CN103479865A

CN103479865A - Traditional Chinese medicinal tablet for treating heart diseases

Info

Publication number: CN103479865A
Application number: CN201210197211.XA
Authority: CN
Inventors: 王磊; 金兆祥; 张宇
Original assignee: Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
Current assignee: Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
Priority date: 2012-06-15
Filing date: 2012-06-15
Publication date: 2014-01-01

Abstract

The invention discloses a traditional Chinese medicinal tablet. The traditional Chinese medicinal tablet is prepared by using Rehmannia glutinosa Libosch, Millettia dielsiana, Radix Ophiopogonis, licorice root, Polygonum multiflorum, donkey-hide gelatin, Chinese magnoliavine, Radix Codonopsis, Tortoiseshell, Chinese date and cassia twig. Medicines comprising the Rehmannia glutinosa Libosch, the Radix Ophiopogonis, and the Millettia dielsiana are selected against qi and ying deficiency type coronary heart diseases, so the tablet has the efficacies of heart nourishing, blood enriching, lactation promoting and pain relieving. The table can be clinically used for treating chest impediment, cardiodynia, severe palpitation and the like.

Description

A kind of Chinese medicinal tablet for the treatment of heart disease

Technical field

The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicinal tablet, and its production and use.

Background technology

It is fast or slow that " arrhythmia " refers to heart beating, surpassed general range.The tachycardia that abnormality of cardiac automaticity or conductive impairment cause, bradycardia or arrhythmia; Psychentonia, a large amount of smoking, to drink, drink strong tea or coffee, overtired, serious insomnia etc. normal be ARR risk factor; Arrhythmia is more common in the cardiac especially, also often occur in anesthesia, the operation in or the operation after.Arrhythmia belongs to the cardiopalmus, palpitation with a distress feeling, the thoracic obstruction of the traditional Chinese medical science, the category such as dizzy, shows as irregularly intermittent pusle, regularly intermittent pulse, irregular-rapid pulse, retarded pulse and rapid pulse etc. on pulse condition.The traditional Chinese medical science, to arrhythmia, is generally treated with decoction.At first should distinguish the type of disease during diagnosis and treatment, and then select different decoction for the treatment according to dissimilar.

1, the deficient type of the motive

Show as palpitation and uneasiness, white, the uncomfortable in chest weak breath of complexion white light, spiritlessness and weakness, pale lips, hands and feet being not warm, the lazy speech of spontaneous perspiration.Pale tongue, white and thin fur, weak pulse is unable.

2, flaccidity of the heart-yang type

Show as shortness of breath and palpitation, weak breath is unable, and low voice breath is short, and painful abdominal mass is vexed in the heart, at nightfall for very.Fear of cold happiness temperature or extreme cold of the limbs, clear urine in large amounts, soft stool.Pale tongue, white and moist fur, deep pulse or deep and slow, late heavy.

3, insufficiency of heart-YIN type

Show as the cardiopalmus agitation, have a dizzy spell, flushed cheeks tinnitus, dry mouth and throat and drink less, the poor dreaminess of sleeping, low grade fever night sweat, body constitution are thin and weak.Red tongue, few tongue or light stripping, thready and rapid pulse.

4, type of insufficiency of heart-blood

Show as that cardiopalmus, palpitation with a distress feeling, the head are giddy, lusterless complexion, dysphoria and insomnia, dreaminess, lethargy, lip and nail color be light.Pale tongue, white and thin fur, thready and weak pulse.

5, type of deficiency of both the heart and spleen

Show as palpitation and amnesia, insomnia and dreamful sleep, lusterless complexion, spiritlessness and weakness, inappetence, abdominal distention loose stool.The woman can have Hypomenorrhea, color is light or not to the utmost dripping.Pale and tender tongue, thready and weak pulse.

6, kidney-essence deficiency

(1) congenital defect hypoplasia: be more common in In Congenital Heart Disease, show as hypoevolutism, of short and small stature, often out of breath, cardiopalmus is uncomfortable in chest, the lip dark purple, when movable, cardiopalmus, sx↑ uncomfortable in chest, out of breath, even apasm of coughing occurs, can alleviate under quiescent condition.Body constitution is thin and weak, easy to catch cold, indigestion and loss of appetite, irregularly intermittent and regularly intermittent pulse.

(2) throw off restraint the day after tomorrow hack wound, kidney essense is exhausted: because health preserving is careless, sexual urge is excessive, unscrupulously hacks wound, damage, exhaustion and geromorphism occurs, deafness and tinnitus, forgetful dimly, body constitution is become thin, fatigue and weak, soreness of waist and knee, impotence and seminal emission, loss of hairs luxated tooth.The symptoms such as severe palpitation, insomnia and dreamful sleep, dizzy dizziness appear then.Deficient and thready pulse unable or the knot generation.

Summary of the invention

The object of the invention is, a kind of Chinese medicinal tablet is provided.

Another object of the present invention is to provide the preparation method of this Chinese medicinal tablet.

Another object of the present invention is to provide the purposes of this Chinese medicinal tablet.

A kind of Chinese medicinal tablet of the present invention is prepared from by ten a herbs such as Radix Rehmanniae, Caulis Spatholobi, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Polygoni Multiflori, Colla Corii Asini, Fructus Schisandrae Chinensis, Radix Codonopsis, Carapax Et Plastrum Testudinis, Fructus Jujubae, Ramulus Cinnamomi.It has selected the medicines such as Radix Rehmanniae, Radix Ophiopogonis, Caulis Spatholobi for coronary artery disease with deficiency of both qi and yin, having nourishes heart enriches blood, the effect of coronary circulation-promoting pain-relieving.Clinically can be used for treating the diseases such as obstruction of qi in the chest and cardialgia, severe palpitation.

