CN103462647A - Integrated IVUS (intravascular ultrasound) image and DSA (digital subtraction angiography) image integrating online real-time treatment device - Google Patents
Integrated IVUS (intravascular ultrasound) image and DSA (digital subtraction angiography) image integrating online real-time treatment device Download PDFInfo
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Abstract
The invention provides an integrated IVUS (intravascular ultrasound) image and DSA (digital subtraction angiography) image integrating online real-time treatment device, which comprises a data acquisition module, a DSA-image-based blood vessel segmentation and reconstruction module, an IVUS-image-based blood vessel measurement module, a blood vessel three-dimensional imaging module, a DSA image and IVUS image linkage module, an image reporting module and a transmission module. According to the treatment device, a blood vessel is multidimensionally treated by combining a DSA image and an IVUS image; a blood vessel measurement result obtained by the DSA-image-based blood vessel segmentation and reconstruction module is compared with a blood vessel measurement result, obtained by the IVUS-image-based blood vessel measurement module, on a cross section, so that an operator can conveniently judge whether to perform interventional therapy on a blood vessel with lesions or not and determine the position of a blood vessel section to be subjected to the interventional therapy to further determine a therapeutic schedule, and is helped to accurately select the size of a stent and locate the stent.
Description
Technical field
The invention belongs to field of medical, specifically refer to the integrated online processing instrument in real time of a kind of integrated intravascular ultrasound (IVUS) image and Digital Subtraction (DSA) image.
Background technology
Coronarography is a kind of effective ways of diagnosis of coronary heart disease.Conduit is inserted through thigh femoral artery, radial artery or other peripheral arterial, deliver to ascending aorta, then seek the left or right coronary ostium and insert, inject contrast agent, coronary artery is developed, can disclose more clearly position, degree and the scope of dissection deformity coronarius and obstructive pulmonary disease thereof.Coronarography is can directly observe the effective ways of coronary artery form at present, and medical circle number is called " goldstandard ".For narrow heavier position in radiography, need to carry out interventional therapy.
In the middle of the clinical practice application, coronarography also shows many weak points.As, it can only show the situation of tube chamber, tube wall and atheromatous plaque that can not the lesions showed place can not provide the details of atheromatous plaque form and character, likely make the patient underestimate the degree of coronary stenosis.This just makes the accuracy reduction of estimating coronary atherosclerosis and interventional therapy curative effect according to coronary angiography.Especially the proposition of this concept of arteria coronaria vascular remodeling, make people have to reappraise the reliability of coronary angiography in the coronary heart disease diagnosis and treatment.Early stage at coronary atherosclerosis, along with the increase of atheromatous plaque area, arteria coronaria is underwent compensatory enlargement, and the tube chamber area can be without narrow, and this process is vascular remodeling, and now coronary angiography is often without extremely showing.
Intravascular ultrasound (IVUS) is to utilize conduit that one high frequency miniature ultrasonic probe is imported to Endovascular to be surveyed, then shows the fine anatomic information of cardiovascular organization structure and geometric shape through electronic imaging system.Because directly being placed in Endovascular, ultrasonic probe surveys, therefore, IVUS not only can the Measurement accuracy tube chamber and the size of atheromatous plaque or fibrous plaque, the more important thing is that it can provide the cardinal principle organizational information of atheromatous plaque, obviously be better than radiography when the pathological change form shown because of the complexity due to interventional therapy.
While for some diffusivity vascular lesions, openings in blood vessels pathological changes and in-stent restenosis etc., needing the interventional therapy of accurate positioning support point of release, often need the guidance of IVUS, yet, some blind spots that limitation, patient and the technician who exists due to perusal links up etc., be difficult to accurately IVUS image and DSA image be combined, further guarantee percutaneous coronary intervene operation (PCI) quality has been proposed to higher difficulty.Therefore, a kind ofly can realize the image processing arrangement of puncta vasculosa to point measurement in conjunction with DSA image and IVUS image, will promote effectively the development of cardiovascular intervene operation, ensure the quality of operation.And this type of technology still belongs to blank at home, therefore there is very large development space and researching value.
