CN103463579B - Traditional Chinese medicine for treating stomach diseases and preparation method thereof - Google Patents
Traditional Chinese medicine for treating stomach diseases and preparation method thereof Download PDFInfo
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- CN103463579B CN103463579B CN201310445916.3A CN201310445916A CN103463579B CN 103463579 B CN103463579 B CN 103463579B CN 201310445916 A CN201310445916 A CN 201310445916A CN 103463579 B CN103463579 B CN 103463579B
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Abstract
The invention discloses a traditional Chinese medicine for treating stomach diseases and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine comprises 10-20wt% of ligusticum wallichii, 15-25wt% of dahurian angelica root, 10-20wt% of turmeric extract, 10-20wt% of rhizoma corydalis extract, 10-20wt% of prepared rhizoma atractylodis, 5-10wt% of ginger-processed pinellia, 5-10wt% of rhizoma nardostachyos and 10-16wt% of citron. The preparation method comprises plant extract extraction and condensation, ginger-processed pinellia preparation, blending and crushing, and particle electuary processing. The traditional Chinese medicine has obviously effects of treating chronic gastritis, atrophic gastritis and alcoholic gastric ulcer.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of gastropathy and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Gastropathy, is actually the general designation of many diseases.They have similar symptom, as upper abdomen gastral cavilty portion discomfort, pain, after meal glutted, belch, return acid, even Nausea and vomiting etc.Gastropathy common clinically has acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer etc.Gastropathy is more common in crowd and one of the disease of refractory, and some patient's medical histories even can reach the more than ten years, and hospital and pharmacy all do not have specific drug to this disease so far.
Enter over 20 years, plant extract is more and more subject to people's attention, because plant has the secondary metabolite of the ground molecular weight of abundant species, in general these compound molecules may as system of defense resist physiology, environment, food chain upstream and pathogen stress pressure, make the environment of plant and surrounding keep harmonious coexistence, these secondary metabolites be mainly present in medicinal plants have positive effect in food and mammalian metabolism.Therefore the plant extract that these Be very effective, mechanism science, definite ingredients are controlled is more and more general in the application of developed country.
Summary of the invention
For the problems referred to above, the invention provides a kind of Chinese medicine for the treatment of gastropathy and preparation method thereof.
Technical scheme of the present invention is as follows:
The invention provides a kind of Chinese medicine for the treatment of gastropathy, containing Rhizoma Corydalis extract and Rhizoma Curcumae Longae extract.
A kind of Chinese medicine for the treatment of gastropathy provided by the invention, its raw material composition and percentage by weight are: Rhizoma Chuanxiong 12-20wt.%; Radix Angelicae Dahuricae 16-25 wt.%; Rhizoma Curcumae Longae extract 12-20 wt.%; Rhizoma Corydalis extract 12-20 wt.%; Rhizoma Atractylodis 12-20 wt.% processed; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5-10 wt.%; Radix Et Rhizoma Nardostachyos 5-10 wt.%; Fructus Citri 10-16 wt.%.
A kind of Chinese medicine for the treatment of gastropathy provided by the invention, its preparation method realizes as follows:
1) prepared plant extracts;
2) Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is prepared;
3) co-grinding: other raw materials except the plant extract of step 1) are mixed and is crushed to 200-300 order;
4) mixing granulation: by the plant extract mixing granulation of the mixture of step 3) and step 1);
5) sterilizing, packed products.
Many in the present invention, plant extract is by being prepared by following steps:
1) raw material screening;
2) the raw material tinning of step 1) is added the pure water of raw material volume four to five times;
3) supersound extraction 15-30min obtains extracting solution;
4) extracting solution of step 3) loading concentration tank is carried out negative pressure of vacuum to concentrate, temperature is 60-70 DEG C, and pressure is-0.04 to 0.08MPa;
5) carry out spraying dry when extracting solution remains the extracting solution of 1/5-1/4 after step 4) concentrates and obtain extract dry powder.
And the preparation of described Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is first by the hot Alumen immersion bubble 12-24h of the Rhizoma Pinelliae at 65-75 DEG C, then obtain Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) with Sucus Zingberis.
Preferably, the temperature of hot Alumen is 70 DEG C.
Beneficial effect of the present invention:
1) Chinese medicine provided by the invention has significant curative effect to chronic gastritis, atrophic gastritis and Alcoholic gastric ulcer.