The medical material used all meet " regulation of Chinese pharmacopoeia comprises:

Radix Rehmanniae: the fresh or dried root that this product is scrophulariaceae rehmannia glutinosa plant Rehmania glutinosa Libosch..Excavate autumn, except removing LU, fibrous root and silt, and using fresh herb; Or Radix Rehmanniae is slowly dried and irons to approximately most probably dry.The former practises title " Radix Rehmanniae ", and the latter practises title " Radix Rehmanniae ".This product should meet the pertinent regulations under the 82nd page of Radix Rehmanniae item of Chinese Pharmacopoeia version First in 2005.

Caulis Spatholobi: formal name used at school: Millettia dielsiana is the plant of pulse family Millettia.

Radix Ophiopogonis: the dried root that this product is liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..Excavate summer, cleans, and repeatedly is exposed to the sun, banks up. to very likely in, remove fibrous root, drying.

Radix Glycyrrhizae: the dry root and rhizome that this product is glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and remove fibrous root, dry.This product should meet the pertinent regulations under the 59th page of Radix Glycyrrhizae item of Chinese Pharmacopoeia version First in 2005.

Radix Polygoni Multiflori Preparata: the Preparation process product that this product is Radix Polygoni Multiflori should meet the pertinent regulations under Chinese Pharmacopoeia version First Radix Polygoni Multiflori Preparata item in 2005.

The dried root that Radix Polygoni Multiflori is the few Plant-Polygonum Polygonum multiflorum Thunb. of section. autumn, two season of winter excavate when leaf is withered, and the two ends of pruning are cleaned, individual large piece, the drying of being cut into.This product should meet the pertinent regulations under Chinese Pharmacopoeia version Radix Polygoni Multiflori item in 2005.

Colla Corii Asini: the dry skin that this product is equine species donkey Equus asinus L. or Cortex Dictamni are through decoction, the dense solid gum of carefully making.This product should meet the pertinent regulations under the 130th page of Colla Corii Asini item of Chinese Pharmacopoeia version First in 2005.

Fructus Schisandrae Chinensis: the dry mature fruit that this product is magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..Practise and claim " Radix Schisandrae Bicoloris ".Pluck during fruit maturation autumn, dry or steam after dry, remove carpopodium and impurity.This product should meet the pertinent regulations under Chinese Pharmacopoeia five tastes subitem.

Radix Codonopsis: the dry root that this product is Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var.modesta (Nannf.) L T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Excavate autumn, cleans, and dries.

Carapax Et Plastrum Testudinis (vinegar system): carapace and sternite that this product is Testudinidae animal Testudinis Chinemys reevresii (Gray).All can catch the whole year, take the autumn, kill after seizure as many in two seasons of winter, or with boiling water, scald deadly, strip carapace and sternite, remove residual meat, dry.This product should meet the pertinent regulations under the 125th page of Carapax Et Plastrum Testudinis (vinegar system) item of Chinese Pharmacopoeia version First in 2005.

Fructus Jujubae: the dry mature fruit that this product is Rhamnaceae plant Fructus Jujubae Ziziphus jujuba Mill..Gather during fruit maturation autumn, dries.This product should meet the pertinent regulations under the 16th page of Fructus Jujubae item of Chinese Pharmacopoeia version First in 2005.

Ramulus Cinnamomi: the dry twig that this product is canella Cortex Cinnamomi Cinnamomum cassia Rresl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.This product should meet the pertinent regulations under the 195th page of Ramulus Cinnamomi item of Chinese Pharmacopoeia version First in 2005.

A kind of Chinese medicinal tablet of the present invention, adopt following raw material medicaments to be prepared from: 50～300 parts of Radix Rehmanniae, 50～300 parts of Caulis Spatholobis, 30～100 parts of Radix Ophiopogonis, 30～100 parts, Radix Glycyrrhizae, 30～100 parts of Radix Polygoni Multiflori, 30～100 parts, Colla Corii Asini, 30～100 parts of Fructus Schisandrae Chinensis, 30～100 parts of Radix Codonopsis, 20～90 parts of Carapax Et Plastrum Testudiniss, 20～90 parts, Fructus Jujubae, 10～30 parts of Ramulus Cinnamomi.

Preferably, a kind of Chinese medicinal tablet of the present invention is prepared from by the medicine of following weight parts: 80～200 parts of Radix Rehmanniae, 80～200 parts of Caulis Spatholobis, 40～80 parts of Radix Ophiopogonis, 40～80 parts, Radix Glycyrrhizae, 40～80 parts of Radix Polygoni Multiflori, 40～80 parts, Colla Corii Asini, 40～80 parts of Fructus Schisandrae Chinensis, 40～80 parts of Radix Codonopsis, 30～70 parts of Carapax Et Plastrum Testudiniss, 30～70 parts, Fructus Jujubae, 15～25 parts of Ramulus Cinnamomi.

Most preferably, a kind of Chinese medicinal tablet of the present invention is prepared from by the medicine of following weight parts: 100 parts of Radix Rehmanniae, 100 parts of Caulis Spatholobis, 60 parts of Radix Ophiopogonis, 60 parts, Radix Glycyrrhizae, 60 parts of Radix Polygoni Multiflori, 60 parts, Colla Corii Asini, 60 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Codonopsis, 40 parts of Carapax Et Plastrum Testudiniss, 40 parts, Fructus Jujubae, 20 parts of Ramulus Cinnamomi.

In order to reach better effect, in a kind of Chinese medicinal tablet of the present invention, Radix Polygoni Multiflori can be selected Radix Polygoni Multiflori Preparata, and Carapax Et Plastrum Testudinis can be selected Carapax et Plastrum Testudinis(processed with vinegar).

A kind of Chinese medicinal tablet of the present invention can adopt following methods to prepare active component for crude drug: as one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, infusion process, percolation, reflux extraction, continuous circumfluence extraction method, macroreticular resin absorbing method.But, in order to make each crude drug of this medicine bring into play better drug effect, the present invention preferably adopts following technique to extract active component to raw material, with together with acceptable adjuvant pharmaceutically, make tablet.

