CN103446212B - A kind of liver protection product - Google Patents
A kind of liver protection product Download PDFInfo
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- CN103446212B CN103446212B CN201310411115.5A CN201310411115A CN103446212B CN 103446212 B CN103446212 B CN 103446212B CN 201310411115 A CN201310411115 A CN 201310411115A CN 103446212 B CN103446212 B CN 103446212B
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- extract
- liver
- protection product
- seed
- liver protection
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Landscapes
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Abstract
The invention provides a kind of liver protection product.Described liver protection product at least comprises seed of Sesamum indicum L. extract and Herba Silybi mariani extract, and the percentage by weight of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract is 1:0.01-0.01:1.Present invention also offers the preparation method of described liver protection product.Liver protection product provided by the invention can prevent the liver organization damage caused by the chemical substance such as ethanol or carbon tetrachloride more all sidedly, improves the ability that liver resists chemical damage.
Description
Technical field
The present invention relates to a kind of biological product, particularly relate to a kind of liver protection product.
Background technology
Liver is the toxin expelling organ that body weight for humans is wanted, and through the noxious substance that the digestive system such as human body intestinal canal absorb, by becoming innocuous substance after liver detoxification, then excretes through bile or urine.The direct menace's health of liver function damage meeting, cause in the factor of hepar damnification many, the hepar damnification that chemical substance causes more and more causes the concern of people.The chemical substance of hepatic injury can be caused to comprise chemical toxicant etc. in ethanol, environment.
Research finds, the damage of ethanol to liver is due to after excessive alcohol enters human body, produces a large amount of NADH(nicotianamine adenine-dinucleotides in metabolic process) and NADP
+(nicotianamine adenine dinucleotide phosphate), and the increase of NADH promotes the synthesis of lipid, thus cause fatty liver; Simultaneously, also a large amount of metabolite acetaldehyde can be produced in alcohol metabolism process, in order to eliminate the toxic and side effects of acetaldehyde, need to consume a large amount of glutathion (GSH), cause the decline of antioxidant glutathion (GSH) content, final destroy cellular redox stable state and induced oxidation stress, produce the reactive oxygen free radical (reactiveoxygenspecies that can not effectively remove in a large number, ROS), superoxide anion (O is comprised
2 -), hydroxy radical (OH) and hydrogen peroxide (H
2o
2) etc., these oxidative stresss may cause mitochondria dysfunction, lipid peroxidation and protein-modified, thus cause the generation and Astrocytic activation etc. of hepatocellular death, inflammatory reaction further.
Chemical toxicant in environment, as carbon tetrachloride, can produce the very strong intermediate product of a kind of oxidability human body metabolism, cause the lipid peroxidation on biomembrane, destroy the phospholipid of film, change the structure and fuction of cell, and disturb synthesis and the transhipment of lipoprotein, form fatty liver.Serum ALT, the AST activity of the acute hepatic infringement patient caused by carbon tetrachloride can obviously raise, and when the liver of patient is badly damaged, its serum bilirubin, prothrombin time also can obviously raise, and serum albumin levels then obviously reduces.
