CN103463069A - Lycojaponicumin C在治疗鼻咽癌药物中的应用 - Google Patents
Lycojaponicumin C在治疗鼻咽癌药物中的应用 Download PDFInfo
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- CN103463069A CN103463069A CN2013104355592A CN201310435559A CN103463069A CN 103463069 A CN103463069 A CN 103463069A CN 2013104355592 A CN2013104355592 A CN 2013104355592A CN 201310435559 A CN201310435559 A CN 201310435559A CN 103463069 A CN103463069 A CN 103463069A
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- lycojaponicumin
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- medicines
- nasopharynx cancer
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- UULHZQYEEKIMDO-CLROSIBMSA-N lycojaponicumin C Natural products CN1CCC[C@@]23[C@@H]1CC[C@]24[C@@H](CC3=O)C(=CCC4=O)C UULHZQYEEKIMDO-CLROSIBMSA-N 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 201000011216 nasopharynx carcinoma Diseases 0.000 title abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 229940079593 drug Drugs 0.000 title abstract description 9
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 title abstract 6
- 208000025848 malignant tumor of nasopharynx Diseases 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 claims description 16
- 230000012010 growth Effects 0.000 abstract description 7
- 101150080924 CNE1 gene Proteins 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 230000000259 anti-tumor effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 abstract 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 11
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 241000927897 Lycopodium japonicum Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 229930185194 lycojaponicumin Natural products 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310435559.2A CN103463069B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin C在制备治疗鼻咽癌药物中的应用 |
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CN201310435559.2A CN103463069B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin C在制备治疗鼻咽癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103463069A true CN103463069A (zh) | 2013-12-25 |
CN103463069B CN103463069B (zh) | 2015-12-02 |
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CN201310435559.2A Expired - Fee Related CN103463069B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin C在制备治疗鼻咽癌药物中的应用 |
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CN (1) | CN103463069B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
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2013
- 2013-09-23 CN CN201310435559.2A patent/CN103463069B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
Non-Patent Citations (1)
Title |
---|
XIAO-JING WANG, ET AL: "Lycojaponicumins A-C,Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum", 《ORGANIC LETTERS》, vol. 14, no. 10, 8 May 2012 (2012-05-08), pages 2614 - 2617, XP055066237, DOI: 10.1021/ol3009478 * |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Hongli Inventor before: Wu Junhua Inventor before: Huang Rong |
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Effective date of registration: 20151103 Address after: 325011, building 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Zhejiang, Wenzhou Applicant after: Wenzhou Chengqiao Technology Co.,Ltd. Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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Effective date of registration: 20181218 Address after: 239000 Jinshan Road Electronic Commerce Industrial Park, Jingkai District, Dingyuan County, Chuzhou City, Anhui Province Patentee after: Anhui Creative Technology Transfer Service Co.,Ltd. Address before: 325011 room 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Wenzhou, Zhejiang. Patentee before: Wenzhou Chengqiao Technology Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151202 Termination date: 20190923 |