Traditional Chinese medicine for treating helicobacter pylori infected peptic ulcer |
| CN106389863A (en) * | 2016-11-28 | 2017-02-15 | 北京中山医院有限公司 | Traditional Chinese medicine decoction for treating helicobacter pylori infection and preparation method thereof |
| CN115364169A (en) * | 2022-04-07 | 2022-11-22 | 中国科学院合肥物质科学研究院 | Anti-helicobacter pylori traditional Chinese medicine composition and preparation method and application thereof |
| CN115957247A (en) * | 2022-03-07 | 2023-04-14 | 上海中医药大学 | Application of rhizoma atractylodis macrocephalae extract in preparation of medicine for treating gastrointestinal mucosa injury |
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