Multiple natural extract confirms elimination after deliberation or to alleviate above-mentioned chemical liver injury useful, such as: seed of Sesamum indicum L. extract and Herba Silybi mariani extract etc.Seed of Sesamum indicum L. extract: comprise sesamin, episesamin, sesamolin, sesamol and sesamolin etc., effectively can alleviate ethanol to the damage of liver and promotion adipose metabolism, reduce liver fat to pile up, such as: suppress serum glutamic pyruvic transminase (ALT), millet straw transferring enzyme (AST), glutathione transferase (GST), and improve the activity of aldehyde dehydrogenase (ADHL), alleviate the damage of ethanol to liver; Also can promote the gene expression of aldehyde dehydrogenase (ADHL), increase the metabolism of ethanol and acetaldehyde, alleviate the toxicity of acetaldehyde, alleviation of alcohol is poisoning; Triglyceride (this causes the primary fat of the fatty liver to originate) level in serum can also be reduced in addition, and by improving the activity of acyl-CoA oxidase, suppress the increase of polyunsaturated fatty acid, promote fat oxidation, reduce the accumulation of liver fat.In addition, also can increase liver glutathion (GSH) content, reduce liver malonaldehyde (MDA) content.Herba Silybi mariani extract: comprising silymarin (comprising silibinin (silybin), Isosilybin (isosilybin), silidianin (silidianin) and silicristin (silihristin)) effectively can eliminate oxygen-derived free radicals, the hepatic injury promoting the biosynthesis of liver internal protein to alleviate oxidative stress to cause, such as: by eliminating the biosynthesis of oxygen-derived free radicals, anti peroxidation of lipid and cell cultured supernatant internal protein, promote the post-equalization of wounded hepatocytes; Stablize liver plasma membrane, protection hepatocyte is without prejudice.In addition, silibinin, by promoting the regeneration of protein synthesis promotion liver, can suppressing the generation of the prostaglandin generating leukotriene (leukotriene) and the reaction that causes inflammation during hepatic injury, has the effects such as the shortage of antioxidation and prevention glutathion.
But, existing research shows to be used alone the liver function damage that above-mentioned two kinds of extracts all can not prevent to be caused by the chemical substance such as ethanol or carbon tetrachloride more all sidedly, especially can not prevent the histologic characteristics of liver from worsening more comprehensively, therefore how to provide one to prevent liver function to damage more all sidedly, the liver protection product that especially can more comprehensively prevent the histologic characteristics of liver from worsening becomes problem to be solved.
Summary of the invention
The object of this invention is to provide a kind of liver protection product, by using the seed of Sesamum indicum L. extract of special ratios and Herba Silybi mariani extract as active component, liver function can be prevented more comprehensively due to the damage of the chemical substance such as ethanol or carbon tetrachloride, especially can prevent the deterioration of liver histological feature more comprehensively.
A kind of liver protection product provided by the invention, at least comprises seed of Sesamum indicum L. extract and Herba Silybi mariani extract, and the percentage by weight of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract is 1:0.01-0.01:1.
In the specific embodiment of the present invention, described seed of Sesamum indicum L. extract can be the sesamin that method described in patent 200610089321.9 obtains.Seed of Sesamum indicum L. extract of the present invention also can be main component with sesamin, also can contain one or more in episesamin, sesamolin, sesamol and sesamolin further.
Described Herba Silybi mariani extract can be the silymarin that method described in patent 200910238368.0 obtains.Herba Silybi mariani extract of the present invention also can be with silymarin (comprising silibinin and Isosilybin) main component, also can contain one or more in Silychristin, silidianin, silybin-N-methylglucamine and SDH further.
In the present invention program, the gross weight of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract accounts for described liver protection product 0.1wt%-25wt%.
Further, the total amount of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract accounts for described liver protection product 5wt%-25wt%.
Further, described liver protection product also comprises: one or more in Fructus Schisandrae Chinensis extrat, Radix Puerariae extract, wolfberry fruit extract and tea extract.Described Fructus Schisandrae Chinensis extrat is deoxyschizandrin, schisandrin B, schisandrin C, schisandrin, schisantherin B, schisantherin A or schisantherin B.Described Fructus Schisandrae Chinensis extrat, Radix Puerariae extract, wolfberry fruit extract and tea extract are all by commercially available, or extracted by water logging and obtain, the condition that water logging is extracted can be generally: temperature 90 DEG C, extraction time is 3 hours, and the liquid-solid mass ratio of leaching process is 15:1.
In the solution of the present invention, one or more in described seed of Sesamum indicum L. extract, Herba Silybi mariani extract, Fructus Schisandrae Chinensis extrat, Radix Puerariae extract, wolfberry fruit extract and tea extract all can be used as the active component (i.e. effective ingredient) of liver protection product of the present invention.
Further, liver protection product provided by the invention can protect the liver medicine or food with effect of hepatic protection.
Further, protect the liver medicine described in and also comprise pharmaceutically acceptable excipient.Further, the dosage form protecting the liver medicine described in can be hard capsule, soft capsule, tablet, granule, powder, suspension, syrup, oral liquid or injection.Further, described tablet can be conventional tablet, dispersible tablet or effervescent tablet.
