CN103417494B - A kind of micropill using tartaric acid as main component - Google Patents
A kind of micropill using tartaric acid as main component Download PDFInfo
- Publication number
- CN103417494B CN103417494B CN201310361565.8A CN201310361565A CN103417494B CN 103417494 B CN103417494 B CN 103417494B CN 201310361565 A CN201310361565 A CN 201310361565A CN 103417494 B CN103417494 B CN 103417494B
- Authority
- CN
- China
- Prior art keywords
- tartaric acid
- micropill
- main component
- microcrystalline cellulose
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of micropill using tartaric acid as main component, it selects content more than 98% tartaric acid as primary raw material, adds microcrystalline Cellulose, polyvidone class as binding agent, adds starch as diluent, add foaming agent simultaneously, be made into micropill by centrifugal granulating technique.The micropill using tartaric acid as main component adopting composition and engineering of the present invention to make, the various gastric solubilities that can be made into, enteric solubility pill, it not only has the good advantage of drug release reproducibility, and has the features such as easy to prepare, cost is low.
Description
Technical field
The present invention relates to a kind of micropill using tartaric acid as main component, belong to medicine food technical field.
Background technology
Tartaric acid (tartaricacid), that is, 2,3 dihydroxybutanedioic acid is a kind of carboxylic acid, is present in various plants, is also one of organic acid main in wine.As the antioxidant added in food, food can be made to have tart flavour.The maximum purposes of tartaric acid is beverage additive, is also the raw material of pharmaceutical preparation.At the medicine of some stable under acidic conditions, tartaric acid can become preparation with these drug regimens, makes its drug substance stable, promotes that it discharges simultaneously, makes it play maximum drug effect.But at present, tartaric acid is made the medicine carrying ball heart, and as base ball, still see there is bibliographical information at home and abroad, more without there being product to come out.
Summary of the invention
The object of the present invention is to provide a kind of micropill using tartaric acid as main component, for sustained-release preparation supplies a model, make pill.This micropill is easily molding not only, can give full play to the original character of tartaric acid, meanwhile, can also alleviate the stimulation of tartaric acid dust to contact personnel, and guarantee the result of use of tartaric acid micropill.
For achieving the above object, the present invention takes following technical measures:
A kind of micropill using tartaric acid as main component of the present invention, select content more than 98% tartaric acid as primary raw material, add microcrystalline Cellulose, polyvidone class as binding agent, add starch as diluent, add foaming agent simultaneously, be made into micropill by centrifugal granulating technique.Its composition weight proportioning is (%):
Polyvidone class binding agent of the present invention is PVP K30 or hydroxypropyl emthylcellulose or hydroxypropyl cellulose or carboxymethyl cellulose sodium or methylcellulose.
Foaming agent of the present invention is that citric acid adds sodium bicarbonate, its effect be produce foaming so that tartaric acid micropill be celphere medicine-feeding after dispersion and medicine stripping release.
According to a kind of micropill using tartaric acid as main component that above-mentioned formula is made, not only easily molding, but also fully maintain the original character of tartaric acid and the feature facilitating medicine carrying, the various gastric solubilities adopting this micropill to make, enteric solubility pill, not only there is the advantage that drug release reproducibility is good, and there is the features such as easy to prepare, cost is low.
Detailed description of the invention
By the following examples the present invention is further described, embodiment is only for the object of illustration, do not limit the scope of the invention, meanwhile, the apparent change that those of ordinary skill in the art make according to the present invention and modification are also contained within scope of the present invention.
Embodiment 1
According to the composition weight proportioning using tartaric acid as the micropill of main component, get tartaric acid: 420g (35%), microcrystalline cellulose: 300g (25%), starch: 180g (15%), citric acid: 120g (10%), sodium bicarbonate: 120g (10%), PVP K30: 60g (5%).
PVP K30 is dissolved in 95% ethanol, secondly after tartaric acid, microcrystalline Cellulose, starch, citric acid, sodium bicarbonate fully being mixed, the centrifugal granulator spheronizator being placed in operation is prepared, the operating parameter of centrifugal granulator spheronizator, to be the scope of normalized air supply be its intake: 0.9-1.1 (m
3/ h)/kg, the rotating speed 160-180rpm of spheronizator centrifugal granulating, spray gun rotating speed 40-50rpm, flow-control, at 50-80rpm, can be prepared into the micropill of 0.2-1.2mm like this.
Embodiment 2
According to the composition weight proportioning using tartaric acid as the micropill of main component, get tartaric acid: 600g (50%), microcrystalline cellulose: 240g (20%), starch: 120g (10%), citric acid: 120g (10%), sodium bicarbonate: 60g (5%), PVP K30: 60g (5%).
PVP K30 is dissolved in 95% ethanol, secondly after tartaric acid, microcrystalline Cellulose, starch, citric acid, sodium bicarbonate fully being mixed, the centrifugal granulator spheronizator being placed in operation is prepared, the operating parameter of centrifugal granulator spheronizator, to be the scope of normalized air supply be its intake: 0.9-1.1 (m
3/ h)/kg, the rotating speed 160-180rpm of spheronizator centrifugal granulating, spray gun rotating speed 40-50rpm, flow-control, at 50-80rpm, can be prepared into the micropill of 0.2-1.2mm like this.
