CN103463680A - Preparation process of medical implant material - Google Patents
Preparation process of medical implant material Download PDFInfo
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- CN103463680A CN103463680A CN2013103641686A CN201310364168A CN103463680A CN 103463680 A CN103463680 A CN 103463680A CN 2013103641686 A CN2013103641686 A CN 2013103641686A CN 201310364168 A CN201310364168 A CN 201310364168A CN 103463680 A CN103463680 A CN 103463680A
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- chitosan
- medical implant
- implant material
- die
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Abstract
The invention discloses a preparation process of a medical implant material, which comprises the following steps: (1) adding 1 kg of chitosan powder into 1L of acetic acid solution so as to prepare a chitosan solution; (2) weighing and adding 200-400 g of hydroxylapatite, 200-400 g of CaCO3 and 200-400 g of Fe3O4 into the chitosan solution, and stirring to obtain a uniform solution; (3) taking and pouring the solution into a die so as to form an intima, filling the die, and putting the die in the solidification liquid for forming; (4) putting the formed die into distilled water for rinsing to obtain a neutral substance, and drying at the temperature of 60 DEG C, so as to obtain the medical implant material. The medical implant material is high in hardness, and excellent in tissue compatibility.
Description
Technical field: the invention belongs to the biomimetic material field.
Technical background:
Adopting the method exploitation of application project and life sciences is that novel medical embedded material is the important topic of present stage organizational project.The synthetic material biocompatibility is often poor, has increased the toxicity of implanting.
Chitosan is the important derivatives of chitin, source is abundant, there is excellent biocompatibility and biodegradability, produce glucosamine during degraded, nontoxic, harmless to human body, existing biomedical applications widely, as postoperative anti-adhesion membrane, dialyzer, medicine controlled release carrier, poisonous substance adsorption separating agent, medicine carrying microballoons, orthopaedics gear division repair materials etc.But simple chitosan hardness is inadequate, is unsuitable for the use of orthopaedics.Therefore, improve the character of chitosan, prepare novel medical embedded material.
Summary of the invention:
The preparation method of a kind of medical embedded material of purpose design of the present invention, hardness is strong, the bionic material of good biocompatibility.
Design of the present invention is that step comprises (1) chitosan powder 1Kg, adds in the 1L acetic acid solution, makes chitosan solution; (2) take respectively hydroxyapatite 200-400g, Ca CO3,200-400g, Fe3 O4,200-400g joins in above-mentioned solution, stirs into uniform solution; (3) get solution injection mould and form inner membrance, then mould is filled with, put into solidification liquid and be shaped; (4) put into the distilled water rinsing to neutral, put into 60 ℃ of oven dry, obtain.
Principle of the present invention: hydroxyapatite is the main component of human body natural's bone, there is fabulous biological activity and the guided bone of bone growth, studies have reported that, around chitosan/hydroxyapatite composite material, new bone formation probability is far longer than simple chitosan material.Also have research to think when hydroxyapatite is absorbed by human body, the C a2 discharged+and PO3+4 ions newly being utilized in bone formation, for fracture, facilitation is arranged.
Beneficial effect of the present invention is: hardness of the present invention is strong, good biocompatibility.
The specific embodiment:
Embodiment 1:(1) chitosan powder 1Kg, add in the 1L acetic acid solution, makes chitosan solution; (2) take respectively hydroxyapatite 200g, Ca CO3 400g, Fe3 O4 300g joins in above-mentioned solution, stirs into uniform solution; (3) get solution injection mould and form inner membrance, then mould is filled with, put into solidification liquid and be shaped; (4) put into the distilled water rinsing to neutral, put into 60 ℃ of oven dry, obtain.
Embodiment 2:(1) chitosan powder 1Kg, add in the 1L acetic acid solution, makes chitosan solution; (2) take respectively hydroxyapatite 400g, Ca CO3 300g, Fe3 O4 200g joins in above-mentioned solution, stirs into uniform solution; (3) get solution injection mould and form inner membrance, then mould is filled with, put into solidification liquid and be shaped; (4) put into the distilled water rinsing to neutral, put into 60 ℃ of oven dry, obtain.