In a specific embodiment of the present invention, the effective ingredient protecting the liver medicine of the present invention comprises the combination of seed of Sesamum indicum L. extract and Herba Silybi mariani extract, this every daily dose protecting the liver medicine depends on many factors: such as according to the amount of the chemical substances such as the ethanol of individuality absorption or the carbon tetrachloride of contact, can use containing treating the hepatic that effective dose (total amount of effective ingredient) is 10-5000mg to individuality every day, those skilled in the art determine the dosage of hepatic as required, as long as the hepatic injury caused by ethanol or carbon tetrachloride can be prevented more all sidedly, especially can prevent the histologic characteristics of liver from worsening more comprehensively.
Degree (such as: the seriousness of fatty liver), the individual age, physical qualification, complication etc. of the hepar damnification (being caused by the chemical substance such as ethanol or carbon tetrachloride) that the described every daily dose protecting the liver medicine can certainly produce according to individuality suitably adjust.Usually can use containing treatment effective dose to hepar damnification individuality every day be the hepatic of 10-5000mg.Further, using containing treatment effective dose for slight hepar damnification individuality is the hepatic of 10-400mg.It is the hepatic of 500-2000mg that individuality for moderate liver damage is used containing treatment effective dose.Using containing treatment effective dose for severe liver impaired individuals is the hepatic of 2500-5000mg.To realize the hepatic injury that alleviation or prevention ethanol or carbon tetrachloride cause, improve the ability that liver resists chemical damage.
Further, protecting the liver medicine described in can be unit formulation.Described unit formulation is for meeting the preparation of effective ingredient needed for single administration, and common unit formulation is as a unit (sheet) tablet, a unit (pin) injection or injectable powder etc.Seed of Sesamum indicum L. extract containing 10-5000mg in described unit formulation and Herba Silybi mariani extract.Further, the seed of Sesamum indicum L. extract containing 10-400mg in described unit formulation and Herba Silybi mariani extract.Further, the seed of Sesamum indicum L. extract containing 500-2000mg in described unit formulation and Herba Silybi mariani extract.Further, the seed of Sesamum indicum L. extract containing 2500-5000mg in described unit formulation and Herba Silybi mariani extract.
In an embodiment of the invention, with injection system use containing treatment effective dose described in protect the liver medicine.Be to patient with the dosed administration of unit formulation better, described unit formulation is for meeting the preparation of effective ingredient needed for single administration, and common unit formulation is as a unit (sheet) tablet, a unit (pin) injection or injectable powder etc.The amount of the medicine needed for patient's applied once can obtain conveniently by the product of per weight dosage needed for the body weight of calculating patient and this patient's a drug.Such as, in the process preparing medicine, it is generally acknowledged that adult's body weight is 50-90kg, can determine dosage by the dose,equivalent conversion relation between the per weight dosage of animals and human beings by experiment at first.Such as, the instruction that can propose according to medicine administrative organs such as FDA, SFDA, also can with reference to (Huang Jihan etc., " dose,equivalent in pharmacological testing between animal and between animals and human beings body converts ", " Chinese Clinical pharmacology and therapeutics ", 2004Sep; 9 (9): 1069-1072) determine.In embodiments of the present invention, body surface area conversion factor 0.018 according to people and rat can be used to the dosage of convert people and rat.According to embodiment of the present invention, it is described that to protect the liver therapeutic effect when seed of Sesamum indicum L. extract in medicine and Herba Silybi mariani extract are applied to rat with 5-200mg/kg rat dosage at every turn better, when with 10-100mg/kg rat dosage, such as 100mg/kg, 50mg/kg, and when 10mg/kg rat dosage is applied to rat, therapeutic effect is better.Pharmaceutical manufacturer can obtain for the active constituent content in the unit formulation of people according to above-mentioned conversion method, in order to be applied in its pharmacy procedure.
