CN103463032A - Lycojaponicumin A在治疗胰腺癌药物中的应用 - Google Patents
Lycojaponicumin A在治疗胰腺癌药物中的应用 Download PDFInfo
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- CN103463032A CN103463032A CN2013104359907A CN201310435990A CN103463032A CN 103463032 A CN103463032 A CN 103463032A CN 2013104359907 A CN2013104359907 A CN 2013104359907A CN 201310435990 A CN201310435990 A CN 201310435990A CN 103463032 A CN103463032 A CN 103463032A
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- lycojaponicumin
- pancreatic cancer
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- medicine
- cancer
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- 206010061902 Pancreatic neoplasm Diseases 0.000 title claims abstract description 25
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 title claims abstract description 16
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title abstract description 21
- 208000008443 pancreatic carcinoma Diseases 0.000 title abstract description 14
- 201000002528 pancreatic cancer Diseases 0.000 title abstract description 8
- 150000001875 compounds Chemical class 0.000 claims description 16
- 229930185194 lycojaponicumin Natural products 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000012010 growth Effects 0.000 abstract description 7
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 230000000259 anti-tumor effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- OAVCWZUKQIEFGG-UHFFFAOYSA-O 2-(5-methyl-2H-tetrazol-1-ium-1-yl)-1,3-thiazole Chemical compound CC1=NN=N[NH+]1C1=NC=CS1 OAVCWZUKQIEFGG-UHFFFAOYSA-O 0.000 abstract 1
- 230000002946 anti-pancreatic effect Effects 0.000 abstract 1
- 239000003560 cancer drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 241000927897 Lycopodium japonicum Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Claims (1)
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Application Number | Priority Date | Filing Date | Title |
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CN201310435990.7A CN103463032B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗胰腺癌药物中的应用 |
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CN201310435990.7A CN103463032B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗胰腺癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103463032A true CN103463032A (zh) | 2013-12-25 |
CN103463032B CN103463032B (zh) | 2015-08-19 |
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CN201310435990.7A Active CN103463032B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗胰腺癌药物中的应用 |
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CN (1) | CN103463032B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
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2013
- 2013-09-23 CN CN201310435990.7A patent/CN103463032B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
Non-Patent Citations (2)
Title |
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WANG XIAOJING等: "Nine new lycopodine-type alkaloids from Lycopodium japonicum", 《TETRAHEDRON》, vol. 69, 13 May 2013 (2013-05-13), pages 1 * |
XIAO-JING WANG,ET AL.: "Lycojaponicumin A-C,Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum", 《ORGANIC LETTERS》, vol. 14, no. 10, 8 May 2012 (2012-05-08), pages 2614 - 2617, XP055066237, DOI: 10.1021/ol3009478 * |
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CN103463032B (zh) | 2015-08-19 |
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Inventor after: Li Hongjian Inventor before: Jiang Chunping Inventor before: Wang Zezheng |
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Effective date of registration: 20161101 Address after: 518000 Guangdong province Shenzhen City Pingshan Kengzi streets Jinhui No. 14 Shenzhen Biomedical Innovation Industrial Park 1 Building No. 605 Patentee after: Shenzhen Ka Di Biotechnology Co. Ltd. Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Patentee before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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Effective date of registration: 20210602 Address after: Room 605, building 1, Shenzhen Biomedical Innovation Industrial Park, 14 Jinhui Road, Kengzi street, Pingshan District, Shenzhen, Guangdong 518000 Patentee after: PREGENE BIOPHARMA COMPANY (SHENZHEN) Address before: Room 605, building 1, Shenzhen Biomedical Innovation Industrial Park, Jinhui 14, Kengzi street, Pingshan New District, Shenzhen, Guangdong 518000 Patentee before: SHENZHEN KADI BIOLOGY TECHNOLOGY Co.,Ltd. |
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Address after: Room 605, building 1, Shenzhen Biomedical Innovation Industrial Park, 14 Jinhui Road, Jinsha community, Kengzi street, Pingshan District, Shenzhen, Guangdong 518000 Patentee after: Shenzhen prijin biopharmaceutical Co.,Ltd. Address before: Room 605, building 1, Shenzhen Biomedical Innovation Industrial Park, 14 Jinhui Road, Kengzi street, Pingshan District, Shenzhen, Guangdong 518000 Patentee before: SHENZHEN PREGENE BIOPHARMA Co.,Ltd. |
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