CN103462590B - Integrated intravascular OCT (optical coherence tomography) image and DSA (digital subtraction angiography) integrating offline treatment system - Google Patents
Integrated intravascular OCT (optical coherence tomography) image and DSA (digital subtraction angiography) integrating offline treatment system Download PDFInfo
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Abstract
The invention provides an integrated intravascular OCT (optical coherence tomography) image and DSA (digital subtraction angiography) integrating offline treatment system, which comprises a data acquisition module, a DSA-image-based blood vessel segmentation and reconstruction module, an OCT-image-based blood vessel measurement module, a blood vessel three-dimensional imaging module, a DSA image and OCT image linkage module, an image reporting module and a transmission module. According to the system, a blood vessel is multidimensionally treated by combining a DSA image and an OCT image to further facilitate the accurate positioning of an interested blood vessel section; a blood vessel measurement result obtained by the DSA-image-based blood vessel segmentation and reconstruction module is compared with a blood vessel measurement result, obtained by the OCT-image-based blood vessel measurement module, on a cross section, so that the blood vessel treatment research accuracy of a doctor or a researcher after an operation is improved to facilitate the supply of a more perfect therapeutic schedule for an interventional operation in a similar case in the future.
Description
Technical field
The invention belongs to field of medical, specifically refer to the integrated off-line processing system of interior coherence of light tomoscan (OCT) image of a kind of integrated blood vessel and Digital Subtraction (DSA) image.
Background technology
Coronarography is a kind of effective ways of diagnosis of coronary heart disease.Conduit is inserted through thigh femoral artery, radial artery or other peripheral arterial, deliver to ascending aorta, then seek left or right coronary ostium and insert, inject contrast agent, coronary artery is developed, can disclose more clearly position, degree and the scope of dissection deformity coronarius and obstructive pulmonary disease thereof.Coronarography is can directly observe the effective ways of coronary artery form at present, and medical circle number is called " goldstandard ".For narrow heavier position in radiography, need to carry out interventional therapy.
In the middle of clinical practice application, coronarography also shows many weak points.As, it can only show the situation of tube chamber, tube wall and atheromatous plaque that can not lesions showed place can not provide the details of atheromatous plaque form and character, likely make patient underestimate the degree of coronary stenosis.This just makes the accuracy of evaluating coronary atherosclerosis and interventional therapy curative effect according to coronary angiography reduce.Especially the proposition of this concept of arteria coronaria vascular remodeling, makes people have to reappraise the reliability of coronary angiography in coronary heart disease diagnosis and treatment.Early stage at coronary atherosclerosis, along with the increase of atheromatous plaque area, arteria coronaria is underwent compensatory enlargement, and tube chamber area can be without narrow, and this process is vascular remodeling, and now coronary angiography is often without Novel presentation.
Optical coherence tomography (OCT), use low-coherent light to carry out transverse section scanning to biological tissue, by recording the correlation curve of the degree of depth of each lateral attitude in scattering cross section and light beam, generate the cross-sectional image of tissue, it has used up-to-date high resolution scanning technology, except the advantage having without wound, favorable repeatability, it can Measurement Resolution≤10 μ m tissue and distance, can carry out Accurate Analysis to the speckle character of blood vessel, support girder steel etc.Because being directly placed in Endovascular, coherence of light tomography probe surveys, therefore, coherence of light tomography not only can Measurement accuracy tube chamber and the size of atheromatous plaque or fibrous plaque in blood vessel, the more important thing is that it can provide the cardinal principle organizational information of atheromatous plaque, when showing because of complicated pathological change form due to interventional therapy, be obviously better than radiography.
The pathological changes that needs Accurate Analysis for some pathological change of thrombus, in-stent restenosis etc., often needs the guidance of OCT.Yet, most DSA image and OCT images have just given patient certain directive significance in art, and after surgery, these data all by hematocrit in CD or server hard disc, when needs call these images again, cannot effectively DSA and OCT image be combined, and then when these cases of research, each doctor or researcher may obtain different data at same vascular lesion place, are a lot of obstacles of having manufactured of clinical research and case review.Therefore, a kind of can be in conjunction with DSA image and OCT image, realize the image processing system of puncta vasculosa to point measurement, to contribute to doctor or clinical research person after surgery case to be looked back and discussed and clinical research, and then provide scheme better for carrying out the next time of intervene operation, promoting the development of cardiovascular intervene operation.And this type of technology still belongs to blank at home, therefore there is very large development space and researching value.