In the inventive solutions, according to the conventional weight of dose,equivalent conversion relation and people, and comprehensive drug safety, cost and drug effect, preferably, described seed of Sesamum indicum L. extract containing 20-800mg in described unit formulation and Herba Silybi mariani extract, the described seed of Sesamum indicum L. extract more preferably containing 40-450mg and Herba Silybi mariani extract.
Further, fructose and/or milk product can also be contained in described food with effect of hepatic protection.
Described fructose realizes by the mode such as high fructose syrup, fructose, Mel of adding containing fructose composition, and addition can for suitably to select according to the mouthfeel of food with effect of hepatic protection and the needs of local flavor.In described food with effect of hepatic protection, add fructose except improving except the local flavor of food with effect of hepatic protection, the metabolism of ethanol can also be accelerated, have anti-intoxication, relieve the effect of alcohol and liver-protective effect.
Described milk product can fresh milk, Yoghourt or cheese.The Yoghourt that described Yoghourt can be obtained by one or more fermentations in bifidobacterium longum, bifidobacterium bifidum, bifidobacteria infantis, bifidobacterium adolescentis, Lactobacillus bulgaricus, streptococcus thermophilus, bacillus acidophilus.The various probiotic bacterias used are the probiotic bacteria of commercially available acquisition, and fermentation process adopts the fermentation process of this area routine.
Further, described food with effect of hepatic protection provided by the invention comprises: the products such as the confection containing above-mentioned active component, chewing gum, milk buccal tablet, milk ball, milk bar or milk grape.These products adopt technique known in the art to be prepared.Described food with effect of hepatic protection can also be dissolving liver-protecting drink, comprises solid beverage and liquid beverage.
In food with effect of hepatic protection provided by the invention, the amount of active component (comprising seed of Sesamum indicum L. extract and Herba Silybi mariani extract) suitably can be determined depending on object (prevention or health promotion).Usually, seed of Sesamum indicum L. extract and Herba Silybi mariani extract (percentage by weight of seed of Sesamum indicum L. extract and Herba Silybi mariani extract is 1:0.01-0.01:1) can be added in described food with effect of hepatic protection with 0.1wt%-25wt%, the preferably total amount of 5wt%-25wt%.
Present invention also offers the preparation method of above-mentioned liver protection product, being included in preparation process interpolation percentage by weight is that 1:0.01-0.01:1 Semen Sesami extracts and Herba Silybi mariani extract.
Having the following advantages of liver protection product provided by the invention and its preparation method:
1, liver protection product of the present invention has the effect of bile duct proliferation that outstanding suppression ethanol or carbon tetrachloride cause, inflammation hepatic injury, and the effect of the rising of mda content in suppression liver, the liver function damage because the chemical substance such as ethanol or carbon tetrachloride causes can be prevented more comprehensively, especially can prevent the deterioration of the histologic characteristics of liver.
2, liver protection product of the present invention can contain Yoghourt, Yoghourt can form the bioactivity-protected film of one deck (ethanol protecting wall) on gastrointestinal mucosa top layer, ethanol stomach function regulating intestinal mucosa is kept apart, effective minimizing human body is to the absorption of ethanol, effectively protect the intestines and stomach not by the direct stimulation of ethanol, and activate the egodefense repair system of the intestines and stomach, make the injury of harmful substance to organ be down to minimum; In addition, the ethanol dehydrogenase (ADH) that in Yoghourt, probiotic bacteria produces and aldehyde dehydrogenase (ADHL), can promote that ethanol decomposes, alleviate the murder by poisoning to liver; And VB1, VB2, VB6, VB12 etc. that probiotic bacteria produces are favourable to relieving the effect of alcohol; The lactic acid simultaneously produced after probiotics fermention can improve the utilization rate of calcium effectively, is also conducive to relieving the effect of alcohol, and improves vigor and the function of kidney cell, gets rid of ethanol in body and derivant thereof and other noxious substance fast.
3, liver protection product of the present invention can contain fructose, except improving except the local flavor of goods, can also accelerate the metabolism of ethanol, have anti-intoxication, relieve the effect of alcohol and liver-protective effect.