Summary of the invention
The problem proposed for background technology, the purpose of this invention is to provide the integrated online processing instrument in real time of a kind of integrated intravascular ultrasound (IVUS) image and Digital Subtraction (DSA) image.For this reason, the present invention is by the following technical solutions:
The present invention includes seven modules: the blood vessel segmentation of data acquisition module, DSA image is rebuild interlocking module, image report module and the transport module of vessel measurement module, blood vessel three-dimensional imaging module, DSA image and the IVUS image of module, IVUS image.Wherein: (1) data acquisition module, be included in computer-internal and embed the high definition capture card containing two-way DVI interface, at art Real-time Collection IVUS image and DSA image, and be stored in the computer local hard drive, (2) blood vessel segmentation of DSA image is rebuild module, out of shape for the DSA image reconstruction blood vessel to gathering, to selecteed interested vessel segment in the blood vessel after rebuilding, sketch the contours vessel centerline, starting point and the end of the final point of mark vessel segment on the vessel centerline of sketching the contours, (3) the vessel measurement module of IVUS image, this module is done reference by self size of IVUS conduit, selecteed interested image on the IVUS image is carried out to the measurement of full-automatic or human-machine interaction vessel lumen, described all automatic measurement refers to the difference of computer according to the gray value on the border of self tube chamber on vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtain measurement result, described human-machine interaction measurement refers at computer to be carried out on the basis of described all automatic measurement to interested image, provide again the operator to revise interface, receive operator's instruction, revise on vessel cross-sections the border of self tube chamber and remaining tube chamber, the vessel measurement module of IVUS image is carried out described measurement again according to the vessel lumen border of newly sketching the contours, described measurement comprises: self tube chamber on vessel cross-sections and the tube chamber area of remaining tube chamber, diameter and speckle load, and the length of blood vessel on longitudinal section, described self tube chamber refers to original vessel lumen, comprises remaining vessel lumen and speckle part, described remaining tube chamber refer to current existing can blood supply the vessel lumen passed through of stream, be exactly that self tube chamber has been rejected remaining vessel lumen after speckle, described speckle load refers to the ratio of the area of plaque area on cross section and self tube chamber, (4) blood vessel three-dimensional imaging module, for to selecteed interested blood vessel, out of shape according to vessel cross-sections and the blood vessel after longitudinal section image and the reconstruction of DSA Image Segmentation of its IVUS image, generate blood vessel three dimensional structure intuitively, (5) interlocking module of DSA image and IVUS image, for the three dimensional structure according to blood vessel, obtain starting point on sketched the contours vessel centerline and the true length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on the IVUS image, and calculate the number of image frames N between start frame and end frame on the IVUS image, and then automatically the starting point on the DSA image and the blood vessel segmentation between end of the final point are become to N equidistant point, each that realizes blood vessel on the DSA image put on corresponding IVUS image corresponding two field picture separately, and rebuild the contrast of the vessel measurements on the cross section that the vessel measurement module of vessel measurements that module obtains and IVUS image obtains by the blood vessel segmentation to the DSA image, facilitate the patient to judge whether the vessel segment position to the capable interventional therapy of lesion vessels and interventional therapy, and then definite therapeutic scheme, and help the patient accurately to select support size and locating support, (6) image report module, for intermediate data and the result data according to by computer is inputted automatically or the artificial above-mentioned module of inputting obtains, according to template, generate image and get involved the report of inspection related data, (7) transport module, for transmitting the integrated online in real time image data that processing instrument generates and reporting the computer to appointment.
Further, the blood vessel segmentation of DSA image is rebuild the method for module based on matched filtering, extracts edge, diameter and the centrage of non-intersect blood vessel, out of shape to the DSA image reconstructing blood vessel blood vessel gathered.
Further, the blood vessel segmentation of DSA image is rebuild the method that module is also followed the tracks of in conjunction with multiscale analysis and border, improves fuzzy, tiny and the management of blood vessels effect of intersecting.
Further, the blood vessel segmentation of DSA image is rebuild module can also do reference with the size of angiography catheter or guiding catheter according to instruction, interested vessel segment on the DSA image is carried out to the measurement of length, reference diameter and tube chamber area.
Further, blood vessel three-dimensional imaging module, can also be according to instruction after the three dimensional structure that generates blood vessel, and the area by the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtain capacity of blood vessel.
The image that " centre that above-mentioned module obtains and result data " described in described image report module can be certain module to be gathered measurement result and result of calculation, certain module of image, the image after certain resume module.