Summary of the invention
The problem proposing for background technology, the object of this invention is to provide the integrated off-line processing system of coherence of light tomoscan (OCT) image and Digital Subtraction (DSA) image in a kind of integrated blood vessel.For this reason, the present invention is by the following technical solutions:
The present invention includes seven modules: the blood vessel segmentation of data acquisition module, DSA image is rebuild interlocking module, image report module and the transport module of vessel measurement module, blood vessel three-dimensional imaging module, DSA image and the OCT image of module, OCT image.Wherein: (1) data acquisition module, for calling DSA image and the OCT image of the required research of storing on local hard drive or remote access designated computer, (2) blood vessel segmentation of DSA image is rebuild module, for out of shape to the DSA image reconstruction blood vessel gathering, to selecteed interested vessel segment in the blood vessel after rebuilding, sketch the contours vessel centerline, in the vessel centerline of sketching the contours, mark starting point and the end of the final point of vessel segment, (3) the vessel measurement module of OCT image, does reference by self size of OCT conduit, selecteed interested image on OCT image is carried out to the measurement of full-automatic or human-machine interaction vessel lumen, described all automatic measurement refers to that computer is according to the difference of the gray value on the border of self tube chamber in vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtain measurement result, described human-machine interaction measurement refers on the basis of at computer, interested image being carried out described all automatic measurement, provide again operator to revise interface, receive operator's instruction, the border of revising in vessel cross-sections self tube chamber and remaining tube chamber, the vessel measurement module of OCT image is carried out described measurement again according to the vessel lumen border of newly sketching the contours, described measurement comprises: self tube chamber in vessel cross-sections and the tube chamber area of remaining tube chamber, diameter and speckle load, and the length of blood vessel on longitudinal section, described self tube chamber refers to original vessel lumen, comprises remaining vessel lumen and speckle part, described remaining tube chamber refer to current existing can blood supply the vessel lumen passed through of stream, be exactly that self tube chamber has been rejected remaining vessel lumen after speckle, described speckle load refers to the ratio of the area of plaque area on cross section and self tube chamber, (4) blood vessel three-dimensional imaging module, for to selecteed interested blood vessel, out of shape according to the blood vessel after the vessel cross-sections of its OCT image and longitudinal section image and the reconstruction of DSA Image Segmentation, generate blood vessel three dimensional structure intuitively, (5) interlocking module of DSA image and OCT image, be used for according to the three dimensional structure of blood vessel, obtain starting point in sketched the contours vessel centerline and the true length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on OCT image, and calculate the number of image frames N between start frame and end frame on OCT image, and then automatically the blood vessel segmentation between the starting point on DSA image and end of the final point is become to N equidistant point, each that realizes blood vessel on DSA image put on corresponding OCT image corresponding two field picture separately, and the blood vessel segmentation by DSA image is rebuild the contrast of the vessel measurements on the cross section that the vessel measurement module of vessel measurements that module obtains and OCT image obtains, improve doctor or the researcher processing research precision to blood vessel after surgery, so that for after the intervene operation of similar cases more perfect therapeutic scheme is provided, (6) image report module, for according to intermediate data and result data by computer is inputted automatically or the artificial above-mentioned module of inputting obtains, according to template, generates correction of image data report, for doctor or clinical research person's discussion, (7) transport module, for transmitting the image data that integrated off-line processing system generates and reporting the computer to appointment.
Further, the blood vessel segmentation of DSA image is rebuild the method for module based on matched filtering, extracts edge, diameter and the centrage of non-intersect blood vessel, out of shape to the DSA image reconstructing blood vessel blood vessel gathering.
Further, the blood vessel segmentation of DSA image is rebuild the method that module is also followed the tracks of in conjunction with multiscale analysis and border, improves fuzzy, tiny and the management of blood vessels effect of intersecting.
Further, the blood vessel segmentation of DSA image is rebuild module can also do reference with the size of angiography catheter or guiding catheter according to instruction, interested vessel segment on DSA image is carried out to the measurement of length, reference diameter and tube chamber area.
Further, blood vessel three-dimensional imaging module, can also be according to instruction after generating the three dimensional structure of blood vessel, and the area by the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtains capacity of blood vessel.
The image that " centre that above-mentioned module obtains and result data " described in described image report module can be certain module to be gathered the measurement result of image and result of calculation, certain module, the image after certain resume module.
