CN103479935A

CN103479935A - Self-adaptive shaped hemorrhoid suppository

Info

Publication number: CN103479935A
Application number: CN201210510340.XA
Authority: CN
Inventors: 李智生
Original assignee: Weifang University
Current assignee: Weifang University
Priority date: 2012-12-04
Filing date: 2012-12-04
Publication date: 2014-01-01
Anticipated expiration: 2032-12-04
Also published as: CN103479935B

Abstract

The invention provides a self-adaptive shaped hemorrhoid suppository, and specifically provides a novel suppository for treating hemorrhoid, and the suppository is prepared from a traditional Chinese medicine composition. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 10-20 parts of catnip, 10-20 parts of pericarpium zanthoxyli, 10-20 parts of mint, 10-20 parts of heydyotis, 25-35 parts of honeysuckle flower, 25-35 parts of Chinese gall, 25-35 parts of smilax glabra, 25-35 parts of sophora flavescens, 25-35 parts of borneol, 25-35 parts of calamine and 0.03-0.09 part of ketone musk. The suppository of the invention is a fiber bag woven by a nontoxic, elastic and slender material; the fiber bag has a wide base part, relatively thin neck part, thick upper part and pointed and circular head part, and the fiber bag is in the shape of a barrel, is thin, soft and good in retractility; and the base part of the bag is supported by a supporting ring prepared from an elastic material. During preparation of the suppository, the bag is filled with medicine, then the surface of the bag is coated with a layer of the medicine, so that the medicine fully covers the bag and the suppository is prepared, and the base part of the suppository is fixedly disposed on a pad, then the suppository is sealed and kept for reservation.

Description

The moulding ZHICHUAN SHUAN of self adaptation

Technical field the present invention relates to one group of Chinese medicine and a kind of manufacture method for the treatment of the suppository of hemorrhoid of making hemorrhoid suppositories.

Background technology

Hemorrhoid are anal and rectal diseases common in one way of life, the anal canal peripheral termination of nerve is abundant, the hemorrhoid morbidity often causes great misery to the patient, portal system lacks venous valve, the anal and intestinal diseases such as Portal Vein Thrombosis inflammation, constipation, perianal abscess, enteritis, Enterozoa, the surrounding tissue inflammation of rectum bottom can directly cause that tube wall becomes fragile, vasodilation is congested, hemorrhoidal plexus pressure raises, and causes hemorrhoid.The traditional Chinese medical science is thought: the pathogenic factor of hemorrhoid is mainly the internal organs deficiency in origin, and " danxi's experiential therapy " pointed out: " hemorrhoid person is all because of the internal organs deficiency in origin, so that the QI and blood tenesmus, the poly-anus of knot, and dyspepsia is not loose, and conflict is hemorrhoid." surfeit is rich, pungent, irregular diet, insobriety are also main causes.The chronic diarrhea chronic dysentery, sitting is stood for a long time, the long journey of bearing a heavy burden, constipation, the women passes through, pregnancy, childbirth, suckling, chronic disease, sexual strain, the pent-up of feelings will, ponder over too, and QI and blood drops, the evil multiple abscess of damp and hot wind-dryness, conflict and be hemorrhoid.Treatment for hemorrhoid, the operative treatment relapse rate is high, painful large, topical medications is a kind of common Therapeutic Method, it is simple that it has treatment, determined curative effect, the characteristics of instant effect, topical therapeutic medicine commonly used mostly is unguentum and suppository at present, their shortcoming is that the inside and outside medicine of anal canal can not with lesion, to keep continuous and effective contact, be distributed in the drug dose of lesion unstable, and the outer medicine of anus is easily glued and goes by medicated clothing, affects the treatment.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Novel suppository of being made by Chinese medicine composition that can effectively treat the various symptoms of hemorrhoid.

For solving above-mentioned technical problem, one group of Chinese medicine provided by the invention is comprised of the pharmacodynamic raw materials of following weight portion: Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, each 10-20 part of Herba Hedyotidis Diffusae, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, each 25-35 part of Calamina, muscone 0.03-0.09 part.

