CN103463732A - Ultrasonic target position pore-forming device and method - Google Patents
Ultrasonic target position pore-forming device and method Download PDFInfo
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Abstract
The invention discloses an ultrasonic target position pore-forming device and method. The device comprises an ultrasonic driving power supply module (1), an ultrasonic transmitting module (2), a feedback adjusting module (3), a control module (4) and a display setting module (5), wherein the ultrasonic driving power supply module (1) is electrically connected with the ultrasonic transmitting module (2); the control module (4) is electrically connected with the ultrasonic driving power supply module (1), the ultrasonic transmitting module (2) and the display setting module (5) respectively; the feedback adjusting module (3) is electrically connected with the control module (4) and the display setting module (5). According to the device, one target point is irradiated by using a plurality of ultrasonic sound sources from different directions, so that the generation of an acoustic pore-forming effect caused by a cavatition effect in local biological tissues is enhanced. The radiation target point is moved sequentially, so that 3D printing type three-dimensional scanning can be realized on a target area, a biological through area is formed by tissues in the target area, and peripheral tissues keep normal structures and functions.
Description
Technical field
The present invention relates to a kind of ultrasound wave and promote the apparatus and method of medium to the transmission of organism inner target tissue, particularly a kind of non-thermal effect low-power multi beam ultrasound wave that utilizes is inputted medium the instrument field of organization internal.
Background technology
Acoustic horn effect is to utilize hyperacoustic cavitation, makes the double-layer of lipoid molecule arranging structure that forms biological tissue's film and cell membrane in radiation scope form the nanometer microfissure, thereby has improved the permeability of cell and tissue, is called again sound pore effect.Sound pore effect can make biological tissue's permeability in ul-trasonic irradiation zone improve, and forms the biological corridor of intensive Gong mass transfer; By hyperacoustic radiation pressure and convective transport effect, the power of material molecule to biological tissue's transmission is provided, make material molecule along established biological corridor to the target tissue directional transmissions, finally form material in local tissue and intracellular enrichment.Adopt this principle, can promote the interior transmission of tissue, gene transfection and the inoculation etc. of medicine.
Ultrasound wave absorbs for the topical transdermal that promotes medicine and the research of substance in vivo transmission has obtained considerable progress, and its know-why and mechanism of action are successfully verified, and enter product development and application stage.From last century the early eighties the former Russian scholar first open the research of ultrasonic local transdermal technology, and be applied to the clinical treatment of inflammation and infection; 1996 masschusetts, u.s.a science and engineering Langer R. find to confirm that low-frequency ultrasonic waves can improve the permeability of cell membrane and tissue film, can be as the power that promotes the medicine topical transdermal.It is theoretical that at first Katherine W. has proposed ultrasonic delivery, points out that ultrasonic urging will solve the gene drug delivery approach thoroughly.Britain Nikolitsa confirms that ultrasonic pore can be drawn and promotes the diffusion of chemotherapeutics from blood vessel to tissue, improves the cytotoxicity of chemotherapeutics.U.S. Bryant J. etc. observes ultrasonic and adriamycin effect effectively slows down the tumor propagation speed of tumor-bearing rat model.Germany Daffertshofer, M. etc. have observed the permeation of TCD,transcranial Doppler change blood brain barrier and can promote the thrombolytic effect of thrombolytic drug.The ultrasonic target position transdermal technical research of one time and exploitation show tempting application prospect, and researcheres are all tried to be the first and entered this research and development field, and have obtained abundant achievement in research.
But ultrasound wave promotes the effect that topical transdermal absorbs and substance in vivo transmits of medicine, depend on the intensity of ultrasonic energy, intensity is effective greatly.Yet large intensity can produce strong cavitation, can cause tissue injury.Therefore, should effectively improve tissue permeability, avoid again tissue injury, just require ultrasonic energy is control effectively and utilizes, reach appropriate cavitation and pore effect.For this reason, people have started the more deep exploratory development of a new round, and ultrasonic energy is efficiently controlled and utilized the important breakthrough of key technology not yet to realize so far.
