CN103454346B - 一种基于声波传感器的微流控芯片分析平台 - Google Patents
一种基于声波传感器的微流控芯片分析平台 Download PDFInfo
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Publication number | Priority date | Publication date | Assignee | Title |
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CN104374930B (zh) * | 2014-02-28 | 2016-06-29 | 深圳市第二人民医院 | 人类免疫缺陷病毒检测装置及其检测方法 |
CN104498353B (zh) * | 2014-11-05 | 2016-08-31 | 苏州国科芯感医疗科技有限公司 | 恒温扩增压电核酸检测系统 |
CN105241505B (zh) * | 2015-10-16 | 2017-03-22 | 中国科学院苏州生物医学工程技术研究所 | 基于单个Lamb波器件的压力和流速多参数测量装置和方法 |
EP3199240A1 (de) * | 2016-01-26 | 2017-08-02 | ThinXXS Microtechnology AG | Mikrofluidische flusszelle mit integrierter elektrode und verfahren zu ihrer herstellung |
US10547282B2 (en) * | 2016-10-31 | 2020-01-28 | Samsung Electro-Mechanics Co., Ltd. | Filter including bulk acoustic wave resonator |
CN106732836B (zh) * | 2016-12-08 | 2022-05-24 | 宁波大学 | 一种声表面波控制开启和关闭的微阀及其控制方法 |
CN108918899B (zh) * | 2018-05-18 | 2021-12-28 | 北京大学深圳研究生院 | 一种化学反应的高通量筛选系统、装置和方法 |
CN109507285B (zh) * | 2018-10-24 | 2021-01-26 | 浙江师范大学 | 一种在血液净化系统中用声表面波实现漏血监测的装置和方法 |
CN111190022A (zh) * | 2020-01-07 | 2020-05-22 | 中国科学院半导体研究所 | 基于谐振式传感器的生化检测系统及检测方法 |
CN111679088A (zh) * | 2020-06-04 | 2020-09-18 | 沈阳工业大学 | 一种用于微全分析系统芯片集成化进样系统及进样方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7191639B2 (en) * | 2003-04-08 | 2007-03-20 | California Institute Of Technology | On-chip magnetic force actuation of microcantilevers by coplanar coils |
CN201517993U (zh) * | 2009-07-16 | 2010-06-30 | 江西科技师范学院 | 一种基于光声技术的微流控芯片检测装置 |
CN101968464A (zh) * | 2010-09-26 | 2011-02-09 | 中国人民解放军第三军医大学第三附属医院 | 倒插式液相声表面波检测装置及其阵列 |
CN203455314U (zh) * | 2013-08-27 | 2014-02-26 | 中国科学院苏州生物医学工程技术研究所 | 一种基于声波传感器的微流控芯片分析平台 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7191639B2 (en) * | 2003-04-08 | 2007-03-20 | California Institute Of Technology | On-chip magnetic force actuation of microcantilevers by coplanar coils |
CN201517993U (zh) * | 2009-07-16 | 2010-06-30 | 江西科技师范学院 | 一种基于光声技术的微流控芯片检测装置 |
CN101968464A (zh) * | 2010-09-26 | 2011-02-09 | 中国人民解放军第三军医大学第三附属医院 | 倒插式液相声表面波检测装置及其阵列 |
CN203455314U (zh) * | 2013-08-27 | 2014-02-26 | 中国科学院苏州生物医学工程技术研究所 | 一种基于声波传感器的微流控芯片分析平台 |
Non-Patent Citations (1)
Title |
---|
微混合器的研究进展;李倩等;《化工学报》;20091231;第28卷(第6期);922-926 * |
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