Adopt technical scheme of the present invention, there is following technique effect:
(1) intuitively obtain true length, vessel lumen diameter, vessel lumen area and volume and the speckle load of blood vessel; (2) obtain blood vessel three dimensional structure intuitively; (3) contrast of the vessel measurements on the cross section that the vessel measurements obtained by the reconstruction of the blood vessel segmentation to described DSA image module and the vessel measurement module of described IVUS image obtain, facilitate the patient to judge whether the vessel segment position to the capable interventional therapy of lesion vessels and interventional therapy, and then definite therapeutic scheme, and help the patient accurately to select support size and locating support.
The accompanying drawing explanation
Fig. 1 is the overall structure frame diagram of system of the present invention and Other related equipment.
Fig. 2 is the implementation route map of system of the present invention.
In figure, 1, the intravascular ultrasound instrument; 2, digital subtraction angiography machine; 3, the integrated online processing instrument in real time of IVUS image and DSA image; 4, image picture dedicated printer; 5, the image central station of hospital; 6, data acquisition module; 7, the blood vessel segmentation of DSA image is rebuild module; 8, the vessel measurement module of IVUS image; 9, the interlocking module of DSA image and IVUS image; 10, blood vessel three-dimensional imaging module; 11, image report module; 12, transport module.
The specific embodiment
According to Fig. 1 and Fig. 2, provided by the present invention is the integrated online processing instrument in real time of integrated intravascular ultrasound (IVUS) image and Digital Subtraction (DSA) image.This system comprises seven modules: the blood vessel segmentation of data acquisition module, DSA image is rebuild vessel measurement module, blood vessel three-dimensional imaging module, DSA image and IVUS image interlocking module, image report module and the transport module of module, IVUS image.Wherein: (1) data acquisition module: be included in computer-internal and embed the high definition capture card containing two-way DVI interface, at art Real-time Collection IVUS image and DSA image, and be stored in the computer local hard drive, (2) blood vessel segmentation of DSA image is rebuild module: the method based on matched filtering, extract the edge of non-intersect blood vessel on the DSA image, diameter and centrage, the reconstruction blood vessel is out of shape, method in conjunction with multiscale analysis and border tracking, improve fuzzy, the tiny management of blood vessels effect with intersecting, and interested blood vessel is sketched the contours to vessel centerline, starting point and the end of the final point of mark interest vessel segment on the vessel centerline of sketching the contours, perhaps, further, according to instruction, do reference by the size with angiography catheter or guiding catheter, interested vessel segment on the DSA image is carried out to length, the measurement of reference diameter and tube chamber area, (3) the vessel measurement module of IVUS image, this module is done reference by self size of IVUS conduit, selecteed interested image on the IVUS image is carried out to the measurement of full-automatic or human-machine interaction vessel lumen, described all automatic measurement refers to the difference of computer according to the gray value on the border of self tube chamber on vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtain measurement result, described human-machine interaction measurement refers at computer to be carried out on the basis of described all automatic measurement to interested image, provide again the operator to revise interface, receive operator's instruction, revise on vessel cross-sections the border of self tube chamber and remaining tube chamber, the vessel measurement module of IVUS image is carried out described measurement again according to the vessel lumen border of newly sketching the contours.Described measurement comprises: self tube chamber on vessel cross-sections and the tube chamber area of remaining tube chamber, diameter and speckle load, and the length of blood vessel on longitudinal section, described self tube chamber refers to original vessel lumen, comprises remaining vessel lumen and speckle part, described remaining tube chamber refer to current existing can blood supply the vessel lumen passed through of stream, be exactly that self tube chamber has been rejected remaining vessel lumen after speckle, described speckle load refers to the ratio of the area of plaque area on cross section and self tube chamber, (4) blood vessel three-dimensional imaging module: for to interested blood vessel, out of shape according to vessel cross-sections and the blood vessel after longitudinal section image and the reconstruction of DSA Image Segmentation of its IVUS image, generate blood vessel three dimensional structure intuitively, perhaps, further, after the three dimensional structure that generates blood vessel, can also be according to instruction, area by the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtain capacity of blood vessel, (5) interlocking module of DSA image and IVUS image: for the three dimensional structure according to blood vessel, obtain starting point on sketched the contours vessel centerline and the true length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on the IVUS image, and calculate the number of image frames N between start frame and end frame on the IVUS image, and then automatically the starting point on the DSA image and the blood vessel segmentation between end of the final point are become to N equidistant point, each that realizes blood vessel on the DSA image put on corresponding IVUS image corresponding two field picture separately, and rebuild the contrast of the vessel measurements on the cross section that the vessel measurement module of vessel measurements that module obtains and IVUS image obtains by the blood vessel segmentation to the DSA image, facilitate the patient to judge whether the vessel segment position to the capable interventional therapy of lesion vessels and interventional therapy, and then definite therapeutic scheme, and help the patient accurately to select support size and locating support, (6) image report module: for the measurement numerical value according to by computer is inputted automatically or the artificial above-mentioned module of inputting obtains, according to template, generate image and get involved the report of inspection related data, (7) transport module: for transmitting the integrated online in real time image data that processing instrument generates and reporting the computer to appointment.