As optimal way, pharmacodynamic raw materials by weight consists of: Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, Herba Hedyotidis Diffusae each 15, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, Calamina each 30, muscone 0.06

Be more than the basic composition of this Chinese medicine composition, can also add and subtract according to practical situation on this basis, with strong curative effect once.

In Chinese medicine composition of the present invention, Herba Schizonepetae, Radix Sophorae Flavescentis, Borneolum Syntheticum can disappear skin ulcer, hemostasis, be aided with Fructus Zanthoxyli, Herba Menthae pain relieving, antibacterial, and Herba Hedyotidis Diffusae, Flos Lonicerae have the effect of heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, and Galla Chinensis, Calamina be the removing dampness sore; Rush down again wetly with the dry soil of Rhizoma Smilacis Glabrae, let out turbid removing toxic substances, with Moschus blood circulation promoting and dispersing pathogen accumulation, alleviating pain and detumescence.

The present invention solves the technical scheme that above technical problem adopts: with nontoxic, elasticity, it is wide that very thin material is made into a kind of basilar part, cervical region is slightly thin, top is thick, head point circle, tubbiness, thin, soft, the fiber sack that retractility is large, the support ring that the basilar part of sack is made by elastomeric material supports, it can prevent that the stype bag from all entering anal, first this bag is filled up to medicine while making stype, and then at its surface coverage one deck medicine, make the whole embedding sacks of medicine make stype, stype is subject to after body temperature heating in vivo can deliquescing, basilar part is fixed on the material liners that is similar to sanitary towel, then sealing, opening the sealing on top during use can use, during taking-up, traction liner bears pushing out ring can take out.

This real beneficial effect of the invention: the ZHICHUAN SHUAN curative effect that the Chinese medicine composition of this weight portion is made ZHICHUAN SHUAN curative effect more in the past is high, medicine is abundant to the contact of pathological tissues.Hemorrhoid are all generally outthrust, the stype bag can change shape to adapt to the anal external series gap under the effect of power, due to the medicated bag parcel medicament good by drug permeability, medicine is unlikely to shrink and be extruded into other places with anal canal, medicine can see through the fine fibre bag and be penetrated into local organization, can slowly be discharged into lesion, due to the stype shape-plastic, medicine can be stablized and is distributed to lesion and continues to work, in addition because it is special formed, to internal hemorrhoid, external hemorrhoid, mixed hemorrhoid can well be fitted, simultaneously under the protection of basilar part mat and sack, medicine can fully contact lesion, and not sticky underwear.

Preparation method

The manufacture method of Chinese medicine composition suppository of the present invention is: by Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, Herba Hedyotidis Diffusae respectively, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, Calamina respectively, muscone carries out respectively calcine and pulverizes rear 200 mesh sieves of crossing, make powder, mixing according to the above ratio with upper composition, the above-mentioned powder of making will be added after fat-soluble suppository substrate heat fused while hot, stirring makes its mix homogeneously, make drug matrices, after slightly cold, pour in the bolt mould, cooling, put the fibrous plug bag of band after the taking-up stype, be coated with the above-mentioned drug matrices of making of last layer on the fibrous plug bag surface that will install stype, after cooling, be fixed on liner, then seal standby.

Below in conjunction with drawings and Examples, the present invention is further described, and figure is depicted as the moulding ZHICHUAN SHUAN schematic diagram of light self adaptation.

In figure, 1 is the stype body, its features of shape is that middle part is thick, top taper section circle is blunt, this moulding is conducive to key and fills in anal canal, 2 is the stype cervical region, position belongs to the thinnest position herein, it connects anal key section and just stype basilar part outdoors, when stype is filled in anus, medicine is subject to thermal softening, this cervical region can become very thin after being pushed by anus, because whole key is wrapped in herein and can rupture by the fiber medicated bag, selected fiber medicated bag has good permeability in addition, ingredient concentration herein can not reduce, 3 elastic rings that are basilar part, its effect is to support fiber medicated bag basilar part, prevent that whole stype from falling into anal, the medicine of protection base part works outside anus, the stype of this moulding is for internal hemorrhoid, external hemorrhoid, mixed hemorrhoid all has good adaptability, particularly aspect the treatment mixed hemorrhoid, compare the special advantage that has more with other ZHICHUAN SHUAN, 4 is gasket material, its effect is that fixedly the stype basilar part is not subject to drug contamination with the protection medicated clothing, when treatment finishes, traction place can be taken out whole stype bag.