Embodiment 3
According to the composition weight proportioning using tartaric acid as the micropill of main component, get tartaric acid: 300g (37.5%), microcrystalline cellulose: 150g (18.75%), starch: 150g (18.75%), citric acid: 70g (8.75%), sodium bicarbonate: 70g (8.75%), PVP K30: 60g (7.5%).
PVP K30 is dissolved in 95% ethanol, secondly after tartaric acid, microcrystalline Cellulose, starch, citric acid, sodium bicarbonate fully being mixed, the centrifugal granulator spheronizator being placed in operation is prepared, the operating parameter of centrifugal granulator spheronizator, to be the scope of normalized air supply be its intake: 0.9-1.1 (m
3/ h)/kg, the rotating speed 160-180rpm of spheronizator centrifugal granulating, spray gun rotating speed 40-50rpm, flow-control, at 50-80rpm, can be prepared into the micropill of 0.2-1.2mm like this.
Claims (2)
1. one kind using tartaric acid as the micropill of main component, select content more than 98% tartaric acid as primary raw material, add microcrystalline Cellulose, polyvidone class as binding agent, add starch as diluent, add foaming agent simultaneously, be made into micropill by centrifugal granulating technique, its composition weight proportioning is %:
Described foaming agent is that citric acid adds sodium bicarbonate.
2. a kind of micropill using tartaric acid as main component according to claim 1, is characterized in that described polyvidone class binding agent is PVP K30 or hydroxypropyl emthylcellulose or hydroxypropyl cellulose or carboxymethyl cellulose sodium or methylcellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310361565.8A CN103417494B (en) | 2013-08-13 | 2013-08-13 | A kind of micropill using tartaric acid as main component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310361565.8A CN103417494B (en) | 2013-08-13 | 2013-08-13 | A kind of micropill using tartaric acid as main component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103417494A CN103417494A (en) | 2013-12-04 |
| CN103417494B true CN103417494B (en) | 2015-12-23 |
Family
ID=49643240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310361565.8A Active CN103417494B (en) | 2013-08-13 | 2013-08-13 | A kind of micropill using tartaric acid as main component |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103417494B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663073A (en) * | 2016-04-06 | 2016-06-15 | 刘建军 | Method for preparing traditional Chinese medicine tablet granulated by adhesive foam state |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166361A (en) * | 2011-04-19 | 2011-08-31 | 杭州高成生物营养技术有限公司 | Quick-collapsed type pellet core and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE390138T1 (en) * | 2006-02-09 | 2008-04-15 | Teva Pharma | EXTENDED RELEASE COMPOSITIONS CONTAINING DIPYRIDAMOL AND METHOD FOR THE PRODUCTION THEREOF |
| WO2009085306A1 (en) * | 2007-12-28 | 2009-07-09 | Impax Laboratories, Inc. | Controlled release formulations of levodopa and uses thereof |
-
2013
- 2013-08-13 CN CN201310361565.8A patent/CN103417494B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166361A (en) * | 2011-04-19 | 2011-08-31 | 杭州高成生物营养技术有限公司 | Quick-collapsed type pellet core and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103417494A (en) | 2013-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20211423T1 (en) | Formulations of enzalutamide | |
| CN103461675B (en) | Livestock and poultry intestinal tract regulator and preparation method thereof | |
| CN104304720A (en) | A pigeon feed | |
| CN106107055A (en) | A kind of feed additive enteric coating butanoic acid and preparation method and a kind of feedstuff | |
| MY161634A (en) | A method for producing high lipophilic antioxidants noodle products | |
| CN102823920A (en) | Aquatic product preservative | |
| CN103417494B (en) | A kind of micropill using tartaric acid as main component | |
| IN2014DE03239A (en) | ||
| ES2757844T3 (en) | Cashew Nut Oil with Enhanced Stability | |
| WO2013128419A3 (en) | Pharmaceutical compositions comprising boronic acid compounds | |
| CN104116056A (en) | Breadcrumb and preparation method thereof | |
| CN104431436A (en) | N-carbamylglutamate-added sturgeon feed with high corn gluten meal content | |
| CN103652366B (en) | A kind of stabilization micro-capsule coating Mercaptamine and preparation method thereof | |
| WO2012003495A3 (en) | Automated equipment for hydration, mixing and delivery of alginate to a pellet forming device | |
| RU2007132154A (en) | MEANS FOR REDUCING THE LOSS OF PRODUCTS OF YOUNG CATTLE AT TRANSPORTATION AND PRE-SLAUGHTER CONTENT | |
| CN103125743A (en) | Nutrient solution for livestock feed and preparation method thereof | |
| CN103098985A (en) | Animal feed | |
| CN104396941A (en) | Chicken sperm diluting liquid and preparation method thereof | |
| CN104522116A (en) | Compound bread preservative | |
| CN102657634A (en) | Nifuroxazide microcapsule powder and production method thereof | |
| CN104306351A (en) | Hard prolamin capsule and preparation method | |
| CN202409909U (en) | Annular fire-extinguishing squirt gun | |
| CN103518996A (en) | Shrimp feed additive | |
| CN104664139A (en) | Feed additive capable of improving egg quality and preparation method thereof | |
| CN103404585B (en) | A kind of fresh-keeping preparation of non-harmful pears and preservation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |