CN103488247A - Clock calibration method, device and system - Google Patents

Clock calibration method, device and system Download PDF

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Publication number
CN103488247A
CN103488247A CN201310425956.1A CN201310425956A CN103488247A CN 103488247 A CN103488247 A CN 103488247A CN 201310425956 A CN201310425956 A CN 201310425956A CN 103488247 A CN103488247 A CN 103488247A
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clock
mistiming
calibrated
reference clock
arbitrary
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高鹏
杨龙
尹柱霞
李楠
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Neusoft Medical Systems Co Ltd
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Neusoft Medical Systems Co Ltd
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Abstract

The invention discloses a clock calibration method, device and system. The method includes: selecting any one of N reference clocks as a reference clock; determining a to-be-calibrated clock from the reference clocks except for the reference clock; measuring a time difference between any rising edge of the current moment reference clock and any rising edge of the to-be-calibrated clock, or a time difference between any falling edge of the reference clock and any falling edge of the to-be-calibrated clock; feeding back the time difference to a generator of the to-be-calibrated clock to enable the generator to regulate a phase of the to-be-calibrated clock to be identical to that of the reference clock according to the time difference so as to complete clock calibration. By the technical scheme, multiple reference clocks are calibrated, so that measurement standards of moments at which photons are detected in a PET (positron emission tomography) system are identical, timing accuracy is guaranteed, and further determined annihilation reaction positions are more accurate.

Description

A kind of clock correcting method, equipment and system
Technical field
The present invention relates to the Time synchronization technique field, particularly relate to a kind of clock correcting method, equipment and system.
Background technology
PET(Positron Emission Tomography, positron emission fault) video picture is the sign of current nuclear medicine highest level, can on molecular level, reflect whether human body exists pathophysiological change, therefore is referred to as again biochemical video picture or molecular imaging.Its ultimate principle comprises the positron annihilation reaction that the radioactive nuclide that is injected in vivo produces in decay process and meets detection principle, specific as follows:
At first the PET imaging need to inject radioactive biological spike medicine in human body, radioelement in these medicines is the indispensable element existed in human body or animal body or the isotope that can replace to a certain extent indispensable element (as: carbon, nitrogen, oxygen, fluorine etc.), harmless.The biological spike medicine be synthesized can inject in human body, and participates in the vital movement of intracorporeal organ, tissue, cell with " identity " of compound in human body or animal body.Due to the biological spike medicine nucleic of rich proton normally, at biological spike medicine, participate in the process of animal or human's body vital movement, nucleic can decay, can produce positron (β+) at the decay process Radionuclide, the quality of positron equates with electronics, electric weight is identical with the electric weight of electronics, and an is-symbol is contrary.The positron that the radioactive nuclide be injected in vivo is launched will the negatron in human body after mobile about lmm in human body be combined annihilation reaction is occurred, as shown in Figure 1, produce the γ photon of two energy identical (511keV) opposite direction during positron-electron annihilation.Then, survey the photon of generation with two detectors staggered relatively, the process of detection of photons is to transfer the γ photon to fluorescence by scintillation crystal, and photomultiplier (PMT) is converted into electric signal by light signal.After the electric impulse signal that front-end electronics is exported photomultiplier carries out filtering and amplification, therefrom obtain the γ photon energy information and time of arrival information, due to the motion path difference of two photons in human body, the time that arrives two detectors has certain difference, if in official hour, detector detects two photons that are mutually 180 degree, and this event is referred to as and meets event, and the process of detection is called and meets detection or meet judgement.The PET system is by recording all events that meet, to described event handling, then the process image reconstruction acquisition tomoscan image of meeting.
Meet event and can be divided into three kinds, the first is the true coincidence event, two photon sources that detect are in same annihilation reaction, and these two photons before arriving detector all less than with medium, any interaction occurring, they contain accurate locating information.The second is that scattering meets event, two photon sources that detect are in same annihilation reaction, but have one at least in arriving detector the first two photon, through scattering, retrodeviate from original direction, therefore this to meet the locating information that event contains be inaccurate.The third is exactly the random coincidence event, and two photons that detect are not from same annihilation reaction.The judgement that meets event is the core of PET system, and the correctness that meets the event judgement is directly determining the quality of PET entire system performance and the accuracy of diagnosis thereof.
In the prior art, the real time difference of two photons arrival crystal that annihilation reaction produces can be measured, utilizes this mistiming, can determine in theory the position of annihilation reaction.Because the PET system is a distributed system, there are a plurality of detectors in front end, each detectors is in a reference clock, these reference clocks are separate, start-up time difference, causing system to obtain the time difference that detector detects photon has certain error, and therefore the determined position of flooding reaction neither an accurate point, causes thus the degree of accuracy of subsequent reconstruction image also to have certain loss.Therefore, the precise time measurement mechanism is very necessary for the PET system.
Summary of the invention
For solving the problems of the technologies described above, the embodiment of the present invention provides a kind of clock correcting method, equipment and system, to solve in prior art, in the PET system, due to reference clock difference start-up time, causes the inaccurate technical matters in position of definite annihilation reaction.The invention provides technical scheme as follows:
A kind of clock correcting method comprises:
Arbitrary reference clock in selected N reference clock is as the reference clock, and N is positive integer;
Determine clock to be calibrated in the reference clock except reference clock;
Mistiming between arbitrary rising edge of measurement current time reference clock and arbitrary rising edge of clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Fed back to the generating means of clock to be calibrated the described mistiming, so that generating means is adjusted the phase place of clock to be calibrated to identical with reference clock according to the described mistiming.
The embodiment of the present invention also provides a kind of clock calibrating device, comprising:
With reference to chosen module, for arbitrary reference clock of selected N reference clock, as the reference clock, N is positive integer;
The gating module, for determining clock to be calibrated in the reference clock except reference clock;
Measurement module, for the mistiming between arbitrary rising edge of arbitrary rising edge of measuring the current time reference clock and clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Feedback module, for being fed back to the generating means of clock to be calibrated the described mistiming, so that generating means is adjusted the phase place of clock to be calibrated to identical with reference clock according to the described mistiming.
The embodiment of the present invention also provides a kind of clock alignment system, comprising:
Arbitrary clock calibrating device as described above and N measurement mechanism, wherein, a measurement mechanism comprises generating means and time measurement device;
Described generating means, for generation of reference clock, and when receiving the mistiming of clock calibrating device feedback, by the rising edge of clock to be calibrated move to left or the move to right length of described mistiming, the rising edge of clock to be calibrated is aimed at the rising edge of reference clock, or, by the negative edge of clock to be calibrated move to left or the move to right length of described mistiming, the negative edge of clock to be calibrated is aimed at the negative edge of reference clock;
Described time measurement device, while for detector, detecting photon, the reference clock of take after calibrating is reference, measures the moment of detecting this photon.
The technical scheme provided from the above embodiment of the present invention, system with a plurality of reference clocks, after reference clock starts, select arbitrarily one of them reference clock as the reference clock, measure the mistiming between the rising edge (or negative edge) of the rising edge (or negative edge) of clock to be calibrated and reference clock, then fed back to the dispensing device of clock to be calibrated this mistiming, calibrated the phase place of clock to be calibrated by generating means according to the mistiming, make it identical with the reference clock phase place.For the PET system, the technical scheme of the application of the invention, when detector detects photon, because the phase place of reference clock is identical, no matter be which two detector has detected this photon, what measure is all correct for the time difference that detects this photon, and according to this time difference, the position of definite annihilation reaction is also accurately, thereby make, to carry out according to the result of annihilation reaction the image that image reconstruction obtains comparatively accurate.
The accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, below will the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described, apparently, the accompanying drawing the following describes is only some embodiment that put down in writing in the present invention, for those of ordinary skills, can also obtain according to these accompanying drawings other accompanying drawing.
The annihilation reaction schematic diagram that Fig. 1 is positron;
The process flow diagram that Fig. 2 is a kind of clock correcting method embodiment 1 provided by the invention;
Fig. 3 is the schematic diagram that reference clock is not calibrated the mistiming that front definite photon reaches;
Fig. 4 is that the schematic diagram of the mistiming that photon reaches is determined in the reference clock adjustment afterwards;
The structural representation that Fig. 5 is a kind of clock calibrating device embodiment 1 provided by the invention;
The structural representation that Fig. 6 is a kind of clock alignment system provided by the invention;
Fig. 7 is a kind of clock calibrating device provided by the invention a kind of structural representation in actual applications;
Fig. 8 is a kind of clock alignment system provided by the invention a kind of structural representation in actual applications.