Claims (1)
1. the preparation technology of a medical embedded material, it is characterized in that: step comprises (1) chitosan powder 1Kg, adds in the 1L acetic acid solution, makes chitosan solution; (2) take respectively hydroxyapatite 200-400g, Ca CO3,200-400g, Fe3 O4,200-400g joins in above-mentioned solution, stirs into uniform solution; (3) get solution injection mould and form inner membrance, then mould is filled with, put into solidification liquid and be shaped; (4) put into the distilled water rinsing to neutral, put into 60 ℃ of oven dry, obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103641686A CN103463680A (en) | 2013-08-21 | 2013-08-21 | Preparation process of medical implant material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103641686A CN103463680A (en) | 2013-08-21 | 2013-08-21 | Preparation process of medical implant material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103463680A true CN103463680A (en) | 2013-12-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013103641686A Pending CN103463680A (en) | 2013-08-21 | 2013-08-21 | Preparation process of medical implant material |
Country Status (1)
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| CN (1) | CN103463680A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1389503A (en) * | 2002-07-15 | 2003-01-08 | 浙江大学 | In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material |
| CN101461963A (en) * | 2009-01-07 | 2009-06-24 | 华南理工大学 | Multiplex composite bone tissue engineering bracket material capable of degrading gradiently and preparation method thereof |
| CN101543646A (en) * | 2009-04-30 | 2009-09-30 | 厦门大学 | Method for preparing hydroxyapatite in-situ reinforced chitosan bar material |
| CN101955174A (en) * | 2010-09-20 | 2011-01-26 | 上海师范大学 | Preparation method of magnetic mesoporous phosphorite microsphere material |
| CN102671245A (en) * | 2012-01-12 | 2012-09-19 | 河南科技大学 | Magnetic bone cement material and method for preparing magnetic bone cement |
| CN102850576A (en) * | 2012-09-07 | 2013-01-02 | 中国科学技术大学 | Nanometer composite scaffolds assembled by adopting chitosan scaffold, preparation method and applications thereof |
-
2013
- 2013-08-21 CN CN2013103641686A patent/CN103463680A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1389503A (en) * | 2002-07-15 | 2003-01-08 | 浙江大学 | In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material |
| CN101461963A (en) * | 2009-01-07 | 2009-06-24 | 华南理工大学 | Multiplex composite bone tissue engineering bracket material capable of degrading gradiently and preparation method thereof |
| CN101543646A (en) * | 2009-04-30 | 2009-09-30 | 厦门大学 | Method for preparing hydroxyapatite in-situ reinforced chitosan bar material |
| CN101955174A (en) * | 2010-09-20 | 2011-01-26 | 上海师范大学 | Preparation method of magnetic mesoporous phosphorite microsphere material |
| CN102671245A (en) * | 2012-01-12 | 2012-09-19 | 河南科技大学 | Magnetic bone cement material and method for preparing magnetic bone cement |
| CN102850576A (en) * | 2012-09-07 | 2013-01-02 | 中国科学技术大学 | Nanometer composite scaffolds assembled by adopting chitosan scaffold, preparation method and applications thereof |
Non-Patent Citations (5)
| Title |
|---|
| 孙文晓等: "两种壳聚糖仿生复合材料对家免桡骨骨缺损修复的实验研究", 《现代生物医学进展》 * |
| 欧阳健明: "生物矿物及其矿化过程", 《化学进展》 * |
| 王敏等: "系列仿生高分子复合材料与小鼠成纤维细胞生物相容性体外实验研究", 《西南国防医药》 * |
| 胡巧玲等: "原位沉析法制备碳酸钙/壳聚糖三维复合材料的研究", 《高等学校化学学报》 * |
| 陈福平等: "原位沉析法制备磁性氧化铁羟基磷灰石/壳聚糖棒材", 《高分子学报》 * |
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Application publication date: 20131225 |