A kind of Chinese medicinal tablet of the present invention adopts following step to be prepared from:

A. according to the following weight portion material of getting it filled: 50～300 parts of Radix Rehmanniae, 50～300 parts of Caulis Spatholobis, 30～100 parts of Radix Ophiopogonis, 30～100 parts, Radix Glycyrrhizae, 30～100 parts of Radix Polygoni Multiflori, 30～100 parts, Colla Corii Asini, 30～100 parts of Fructus Schisandrae Chinensis, 30～100 parts of Radix Codonopsis, 20～90 parts of Carapax Et Plastrum Testudiniss, 20～90 parts, Fructus Jujubae, 10～30 parts of Ramulus Cinnamomi;

B. get Fructus Schisandrae Chinensis, supercritical extraction, obtain extract standby; Get Radix Polygoni Multiflori, alcohol reflux, obtain extract standby; Get Ramulus Cinnamomi, supercritical extraction, obtain extract standby; Except Colla Corii Asini, all the other medical material extracting in waters, obtain extracting solution, adds the ethanol precipitation, reclaims ethanol and obtain extractum, standby; Colla Corii Asini is worn into fine powder,

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, gets Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, the first water decoction of Fructus Schisandrae Chinensis Six-element medical material, precipitate with ethanol after merging decocting liquid, supernatant concentration becomes extractum, standby; Medicinal residues are used alcohol reflux again, and extracting solution is condensed into extractum, standby; Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi alcohol reflux, extracting solution is crossed polyamide column, and first water rinses, use again the aqueous alkali eluting, collect eluent and regulate pH value with hydrochloric acid, be condensed into extractum and be ground into fine powder with Carapax Et Plastrum Testudinis and Colla Corii Asini and mix, drying, obtain the hybrid medicine powder standby;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, gets Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction, precipitate with ethanol after merging decocting liquid, supernatant concentration is to becoming extractum, standby; Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi supercritical CO ₂extraction, get extract, adds appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate, standby; Caulis Spatholobi, Radix Polygoni Multiflori ethanol extraction, extracting solution is crossed the aluminium sesquioxide post, and first water rinses, then uses the aqueous alkali eluting, collects eluent and regulates pH value with hydrochloric acid, is condensed into extractum and mixes with donkey-hide gelatin fine powder, clathrate with Carapax Et Plastrum Testudinis, and drying, obtain the hybrid medicine powder standby;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder; Get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction, collect extracting solution, concentrated, cross macroporous resin column, first wash with water to colourless, then use ethanol elution, collect eluent and be condensed into extractum, standby; Caulis Spatholobi, Radix Polygoni Multiflori ethanol extraction, extracting solution is condensed into extractum, standby; The Ramulus Cinnamomi supercritical CO ₂extraction volatile oil, add appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate, with Carapax Et Plastrum Testudinis, donkey-hide gelatin fine powder, extractum, mixes, and drying, obtain the hybrid medicine powder standby;

C. the extract obtained in step b mixes, and together with suitable adjuvant, makes tablet.

Preferably, a kind of Chinese medicinal tablet of the present invention adopts following step to be prepared from:

A. according to the following weight portion material of getting it filled: 80～200 parts of Radix Rehmanniae, 80～200 parts of Caulis Spatholobis, 40～80 parts of Radix Ophiopogonis, 40～80 parts, Radix Glycyrrhizae, 40～80 parts of Radix Polygoni Multiflori, 40～80 parts, Colla Corii Asini, 40～80 parts of Fructus Schisandrae Chinensis, 40～80 parts of Radix Codonopsis, 30～70 parts of Carapax Et Plastrum Testudiniss, 30～70 parts, Fructus Jujubae, 15～25 parts of Ramulus Cinnamomi;

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 20～30MPa, 40～50 ℃ of conditions, use supercritical CO ₂extract 1～3h and carry out supercritical extraction, obtain extract standby; Get Radix Polygoni Multiflori, with 6～8 times of amount 70～90% alcohol reflux 1～3 time, extract 1～3 hour at every turn, obtain extract standby; Get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 20～30MPa, 30～50 ℃ of conditions, use supercritical CO ₂extract 3～5h and carry out supercritical extraction, obtain extract standby; Except Colla Corii Asini, all the other medical materials decoct with water 2-3 time, and 2-3 hour, decoct 0.5-1 hour the 2-3 time for the first time, merges decoction liquor, filters, and adds the ethanol precipitation, and standing over night, reclaim ethanol, is condensed into extractum (relative density 1.10～1.30); It is standby that Colla Corii Asini is worn into fine powder;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, getting the first water of Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material decocts 2～3 times, each 1～3 hour, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 50～70% containing the alcohol amount, supernatant concentration becomes the extractum of relative density 1.10～1.30 (60 ℃), standby; Medicinal residues are used alcohol reflux 2～3 times again, and each 1～3 hour, it is standby that extracting solution is condensed into the extractum of relative density 1.10～1.30 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi alcohol reflux 2～3 times, each 1～3 hour, extracting solution is crossed polyamide column, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 8～10 with hydrochloric acid, be condensed into the extractum of relative density 1.10～1.30 (60 ℃), with Carapax Et Plastrum Testudinis, with the Colla Corii Asini powder and fine powder, mix, drying, obtain the hybrid medicine powder standby again;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction 2～3 times, each 1～3 hour, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 50～70% containing the alcohol amount, supernatant concentration is standby to the extractum that becomes relative density 1.10～1.30 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi supercritical CO ₂extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂flow velocity 20-35L/h, extraction 2-5h, get extract, adds appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate standby; 60～80% alcohol reflux 2～3 times for Caulis Spatholobi, Radix Polygoni Multiflori, each 1～3 hour, extracting solution is crossed the aluminium sesquioxide post, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 8～10 with hydrochloric acid, be condensed into the extractum of relative density 1.10～1.30 (60 ℃), with Carapax Et Plastrum Testudinis, with Colla Corii Asini powder and fine powder, clathrate, mix, drying, obtain the hybrid medicine powder standby again;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder; Get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction 2～3 times, each 1～3 hour, collect extracting solution, concentrated, cross macroporous resin column, first wash with water to colourless, then use 30～40% ethanol elutions, collecting eluent, to be condensed into the extractum of relative density 1.10～1.30 (60 ℃) standby; 50～70% alcohol reflux 2～3 times for Caulis Spatholobi, Radix Polygoni Multiflori, each 1～3 hour, it is standby that extracting solution is condensed into the extractum of relative density 1.10～1.30 (60 ℃); The Ramulus Cinnamomi supercritical CO ₂extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂flow velocity 20-35L/h, extraction 2-5h, add appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate, with Carapax Et Plastrum Testudinis, donkey-hide gelatin fine powder, extractum, mixes, and drying, obtain the hybrid medicine powder standby;