Embodiment
In order to make those skilled in the art person understand better the technical scheme in the present invention, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Embodiment based in the present invention, the every other embodiment that those of ordinary skills obtain, should belong to the scope of protection of the invention.
Definite correctness of annihilation reaction position has direct impact to the accuracy of PET image, thereby the diagnosis of disease is exerted an influence.And while measuring the annihilation reaction position in the PET system, because there is error in timing, make definite position of flooding reaction neither an accurate point, but limit point within the specific limits, if timing error is excessive, to cause the position of actual generation annihilation reaction not drop in definite scope, and then affect the degree of accuracy (image likely obtained is wrong) of image.Therefore, the precise time measurement mechanism is very necessary for the PET system.A kind of clock correcting method provided by the invention, equipment and system, before the system operation, phase place to the reference clock as detecting photon timing reference is constantly adjusted, make the phase place of output signal of all reference clocks identical, no matter be which two detector detects photon, can guarantee that the mistiming that timing obtains is exactly, the position of the annihilation reaction obtained thus is also accurately.Below, at first to a kind of clock correcting method provided by the invention, describe in detail.
As shown in Figure 2, for the process flow diagram of a kind of clock correcting method embodiment 1 provided by the invention, the technical scheme that the present embodiment provides can apply with multiple systems in, such as PET, PETCT, the present embodiment be take the PET system and is described as example, and the present embodiment specifically can comprise the steps:
S201: the arbitrary reference clock in selected N reference clock is as the reference clock.
The PET system is a distributed system, be provided with a plurality of detectors and be used for surveying the photon that annihilation reaction produces, corresponding each detector all has the module of a Measuring Time, it is the timing foundation that this module be take to reference clock that should detector, in reality, the general rising edge that adopts reference clock to start rear generation is the moment that timing starts, because different reference clock is asynchronous start-up time, the mistiming timing that causes two detectors are detected photon is wrong, therefore, after startup, need reference clock is calibrated, with the frequency (generally all consistent) that guarantees all reference clocks, phase place is consistent.
Described N is positive integer, is physically the number of reference clock, when reference clock is calibrated, can select arbitrarily a reference clock as the reference clock, and remaining all reference clocks are calibrated with reference to the reference clock of selecting.
S202: determine clock to be calibrated in the reference clock except reference clock.
Although will be calibrated all reference clocks, in practical operation, according to reference clock, carry out one by one, after selecting clock to be calibrated, need to be with reference to the signal gating of clock and clock to be calibrated, to obtain the pulse signal of two reference clock outputs.
S203: the mistiming between arbitrary rising edge of measurement current time reference clock and arbitrary rising edge of clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated.
S204: fed back to the generating means of clock to be calibrated the described mistiming, so that generating means is adjusted the phase place of clock to be calibrated to identical with reference clock according to the described mistiming.
Concrete, the length of the described mistiming that the rising edge of clock to be calibrated can be moved to left or moves to right, make the rising edge of clock to be calibrated aim at the rising edge of reference clock; Or, by the negative edge of clock to be calibrated move to left or the move to right length of described mistiming, the negative edge of clock to be calibrated is aimed at the negative edge of reference clock.In practical operation, clock to be calibrated is moved to left or is moved to right depend on the symbol of the mistiming obtained.After aforesaid operations, reference clock is exactly identical with the phase place of clock to be calibrated, follow-up when the difference that detects photon is calculated, and the clock of described calibration is as detecting photon beasurement base constantly.
The technical scheme that the present embodiment provides, system with a plurality of reference clocks, after reference clock starts, select arbitrarily one of them reference clock as the reference clock, measure the mistiming between the rising edge (or negative edge) of the rising edge (or negative edge) of clock to be calibrated and reference clock, then fed back to the dispensing device of clock to be calibrated this mistiming, calibrated the phase place of clock to be calibrated by generating means according to the mistiming, make it identical with the reference clock phase place.For the PET system, the technical scheme of the application of the invention, when detector detects photon, because the phase place of reference clock is identical, no matter be which two detector has detected this photon, what measure is all correct for the time difference that detects this photon, and according to this time difference, the position of definite annihilation reaction is also accurately, thereby make, to carry out according to the result of annihilation reaction the image that image reconstruction obtains comparatively accurate.