The target area of desirable ultrasonic pore should be the scope of the 3D stereochemical structure of pathological tissues, if there is a kind of method can make appropriate cavitation effect only occur in lesion region, just can both meet the purpose that the target area tissue permeability improves, can avoid the generation of tissue injury again, the real target that realizes target position mass transfer in tissue.
Summary of the invention:
The present invention promotes the effect problem that topical transdermal absorbs and substance in vivo transmits of medicine in order to solve ultrasound wave of the prior art, the apparatus and method of a kind of ultrasound wave target position pore are provided, and its technical scheme is as follows:
A kind of ultrasound wave target position pore device, comprise that ultrasound wave driving power module, ultrasonic emitting module, feedback regulation module, control module and demonstration arrange module, described ultrasound wave driving power module and ultrasonic emitting module are electrically connected to, described control module arranges module with described ultrasound wave driving power module, ultrasonic emitting module and demonstration respectively and is electrically connected to, and described feedback regulation module arranges module with control module and demonstration and is electrically connected to.
Described ultrasound wave driving power module is used for generation, amplification and the modulation of the ultrasound-driven signal of telecommunication, and gives described ultrasonic emitting module by generated ultrasound-driven electrical signal transfer; Described ultrasonic emitting module, comprise M ultrasound wave conversion and transmitter unit, and the driving signal of telecommunication produced for receiving described ultrasound wave driving power module, be converted to ultrasound wave by the described driving signal of telecommunication, and by the different directions of setting by ultrasonic emitting out; Described M ultrasound wave changed and transmitter unit, can be according to the hyperacoustic transmit direction of routine change, cause ultrasonic beam to converge in the local appointed area of biological tissue inside, and the setting regions of organization internal is carried out to the scanning of 3D printing by adjusting convergent point; M >=2; Described feedback regulation module, the local organization density that gathers the sound wave convergent point for Real-time and Dynamic changes data signal, and be transferred to described control module, make described control module send corresponding control signal to described ultrasonic emitting module, with change launched power and the scanning speed of ultrasonic signal, and signal is transferred to described demonstration the real-time shows signal parameter of module is set; Described control module, arrange for accepting described demonstration command signal and the established procedure that module arranges, and the feedback signal of described feedback regulation module collection, in order to control described ultrasound wave driving power module, produces the power that ultrasound wave drives the signal of telecommunication; Simultaneously according to described command signal, established procedure and feedback signal, control M ultrasound wave conversion of described ultrasonic emitting module and transmitter unit ultrasonic emitting action time, transmit direction and regulate the speed, make the sequential layer by layer movement in tissue of described ultrasonic beam convergent point, realize converging the scanning of sound wave to the 3D printing of organizing local; Described demonstration arranges module and sends to described control module for command signal will be set, and shows the order parameter that arranges and carry out in real time.
Further, described ultrasound wave driving power module comprises signal of telecommunication generating unit, signal of telecommunication amplifying unit and signal of telecommunication modulating unit; Described signal of telecommunication modulating unit is electrically connected to parallel way with ultrasound wave conversion and the transmitter unit of described ultrasonic emitting module.
Further, the frequency of described ultrasound wave driving power module is 0.02-0.5MHz.
Further, described ultrasonic emitting module also comprises the linkage rotation unit be connected with each ultrasound wave conversion and transmitter unit.
Further, described feedback module comprises: signals collecting and transmission circuit.
Further, described control module comprises data processing unit, data storage cell and command signal transmitting element.
Further, described demonstration arranges module and comprises parameter setting circuit and operation display panel.