C. the extractum obtained in step b mixes, and together with suitable adjuvant, makes tablet.

Most preferably, a kind of Chinese medicinal tablet of the present invention adopts following step to be prepared from:

A. according to the following weight portion material of getting it filled: 100 parts of Radix Rehmanniae, 100 parts of Caulis Spatholobis, 60 parts of Radix Ophiopogonis, 60 parts, Radix Glycyrrhizae, 60 parts of Radix Polygoni Multiflori, 60 parts, Colla Corii Asini, 60 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Codonopsis, 40 parts of Carapax Et Plastrum Testudiniss, 40 parts, Fructus Jujubae, 20 parts of Ramulus Cinnamomi;

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 45 ℃ of conditions, use supercritical CO ₂extract 2h and carry out supercritical extraction, obtain extract standby; Get Radix Polygoni Multiflori, with 7 times of amount 80% alcohol reflux 2 times, extract 2 hours at every turn, obtain extract standby; Get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 40 ℃ of conditions, use supercritical CO ₂extract 4h and carry out supercritical extraction, obtain extract standby; Except Colla Corii Asini, all the other medical materials decoct with water 3 times, and 2 hours for the first time, decoct 1 hour for the 2-3 time, merge decoction liquor, filter, add the ethanol precipitation, standing over night, reclaim ethanol, is condensed into extractum (relative density 1.20); It is standby that Colla Corii Asini is worn into fine powder;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, getting the first water of Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material decocts 2 times, each 2 hours, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 60% containing the alcohol amount, supernatant concentration becomes the extractum of relative density 1.20 (60 ℃), standby; Medicinal residues are used alcohol reflux 3 times again, and each 2 hours, it is standby that extracting solution is condensed into the extractum of relative density 1.20 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi alcohol reflux 2 times, each 2 hours, extracting solution is crossed polyamide column, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 9 with hydrochloric acid, be condensed into the extractum of relative density 1.20 (60 ℃), with Carapax Et Plastrum Testudinis, with the Colla Corii Asini powder and fine powder, mix, drying, obtain the hybrid medicine powder standby again;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction 3 times, each 2 hours, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 60% containing the alcohol amount, supernatant concentration is standby to the extractum that becomes relative density 1.20 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi supercritical CO ₂extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂flow velocity 20-35L/h, extraction 2-5h, get extract, adds appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate standby; 70% alcohol reflux 3 times for Caulis Spatholobi, Radix Polygoni Multiflori, each 2 hours, extracting solution is crossed the aluminium sesquioxide post, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 9 with hydrochloric acid, be condensed into the extractum of relative density 1.20 (60 ℃), with Carapax Et Plastrum Testudinis, with Colla Corii Asini powder and fine powder, clathrate, mix, drying, obtain the hybrid medicine powder standby again;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder; Get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction 3 times, each 2 hours, collect extracting solution, concentrated, cross macroporous resin column, first wash with water to colourless, then use 35% ethanol elution, collecting eluent, to be condensed into the extractum of relative density 1.20 (60 ℃) standby; 60% alcohol reflux 2 times for Caulis Spatholobi, Radix Polygoni Multiflori, each 2 hours, it is standby that extracting solution is condensed into the extractum of relative density 1.20 (60 ℃); The Ramulus Cinnamomi supercritical CO ₂extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂flow velocity 20-35L/h, extraction 2-5h, add appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate, with Carapax Et Plastrum Testudinis, donkey-hide gelatin fine powder, extractum, mixes, and drying, obtain the hybrid medicine powder standby;

Wherein, in order to reach better effect, in a kind of Chinese medicinal tablet of the present invention, Radix Polygoni Multiflori can be selected Radix Polygoni Multiflori Preparata, and Carapax Et Plastrum Testudinis can be selected Carapax et Plastrum Testudinis(processed with vinegar).A kind of Chinese medicinal tablet of the present invention, as active component, make arbitrary pharmaceutically acceptable tablet with suitable pharmaceutics adjuvant by Chinese medicine extract.According to absorption approach difference, tablet can be divided into oral tablet, buccal tablet, external sheet and other administration purposes tablets.For example, oral tablet comprises conventional tablet, slow releasing tablet, multilayer tablet, chewable tablet etc.; Buccal tablet, comprise oral cavity disintegration tablet, buccal tablet, Sublingual tablet etc.; The other administration route tablet comprises effervescent tablet, implant and hypodermic tablet etc.The concrete clinical indication of medicine according to the present invention, tablet of the present invention can be, but not limited to: conventional tablet, slow releasing tablet, multilayer tablet, oral cavity disintegration tablet, buccal tablet and Sublingual tablet etc.Described suitable adjuvant refers to the tablet that can together with Chinese medicine extract, make Chinese medicine, and for example filler, comprise starch, pregelatinized Starch, dextrin, lactose, mannitol, microcrystalline Cellulose, calcium sulfate etc.; Wetting agent, comprise distilled water and ethanol (common 30～70%); Binding agent, comprise hydroxypropyl cellulose (HPMC), polyvidone (PVP), starch slurry, rubber cement, CMC etc.; Disintegrating agent, comprise cross-linking sodium carboxymethyl cellulose, hydroxypropyl starch, polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose (L-HPC); Lubricant, comprise Talcum, magnesium stearate etc.