Detailed description of the invention
Hereafter, the present invention will be described in more detail by example.But following instance is only for understanding the present invention and it does not limit the present invention.In following examples if no special instructions, the sesamin that described seed of Sesamum indicum L. extract obtains for method described in patent 200610089321.9, the silymarin that described Herba Silybi mariani extract obtains for method described in patent 200910238368.0.
Embodiment 1 zoopery
One. experiment material
1, animal: purchased from 60 male rats (SD kind) (average weight=120-130g) at University of the Inner Mongol's Animal Experimental Study center.
2, medicine, reagent and instrument:
Positive drug 1: seed of Sesamum indicum L. extract; Positive drug 2: Herba Silybi mariani extract.
Olive oil and CCL
4all commercially available.
3, grouping and drug dose
Above-mentioned 60 rats are divided into 6 groups at random, and rat often organizes 10, is respectively:
1) blank group (using olive oil); 2) model group (uses olive oil and CCL
4);
3) positive drug group 1(uses olive oil and CCL
4, and show the seed of Sesamum indicum L. extract of corresponding dosage in 1-3); Positive drug group 2(uses olive oil and CCL
4, and show the Herba Silybi mariani extract group of corresponding dosage in 1-3);
4) high dose group, 5) in dosage group, 6) low dose group (uses olive oil and CCL
4, and table 1-3 in corresponding treatment effective dose protect the liver medicine).
Two, experimentation
Test the 1st day, the olive oil of blank group lumbar injection 0.75ml/kg rat body weight, once in a week, totally 8 weeks.All the other respectively organize rat: model group, high dose group, middle dosage group, low dose group, positive drug group, respectively lumbar injection CCL
4with the mixture of olive oil, amount of application is 0.75ml/kg rat body weight, CCL in this mixture
4account for 40%(volume), once in a week, totally 8 weeks.Above-mentioned, lumbar injection CCL is carried out to each group of rat except blank group
4with the mixture of olive oil on the same day, the liver protection product of corresponding dosage is not used once to high, medium and low dosage component, corresponding positive drug is used respectively once to positive drug group 1,2.
After last administration terminates, to blank group, model group, high, medium and low dosage group, and the rat of positive drug group stops 12 hours for food, then lumbar injection 10% chloral hydrate is anaesthetized respectively, gets blood and collects serum, and the operation requirements according to test kit detects AST and ALT value in serum.
After collecting serum, rats'liver is used ice normal saline cleansing tissue surface, filter paper blots, preparation liver tissue homogenate: get lobus sinister hepatic tissue 10% homogenate, with 3000rpm centrifugal 10 minutes, get supernatant, the operation requirements according to test kit detects SOD, GPX, GSH, MDA level in hepatic tissue.
Remaining hepatic tissue is placed in 10% neutral formalin solution and fixes 24 hours, routine paraffin wax embeds, 4 μm of sections, HE dyes, the histologic characteristics carrying out liver under optical microscope checks, comprising: the situation etc. checking the necrosis of liver bile duct proliferation, inflammation, liver fat cytopathy, liver cell and hepatic fibrosis.Degree is from light to heavy labeled as 1 point respectively, 2 points, 3 points, 4 points, is 0 point without obvious pathological changes, and extremely slight pathological changes is 0.5 point, cumulative all marks, and calculates and often organize dividing equally (± SD) of every animal, and score value higher prompting lesion degree is heavier.The rank test that two samples compare is carried out to lesion score result, compares with model group.
Three, date processing: date processing is carried out to all data, adopt rank test to histological scores, other data acquisitions t checks, and statistic analysis result.
Four, result is as shown in table 1-3
As can be seen from showing the data of 1-3 all, the content of model group rats blood AST and ALT raises due to the induction of carbon tetrachloride, though have certain decline at the content of rat blood AST and ALT of the positive drug group 1 using separately seed of Sesamum indicum L. extract or the positive drug group 2 of using separately Herba Silybi mariani extract compared to model group, use seed of Sesamum indicum L. extract simultaneously and compare model group with the content protecting the liver medicine high, medium and low dosage group rat blood AST with ALT of Herba Silybi mariani extract and decline more obvious.