In doing cardiovascular intervene operation process, the guidance that some special pathological changes (as: diffusivity vascular lesion, openings in blood vessels pathological changes and in-stent restenosis etc.) often need intravascular ultrasound to check, now, the present invention will enter operational phase, and its concrete implementation step is as follows:
1, the present invention is connected with the image output interface of IVUS machine with the DSA machine respectively interposing catheter is indoor, by the high-definition data capture card, DSA image and IVUS image in the Real-time Obtaining art;
2, by the paired observation of DSA image and IVUS image, found interested lesion vessels on the DSA image by the operator, according to operator's instruction, by computer run, rebuild module to interested blood vessel on the DSA image by the blood vessel segmentation of DSA image, rebuild blood vessel out of shape, and to the blood vessel after rebuilding, sketch the contours centrage, and automatically generate the removable line perpendicular to centrage, starting point and the end of the final point of the interested lesion vessels of mark on centrage.Described interested lesion vessels is also selecteed blood vessel, i.e. processing object of the present invention.
3,, according to operator's instruction, by computer run, the blood vessel after rebuilding according to the vessel cross-sections of the IVUS image of selected blood vessel and longitudinal section image and DSA Image Segmentation is out of shape, by blood vessel three-dimensional imaging module, generates blood vessel three dimensional structure intuitively.
4, according to operator's instruction, by computer run, interlocking module with DSA image and IVUS image, mark starting point and the end of the final point corresponding with the starting point of lesion vessels section on centrage and end of the final point on the blood vessel three dimensional structure of aforementioned generation, and then obtain the true length of the blood vessel between 2; And according to starting point and end of the final point, determine corresponding start frame and end frame image on the IVUS image, obtain the number of image frames N between start frame and end frame on the IVUS image, and then automatically the starting point on the DSA image and the blood vessel segmentation between end of the final point being become to N equidistant point, each that realizes blood vessel on the DSA image put on corresponding IVUS image corresponding two field picture separately.
5,, after selecting combined operation, while between N point on the selecteed blood vessel of DSA image, moving removable line, the two field picture on the IVUS image can correspondingly seesaw; Otherwise, while seesawing two field picture between the start frame on the IVUS image and end frame, the removable line on the DSA image can corresponding movement.And then realize the interlock of DSA image and IVUS image, and guarantee that the current frame image of the residing vessel segment of removable line and IVUS image matches, facilitate the patient to carry out paired observation to DSA image and IVUS image.
By the interlocking module of DSA image and IVUS image, for the contrast processing procedure at DSA image and IVUS image provides very directly perceived and interface easily.Vessel measurement module by the IVUS image is carried out the measurement of vessel lumen to interested vessel segment, and rebuild module by the blood vessel segmentation of DSA image and corresponding vessel segment is carried out to the measurement of length, reference diameter and vessel lumen area, and then facilitate the patient in the identical lesion of blood vessel, contrast the two measurement result, according to comparing result, judge whether the vessel segment position to the capable interventional therapy of lesion vessels and interventional therapy, and then definite therapeutic scheme, and help the patient accurately to select support size and locating support.
6, as required, by the three-dimensional imaging module of blood vessel, after generating the blood vessel three dimensional structure, according to instruction, the area by the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtain capacity of blood vessel.
7, according to operator's instruction, by computer run, by the image report module, according to manually input or the computer radiographic measurement data of input automatically, generate report and with the image after measuring, together with transport module, be uploaded to the computer of appointment, in order to again utilizing.