A kind of Chinese medicinal tablet of the present invention, described conventional tablet adopts following step to be prepared from:

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 45 ℃ of conditions, use supercritical CO ₂extract 2h and carry out supercritical extraction, obtain extract standby; Get Radix Polygoni Multiflori, with 7 times of amount 80% alcohol reflux 2 times, extract 2 hours at every turn, obtain extract standby; Get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 40 ℃ of conditions, use supercritical CO ₂extract 4h and carry out supercritical extraction, obtain extract standby; Except Colla Corii Asini, all the other medical materials decoct with water 3 times, and 2 hours for the first time, decoct 1 hour for the 2-3 time, merge decoction liquor, filter, add the ethanol precipitation, standing over night, reclaim ethanol, is condensed into extractum (relative density 1.20); Colla Corii Asini is worn into fine powder, standby;

Perhaps, above ten a herbs, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction 3 times, each 2 hours, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 60% containing the alcohol amount, supernatant concentration is standby to the extractum that becomes relative density 1.20 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori, Ramulus Cinnamomi supercritical CO ₂extraction, extracting pressure 5-40M Pa, temperature 35-60 ℃, CO ₂flow velocity 20-35L/h, extraction 2-5h, get extract, adds appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate standby; 70% alcohol reflux 3 times for Caulis Spatholobi, Radix Polygoni Multiflori, each 2 hours, extracting solution is crossed the aluminium sesquioxide post, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 9 with hydrochloric acid, be condensed into the extractum of relative density 1.20 (60 ℃), with Carapax Et Plastrum Testudinis, with Colla Corii Asini powder and fine powder, clathrate, mix, drying, obtain the hybrid medicine powder standby again;

C. the extractum that obtains in step b mixes, and adds starch, adds suitable water, makes soft material, crosses 30 mesh sieves and granulates, 50～60 ℃ of dryings 1～3 hour, granulate, tabletting.

A kind of Chinese medicinal tablet of the present invention, described dispersible tablet adopts following step to be prepared from:

The medical material selection is identical with conventional tablet with leaching process, and difference is the preparation process of dispersant: 5～20% microcrystalline Cellulose, 3～10% low-substituted hydroxypropyl celluloses, 2～12% polyvinylpolypyrrolidone, 1～5% sodium carboxymethyl cellulose; By Chinese medical concrete, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose, adopt 1～15% polyvinylpolypyrrolidone aqueous solution to make soft material, sieve (30 order), 30～50 ℃ of oven dry, granulate, tabletting.

The preparation method of a kind of Chinese medicinal tablet of the present invention, comprise the steps:

B. get Fructus Schisandrae Chinensis, supercritical extraction, obtain extract standby; Get Radix Polygoni Multiflori, alcohol reflux, obtain extract standby; Get Ramulus Cinnamomi, supercritical extraction, obtain extract standby; Except Colla Corii Asini, all the other medical material extracting in waters, obtain extracting solution, adds the ethanol precipitation, reclaims ethanol and obtain extractum, standby; Colla Corii Asini is worn into fine powder, standby;

Preferably, the preparation method of a kind of Chinese medicinal tablet of the present invention, comprise the steps:

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 20～30MPa, 40～50 ℃ of conditions, use supercritical CO ₂extract 1～3h and carry out supercritical extraction, obtain extract standby; Get Radix Polygoni Multiflori, with 6～8 times of amount 70～90% alcohol reflux 1～3 time, extract 1～3 hour at every turn, obtain extract standby; Get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 20～30MPa, 30～50 ℃ of conditions, use supercritical CO ₂extract 3～5h and carry out supercritical extraction, obtain extract standby; Except Colla Corii Asini, all the other medical materials decoct with water 2-3 time, and 2-3 hour, decoct 0.5-1 hour the 2-3 time for the first time, merges decoction liquor, filters, and adds the ethanol precipitation, and standing over night, reclaim ethanol, is condensed into extractum (relative density 1.10～1.30); Colla Corii Asini is worn into fine powder, standby;

Most preferably, the preparation method of a kind of Chinese medicinal tablet of the present invention, comprise the steps:

Wherein, in order to reach better effect, in a kind of Chinese medicinal tablet of the present invention, Radix Polygoni Multiflori can be selected Radix Polygoni Multiflori Preparata, and Carapax Et Plastrum Testudinis can be selected Carapax et Plastrum Testudinis(processed with vinegar).

C. with step b, in the extractum that obtains mix, add starch, add suitable water, make soft material, cross 30 mesh sieves and granulate, 50～60 ℃ of dryings 1～3 hour, granulate, tabletting.

A. the medical material selection is identical with conventional tablet with leaching process, and difference is the preparation of dispersant: 5～20% microcrystalline Cellulose, 3～10% low-substituted hydroxypropyl celluloses, 2～12% polyvinylpolypyrrolidone, 1～5% sodium carboxymethyl cellulose; By Chinese medical concrete, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose, adopt 1～15% polyvinylpolypyrrolidone aqueous solution to make soft material, sieve (30 order), 30～50 ℃ of oven dry, granulate, tabletting.

The application of a kind of Chinese medicinal tablet of the present invention in preparation treatment antiarrhythmic medicament.

Tablet of the present invention has the effect of supplementing QI and nourishing YIN, coronary circulation-promoting pain-relieving, the clinical disease of the deficiency of both QI and YIN for coronary heart diseases and angina pectoris and arrhythmia, and disease is seen chest pain, uncomfortable in chest, cardiopalmus, is breathed hard, irregularly intermittent and regularly intermittent pulse.

Above composition can increase or reduce according to corresponding ratio when producing, as large-scale production can or be take ton as unit with kilogram, small-scale production also can be in grams, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

A kind of Chinese medicinal tablet of the present invention has reasonable recipe, and determined curative effect has no adverse reaction etc. a little.