A kind of ultrasound wave target position pore method comprises the following steps:
Step 1: described ultrasound wave driving power module produces the ultrasound-driven signal of telecommunication, and M the ultrasound wave that is transferred to respectively described ultrasonic emitting module changed and transmitter unit;
Step 2: the M of described ultrasonic emitting module ultrasound wave changed and transmitter unit, will drive the signal of telecommunication to be converted to ultrasound wave, and emits by the different directions of setting, and through organizing interior conduction, makes M ultrasound beamformer converge in the appointed area of organization internal;
Step 3: described feedback regulation module changes data signal by the described density of sound wave convergent point of organizing of Real-time Collection, be transferred to described control module, make described control module send the power of corresponding change ultrasonic signal and the signal of scanning speed, and be transferred to described demonstration module is set.
Step 4: described control module is according to the established procedure of described setting and display module, send the instruction that changes beam direction to described ultrasonic emitting module, make the sequential layer by layer movement in tissue of described ultrasonic beam convergent point, realize converging the scanning of sound wave to the 3D printing of organizing local.
The beneficial effect of technique scheme of the present invention is as follows:
Adopt a plurality of ultrasonic sound sources (undercapacity of each sound source is so that tissue produces cavitation), from different orientation to a target spot irradiation, cause artificial sound wave stack, the sound pore effect that the cavitation of reinforcement causes occurs at the local tissue.The sequential mobile target spot of interfering, just can carry out the stereoscan of 3D printing to target area, make the tissue in target area form biological penetrating district, and surrounding tissue keeps normal configuration and function.So for realizing that ultrasonic target position mass transfer truly creates conditions.
Utilize the multi beam ultrasound wave to produce stack controlled, selectable, localization, carry out target position build up pore, improved the permeability of target area inner tissue to medium, form the penetrating district of biology of medium target position transmission in tissue, realization realizes the cavitation pore effect of maximum zone of control with lower ultrasonic power, then under ultrasonic power drive, make medium form the pinpoint enrichment of organizing, avoid the untoward reaction that outside the target area, not guilty radiation causes, can obtain border, the zone of action clearly.
The accompanying drawing explanation
The structural representation that Fig. 1 is the embodiment of the present invention 1,
The mice fluorescence living imaging analysis chart of the experiment ultrasound wave target position pore action effect that Fig. 2 is the embodiment of the present invention 1,
The experiment contrast figure that Fig. 3 is the embodiment of the present invention 1,
The experiment effect figure that Fig. 4 is the embodiment of the present invention 2, in figure, A is ultrasound wave target position pore action effect, B is the contrast effect,
The in vitro thrombosis thrombolytic rate changing trend diagram of different periods that Fig. 5 is the embodiment of the present invention 3.
The specific embodiment
For technical problem, technical scheme and advantage that the present invention is solved is clearer, be described in detail below in conjunction with the accompanying drawings and the specific embodiments.
Embodiment 1:
As shown in Figure 1, ultrasound wave target position pore device of the present invention, comprise that ultrasound wave driving power module 1, ultrasonic emitting module 2, feedback regulation module 3, control module 4 and demonstration arrange module 5, described ultrasound wave driving power module 1 and ultrasonic emitting module 2 are electrically connected to, described control module 4 arranges module 5 with described ultrasound wave driving power module 1, ultrasonic emitting module 2 and demonstration respectively and is electrically connected to, and described feedback regulation module 3 arranges module 5 with control module 4 and demonstration and is electrically connected to.
Described ultrasound wave driving power module 1 generation for the ultrasound-driven signal of telecommunication, amplification and modulation, and give described ultrasonic emitting module 2 by generated electrical signal transfer.The signal that ultrasound wave driving power module 1 produces low frequency signal source is amplified to the required power for the treatment of.Described ultrasound wave driving power module 1 comprises 1 signal of telecommunication generating unit, and such as low-frequency power, clock oscillator etc. drives the signal of telecommunication for generation of ultrasound wave; This module 1 also comprises 1 signal of telecommunication amplifying unit, and the amplification signal generating unit produces ultrasound wave and drives the signal of telecommunication; This module 1 also comprises 1 signal of telecommunication modulating unit, and the ultrasound wave after modulation is amplified drives the signal of telecommunication, and the generated signal of telecommunication is passed to ultrasound wave conversion and the transmitter unit of described ultrasonic emitting module 2, to produce the optimum current output program.The frequency of described ultrasound wave driving power module 1 is 0.5MHz.