2) the method extraction equipment that the present invention adopts vacuum and low temperature ultrasonic extracts Chinese medicinal plant extract, can guarantee that the loss of effective components of Chinese medicine is minimum.
3), in the preparation of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) of the present invention, the Rhizoma Pinelliae, after the process of Alumen liquid, effectively can absorb Sucus Zingberis, heighten the effect of a treatment.
Detailed description of the invention
Word " exemplary " special here means " as example, embodiment or illustrative ".Here need not be interpreted as being better than or being better than other embodiment as any embodiment illustrated by " exemplary ".
In addition, in order to better the present invention is described, in detailed description of the invention hereafter, give numerous details.It will be appreciated by those skilled in the art that do not have these details, the present invention can implement equally.In other example, known method, means and material are not described in detail, so that highlight purport of the present invention.
rhizoma Chuanxiong:rhizoma Chuanxiong acrid in the mouth, warm in nature; Return liver, gallbladder, heart channel; Gas perfume rises loose; There is blood-activating and qi-promoting, wind-expelling pain-stopping, effect of activating QI to alleviate the depression; Effect of its activating QI to alleviate the depression is mainly reflected in: for the upper abdomen distending pain over the hypochondrium of cholecystitis, can be equal to use with Radix Bupleuri, Radix Scutellariae; For the card such as abdominal distention and pain on gastritis, acid regurgitation be heartburn, can be equal to Herba Taraxaci, the Radix Aucklandiae and use.
the Radix Angelicae Dahuricae:radix Angelicae Dahuricae acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose; There is expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidify sensible, effect of detumescence and apocenosis; Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, venom.The Radix Angelicae Dahuricae contains the organic acid of angelicin (Byak-angelicin), byak-angelicin (Byak-angelicol), oxypeucedanin (Oxypencedanin), phellopterin (Phellopterin) and a kind angelic acid (Angelic acid).In addition also containing angelicotoxin (Angelicotoxin), the effect of loose wind, cold relieving, dampness and pain relieving is had.
rhizoma Curcumae Longae:rhizoma Curcumae Longae rhizome is containing curcumin chemical compounds: have removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea, lump in the abdomen, rheumatism, shoulder arm pain, tumbling and swelling.
rhizoma Corydalis: Rhizoma Corydalis acrid in the mouth, hardship, warm in nature.There is promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.Be mainly used in whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.Chemical composition is mainly Rhizoma Corydalis and contains multiple alkaloid: d-corydaline (d-corydaline), dl-Tetrahydropalmatine (dltetrahydropalmatine), protopine (protopine), l-Tetrahydrocoptisine (1-tetrahydrocoFtisine), d1-Tetrahydrocoptisine (dltetrahydrocoptisine), coptisine (coptisine) etc.Corydalis remota contains purple Dong's alkali, Tetrahydropalmatine, Bicuculline (bicuculline) etc.Cure mainly stomachache, dysmenorrhea, traumatic injury etc.Spleen invigorating, dampness, resolving depression, wards off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, and seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.
rhizoma Atractylodis: spleen invigorating, dampness, resolving depression, wards off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, and seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.
the Rhizoma Pinelliae: have antitussive, suppress the effect of glandular secretion, Tuhe, town emetic action, hypotensive effect, cures mainly cough with asthma abundant expectoration; Vomiting regurgitation; Feeling of oppression and fullness in the chest and epigastrium headache is dizzy; Uneasy sleeping at night; Gall subcutaneous nodule; Swollen ulcer drug.
radix Et Rhizoma Nardostachyos:control the poor appetite of worry impairing spleen or Deficiency and coldness of spleen and stomach, eat many abdominal distention, lassitude, pale tongue with white fur, deep-slow pulse weak person, Radix Et Rhizoma Nardostachyos and Rhizoma Kaempferiae mutual reinforcement between are use, and to increase the effect of regulating QI to relieve pain, the unstrong swollen abdominal distention of tripe of insufficiency of the spleen transporting controlled by Radix Et Rhizoma Nardostachyos, the medicine of invigorating the spleen and regulating the stomach.Radix Et Rhizoma Nardostachyos also can control the stagnation of QI distending pain because trembling with fear, can warming middle-JIAO to promote flow of QI.
fructus Citri:contained volatile oil has gentle stimulation to gastrointestinal tract, can promote to wriggle and digestive juice secretion in the intestines and stomach, gets rid of enteral pneumatosis, and has phlegm-dispelling functions.
