CN103446172A

CN103446172A - Application of fructus camptothecae acuminatae extractive vincoside lactam

Info

Publication number: CN103446172A
Application number: CN2013103882771A
Authority: CN
Inventors: 不公告发明人
Original assignee: SUZHOU TIANNAN STAR BIOLOGICAL TECHNOLOGY Co Ltd
Current assignee: SUZHOU TIANNAN STAR BIOLOGICAL TECHNOLOGY Co Ltd
Priority date: 2013-08-30
Filing date: 2013-08-30
Publication date: 2013-12-18

Abstract

The invention belongs to the technical field of medicines, and relates to application of a fructus camptothecae acuminatae extractive vincoside lactam in hypertension prevention, and a vincoside lactam containing composition for preventing and treating hypertension.

Description

The purposes of common camptotheca fruit glycosides of common camptotheca fruit extract

Technical field

The invention belongs to medical technical field, relate to the purposes of common camptotheca fruit glycosides of common camptotheca fruit extract.

Background technology

Hypertension is modal chronic disease, is also the topmost risk factor of cardiovascular and cerebrovascular disease, and apoplexy, myocardial infarction, heart failure and chronic kidney disease are its major complications.Both domestic and external facts have proved, hypertension is the disease that can prevent and control, reduces hyperpietic's blood pressure level, can obviously reduce apoplexy and the events of heart attack, significantly improves patient's life quality, effectively reduces the disease burden.Hypertensive hazardness and patient's blood pressure level mutually outside the Pass, also depend on the situation of the other diseases of simultaneous other cardiovascular risk factors, target organ damage and merging.Therefore in hypertensive definition and classification, by hypertensive diagnostic criteria fix on systolic pressure >=140mmHg and (or) diastolic pressure >=90mmHg, be divided into normally, outside normal high value blood pressure and 1,2,3 grade of hypertension, also according to the other diseases of risk factor, target organ damage and merging simultaneously, carry out risk stratification simultaneously according to blood pressure level.

Prevalence of Hypertension raises with age growth; Women's prevalence before climacteric, a little less than the male, but raises rapidly after climacteric, even higher than the male; High latitude cold district prevalence is higher than the warm area of low latitudes, and high altitude localities is higher than low altitude area; Relevant with dietary habit, salt and saturated fat are taken in higher, and mean blood pressure level and prevalence are also higher.Population of China hypertension is popular two relatively outstanding features: from south to the north, Prevalence of Hypertension is and increases progressively trend; Between different nationalities, Prevalence of Hypertension also has some differences, the national prevalence of living in the north or highlands is higher, the national prevalence of living in south or non-highlands is lower, this species diversity may be relevant with geographical environment, life style etc., not yet finds between various nationalities to have obvious genetic background difference.

Treating hypertensive main purpose is to reduce to greatest extent cardiovascular and cerebrovascular vessel morbidity and dead total danger, therefore require the doctor in the hypertensive while for the treatment of, intervene the clinical disease that all reversibility cardiovascular risk factors of patient, target organ damage and merging exist.For general hyperpietic's blood pressure lowering target, be below 140/90mmHg, for high-risk patients such as complication with diabetes or nephropathy, blood pressure should be taken the circumstances into consideration to be down to more low-level in the tolerant situation of patient.

Common depressor has: the Chinese medicine for lowering high blood pressure medicines such as calcium antagonists, RAS depressant, receptor,β blocking agent, diuretic antihypertensive medicine, Niuhuang Jiangya sheet.

Summary of the invention

The object of the present invention is to provide the purposes of common camptotheca fruit glycosides of common camptotheca fruit extract in preparing Altace Ramipril, further, for preventing and treating the hypertensive compositions that contains vincoside-lactam.

Vincoside-lactam can effectively reduce blood pressure, and controls preferably the systolic pressure of spontaneous hypertensive rat (SHR).

The specific embodiment

Embodiment 1. common camptotheca fruit glycosides of common camptotheca fruit extract hypotensive activities

Spontaneous hypertensive rat in 10～13 week age (SHR) is pressed to the blood pressure grouping, and concrete dosage is in Table 1, and oral administration is the arteria caudalis pressure measurement after 7 days.

Statistical analysis: measurement data mean+SD

mean t check between relatively employing group of data between two groups.Take P<0.05 as the significance standard.

Result: common camptotheca fruit glycosides of common camptotheca fruit extract can effectively reduce the SHR rat blood pressure, and with model control group, relatively there were significant differences (P<0.05), in Table 1.

The impact of table 1. vincoside-lactam successive administration on the SHR rat blood pressure

With model control group, compare ^△p<0.05.

Claims

1. the purposes of common camptotheca fruit glycosides of common camptotheca fruit extract, is characterized in that: the purposes of vincoside-lactam in preparing Altace Ramipril.

2. the purposes of common camptotheca fruit glycosides of common camptotheca fruit extract according to claim 1, is characterized in that: for preventing and treating the hypertensive compositions that contains vincoside-lactam.