Described ultrasonic emitting module 2, comprise 2 ultrasound wave conversions and transmitter unit, with signal of telecommunication modulating unit, with parallel way, is connected, and for receiving the described driving signal of telecommunication, the described driving signal of telecommunication is converted to ultrasound wave, and ultrasonic transmission is gone out; Described 2 ultrasound wave conversion and transmitter unit, can cause acoustic wave beam to converge in the part of biological tissue according to the hyperacoustic transmit direction of routine change, and the setting regions of organization internal is carried out to the scanning of 3D printing by adjusting convergent point; Signal source guarantees that the same phase ultrasonic signal occurs, and its frequency is at 0.5MHz.Described ultrasonic emitting module 2 also comprises the linkage rotation unit be connected with each ultrasound wave conversion and transmitter unit.For regulating the transmit direction of ultrasound beamformer.
The density that described feedback regulation module 3 receives for the Real-time and Dynamic collection local organization that converges sound wave changes data signal and is transferred to described control module 4, make it to send corresponding signal give described ultrasonic emitting module 2 with change launched power and the scanning speed of ultrasonic signal, and signal is transferred to described demonstration module 5 is set; Described feedback module 3 comprises: signals collecting and transmission circuit.
Described control module 4, arrange the command signal of module 5 settings and the feedback signal that described feedback regulation module 3 gathers for accepting described demonstration, in order to control described ultrasound wave driving power module 1, produces the power that ultrasound wave drives the signal of telecommunication; Simultaneously according to program and feedback signal instruction control 2 ultrasound wave conversions of described ultrasonic emitting module 2 and transmitter unit ultrasonic emitting action time, transmit direction and regulate the speed; Control module have control location, regularly, the described control module 4 of effect of energy adjustment comprises data processing unit, data storage cell and command signal transmitting element.Control module 4 can adopt single-chip microcomputer or PLC to realize controlling.
Described demonstration arranges module 5 and sends to described control module 4 for command signal will be set, and shows the order parameter that arranges and carry out in real time.Described demonstration arranges module 5 and comprises parameter setting circuit and operation display panel, can adopt button liquid crystal display screen or touch screen to realize man-machine interactive operation.
Using ultrasound ripple target position pore device of the present invention, the intravital mouse that a skin is scribbled to fluorescent enzyme gene plasmid gel carries out ultrasonic target position pore experiment, and operational approach comprises the following steps:
Step 1: described ultrasound wave driving power module 1 produces the ultrasound-driven signal of telecommunication, and 2 ultrasound wave that are transferred to respectively described ultrasonic emitting module 2 are changed and transmitter unit;
Step 2: the conversion of 2 ultrasound wave of described ultrasonic emitting module 2 and transmitter unit are placed on a fixed mount at a distance of the 3cm distance, be placed on the desired location of mouse web portion, and make 2 ultrasound wave conversions and transmitter unit transmit direction form the angle of 50 degree left and right, emit by the different directions of setting after driving the signal of telecommunication to be converted to ultrasound wave, make 2 ultrasound beamformers converge in the appointment target area in Mice Body; And, on ultrasound wave conversion and transmitter unit with the ultrasonic wave-coupled medium.
Step 3: described feedback regulation module 3 is placed on the desired location of mouse web portion, the density of the described sound wave convergent point of Real-time Collection is changed to data signal, be transferred to described control module 4, make it to send the power of corresponding change ultrasonic signal and the signal of scanning speed, and be transferred to described demonstration module 5 is set.