Further, consider that reference clock is high-precision clock, can be as accurate as tens ps(psecs), in order to keep the precision of calibration, clock to be calibrated for each, all can divide a plurality of moment to measure respectively the time value of rising edge or negative edge, often obtaining a time difference is first stored, after the time difference engraved when a plurality of all gets, after a plurality of differences are added up and are averaging, give the dispensing device of clock to be calibrated as final reference feedback, generating means is adjusted the phase place of calibration clock according to the difference after average.
For the effect that the embodiment of the present invention is brought has one to understand more intuitively, shown in figure 3 and Fig. 4, be respectively the timing mode that timing mode of the prior art and the embodiment of the present invention provide.The frequency of supposing reference clock is 4M Hz, take this clock as benchmark, and the generation that meets event is marked constantly.The temporal information of mark can be used as by follow-up circuit the criterion that meets event.
As shown in Figure 3, ChannleM and ChannleN mean two distributed modules (time measuring unit) of front end, all for the accurate measurement of time.CLK_4M-M and CLK_4M-N are the reference clocks that two distributed modules adopt.When we carry out time measurement, actual measurement be moment of arriving of photon detection and the mistiming between the reference clock rising edge.Due to what adopt, it is distributed system, so be inconsistent the start-up time of each submodule reference clock, this has just caused having had certain phase difference between each reference clock, as shown in Figure 3, the rising edge clock of CLk_4M-M and CLK_4M-N there are differences, the skew that this will cause measuring basis, cause the inaccuracy of measurement result, thereby have influence on the judgement that meets event.As shown in Figure 4, be the reference clock after calibration, as can be seen from Figure 4, the mistiming obtained according to the reference clock after calibration is accurately.
Corresponding to top embodiment of the method, the present invention also provides a kind of clock calibrating device, shown in figure 5, is the structural representation of described clock calibrating device embodiment 1, and described device comprises:
With reference to chosen module 510, for arbitrary reference clock of selected N reference clock, as the reference clock, N is positive integer;
Gating module 520, for determining clock to be calibrated in the reference clock except reference clock;
Measurement module 530, for the mistiming between arbitrary rising edge of arbitrary rising edge of measuring the current time reference clock and clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Feedback module 540, for being fed back to the generating means of clock to be calibrated the described mistiming, so that generating means is adjusted the phase place of clock to be calibrated to identical with reference clock according to the described mistiming.
Preferably, described clock calibrating device can also comprise: memory module, the mistiming obtained for preserving current time;
Described measurement module, during also for a plurality of after current time, engrave, mistiming between arbitrary rising edge of difference witness mark clock and arbitrary rising edge of clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Described memory module, also engrave the mistiming measured when being stored in a plurality of after current time;
Accumulator module, for by preserve described a plurality of the time engrave the mistiming corresponding with current time corresponding mistiming and tire out;
Described feedback module, specifically for the cumulative mistiming obtained is averaged, the mistiming using average as feedback.
The present invention also provides a kind of clock alignment system, shown in figure 6, is the structural representation of described clock alignment system, and described system comprises:
Clock calibrating device 610 described above and N measurement mechanism 620, wherein, a described measurement mechanism 620 comprises generating means 621 and time measurement device 622;
Described generating means 621, for generation of reference clock, and when receiving the mistiming of clock calibrating device feedback, by the rising edge of clock to be calibrated move to left or the move to right length of described mistiming, the rising edge of clock to be calibrated is aimed at the rising edge of reference clock, or, by the negative edge of clock to be calibrated move to left or the move to right length of described mistiming, the negative edge of clock to be calibrated is aimed at the negative edge of reference clock;
Described time measurement device 622, while for detector, detecting photon, the reference clock of take after calibrating is reference, measures the moment of detecting this photon.
Preferably, shown in figure 7 and Fig. 8, be respectively clock calibrating device and a kind of implementation corresponding to system that the embodiment of the present invention provides, system is comprised of N distributed module (or be called the measurement submodule, corresponding to described measurement mechanism 620) and a clock measurement module (corresponding to clock calibrating device).Measure submodule and mainly comprise reference clock generation unit (corresponding to generating means 621) and split-second precision measuring unit (corresponding to time measurement device 622).The major function of measuring submodule is produce reference clock and carry out high-precision time measurement.The clock measurement module mainly comprises the clock selecting unit, rising edge difference measurements unit and feedback unit etc.Its major function is the reference clock that gating will be measured, and completes the time difference value measurement between institute's gating rising edge clock, go forward side by side line item and feedback by rising edge difference measurements unit.
