CN103442722A - Cox-2抑制剂和相关的化合物、及其递送系统和方法 - Google Patents

Cox-2抑制剂和相关的化合物、及其递送系统和方法 Download PDF

Info

Publication number
CN103442722A
CN103442722A CN2011800686152A CN201180068615A CN103442722A CN 103442722 A CN103442722 A CN 103442722A CN 2011800686152 A CN2011800686152 A CN 2011800686152A CN 201180068615 A CN201180068615 A CN 201180068615A CN 103442722 A CN103442722 A CN 103442722A
Authority
CN
China
Prior art keywords
composition
concentration
present
weight
cox
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800686152A
Other languages
English (en)
Chinese (zh)
Inventor
E.T.福瑟尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STRATEGIC SCIENCE &AMP
Original Assignee
STRATEGIC SCIENCE &AMP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STRATEGIC SCIENCE &AMP filed Critical STRATEGIC SCIENCE &AMP
Publication of CN103442722A publication Critical patent/CN103442722A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800686152A 2010-12-29 2011-12-29 Cox-2抑制剂和相关的化合物、及其递送系统和方法 Pending CN103442722A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061428213P 2010-12-29 2010-12-29
US201061428057P 2010-12-29 2010-12-29
US61/428,213 2010-12-29
US61/428,057 2010-12-29
PCT/US2011/067990 WO2012092525A1 (en) 2010-12-29 2011-12-29 Cox-2 inhibitors and related compounds, and systems and methods for delivery thereof

Publications (1)

Publication Number Publication Date
CN103442722A true CN103442722A (zh) 2013-12-11

Family

ID=46383540

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800686152A Pending CN103442722A (zh) 2010-12-29 2011-12-29 Cox-2抑制剂和相关的化合物、及其递送系统和方法

Country Status (5)

Country Link
US (1) US20140004177A1 (enExample)
EP (1) EP2658553A4 (enExample)
JP (2) JP2014501284A (enExample)
CN (1) CN103442722A (enExample)
WO (1) WO2012092525A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629384B2 (en) * 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
AU2005235308B2 (en) * 2004-04-19 2011-12-01 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
WO2010151241A1 (en) 2009-06-24 2010-12-29 Strategic Science & Technologies, Llc Topical composition containing naproxen
WO2010151240A1 (en) 2009-06-24 2010-12-29 Strategic Science & Technologies, Llc Topical composition containing ibuprofen
DK2658551T3 (da) 2010-12-29 2020-09-21 Strategic Science & Tech Llc Behandling af erektil dysfunktion og andre indikationer
CN105878172A (zh) 2010-12-29 2016-08-24 战略科学与技术有限责任公司 治疗变态反应和其它适应症的系统和方法
WO2014152280A1 (en) * 2013-03-15 2014-09-25 Strategic Science & Technologies, Llc Transdermal formulations of fluticasone
WO2016112201A1 (en) * 2015-01-07 2016-07-14 Strategic Science & Technologies, Llc Techniques and systems for transdermal delivery involving treatment of psoriasis, skin cancer, and other indications
JP6992057B2 (ja) 2016-06-10 2022-01-13 クラリティ コスメティックス インコーポレイテッド 非面皰形成性の毛髪および頭皮ケア製剤ならびにその使用方法
US12440438B2 (en) * 2019-07-22 2025-10-14 Novilla Pharmaceuticals, Inc. Method of remotely controlling pain
KR20230051117A (ko) * 2020-01-10 2023-04-17 브리오리 바이오테크 인코포레이티드 로페콕시브를 함유하는 국소 조성물 및 이의 제조 및 사용 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080233183A1 (en) * 2007-03-22 2008-09-25 Pathfinder Management, Inc. Topical formulations having enhanced bioavailability
US20100280122A1 (en) * 2004-04-19 2010-11-04 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090105336A1 (en) * 2004-04-19 2009-04-23 Strategic Science & Technologies, Llc Beneficial Effects of Increasing Local Blood Flow
US20100099766A1 (en) * 2008-10-16 2010-04-22 Novartis Ag Topical NSAID compositions having sensate component
WO2010151240A1 (en) * 2009-06-24 2010-12-29 Strategic Science & Technologies, Llc Topical composition containing ibuprofen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100280122A1 (en) * 2004-04-19 2010-11-04 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
US20080233183A1 (en) * 2007-03-22 2008-09-25 Pathfinder Management, Inc. Topical formulations having enhanced bioavailability

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王素云，牛瑞芳: "塞来考昔在肺癌防治中的研究进展", 《世界临床药物》, vol. 26, no. 1, 31 December 2005 (2005-12-31), pages 16 - 20 *

Also Published As

Publication number Publication date
EP2658553A4 (en) 2015-01-07
WO2012092525A1 (en) 2012-07-05
JP2016033168A (ja) 2016-03-10
JP2014501284A (ja) 2014-01-20
US20140004177A1 (en) 2014-01-02
EP2658553A1 (en) 2013-11-06

Similar Documents

Publication Publication Date Title
JP7459200B2 (ja) 勃起不全および他の適応症の処置
CN103442722A (zh) Cox-2抑制剂和相关的化合物、及其递送系统和方法
CN103429246A (zh) 真菌感染和其它适应症的治疗的透皮递送
CN102481275B (zh) 含有布洛芬的表面组合物
CN103458909A (zh) 治疗偏头痛和其它适应症的方法和系统
CN105307635A (zh) 西地那非和其他5型磷酸二酯酶抑制剂的透皮递送
US9289495B2 (en) Systems and methods for treatment of allergies and other indications
CN105377233A (zh) 氟替卡松的透皮制剂
WO2016112201A1 (en) Techniques and systems for transdermal delivery involving treatment of psoriasis, skin cancer, and other indications
JP2025183462A (ja) 勃起不全および他の適応症の処置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20131211