The specific embodiment

During treatment, the patient gets dorsal position or the position of squatting down, first the sealing outer package of stype is gone out, expose stype and liner, live the pad centers position with hand rest, stype is slowly inserted to anus, allow basilar part remain on outside anus, then put on underwear, use twice, 7 day course for the treatment of every day, administration time 2-3 course for the treatment of.

Example 1: the suppository Chinese medicine composition for the treatment of hemorrhoid forms by the pharmacodynamic raw materials of following weight portion: Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, Herba Hedyotidis Diffusae each 15, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, Calamina each 30, muscone 0.06.

Example 2: the suppository Chinese medicine composition for the treatment of hemorrhoid forms by the pharmacodynamic raw materials of following weight portion: Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, Herba Hedyotidis Diffusae each 10, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, Calamina each 25, muscone 0.03.

Example 1: the suppository Chinese medicine composition for the treatment of hemorrhoid forms by the pharmacodynamic raw materials of following weight portion: each 20 parts of Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, Herba Hedyotidis Diffusae, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, Calamina each 35, muscone 0.09.

Clinical curative effect analysis

1. general material and Therapeutic Method: selected case is the following mixed hemorrhoid of moderate, and treatment group 47 examples, carry out clinical treatment observation by hemorrhoid suppositories of the present invention, each one piece, fill in anuses, matched group 38 examples 2 every day, by HUAZHI SHUAN each one piece, every day 2 plug anuses, two groups for the treatment of times are 3 weeks.

2. curative effect determinate standard

Recovery from illness: the transference cures such as pain, stool band blood, pruritus, the hemorrhoid body narrows down to original below 20%

Take a turn for the better: the pain symptom transference cures such as being with blood that substantially disappears, defecate, the hemorrhoid body narrows down to original 20%-80%.

Invalid: after treatment, symptom has no and alleviates or increase the weight of.

3. therapeutic outcome

Take a turn for the better	Number of cases	Recovery from illness (%)	Take a turn for the better (%)	Invalid (%)	Effectively (%)
						Treatment group	47	31（66.0％）	16（34.0％）	0（0.0％）	47（100％）
Matched group	43	21（48.8％）	12（27.9％）	5（11.6％）	33（76.7％）

[0026]?

Claims

1. the moulding ZHICHUAN SHUAN of self adaptation, the raw material that it is characterized in that this effective ingredient forms, its weight proportion (Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, each 10-20 part of Herba Hedyotidis Diffusae, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, each 25-35 part of Calamina, muscone 0.03-0.09 part), and the material of ZHICHUAN SHUAN, shape structure: with nontoxic, elasticity, it is wide that very thin material is made a kind of basilar part, cervical region is slightly thin, top is thick, head point circle, tubbiness, thin, soft, the sack that retractility is large, the support ring that the basilar part of sack is made by elastomeric material supports, fill up medicine in bag, and at its surface coverage one deck medicine, make medicine embedding bolt bag.

2. Chinese medicine composition according to claim 1, it is characterized in that being made by the pharmacodynamic raw materials of following weight portion: Herba Schizonepetae, Fructus Zanthoxyli, Herba Menthae, each 10-20 part of Herba Hedyotidis Diffusae, Flos Lonicerae, Galla Chinensis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Borneolum Syntheticum, each 25-35 part of Calamina, muscone 0.03-0.09 part.

3. the moulding ZHICHUAN SHUAN of self adaptation according to claim 1, it is characterized in that: key can adapt to the anal canal surrounding, can be automatically moulding, reliably keep that medicine contacts with pathological tissues, the sustained release drug effect, comprise above-mentioned fibrous plug bag, support ring, key shape.