When system is started working, distributed module is measured submodule and is started working.Produce self reference clock CLK0 to CLKn while measuring submodule work.Wherein CLK0 and clock CLKn can produce by the FPGA in module, 4M while supposing frequency of operation, and frequency setting value can be determined according to the system of actual design.Because whole system is distributed system, there is power-on time difference, so the time that each measurement submodule is started working is inconsistent, each phase place of measuring the reference clock CLK0 to CLKn produced in submodule is inconsistent, i.e. the rising edge life period difference of clock.These differences can cause time measurement information inaccurate, and we need to eliminate these differences.Take rising edge as example, and the principle of work of Fig. 7 and Fig. 8 shown device and system is as follows:
By data cable, reference clock CLK0 to CLKn is connected to the clock measurement module.The clock measurement module mainly comprises the clock gating unit, rising edge difference measurements unit, time difference storage unit and feedback unit.
A: clock gating module is connecting the reference clock produced in all measurement submodules.
B: in these reference clocks, select arbitrarily a clock as adjusting the reference clock used.And take this reference clock as basis, carry out subsequent adjustment.Suppose to select clk3 as reference clock.
C: in remaining clock, select arbitrarily a clock to start to be regulated.Suppose to choose clk18 as being conditioned clock.
D: the work of clock gating module, with reference to clock, from the output of clka port, clock to be regulated is exported from the clkb port.
E: clock CLK3 and CLK18 will be transferred to the rising edge measuring unit by clka port and clkb port.
F: the major function of rising edge measuring unit has been the poor measurement of rising time between clock CLK3 and CLK18.The rising edge measuring unit can adopt asic chip to realize, can realize the measurement of split-second precision.
G: by the rising edge measuring unit, will obtain the difference of rising edge between CLK3 and CLK18, this difference is stored by the mistiming storage unit.
H: feedback unit is passed to corresponding systematic survey submodule (being now to measure submodule 18) by difference value by data link.Now, suppose the difference value Δ=clk18-clk3(or the clk3-clk18 that measure), according to the Δ value, clk18 is regulated.
I: the systematic survey submodule, by the relevant parameter Δ, is used FPGA to adjust the phase place of its reference clock, and the phase place of regulating clk18, make clk18 aim at the clk3 rising edge.
Concrete, if Δ=clk18-clk3 > 0, clk18 is moved to left to aiming at the rising edge of clk3; Otherwise, clk18 is moved to right to aiming at the rising edge of clk3;
Adjustment to other reference clocks of system spare, can refer step C to step I, remaining measurement submodule in adjustment System, after adjusting and finishing, the reference clock phase place produced in all distributed modules (measurement submodule) is consistent, does not have the time difference between rising edge.
Being divided into various unit with function while for convenience of description, describing above device describes respectively.Certainly, when enforcement is of the present invention, can realize the function of each unit in same or a plurality of software and/or hardware.
Each embodiment in this instructions all adopts the mode of going forward one by one to describe, and between each embodiment, identical similar part is mutually referring to getting final product, and each embodiment stresses is the difference with other embodiment.Especially, for system embodiment, due to it, substantially similar in appearance to embodiment of the method, so describe fairly simplely, relevant part gets final product referring to the part explanation of embodiment of the method.The above is only the specific embodiment of the present invention, for those skilled in the art, under the premise without departing from the principles of the invention, can also make some improvements and modifications, and these improvements and modifications also should be considered as protection scope of the present invention.

Claims (7)

1. a clock signal calibration steps, is characterized in that, comprising:
Arbitrary reference clock in selected N reference clock is as the reference clock, and N is positive integer;
Determine clock to be calibrated in the reference clock except reference clock;
Mistiming between arbitrary rising edge of measurement current time reference clock and arbitrary rising edge of clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Fed back to the generating means of clock to be calibrated the described mistiming, so that generating means is adjusted the phase place of clock to be calibrated to identical with reference clock, to complete the calibration of clock according to the described mistiming.
2. method according to claim 1, is characterized in that, generating means is adjusted the phase place of clock to be calibrated to identical with reference clock according to the described mistiming, comprising:
By the rising edge of clock to be calibrated move to left or the move to right length of described mistiming, the rising edge of clock to be calibrated is aimed at the rising edge of reference clock;
Or,
By the negative edge of clock to be calibrated move to left or the move to right length of described mistiming, the negative edge of clock to be calibrated is aimed at the negative edge of reference clock.