Step 4: described control module 4 is sent the instruction that changes beam direction to described ultrasonic emitting module 2, make described ultrasonic beam by the couplant between ultrasound wave conversion and transmitter unit and target area, converge in the abdominal part of mice, from an end of target area, start with certain speed, in tissue, back and forth sequential movement layer by layer, converge the scanning of sound wave to the 3D printing of target area organized whole until complete.
Effect: scan latter 24 hours, the effect mice carried out to the fluorescence living imaging and analyze (see figure 2), and with smear gene after adopt the mice with the single ultrasonic beam radiation of metering to be contrasted (see figure 3).The visible gene expression intensity that converges ultrasonication significantly is greater than the effect of single acoustic beam.
Embodiment 2:
The ultrasound wave driving power module 1 of ultrasound wave target position pore device of the present invention comprises 1 signal of telecommunication generating unit, such as low-frequency power, clock oscillator etc., drive the signal of telecommunication for generation of ultrasound wave, also comprise 1 signal of telecommunication amplifying unit, with 1 signal of telecommunication modulating unit, ultrasound wave after modulation is amplified drives the signal of telecommunication, and generated electrical signal transfer is given to ultrasound wave conversion and the transmitter unit of described ultrasonic emitting module 2, to produce the optimum current output program.The frequency of described ultrasound wave driving power module 1 is 0.1MHz.
The ultrasonic emitting module 2 of ultrasound wave target position pore device of the present invention, comprise 5 ultrasound wave conversions and transmitter unit, with the mode cubic arrangement of array, sent ultrasonic beam can be converged at same tissue regions.Described 5 ultrasound wave conversion and transmitter unit, can cause the movement of acoustic wave beam at the local convergent point of biological tissue according to the hyperacoustic transmit direction of routine change, and the setting regions of organization internal is carried out to the scanning of 3D printing by adjusting convergent point; Signal source guarantees that the same phase ultrasonic signal occurs, and its frequency is at 0.1MHz.Described ultrasonic emitting module 2 also comprises the linkage rotation unit be connected with each ultrasound wave conversion and transmitter unit, for regulating the transmit direction of ultrasound beamformer.
Using ultrasound ripple target position pore device of the present invention, carry out ultrasonic target position pore to the tissue of the animal livers as target area be immersed in the brazilwood dye aqueous solution, and concrete grammar comprises the following steps:
Step 1: described ultrasound wave driving power module 1 produces the ultrasound-driven signal of telecommunication, and 5 ultrasound wave that are transferred to respectively described ultrasonic emitting module 2 are changed and transmitter unit;
Step 2: the conversion of 5 ultrasound wave of described ultrasonic emitting module 2 and transmitter unit be placed on the wall of a canister that is full of aqueous solution at a distance of the 5cm distance and make both transmit directions form the angles of 30 degree left and right, emit by the different directions of setting after driving the signal of telecommunication to be converted to ultrasound wave, make 5 ultrasound beamformers converge in the appointment target area of aqueous solution liver organization inside;
Step 3: described feedback regulation module 3 is placed on the desired location of canister wall, the density of sound wave convergent point in the described liver organization of Real-time Collection is changed to data signal, be transferred to described control module 4, make it to send the power of corresponding change ultrasonic signal and the signal of scanning speed, and be transferred to described demonstration module 5 is set.
Step 4: described control module 4 is sent the instruction that changes beam direction to described ultrasonic emitting module 2, make described ultrasonic beam converge in the target area of animal livers tissue, from an end of target area, start, with the successively back and forth sequential movement of certain speed, until complete, to converge the scanning of sound wave to the 3D printing of target area hepatic tissue.
Effect: powered-down after scanning, keep somewhere liver organization and soak taking-up after 60 minutes in dyestuff, to organize from middle part along the ultrasonic radiation axle is transversal and cut open, the dye level in the organization center zone of visible ultrasonic scanning obviously is greater than perienchyma, and boundary is clear and definite, with adopt with after the single ultrasonic beam radiation of metering, in dyestuff, soak within 60 minutes, take out the liver organization section contrasted, the comparative effectiveness obvious difference, be shown in Fig. 4.