Adopt technical scheme of the present invention, there is following technique effect:
(1) intuitively obtain true length, vessel lumen diameter, vessel lumen area and volume and the speckle load of blood vessel; (2) obtain blood vessel three dimensional structure intuitively; (3) blood vessel segmentation by the DSA image to described is rebuild the contrast of the vessel measurements on the cross section that the vessel measurement module of vessel measurements that module obtains and described OCT image obtains, and then can observe fine vascular lesion, help doctor or clinical research person to study better case, for intervene operation afterwards, make place mat better, more suitable operation plan is provided.
Accompanying drawing explanation
Fig. 1 is the overall structure frame diagram of system of the present invention and Other related equipment.
Fig. 2 is the implementation route map of system of the present invention.
In figure, 1, coherence of light tomoscanner in blood vessel; 2, digital subtraction angiography machine; 3, OCT image and the integrated off-line processing system of DSA image; 4, image picture dedicated printer; 5, the image central station of hospital; 6, data acquisition module; 7, the blood vessel segmentation of DSA image is rebuild module; 8, the vessel measurement module of OCT image; 9, the interlocking module of DSA image and OCT image; 10, blood vessel three-dimensional imaging module; 11, image report module; 12, transport module.
The specific embodiment
According to Fig. 1 and Fig. 2, provided by the present invention is the integrated off-line processing system of interior coherence of light tomoscan (OCT) image of integrated blood vessel and Digital Subtraction (DSA) image.This system comprises seven modules: the blood vessel segmentation of data acquisition module, DSA image is rebuild vessel measurement module, blood vessel three-dimensional imaging module, DSA image and OCT image interlocking module, image report module and the transport module of module, OCT image.Wherein: (1) data acquisition module: for calling DSA image and the OCT image of the required research of storing on local hard drive or remote access designated computer, (2) blood vessel segmentation of DSA image is rebuild module: the method based on matched filtering, on DSA image, extract the edge of non-intersect blood vessel, diameter and centrage, reconstruction blood vessel is out of shape, method in conjunction with multiscale analysis and border tracking, improve fuzzy, the tiny management of blood vessels effect with intersecting, and interested blood vessel is sketched the contours to vessel centerline, in the vessel centerline of sketching the contours, mark starting point and the end of the final point of interest vessel segment, or, further, according to instruction, by doing reference with the size of angiography catheter or guiding catheter, interested vessel segment on DSA image is carried out to length, the measurement of reference diameter and tube chamber area, (3) the vessel measurement module of OCT image: self size by OCT conduit is done reference, carries out the measurement of full-automatic or human-machine interaction vessel lumen to selecteed interested image on OCT image, described all automatic measurement refers to that computer is according to the difference of the gray value on the border of self tube chamber in vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtain measurement result, described human-machine interaction measurement refers on the basis of at computer, interested image being carried out described all automatic measurement, provide again operator to revise interface, receive operator's instruction, the border of revising in vessel cross-sections self tube chamber and remaining tube chamber, the vessel measurement module of OCT image is carried out described measurement again according to the vessel lumen border of newly sketching the contours.Described measurement comprises: self tube chamber in vessel cross-sections and the tube chamber area of remaining tube chamber, diameter and speckle load, and the length of blood vessel on longitudinal section, described self tube chamber refers to original vessel lumen, comprises remaining vessel lumen and speckle part, described remaining tube chamber refer to current existing can blood supply the vessel lumen passed through of stream, be exactly that self tube chamber has been rejected remaining vessel lumen after speckle, described speckle load refers to the ratio of the area of plaque area on cross section and self tube chamber, (4) blood vessel three-dimensional imaging module: for to interested blood vessel, out of shape according to the blood vessel after the vessel cross-sections of its OCT image and longitudinal section image and the reconstruction of DSA Image Segmentation, generate blood vessel three dimensional structure intuitively, or, further, after generating the three dimensional structure of blood vessel, can also be according to instruction, area by the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtains capacity of blood vessel, (5) interlocking module of DSA image and OCT image: for according to the three dimensional structure of blood vessel, obtain starting point in sketched the contours vessel centerline and the true length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on OCT image, and calculate the number of image frames N between start frame and end frame on OCT image, and then automatically the blood vessel segmentation between the starting point on DSA image and end of the final point is become to N equidistant point, each that realizes blood vessel on DSA image put on corresponding OCT image corresponding two field picture separately, the contrast of the vessel measurements on the cross section that the vessel measurements obtaining by the blood vessel segmentation reconstruction module to DSA image and the vessel measurement module of OCT image obtain, can observe fine vascular lesion, help doctor or clinical research person to study better case, for intervene operation is afterwards made place mat better, more suitable operation plan is provided, (6) image report module: for according to the measurement numerical value by computer is inputted automatically or the artificial above-mentioned module of inputting obtains, according to template, generate correction of image data report, for doctor or clinical research person's discussion, (7) transport module: for transmitting the image data that integrated off-line processing system generates and reporting the computer to appointment.