Model group rats liver SOD, GPX, GSH activity level reduce due to the induction of carbon tetrachloride, though rat liver SOD, GPX, GSH activity level of positive drug group 1 or positive drug group 2 compares model group certain rise, protect the liver medicine high, medium and low dosage group rat liver SOD, GPX, GSH activity level compare model group go up more obvious.Model group rats liver MDA activity level raises due to the induction of carbon tetrachloride, though positive drug group 1 or positive drug group 2 rat liver MDA activity level compare model group certain decline, use the high, medium and low dosage group rat liver MDA activity level protecting the liver medicine compare model group decline more obvious.
Positive drug group 1 or positive drug group 2 rat all have reduction compared to model group rats by the rat liver bile duct proliferation of the induction of carbon tetrachloride and fibrosis integration, and high, medium and low dosage group rat bile duct proliferation and fibrosis integration to compare model group decline degree more obvious.
Positive drug group 1 or positive drug group 2 rat compare the reduction that liver fat cytopathy, liver cell necrotic score almost do not appear in model group rats, but high, medium and low dosage group rat unexpectedly achieves the effect better reducing liver fat cytopathy, liver cell necrotic score than positive drug group 1 or positive drug group 2 rat; The reduction that positive drug group 1 or positive drug group 2 rat liver inflammation integration compare model group is all not obvious, but use high, medium and low dosage group inflammation score value and there is than positive drug group 1 or positive drug group 2 effect unexpectedly that better reduce inflammation integration, compare model group and be almost reduced to normal level.
Above data, illustrate to use and protect the liver the high, medium and low dosage group of medicine and the liver function caused by the chemical substance such as ethanol or carbon tetrachloride can be prevented to damage compared to the positive drug group 1 or 2 using positive drug more comprehensively, especially can prevent the deterioration of the histologic characteristics of liver more comprehensively.
Embodiment 1 protects the liver medicine (tablet):
(1) sesamin that obtains for method described in patent 200610089321.9 of seed of Sesamum indicum L. extract, the silymarin that described Herba Silybi mariani extract obtains for method described in patent 200910238368.0.
(2) composition and process is configured:
Seed of Sesamum indicum L. extract: 10-200mg
Herba Silybi mariani extract: 10-400mg
Starch: add to 200-800mg
By above-mentioned each composition mix homogeneously, make granule, drying about 4h at 80 DEG C, chemical examination seed of Sesamum indicum L. extract and the content of silibinin, calculate loading amount, after checking full item qualified, tabletting and get final product.
Embodiment 2: protect the liver medicine (powder):
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1, and the formula protecting the liver medicine in the present embodiment is:
Seed of Sesamum indicum L. extract: 10-200mg
Herba Silybi mariani extract: 10-400mg
Starch: add to 200-800mg
By above-mentioned each composition mix homogeneously, make powder, drying about 4h at 80 DEG C, the content of chemical examination seed of Sesamum indicum L. extract and Herba Silybi mariani extract, calculate loading amount, after checking full item qualified, and be sealed in polyethylene coating bag.
Embodiment 3: protect the liver medicine (hard capsule):
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1, and the formula (content of every hard capsule) protecting the liver medicine in the present embodiment is:
Seed of Sesamum indicum L. extract: 10-200mg
Herba Silybi mariani extract: 10-400mg
Starch: add to 200-800mg
By above-mentioned each composition mix homogeneously, make granule, drying about 4h at 80 DEG C, the content of chemical examination seed of Sesamum indicum L. extract, Herba Silybi mariani extract, calculates loading amount, after checking full item qualified, and is filled in snap fit capsule according to normal capsule method for making.
Embodiment 4: protect the liver medicine (soft capsule)
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1, and in the present embodiment, the formula (content of every soft capsule) of liver protection product is:
Seed of Sesamum indicum L. extract: 50mg
Herba Silybi mariani extract: 10mg
PEG400: 340mg
Glycerol: 35mg
Tween 80: 20mg
Water for injection: 15mg
Polyethylene Glycol, glycerol are mixed with Tween 80 and adds pure water.Continuing heated and stirred goes to the bottom its mix homogeneously at about 60 DEG C, adds seed of Sesamum indicum L. extract and silibinin, and uses blender with about 1,500rpm Homogeneous phase mixing.While slowly stirring, make mixture progressively cool to room temperature, use vacuum pump removing air subsequently.