Beneficial effect

In order to understand better the present invention, below by " tablet of the present invention " and commercially available " TONGMAIYANGXINWAN ", having carried out comparative study aspect arrhythmia, its beneficial effect is described.

1 test material

1.1 laboratory animal

The KM mice, male and female half and half, be purchased from Beijing China Fukang biotech inc, the quality certification number: SCXK (capital) 2009-0004.

1.2 given the test agent

TONGMAIYANGXINWAN (commercially available), lot number B107327, provided by Lerentang Pharmaceutical Factory, Zhongxin Pharmaceutical Group Co., Ltd., Tianj.

Experimental agents: " tablet of the present invention " (calling in the following text: " medicine of the present invention ") is prepared according to the method for embodiment 1.

1.3 medicine and reagent

Lidocaine hydrochloride injection, lot number 1008051, Tianjin gold credit aminoacid company limited.

Chloroform, analytical pure, lot number 20110516, Tianjin Kermel Chemical Reagent Co., Ltd..

1.4 experimental apparatus

Analytical balance, Sartorius BP211D type, Sartorius AG.

2. test method

The KM mice is according to the body weight random packet, the blank group, positive drug lignocaine group (15mg/kg), " medicine of the present invention " basic, normal, high dosage group (5,10,20g crude drug/kg), " TONGMAIYANGXINWAN " basic, normal, high dosage group (5,10,20g crude drug/kg), every group 10, male and female half and half.

The lignocaine group is immediate observation after the tail vein injection single-dose.All the other each groups are gastric infusion, administration every day 1 time, successive administration 14 days.After last administration 60min, mice is dropped in the 500ml beaker of back-off, put a 0.5g rayon balls that contains the 5ml chloroform in beaker, mouse breathing stops taking out immediately cuts thoracic cavity open, and a situation arises for the perusal ventricular fibrillation, the chamber of the calculating every group of laboratory animal incidence rate of quivering.Increase the 1ml chloroform after mice of every test in cotton balls.Result of the test is carried out Fisher check and X 2 test with SPSS11.5 software.

Incidence rate %=(generation chamber quiver number of animals/this group all animals number) * 100% quivers in chamber

3. result of the test

3.1Fisher inspection statistics result:

The results are shown in Table 1.

Table 1 " medicine of the present invention " causes the impact (Fisher check) of quivering the mice chamber on chloroform

Compare * * P<0.01, * P<0.05 with the blank group

As shown in Table 1, the lidocaine injection single-dose of 15mg/kg can reduce chloroform and cause the incidence rate of quivering in the mice chamber, with matched group, compares, and utmost point significant difference (P<0.01) is arranged." medicine of the present invention " and 10 of 20g crude drug/kg, " TONGMAIYANGXINWAN " of 20g crude drug/kg can reduce chloroform and cause the incidence rate of quivering in the mice chamber, with matched group, compare, and significant difference (P<0.05, P<0.01) is arranged.

3.2 X 2 test statistical result:

The results are shown in Table 2.

Table 2 " medicine of the present invention " causes the impact (X 2 test) of quivering the mice chamber on chloroform

Compare * * P<0.01, * P<0.05 with the blank group

As shown in Table 2, the lidocaine injection single-dose of 15mg/kg can reduce chloroform and cause the incidence rate of quivering in the mice chamber, with matched group, compares, and utmost point significant difference (P<0.01) is arranged.10,20g crude drug/kg " medicine of the present invention " and 5,10,20g crude drug/kg TONGMAIYANGXINWAN can reduce chloroform and cause the incidence rate of quivering in the mice chamber, and comparing difference with matched group has statistical significance.

4 conclusions

Result of the test shows, commercially available " TONGMAIYANGXINWAN " and " medicine of the present invention " all has the reduction chloroform and bring out the quiver pharmacological action of incidence rate of mice chamber.Prompting " tablet of the present invention " has antiarrhythmic effect.

The specific embodiment

Further set forth by the following examples the preparation method of medicine of the present invention.

Embodiment 1

A. according to the following weight portion material of getting it filled: Radix Rehmanniae 100g, Caulis Spatholobi 100g, Radix Ophiopogonis 60g, Radix Glycyrrhizae 60g, Radix Polygoni Multiflori Preparata 60g, Colla Corii Asini 60g, Fructus Schisandrae Chinensis 60g, Radix Codonopsis 60g, Carapax Et Plastrum Testudinis (vinegar system) 40g, Fructus Jujubae 40g, Ramulus Cinnamomi 20g;

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 45 ℃ of conditions, use supercritical CO ₂extract 2h and carry out supercritical extraction, obtain extract standby;

C. get Radix Polygoni Multiflori, with 7 times of amount 80% alcohol reflux 2 times, extract 2 hours at every turn, obtain extract standby;

D. get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 40 ℃ of conditions, use supercritical CO ₂extract 4h and carry out supercritical extraction, obtain extract standby;

E. except Colla Corii Asini, all the other medical materials decoct with water 3 times, and 2 hours for the first time, decoct 1 hour for the 2-3 time, merge decoction liquor, filter, add the ethanol precipitation, standing over night, reclaim ethanol, is condensed into extractum (relative density 1.20);

F. Colla Corii Asini is worn into fine powder, with the extractum obtained in step b, step c, steps d and step e, mixes, and adds starch, makes soft material, granulates, and drying, arrange tabletting.