Claims (5)
1. the integrated online processing instrument in real time of integrated intravascular ultrasound (IVUS) image and Digital Subtraction (DSA) image, comprise with lower module: the blood vessel segmentation of data acquisition module, DSA image is rebuild interlocking module, image report module and the transport module of vessel measurement module, blood vessel three-dimensional imaging module, DSA image and the IVUS image of module, IVUS image;
Described data acquisition module, be included in computer-internal and embed the high definition capture card containing two-way DVI interface, at art Real-time Collection IVUS image and DSA image, and is stored in the computer local hard drive;
The blood vessel segmentation of described DSA image is rebuild module, out of shape for the DSA image reconstruction blood vessel to gathering, to selecteed interested vessel segment in the blood vessel after rebuilding, sketch the contours vessel centerline, starting point and the end of the final point of mark vessel segment on the vessel centerline of sketching the contours;
The vessel measurement module of described IVUS image, do reference by self size of IVUS conduit, selecteed interested image on the IVUS image carried out to the measurement of full-automatic or human-machine interaction vessel lumen; Described all automatic measurement refers to the difference of computer according to the gray value on the border of self tube chamber on vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtain measurement result; Described human-machine interaction measurement refers at computer to be carried out on the basis of described all automatic measurement to interested image, provide again the operator to revise interface, receive operator's instruction, revise on vessel cross-sections the border of self tube chamber and remaining tube chamber, the vessel measurement module of IVUS image is carried out described measurement again according to the vessel lumen border of newly sketching the contours; Described measurement comprises: self tube chamber on vessel cross-sections and the tube chamber area of remaining tube chamber, diameter and speckle load, and the length of blood vessel on longitudinal section; Described self tube chamber refers to original vessel lumen, comprises remaining vessel lumen and speckle part; Described remaining tube chamber refer to current existing can blood supply the vessel lumen passed through of stream, be exactly that self tube chamber has been rejected remaining vessel lumen after speckle; Described speckle load refers to the ratio of the area of plaque area on cross section and self tube chamber;
Described blood vessel three-dimensional imaging module, for to selecteed interested blood vessel, out of shape according to vessel cross-sections and the blood vessel after longitudinal section image and the reconstruction of DSA Image Segmentation of its IVUS image, generate blood vessel three dimensional structure intuitively;
The interlocking module of described DSA image and IVUS image, for the three dimensional structure according to blood vessel, obtain starting point on sketched the contours vessel centerline and the true length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on the IVUS image, and calculate the number of image frames N between start frame and end frame on the IVUS image, and then automatically the starting point on the DSA image and the blood vessel segmentation between end of the final point are become to N equidistant point, each that realizes blood vessel on the DSA image put on corresponding IVUS image corresponding two field picture separately, facilitate the accurate measurement of vessel lumen and the accurate location of support,
Described image report module, for intermediate data and the result data according to by computer is inputted automatically or the artificial above-mentioned module of inputting obtains, according to template, generate image and get involved the report of inspection related data;
Described transport module, for transmitting the integrated online in real time image data that processing instrument generates and reporting the computer to appointment.
2. integrated online processing instrument in real time as claimed in claim 1, the blood vessel segmentation that it is characterized in that described DSA image is rebuild the method for module based on matched filtering, extract edge, diameter and the centrage of non-intersect blood vessel, out of shape to the DSA image reconstruction blood vessel collected.
3. integrated online processing instrument in real time as claimed in claim 2, the blood vessel segmentation that it is characterized in that described DSA image is rebuild the method that module is also followed the tracks of in conjunction with multiscale analysis and border, improves fuzzy, tiny and the management of blood vessels effect of intersecting.
4. integrated online processing instrument in real time as claimed in claim 2 or claim 3, the blood vessel segmentation that it is characterized in that described DSA image is rebuild module also according to instruction, size with angiography catheter or guiding catheter is done reference, interested vessel segment on the DSA image is carried out to the measurement of length, reference diameter and tube chamber area.
5. integrated online processing instrument in real time as claimed in claim 1, it is characterized in that described blood vessel three-dimensional imaging module, after the three dimensional structure that generates blood vessel, also the area by the length of vessel on longitudinal section and the remaining tube chamber on cross section according to instruction, obtain capacity of blood vessel.
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