According to common method, 132mg gelatin, 52mg concentrated glycerin, 6mg70%d-sorbitol solution, qs Fragrance ethyl vanillin and coated substrate Brazil wax (carnaubawax) (content is the content of every capsule) is used to prepare the coating of soft capsule.
Embodiment 5: injection
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1, and in the present embodiment, the formula (content of per ampoule) of liver protection product is:
Seed of Sesamum indicum L. extract: 50mg
Herba Silybi mariani extract: 100mg
Polyethylene Glycol: 3mg
Distilled water for injection adds to 20ml
According to common method, said components mixing is sub-packed in ampoule (2mL).
Embodiment 6: Yoghourt food with effect of hepatic protection:
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1, and in the present embodiment, the formula (content of 100ml box Yoghourt) of liver protection product is:
Seed of Sesamum indicum L. extract: 10-200mg
Herba Silybi mariani extract: 10-400mg
Edible essence: 0.01-0.5mg
High fructose syrup: 5-60g
Magnesium stearate: 0.1-1.0g
Probiotics leaven: 2-5g
Milk: standardize solution is 100ml
Processing step comprises:
Step 1, in the mixture of seed of Sesamum indicum L. extract and Herba Silybi mariani extract, add standardized milk through clean breast process, add high fructose syrup, magnesium stearate, then carry out mixing homogenizing, sterilization.
Step 2, probiotics leaven to be joined in above-mentioned sterilized milk, ferment.Ferment by the end of add edible essence.
Described probiotics leaven is streptococcus thermophilus, bulgaricus bacillus and bacillus acidophilus.
After step 3, fermentation ends, use high pressure spray drying machine to carry out homogenizing, spraying, then above-mentioned spray drying powder is put into press compacting, every heavy 2 grams.
Step 4, the milk deli suppressed adopted two to pack.Then the Yoghourt of some good seals is carried out vacuum seal containing product to pack again.
Above-mentioned processing step also can be: the standardized milk of the clean breast process of described warp, after homogenizing, sterilization, the described probiotics leaven of access ferments, after fermentation ends, Yoghourt powder is made through high-pressure spray-drying, then mix with seed of Sesamum indicum L. extract and Herba Silybi mariani extract, and add high fructose syrup, magnesium stearate mixing, put into press compressing, pack, each process conditions are identical with above-mentioned steps 1-4.
Above-mentioned Yoghourt all meets the requirement of national sour milk food standard containing each index of product, has the natural flavor of Yoghourt and the tart flavour of Yoghourt; Structural state, smooth surface, neat in edge, block shape is complete, without sliver.Embodiment 7: confection class food with effect of hepatic protection
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1.Soft sweet and the large class of hard sugar two can be divided according to different ways.The formula of described carbohydrate food is:
(1) soft sweet: high fructose syrup (F55) 20-60wt%, hyper-methoxy pectin 1.0-3.0wt%, citric acid 0.1-1.0wt%, essence 0.01-0.5wt%, water 15.0-25.0wt%, seed of Sesamum indicum L. extract 20-60wt%, Herba Silybi mariani extract 2-5wt%, wherein each component sum is 100wt%.
(2) hard sugar: high fructose syrup (F55) 20-60wt%, citric acid 0.1-1.0wt%, essence 0.1-1.0wt%(a certain proportion of vanillin and edible essence, following essence therewith with), seed of Sesamum indicum L. extract 20-60wt%, Herba Silybi mariani extract 2-5wt%, wherein each component sum is 100wt%.