Rhizoma Corydalis: Rhizoma Corydalis composition contains Rhizoma Corydalis and contains multiple alkaloid: d-corydaline (d-corydaline), dl-Tetrahydropalmatine (dltetrahydropalmatine), protopine (protopine), l-Tetrahydrocoptisine (1-tetrahydrocoFtisine), d1-Tetrahydrocoptisine (dltetrahydrocoptisine), coptisine (coptisine) etc.Corydalis remota contains purple Dong's alkali, Tetrahydropalmatine, Bicuculline (bicuculline) etc., and pharmacological action zoopery proves, corydaline, Tetrahydropalmatine have analgesic activity, and Tetrahydropalmatine analgesia index is higher.Tetrahydropalmatine can suppress cerebral cortex and infracortical electrical activity, especially comparatively responsive with motor cortex.The Experimental Gastric Ucler that 13-Methylpalmatine can protect rat to produce because of hungry or injection cortisone and reserpine etc., reduces gastric secretion, reduces gastric acid and pepsic amount.
rhizoma Curcumae Longae: Rhizoma Curcumae Longae is a kind of perennial dulcet herbaceous plant, and existing medical value, can make food seasoning again.Xin Xiang is pastel, slightly Fructus Piperis, Moschus taste and Fructus Citri sinensis and Rhizoma Zingiberis Recens mix taste, slightly pungent, bitterness, pungent sense.Cure mainly removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.Be mainly used in the heart of caused by energy stagnation and blood stasis, breast, the side of body, all pains of abdomen, rheumatic arthralgia (curing mainly upper limb arthralgia pain).
embodiment 1:
1) prepared plant extracts: the Rhizoma Corydalis raw material 100 grams screened is put into tank, then add 4 times of volumes to carry out supersound extraction in the pure water of Rhizoma Corydalis and obtain extracting solution in 15 minutes, subsequently extracting solution is drawn into and under 65 DEG C and-0.02MPa pressure, carries out negative pressure of vacuum in concentrated filling and concentrate, when concentration of liquid medicine remain to 1/4 time carry out spraying dry, and then obtain extract dry powder and take out 15 grams for subsequent use; The preparation 17 grams of Rhizoma Curcumae Longae extracts that use the same method are for subsequent use;
2) prepare Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): soaked 12 hours in the Alumen liquid of 70 DEG C by 20 grams of Rhizoma Pinelliaes, then with Sucus Zingberis, obtain Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), and take out 8 grams for subsequent use;
3) co-grinding: by Rhizoma Chuanxiong 15 grams; The Radix Angelicae Dahuricae 18 grams; Rhizoma Atractylodis processed 12 grams; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams; Radix Et Rhizoma Nardostachyos 7 grams; Fructus Citri 12 grams carries out mixing and is crushed to 200 orders;
4) mixing granulation: the 15 grams of Rhizoma Corydalis extracts mixture of step 3) and step 1) obtained and 17 grams of Rhizoma Curcumae Longae extracts are mixed and made into granule;
5) sterilizing, packed products.
embodiment 2:
1) prepared plant extracts: the Rhizoma Corydalis raw material 100 grams screened is put into tank, then add 5 times of volumes to carry out supersound extraction in the pure water of Rhizoma Corydalis and obtain extracting solution in 30 minutes, subsequently extracting solution is drawn into and under 60 DEG C and-0.01MPa pressure, carries out negative pressure of vacuum in concentrated filling and concentrate, carry out spraying dry when extracting solution is concentrated into 1/5, so obtain extract dry powder take out 12 grams for subsequent use; The preparation 14 grams of Rhizoma Curcumae Longae extracts that use the same method are for subsequent use;
2) prepare Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): soaked 15 hours in the Alumen liquid of 68 DEG C by 20 grams of Rhizoma Pinelliaes, then with Sucus Zingberis, obtain Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), and take out 6 grams for subsequent use;
3) co-grinding: by Rhizoma Chuanxiong 12 grams; The Radix Angelicae Dahuricae 20 grams; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6 grams; Radix Et Rhizoma Nardostachyos 5 grams; Fructus Citri 12 grams carries out mixing and is crushed to 200 orders;
4) mixing granulation: the 12 grams of Rhizoma Corydalis extracts mixture of step 3) and step 1) obtained and 14 grams of Rhizoma Curcumae Longae extracts are mixed and made into granule;
5) sterilizing, packed products.