3. method according to claim 1, is characterized in that, before being fed back to the generating means of clock to be calibrated the described mistiming, also comprises:
Preserve the mistiming that current time obtains;
Engrave during a plurality of after current time, measure respectively and preserve the mistiming between arbitrary rising edge of arbitrary rising edge of reference clock and clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
By preserve described a plurality of the time engrave the mistiming corresponding with current time corresponding mistiming and tire out;
Be averaged to the mistiming using average as feedback the cumulative mistiming obtained.
4. method according to claim 1, is characterized in that, comprising:
The clock of described calibration is as detecting photon beasurement base constantly.
5. a clock calibrating device, is characterized in that, comprising:
With reference to chosen module, for arbitrary reference clock of selected N reference clock, as the reference clock, N is positive integer;
The gating module, for determining clock to be calibrated in the reference clock except reference clock;
Measurement module, for the mistiming between arbitrary rising edge of arbitrary rising edge of measuring the current time reference clock and clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Feedback module, for being fed back to the generating means of clock to be calibrated the described mistiming, so that generating means is adjusted the phase place of clock to be calibrated to identical with reference clock according to the described mistiming.
6. device according to claim 5, is characterized in that, also comprises:
Memory module, the mistiming obtained for preserving current time;
Described measurement module, during also for a plurality of after current time, engrave, mistiming between arbitrary rising edge of difference witness mark clock and arbitrary rising edge of clock to be calibrated, or, the mistiming between arbitrary negative edge of reference clock and arbitrary negative edge of clock to be calibrated;
Described memory module, also engrave the mistiming measured when being stored in a plurality of after current time;
Accumulator module, for by preserve described a plurality of the time engrave the mistiming corresponding with current time corresponding mistiming and tire out;
Described feedback module, specifically for the cumulative mistiming obtained is averaged, the mistiming using average as feedback.
7. a clock alignment system, is characterized in that, comprising:
As the described clock calibrating device of claim 5-6 any one and N measurement mechanism, wherein, a measurement mechanism comprises generating means and time measurement device;
Described generating means, for generation of reference clock, and when receiving the mistiming of clock calibrating device feedback, by the rising edge of clock to be calibrated move to left or the move to right length of described mistiming, the rising edge of clock to be calibrated is aimed at the rising edge of reference clock, or, by the negative edge of clock to be calibrated move to left or the move to right length of described mistiming, the negative edge of clock to be calibrated is aimed at the negative edge of reference clock;
Described time measurement device, while for detector, detecting photon, the reference clock of take after calibrating is reference, measures the moment of detecting this photon.
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CN102625428A (en) * 2012-04-24 2012-08-01 苏州摩多物联科技有限公司 Time synchronization method of wireless sensor networks
CN103178920A (en) * 2012-07-12 2013-06-26 深圳市康必达中创科技有限公司 Multi-channel synchronization method in test system of digital transformer substation
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CN105187033A (en) * 2015-09-07 2015-12-23 沈阳东软医疗系统有限公司 Clock calibration method and device
CN105187033B (en) * 2015-09-07 2018-02-27 沈阳东软医疗系统有限公司 A kind of clock correcting method and device
CN106097496A (en) * 2016-06-07 2016-11-09 北京千丁互联科技有限公司 Control of bluetooth access management system, control of bluetooth access equipment and time calibrating method thereof
WO2018090901A1 (en) * 2016-11-15 2018-05-24 武汉中派科技有限责任公司 Device and method for measuring time information of photon
CN107422364A (en) * 2017-06-26 2017-12-01 沈阳东软医疗系统有限公司 The time timing correction method and device of a kind of detector
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US10755452B2 (en) 2017-07-10 2020-08-25 Shanghai Neusoft Medical Technology Co., Ltd. Calibrating time in PET device
CN109150179A (en) * 2018-08-23 2019-01-04 上海联影医疗科技有限公司 clock distribution system and method
US11931197B2 (en) 2019-05-29 2024-03-19 Shanghai United Imaging Healthcare Co., Ltd. Systems and methods for clock synchronization
CN111466936A (en) * 2020-03-31 2020-07-31 上海联影医疗科技有限公司 Clock synchronization method and device and computer equipment
CN111466936B (en) * 2020-03-31 2021-07-16 上海联影医疗科技股份有限公司 Clock synchronization method and device and computer equipment
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