The present invention can adopt computer as hardware, to carry out the processing of said process.After finishing blood vessel intervention operation, when needs call these DSA and OCT image data when carrying out case review and research, the present invention will enter operational phase, and its concrete implementation step is as follows:
1, utilize data acquisition module of the present invention, directly transfer DSA image and the OCT image of the required research of storing on local hard drive or remote access designated computer;
2, by the paired observation of DSA image and OCT image, by operator, on DSA image, found interested lesion vessels, according to operator's instruction, by computer run, by the blood vessel segmentation of DSA image, rebuild module to interested blood vessel on DSA image, rebuild blood vessel out of shape, and to the blood vessel after rebuilding, sketch the contours centrage, and automatically generate the removable line perpendicular to centrage, on centrage, mark starting point and the end of the final point of interested lesion vessels.Described interested lesion vessels is also selecteed blood vessel, i.e. processing object of the present invention.
3, according to operator's instruction, by computer run, out of shape according to the blood vessel after the vessel cross-sections of the OCT image of selected blood vessel and longitudinal section image and the reconstruction of DSA Image Segmentation, by blood vessel three-dimensional imaging module, generate blood vessel three dimensional structure intuitively.
4, according to operator's instruction, by computer run, interlocking module with DSA image and OCT image, on the blood vessel three dimensional structure of aforementioned generation, mark starting point and the end of the final point corresponding with the starting point of lesion vessels section on centrage and end of the final point, and then obtain the true length of the blood vessel between 2; And according to starting point and end of the final point, determine corresponding start frame and end frame image on OCT image, obtain the number of image frames N between start frame and end frame on OCT image, and then automatically the blood vessel segmentation between the starting point on DSA image and end of the final point being become to N equidistant point, each that realizes blood vessel on DSA image put on corresponding OCT image corresponding two field picture separately.
5, select after combined operation, while moving removable line between N point on the selecteed blood vessel of DSA image, the two field picture on OCT image can correspondingly seesaw; Otherwise while seesawing two field picture between the start frame on OCT image and end frame, the removable line on DSA image can corresponding movement.And then realize the interlock of DSA image and OCT image, and guarantee that the current frame image of the residing vessel segment of removable line and OCT image matches, facilitate doctor or clinical research person to carry out paired observation to DSA image and OCT image.
By the interlocking module of DSA image and OCT image, for the contrast processing procedure at DSA image and OCT image provides very directly perceived and interface easily.Vessel measurement module by OCT image is carried out the measurement of vessel lumen to interested vessel segment, and by the blood vessel segmentation of DSA image, rebuild module and corresponding vessel segment is carried out to the measurement of length, reference diameter and vessel lumen area, and then facilitate doctor or clinical research person in the identical lesion of blood vessel, contrast the two measurement result, form the basic data that supplies intuitively Cases Discussion and research, for similar pathological changes afterwards provides more suitable therapeutic scheme.
6, as required, by the three-dimensional imaging module of blood vessel, after generating blood vessel three dimensional structure, according to instruction, the area by the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtains capacity of blood vessel.
7, according to operator's instruction, by computer run, by image report module, according to manually input or the computer radiographic measurement data of input automatically, generate report and with the image after measuring, together with transport module, be uploaded to the computer of appointment, in order to again utilizing.