clinic Case:clinical verification totally 247 examples of this formula treatment gi system disease, result shows, this case with gastric and duodenal ulcers, hemorrhagic gastritis, with drink, eat pungent stiff food and dyspepsia, the abdominal distention stagnation of QI for many.This is dialectically divided into that stomach-fire is red-hot, insufficiency of stomach-QI is not taken the photograph, insufficiency of stomach trembles with fear pain person for treating at all, cure 175 examples, effective improvement 59 example, invalid 13 examples, this clinical summary in JIUYUE, 1996 to 2000 year respectively at Jinzhou Dalian Hou Shi institute of traditional Chinese medicine, development zone, Dalian Changchun traditional Chinese medical science clinic internal clinic and ward specific aim clinical generalization and analysis, in 247 examples, male
127 examples, women 120 example; The oldest person 86 years old, reckling 16 years old; Its Middle-young age (16 ~ 39 years old) 52 example, middle aged group (40 ~ 59 years old) 183 is routine, old group 12 example.
To summarize analysis to 247 routine upper gastrointestinal hemorrhage cases, result shows, this formula combination has obvious curative effects for gastric and duodenal ulcers, hemorrhagic gastritis, the poisoning gastric ulcer of Alcoholic and common chronic gastritis, atrophic gastritis.
instructions of taking: every day, ante cibum was each once sooner or later, or took during stomachache, each 10 grams.
The above; be only the present invention's preferably detailed description of the invention; mainly the embodiment making granule is described; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (2)
1. treat a Chinese medicine for gastropathy, it is characterized in that, the raw material composition of described treatment gastropathy Chinese medicine and percentage by weight are: Rhizoma Chuanxiong 12-20wt.%; Radix Angelicae Dahuricae 16-25 wt.%; Rhizoma Curcumae Longae extract 12-20 wt.%; Rhizoma Corydalis extract 12-20 wt.%; Rhizoma Atractylodis 12-20 wt.% processed; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5-10 wt.%; Radix Et Rhizoma Nardostachyos 5-10 wt.%; Fructus Citri 10-16 wt.%; The preparation method of described Chinese medicine comprises the steps:
1) prepared plant extracts: a raw material screening; B is by the raw material tinning of step a and add the pure water of raw material volume four to five times; C supersound extraction 15-30min obtains extracting solution; The extracting solution of step c loading concentration tank is carried out negative pressure of vacuum and concentrates by d, and temperature is 60-70 DEG C, and pressure is-0.04 to 0.08MPa; E extracting solution carries out spraying dry when remaining the extracting solution of 1/5-1/4 after steps d concentrates and obtains extract dry powder;
2) Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is prepared: the preparation of described Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is first soak 12-24 hour in the hot Alumen liquid of 65-75 DEG C in temperature by the Rhizoma Pinelliae, then obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) with Sucus Zingberis;
3) co-grinding: the raw material except the plant extract described in step 1) is mixed and is crushed to 200-300 order;
4) mixing granulation: by the plant extract mixing granulation of the mixture of step 3) and step 1);
5) sterilizing, packed products.
2. one according to claim 1 treats gastropathy Chinese medicine, it is characterized in that, the temperature of described hot Alumen is 70 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105362885A (en) * | 2015-11-27 | 2016-03-02 | 王亚鹤 | Medicine composition for treating gastric mucosa intestinal metaplasia |
| CN106074718A (en) * | 2016-08-10 | 2016-11-09 | 翔天农业开发集团股份有限公司 | A kind of electuary treating gastropathy and preparation method thereof |
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| CN1965968A (en) * | 2006-11-14 | 2007-05-23 | 赵玉民 | Orally administered medicinal powder for treating gastric diseases |
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2013
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Patent Citations (5)
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|---|---|---|---|---|
| CN1174717A (en) * | 1996-08-23 | 1998-03-04 | 李建华 | Traditional Chinese medicine for curing gastric disease |
| CN1383855A (en) * | 2002-03-20 | 2002-12-11 | 郑国芃 | Gastropathy treating Chinese medicine |
| CN1965968A (en) * | 2006-11-14 | 2007-05-23 | 赵玉民 | Orally administered medicinal powder for treating gastric diseases |
| CN1966040A (en) * | 2006-11-17 | 2007-05-23 | 郑新年 | Chinese medicinal decoction for treating gastrointestinal diseases |
| CN101361878A (en) * | 2008-09-10 | 2009-02-11 | 马文才 | Gastrosis treating medicine |
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| 姜黄疗胃病;无名;《武警医学》;20000630;第11卷(第6期);383 * |
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