Preparation technology's flow process of described carbohydrate food comprises:
(1) soft sesame sweets fabrication processing: after hyper-methoxy pectin and citric acid mixing, be dissolved in water, then high fructose syrup, seed of Sesamum indicum L. extract, Herba Silybi mariani extract is added, mix in a heated condition, be cooled to 55 ~ 60 DEG C, add citric acid, essence, again stir, successively through reverse mould molding, after demoulding drying, be packaged as finished product.。
(2) Semen Sesami hard sugar fabrication processing: after high fructose syrup is heated to 100-115 DEG C, then add seed of Sesamum indicum L. extract, Herba Silybi mariani extract mixing, be cooled to 55 ~ 60 DEG C, add citric acid, essence, again stir, successively through reverse mould molding, after demoulding drying, be packaged as finished product.
Embodiment 8: solid beverage:
Seed of Sesamum indicum L. extract and Herba Silybi mariani extract are with embodiment 1, and in the present embodiment, the formula (in 1000mg) of liver protection product is:
Seed of Sesamum indicum L. extract: 10-200mg
Herba Silybi mariani extract: 20-500mg
Sodium carboxymethyl cellulose (CMC): 1mg
Carrageenan: 0.5mg
Fruity flavor: 0.6mg
White sugar: 100mg
Fructus Hippophae powder: 40mg
Fructus Crataegi powder: 50mg
Sodium citrate: 1.1mg
Said components is mixed, becomes powder or tablet, pack after sterilizing.
Claims (10)
1. a liver protection product, it is characterized in that, at least comprise active component seed of Sesamum indicum L. extract and Herba Silybi mariani extract, the weight of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract is 1:0.01-0.01:1, described seed of Sesamum indicum L. extract is sesamin, and described Herba Silybi mariani extract is silymarin.
2. liver protection product according to claim 1, the gross weight of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract accounts for described liver protection product 0.1wt%-25wt%.
3. liver protection product according to claim 1, the total amount of described seed of Sesamum indicum L. extract and Herba Silybi mariani extract accounts for described liver protection product 5wt%-25wt%.
4. liver protection product according to claim 1, also comprises: one or more in Fructus Schisandrae Chinensis extrat, Radix Puerariae extract, wolfberry fruit extract and tea extract.
5. the liver protection product according to any one of claim 1-4, described liver protection product is for protecting the liver medicine or food with effect of hepatic protection.
6. liver protection product according to claim 5, described in protect the liver medicine and also comprise pharmaceutically acceptable excipient.
7. liver protection product according to claim 5, described in protect the liver medicine dosage form be hard capsule, soft capsule, tablet, granule, powder, oral liquid or injection.
8. liver protection product according to claim 7, described in protect the liver medicine be unit preparation, the seed of Sesamum indicum L. extract containing 10-5000mg in described unit formulation and Herba Silybi mariani extract.
9. liver protection product according to claim 5, also containing fructose and/or milk product in described food with effect of hepatic protection.
10. liver protection product according to claim 9, described milk product is fresh milk, Yoghourt or cheese.
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| CN105724875A (en) * | 2014-12-08 | 2016-07-06 | 恩施盛硒生物工程有限公司 | Selenium-rich fruit-and-vegetable essence slice with liver protecting function |
| CN105361029A (en) * | 2015-11-19 | 2016-03-02 | 陈丽 | Fatty liver preventing coarse cereal food, preparation method and use thereof |
| CN115161149A (en) * | 2022-07-21 | 2022-10-11 | 贵州九龙天麻有限公司 | Gastrodia elata compound wine and preparation process and application thereof |
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| CN102079745A (en) * | 2009-12-01 | 2011-06-01 | 白心亮 | Production method of silymarin |
| CN103300165A (en) * | 2012-03-12 | 2013-09-18 | 盘锦天源药业有限公司 | Healthcare edible blend oil with silybum marianum |
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| CN101092421A (en) * | 2006-06-20 | 2007-12-26 | 白心亮 | New technique for extracting sesamin |
| CN102079745A (en) * | 2009-12-01 | 2011-06-01 | 白心亮 | Production method of silymarin |
| CN103300165A (en) * | 2012-03-12 | 2013-09-18 | 盘锦天源药业有限公司 | Healthcare edible blend oil with silybum marianum |
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