CN103405420B - Chukrasone B在制备治疗鼻咽癌药物中的应用 - Google Patents
Chukrasone B在制备治疗鼻咽癌药物中的应用 Download PDFInfo
- Publication number
- CN103405420B CN103405420B CN201310386098.4A CN201310386098A CN103405420B CN 103405420 B CN103405420 B CN 103405420B CN 201310386098 A CN201310386098 A CN 201310386098A CN 103405420 B CN103405420 B CN 103405420B
- Authority
- CN
- China
- Prior art keywords
- chukrasone
- nasopharyngeal
- medicine
- application
- present
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- Expired - Fee Related
Links
- 229930187319 chukrasone Natural products 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims description 7
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 abstract description 13
- 206010061306 Nasopharyngeal cancer Diseases 0.000 abstract description 13
- 201000011216 nasopharynx carcinoma Diseases 0.000 abstract description 13
- 230000012010 growth Effects 0.000 abstract description 7
- 101150080924 CNE1 gene Proteins 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 description 9
- 229940079593 drug Drugs 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 108010087141 Kv1.2 Potassium Channel Proteins 0.000 description 2
- 102000006628 Kv1.2 Potassium Channel Human genes 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001156380 Chukrasia tabularis Species 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 239000003450 potassium channel blocker Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310386098.4A CN103405420B (zh) | 2013-08-29 | 2013-08-29 | Chukrasone B在制备治疗鼻咽癌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310386098.4A CN103405420B (zh) | 2013-08-29 | 2013-08-29 | Chukrasone B在制备治疗鼻咽癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103405420A CN103405420A (zh) | 2013-11-27 |
CN103405420B true CN103405420B (zh) | 2015-08-05 |
Family
ID=49598495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310386098.4A Expired - Fee Related CN103405420B (zh) | 2013-08-29 | 2013-08-29 | Chukrasone B在制备治疗鼻咽癌药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103405420B (zh) |
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2013
- 2013-08-29 CN CN201310386098.4A patent/CN103405420B/zh not_active Expired - Fee Related
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Publication number | Publication date |
---|---|
CN103405420A (zh) | 2013-11-27 |
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C06 | Publication | ||
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Wu Junhua Inventor after: Liu Yue Inventor after: Huang Rong Inventor after: Wang Hui Inventor after: Wu Junyi Inventor after: Zhang Guang Inventor after: Jiang Chunping Inventor before: Huang Rong Inventor before: Wang Hui Inventor before: Wu Junyi Inventor before: Zhang Guang Inventor before: Jiang Chunping Inventor before: Wu Junhua |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: HUANG RONG WANG HUI WU JUNYI ZHANG GUANG JIANG CHUNPING WU JUNHUA TO: WU JUNHUA LIU YUE HUANG RONG WANG HUI WU JUNYI ZHANG GUANG JIANG CHUNPING |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information |
Inventor after: Liu Yue Inventor after: Jiang Chunping Inventor after: Wu Junhua Inventor after: Huang Rong Inventor after: Wang Hui Inventor after: Wu Junyi Inventor after: Zhang Guang Inventor before: Wu Junhua Inventor before: Liu Yue Inventor before: Huang Rong Inventor before: Wang Hui Inventor before: Wu Junyi Inventor before: Zhang Guang Inventor before: Jiang Chunping |
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COR | Change of bibliographic data | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150805 Termination date: 20160829 |