Embodiment 2

A. according to the following weight portion material of getting it filled: Radix Rehmanniae 50g, Caulis Spatholobi 50g, Radix Ophiopogonis 30g, Radix Glycyrrhizae 30g, Radix Polygoni Multiflori Preparata 30g, Colla Corii Asini 30g, Fructus Schisandrae Chinensis 30g, Radix Codonopsis 30g, Carapax Et Plastrum Testudinis (vinegar system) 20g, Fructus Jujubae 20g, Ramulus Cinnamomi 10g;

Embodiment 3

A. according to the following weight portion material of getting it filled: Radix Rehmanniae 300g, Caulis Spatholobi 300g, Radix Ophiopogonis 100g, Radix Glycyrrhizae 100g, Radix Polygoni Multiflori Preparata 100g, Colla Corii Asini 100g, Fructus Schisandrae Chinensis 100g, Radix Codonopsis 100g, Carapax Et Plastrum Testudinis (vinegar system) 90g, Fructus Jujubae 90g, Ramulus Cinnamomi 30g;

Embodiment 4

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 30MPa, 50 ℃ of conditions, use supercritical CO ₂extract 3h and carry out supercritical extraction, obtain extract standby;

C. get Radix Polygoni Multiflori, with 8 times of amount 90% alcohol reflux 3 times, extract 3 hours at every turn, obtain extract standby;

D. get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 30MPa, 50 ℃ of conditions, use supercritical CO ₂extract 5h and carry out supercritical extraction, obtain extract standby;

E. except Colla Corii Asini, all the other medical materials decoct with water 3 times, and 2 hours for the first time, decoct 1 hour for the 2-3 time, merge decoction liquor, filter, add the ethanol precipitation, standing over night, reclaim ethanol, is condensed into extractum (relative density 1.30);

Embodiment 5

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 20MPa, 40 ℃ of conditions, use supercritical CO ₂extract 3h and carry out supercritical extraction, obtain extract standby;

C. get Radix Polygoni Multiflori, with 6 times of amount 70% alcohol reflux 3 times, extract 3 hours at every turn, obtain extract standby;

Embodiment 6

B. ten a herbs more than, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, getting the first water of Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material decocts 3 times, each 1 hour, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 50% containing the alcohol amount, supernatant concentration becomes the extractum of relative density 1.10 (60 ℃), standby; Medicinal residues are used alcohol reflux 3 times again, and each 1 hour, it is standby that extracting solution is condensed into the extractum of relative density 1.10 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori Preparata, Ramulus Cinnamomi alcohol reflux 2 times, each 1 hour, extracting solution is crossed polyamide column, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 8 with hydrochloric acid, be condensed into the extractum of relative density 1.10 (60 ℃), with Carapax Et Plastrum Testudinis, with the Colla Corii Asini powder and fine powder, mix, drying, obtain the hybrid medicine powder standby again;

C. add appropriate sodium carboxymethyl cellulose, Icing Sugar to above-mentioned drug powder, mix, granule processed, sieve, drying, tabletting and get final product.

Embodiment 7

A. according to the following weight portion material of getting it filled: Radix Rehmanniae 200g, Caulis Spatholobi 200g, Radix Ophiopogonis 80g, Radix Glycyrrhizae 80g, Radix Polygoni Multiflori Preparata 80g, Colla Corii Asini 80g, Fructus Schisandrae Chinensis 80g, Radix Codonopsis 80g, Carapax Et Plastrum Testudinis (vinegar system) 70g, Fructus Jujubae 70g, Ramulus Cinnamomi 25g;

F. Colla Corii Asini is worn into fine powder, with the extractum obtained in step b, step c, steps d and step e, mixes, and to above-mentioned drug powder, adds appropriate sodium carboxymethyl cellulose, Icing Sugar, mixes, and granule processed, sieve, drying, tabletting and get final product.

Embodiment 8

D. get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 30MPa, 50 ℃ of conditions, use supercritical CO ₂extract 4h and carry out supercritical extraction, obtain extract standby;

F. Colla Corii Asini is worn into fine powder, to above-mentioned drug powder, 20% microcrystalline Cellulose, 10% low-substituted hydroxypropyl cellulose and 5% sodium carboxymethyl cellulose, adopts 12% polyvinylpolypyrrolidone aqueous solution to make soft material, (30 order) sieves, 30～50 ℃ of oven dry, granulate, tabletting.

Embodiment 9

G. embodiment 10

A. take off the row medical material: Radix Rehmanniae 100g, Caulis Spatholobi 100g, Radix Ophiopogonis 60g, Radix Glycyrrhizae 60g, Radix Polygoni Multiflori Preparata 60g, Colla Corii Asini 60g, Fructus Schisandrae Chinensis 60g, Radix Codonopsis 60g, Carapax Et Plastrum Testudinis (vinegar system) 40g, Fructus Jujubae 40g, Ramulus Cinnamomi 20g is standby;

B. ten a herbs more than, it is standby that Carapax Et Plastrum Testudinis and Colla Corii Asini are ground into fine powder, get Radix Rehmanniae, Radix Codonopsis, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Fructus Schisandrae Chinensis Six-element medical material water extraction 3 times, each 3 hours, after merging decocting liquid, add 90% ethanol to be precipitated, make to reach 70% containing the alcohol amount, supernatant concentration is standby to the extractum that becomes relative density 1.30 (60 ℃); Get Caulis Spatholobi, Radix Polygoni Multiflori Preparata, Ramulus Cinnamomi supercritical CO ₂extraction, extracting pressure 40MPa, temperature 60 C, CO ₂flow velocity 35L/h, extraction 5h, get extract, adds appropriate anhydrous alcohol solution, with appropriate β-CD, carries out enclose, and drying, obtain clathrate standby; 80% alcohol reflux 3 times for Caulis Spatholobi, Radix Polygoni Multiflori Preparata, each 3 hours, extracting solution is crossed the aluminium sesquioxide post, first water rinses to nothing alcohol flavor, then uses the aqueous alkali eluting, collects eluent and regulates pH value 10 with hydrochloric acid, be condensed into the extractum of relative density 1.30 (60 ℃), with Carapax Et Plastrum Testudinis, with Colla Corii Asini powder and fine powder, clathrate, mix, drying, obtain the hybrid medicine powder standby again;

C. to above-mentioned drug powder, 5% microcrystalline Cellulose, 3% low-substituted hydroxypropyl cellulose and 1% sodium carboxymethyl cellulose, adopt 12% polyvinylpolypyrrolidone aqueous solution to make soft material, sieve (30 order), 30～50 ℃ of oven dry, granulate, tabletting.

Claims

1. a Chinese medicinal tablet adopts following step to be prepared from:

B. get Fructus Schisandrae Chinensis, supercritical extraction, obtain extract standby, get Radix Polygoni Multiflori, alcohol reflux, obtain extract standby, get Ramulus Cinnamomi, supercritical extraction, obtain extract standby, except Colla Corii Asini, all the other medical material extracting in waters, obtain extracting solution, adds the ethanol precipitation, it is standby that recovery ethanol obtains extractum, and Colla Corii Asini is worn into fine powder;

C. mix with the arbitrary extractum or the powder that obtain in step b, together with applicable adjuvant, make tablet.

2. tablet claimed in claim 1, wherein in step c, the preparation of tablet comprises one of following two kinds of methods:

Add starch, add suitable water, make soft material, cross 30 mesh sieves and granulate, 50～60 ℃ of dryings 1～3 hour, granulate, tabletting;

Perhaps, according to total amount, take off the row adjuvant: 5～20% microcrystalline Cellulose, 3～10% low-substituted hydroxypropyl celluloses, 2～12% polyvinylpolypyrrolidone, 1～5% sodium carboxymethyl cellulose; By Chinese medical concrete, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose, adopt 1～15% polyvinylpolypyrrolidone aqueous solution to make soft material, sieve (30 order), 30～50 ℃ of oven dry, granulate, tabletting.

3. tablet claimed in claim 2 adopts following step to be prepared from:

A. according to the following weight portion material of getting it filled: 80～200 parts of Radix Rehmanniae, 80～200 parts of Caulis Spatholobis, 40～80 parts of Radix Ophiopogonis, 40～80 parts, Radix Glycyrrhizae, 40～80 parts of Radix Polygoni Multiflori, 40～80 parts, Colla Corii Asini, 40～80 parts of Fructus Schisandrae Chinensis, 4080 parts of Radix Codonopsis, 30～70 parts of Carapax Et Plastrum Testudiniss, 30～70 parts, Fructus Jujubae, 15～25 parts of Ramulus Cinnamomi;

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 20～30MPa, 40～50 ℃ of conditions, use supercritical CO ₂extract 1～3h and carry out supercritical extraction, obtain extract standby, get Radix Polygoni Multiflori, with 6～8 times of amount 70～90% alcohol reflux 1～3 time, extract 1～3 hour at every turn, obtain extract standby, get Ramulus Cinnamomi, pulverize, in the supercritical extraction of packing into tank, under 20～30MPa, 30～50 ℃ of conditions, use supercritical CO ₂extract 3～5h and carry out supercritical extraction, obtain extract standby, except Colla Corii Asini, all the other medical materials decoct with water 2-3 time, the 1st 2-3 hour, decoct 0.5-1 hour the 2-3 time, merges decoction liquor, filter, add the ethanol precipitation, standing over night, reclaim ethanol, be condensed into the extractum of relative density 1.10～1.30, Colla Corii Asini is worn into fine powder;

C. mix with the arbitrary extractum or the powder that obtain in step b, add starch, add suitable water, make soft material, cross 30 mesh sieves and granulate, dry 2 hours of 40～50 ℃ of C, granulate, tabletting.

4. tablet claimed in claim 2 adopts following step to be prepared from:

B. get Fructus Schisandrae Chinensis, pulverize, in the supercritical extraction of packing into tank, under 25MPa, 45 ℃ of conditions, use supercritical CO ₂extract 2h and carry out supercritical extraction, obtain extract standby, get Radix Polygoni Multiflori, with 7 times of amount 80% alcohol reflux 2 times, extract 2 hours at every turn, obtain extract standby, get Ramulus Cinnamomi, pulverizing, in the supercritical extraction of packing into tank, under 25MPa, 40 ℃ of conditions, use supercritical CO ₂extract 4h and carry out supercritical extraction, obtain extract standby, except Colla Corii Asini, all the other medical materials decoct with water 3 times, the 1st time 2 hours, decoct 1 hour for the 2-3 time, merge decoction liquor, filter, add the ethanol precipitation, standing over night, reclaim ethanol, is condensed into the extractum of relative density 1.20, and Colla Corii Asini is worn into fine powder;

C. mix and add starch with the arbitrary extractum obtained in step b or powder, according to total amount, take off the row adjuvant: 5～20% microcrystalline Cellulose, 3～10% low-substituted hydroxypropyl celluloses, 2～12% polyvinylpolypyrrolidone, 1～5% sodium carboxymethyl cellulose; By Chinese medical concrete, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose, adopt 1～15% polyvinylpolypyrrolidone aqueous solution to make soft material, sieve (30 order), 30～50 ℃ of oven dry, granulate, tabletting.

5. the preparation method of a Chinese medicinal tablet is comprised of following steps:

B. get Fructus Schisandrae Chinensis, supercritical extraction, obtain extract standby, gets Radix Polygoni Multiflori, and alcohol reflux obtains extract standby; Get Ramulus Cinnamomi, supercritical extraction, obtain extract standby, and except Colla Corii Asini, all the other medical material extracting in waters, obtain extracting solution, adds the ethanol precipitation, and it is standby that recovery ethanol obtains extractum, and Colla Corii Asini is worn into fine powder;

C. mix with the extractum or the powder that obtain in step b, together with suitable adjuvant, make tablet.

6. the method for claim 5, wherein in step c, the preparation of tablet comprises one of following two kinds of methods:

7. method claimed in claim 5 is comprised of following steps:

C. mix with the arbitrary extractum or the powder that obtain in step b, add starch, add suitable water, make soft material, cross 30 mesh sieves and granulate, 40～50 ℃ of dryings 2 hours, granulate, tabletting.

8. method claimed in claim 5 is comprised of following steps:

9. the application of the described arbitrary tablet of claim 1～3 in preparing antiarrhythmic drug.