Embodiment 3:
The ultrasonic emitting module 2 of ultrasound wave target position pore device of the present invention, comprise 3 transmitting probes, be ultrasound wave conversion and transmitter unit, wherein, transmitting probe is according to the hyperacoustic transmit direction of routine change, cause acoustic wave beam to converge in the part of biological tissue, and the setting regions of organization internal is formed to array carry out the scanning of 3D printing by adjusting convergent point; Signal source guarantees that the same phase ultrasonic signal occurs, and its frequency is at 0.02MHz.Described ultrasonic emitting module 2 also comprises the linkage rotation unit be connected with each ultrasound wave conversion and transmitter unit, for regulating the transmit direction of ultrasound beamformer, the array arrangement shape is adapted to and organize shape.
Using ultrasound ripple target position pore device of the present invention, carry out ultrasonic target position pore to the sludged blood of the human blood as the target area tissue be immersed in urokinase solution, and concrete grammar comprises the following steps:
Step 1: described ultrasound wave driving power module 1 produces the ultrasound-driven signal of telecommunication, and 5 ultrasound wave that are transferred to respectively described ultrasonic emitting module 2 are changed and transmitter unit;
Step 2: be placed on the wall of a canister that is full of aqueous solution at a distance of the 3cm distance by the conversion of 3 ultrasound wave of described ultrasonic emitting module 2 and transmitter unit, and make transmit direction in twos form the angle about 40 degree, emit by the different directions of setting after driving the signal of telecommunication to be converted to ultrasound wave, make 3 ultrasound beamformers converge in the zone of human blood sludged blood tissue;
Step 3: described feedback regulation module 3 changes data signal by the described density of sound wave convergent point of organizing of Real-time Collection, be transferred to described control module 4, make it to send the power of corresponding change ultrasonic signal and the signal of scanning speed, and be transferred to described demonstration module 5 is set.
Step 4: described control module 4 is sent the instruction that changes beam direction to described ultrasonic emitting module 2, described ultrasonic beam is converged in and be immersed in the sludged blood of the human blood as a target area tissue in urokinase solution, from an end of target area, start, with the successively back and forth sequential movement of certain speed, until complete, to converge the scanning of sound wave to the 3D printing of target area sludged blood tissue.
Effect: powered-down after scanning, keep somewhere sludged blood and be organized in solution to soak after 60 minutes and take out, clot moisture is absorbed and is weighed, and and blank group, simple group of solvents and 3 experiment contrast groups of single sound head group of solvents contrasted, result is as shown in Fig. 5 and following table.Following table is different time sections thrombolytic rate measurement result.