Claims (5)
1. an integrated off-line processing system for coherence of light tomoscan (OCT) image and Digital Subtraction (DSA) image in integrated blood vessel, comprises with lower module: the blood vessel segmentation of data acquisition module, DSA image is rebuild interlocking module, image report module and the transport module of vessel measurement module, blood vessel three-dimensional imaging module, DSA image and the OCT image of module, OCT image;
Described data acquisition module, for calling DSA image and the OCT image of the required research of storing on local hard drive or remote access designated computer;
The blood vessel segmentation of described DSA image is rebuild module, for out of shape to the DSA image reconstruction blood vessel gathering, to selecteed interested vessel segment in the blood vessel after rebuilding, sketch the contours vessel centerline, in the vessel centerline of sketching the contours, mark starting point and the end of the final point of vessel segment;
The vessel measurement module of described OCT image, does reference by self size of OCT conduit, selecteed interested image on OCT image is carried out to the measurement of full-automatic or human-machine interaction vessel lumen; Described all automatic measurement refers to that computer is according to the difference of the gray value on the border of self tube chamber in vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtain measurement result; Described human-machine interaction measurement refers at computer to be carried out on the basis of described all automatic measurement to interested image, provide again operator to revise interface, receive operator's instruction, the border of revising in vessel cross-sections self tube chamber and remaining tube chamber, the vessel measurement module of OCT image is carried out described measurement again according to the vessel lumen border of newly sketching the contours; Described measurement comprises: self tube chamber in vessel cross-sections and the tube chamber area of remaining tube chamber, diameter and speckle load, and the length of blood vessel on longitudinal section; Described self tube chamber refers to original vessel lumen, comprises remaining vessel lumen and speckle part; Described remaining tube chamber refer to current existing can blood supply the vessel lumen passed through of stream, be exactly that self tube chamber has been rejected remaining vessel lumen after speckle; Described speckle load refers to the ratio of the area of plaque area on cross section and self tube chamber;
Described blood vessel three-dimensional imaging module, for to selecteed interested blood vessel, out of shape according to the blood vessel after the vessel cross-sections of its OCT image and longitudinal section image and the reconstruction of DSA Image Segmentation, generate blood vessel three dimensional structure intuitively;
Described DSA image and the interlocking module of OCT image, be used for according to the three dimensional structure of blood vessel, obtain starting point in sketched the contours vessel centerline and the true length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on OCT image, and calculate the number of image frames N between start frame and end frame on OCT image, and then automatically the blood vessel segmentation between the starting point on DSA image and end of the final point is become to N equidistant point, each that realizes blood vessel on DSA image put on corresponding OCT image corresponding two field picture separately, convenient accurate measurement and research to interest vessel lumen,
Described image report module, be used for according to the data acquisition module of automatically inputting or manually inputting by computer, the blood vessel segmentation of DSA image is rebuild intermediate data and the result data that the interlocking module of vessel measurement module, blood vessel three-dimensional imaging module, DSA image and the OCT image of module, OCT image obtains, according to template, generate correction of image data report, for doctor or clinical research person, discuss;
Described transport module, for transmitting the image data that integrated off-line processing system generates and reporting the computer to appointment.
2. integrated off-line processing system as claimed in claim 1, the blood vessel segmentation that it is characterized in that described DSA image is rebuild the method for module based on matched filtering, extract edge, diameter and the centrage of non-intersect blood vessel, out of shape to the DSA image reconstruction blood vessel collecting.
3. integrated off-line processing system as claimed in claim 2, the blood vessel segmentation that it is characterized in that described DSA image is rebuild the method that module is also followed the tracks of in conjunction with multiscale analysis and border, improves fuzzy, tiny and the management of blood vessels effect of intersecting.
4. integrated off-line processing system as claimed in claim 2 or claim 3, the blood vessel segmentation that it is characterized in that described DSA image is rebuild module also according to instruction, size with angiography catheter or guiding catheter is done reference, interested vessel segment on DSA image is carried out to the measurement of length, reference diameter and tube chamber area.
5. integrated off-line processing system as claimed in claim 1, it is characterized in that described blood vessel three-dimensional imaging module, after generating the three dimensional structure of blood vessel, also according to instruction by the area of the length of vessel on longitudinal section and the remaining tube chamber on cross section, obtain capacity of blood vessel.
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| CN104156931B (en) * | 2014-09-04 | 2017-03-29 | 成都金盘电子科大多媒体技术有限公司 | A kind of digital subtraction angiography method |
| CN107872963B (en) | 2014-12-12 | 2021-01-26 | 光学实验室成像公司 | System and method for detecting and displaying intravascular features |
| CN107492145A (en) * | 2016-12-23 | 2017-12-19 | 哈尔滨医科大学附属第二医院 | Three-dimensional reconstruction is peeped in a kind of true posture in space |
| CN109222980A (en) * | 2018-06-19 | 2019-01-18 | 北京红云智胜科技有限公司 | Method of the measurement coronarogram based on deep learning as blood vessel diameter |
| CN110517244B (en) * | 2019-08-23 | 2023-04-28 | 首都医科大学宣武医院 | Positioning method and system based on DSA image |
| CN110910374A (en) * | 2019-11-25 | 2020-03-24 | 华中科技大学同济医学院附属协和医院 | Intelligent processing system and method for aorta image |
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| CN111920388A (en) * | 2020-08-25 | 2020-11-13 | 南京沃福曼医疗科技有限公司 | Method for evaluating plaque load based on OCT (optical coherence tomography) image |
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