The above is the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite that does not break away from principle of the present invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (8)
1. a ultrasound wave target position pore device, it is characterized in that: comprise ultrasound wave driving power module (1), ultrasonic emitting module (2), feedback regulation module (3), control module (4) and demonstration arrange module (5), described ultrasound wave driving power module (1) and ultrasonic emitting module (2) are electrically connected to, described control module (4) respectively with described ultrasound wave driving power module (1), ultrasonic emitting module (2) and demonstration arrange module (5) and are electrically connected to, described feedback regulation module (3) arranges module (5) with control module (4) and demonstration and is electrically connected to, wherein,
Described ultrasound wave driving power module (1) is for generation, amplification and the modulation of the ultrasound-driven signal of telecommunication, and gives described ultrasonic emitting module (2) by generated ultrasound-driven electrical signal transfer; Described ultrasonic emitting module (2), comprise M ultrasound wave conversion and transmitter unit, produce the driving signal of telecommunication for receiving described ultrasound wave driving power module (1), the described driving signal of telecommunication is converted to ultrasound wave, and by the different directions of setting by ultrasonic emitting out; Described M ultrasound wave changed and transmitter unit, can be according to the hyperacoustic transmit direction of routine change, cause ultrasonic beam to converge in the local appointed area of biological tissue inside, and the setting regions of organization internal is carried out to the scanning of 3D printing by adjusting convergent point; M >=2;
The local organization density that described feedback regulation module (3) gathers the sound wave convergent point for Real-time and Dynamic changes data signal and is transferred to described control module (4), make described control module (4) send corresponding control signal and to change, launched power and the scanning speed of ultrasonic signal to described ultrasonic emitting module (2), and signal is transferred to described demonstration the real-time shows signal parameter of module (5) is set;
Described control module (4), for accepting described demonstration, command signal and the established procedure that module (5) arranges is set, and the feedback signal of described feedback regulation module (3) collection, produce in order to control described ultrasound wave driving power module (1) power that ultrasound wave drives the signal of telecommunication; Simultaneously according to described command signal, established procedure and feedback signal, control M ultrasound wave conversion of described ultrasonic emitting module (2) and transmitter unit ultrasonic emitting action time, transmit direction and regulate the speed, make the sequential layer by layer movement in the local appointed area of biological tissue inside of described ultrasonic beam convergent point, realize converging the scanning of sound wave to the 3D printing of local appointed area;
Described demonstration arranges module (5) and sends to described control module (4) for command signal will be set, and shows the order parameter that arranges and carry out in real time.
2. a kind of ultrasound wave target position pore device according to claim 1, is characterized in that, described ultrasound wave driving power module (1) comprises signal of telecommunication generating unit, signal of telecommunication amplifying unit and signal of telecommunication modulating unit; Described signal of telecommunication modulating unit is electrically connected to parallel way with ultrasound wave conversion and the transmitter unit of described ultrasonic emitting module (2).
3. a kind of ultrasound wave target position pore device according to claim 1, is characterized in that, described ultrasound wave driving power module (1) produces and drives the frequency of pulsating current is 0.02-0.5MHz.
4. a kind of ultrasound wave target position pore device according to claim 1, is characterized in that, described ultrasonic emitting module (2) also comprises the linkage rotation unit be connected with each ultrasound wave conversion and transmitter unit.
5. a kind of ultrasound wave target position pore device according to claim 1, is characterized in that, described feedback module (3) comprising: signals collecting and transmission circuit.
6. a kind of ultrasound wave target position pore device according to claim 1, is characterized in that, described control module (4) comprises data processing unit, data storage cell and command signal transmitting element.
7. a kind of ultrasound wave target position pore device according to claim 1, is characterized in that, described demonstration arranges module (5) and comprises parameter setting circuit and operation display panel.
8. the method for ultrasound wave target position pore is characterized in that: application, according to the described ultrasonic target position pore device of one of claim 1 to 7, produces target position and organizes the pore effect, comprises the following steps:
Step 1: described ultrasound wave driving power module (1) produces the ultrasound-driven signal of telecommunication, and M the ultrasound wave that is transferred to respectively described ultrasonic emitting module (2) changed and transmitter unit;
Step 2: M ultrasound wave of described ultrasonic emitting module (2) changed and transmitter unit, will drive the signal of telecommunication to be converted to ultrasound wave, and emits by the different directions of setting, and makes M ultrasound beamformer converge in the appointed area of organization internal;
Step 3: described feedback regulation module (3) changes data signal by the described density of sound wave convergent point of organizing of Real-time Collection, be transferred to described control module (4), make described control module (4) send the power of corresponding change ultrasonic signal and the signal of scanning speed, and be transferred to described demonstration module (5) is set.
Step 4: described control module (4) is according to the established procedure of described setting and display module (5), send the instruction that changes beam direction to described ultrasonic emitting module (2), make the sequential layer by layer movement in tissue of described ultrasonic beam convergent point, realize converging the scanning of sound wave to the 3D printing of organizing local.
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