CN1034007C - Child-resistant package having preloaded locking mechansim - Google Patents

Child-resistant package having preloaded locking mechansim Download PDF

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Publication number
CN1034007C
CN1034007C CN92111072.3A CN92111072A CN1034007C CN 1034007 C CN1034007 C CN 1034007C CN 92111072 A CN92111072 A CN 92111072A CN 1034007 C CN1034007 C CN 1034007C
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China
Prior art keywords
closure member
head board
end part
top end
container
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Expired - Fee Related
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CN92111072.3A
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Chinese (zh)
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CN1071635A (en
Inventor
P·W·汉密尔顿
G·G·奥滕
R·S·德克辛
R·E·奥达
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Procter and Gamble Co
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Procter and Gamble Co
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Publication of CN1071635A publication Critical patent/CN1071635A/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D50/00Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures
    • B65D50/02Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions
    • B65D50/04Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of simultaneous actions, e.g. depressing and turning, lifting and turning, maintaining a part and turning another one
    • B65D50/045Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of simultaneous actions, e.g. depressing and turning, lifting and turning, maintaining a part and turning another one where one action elastically deforms or deflects at least part of the closure, the container or an intermediate element, e.g. a ring
    • B65D50/046Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of simultaneous actions, e.g. depressing and turning, lifting and turning, maintaining a part and turning another one where one action elastically deforms or deflects at least part of the closure, the container or an intermediate element, e.g. a ring and such deformation causes the disengagement of locking means, e.g. the release of a pawl-like element from a tooth or abutment, to allow removal of the closure by simultaneous rotation

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Soil Working Implements (AREA)
  • Bag Frames (AREA)
  • Pens And Brushes (AREA)
  • Prostheses (AREA)
  • Catching Or Destruction (AREA)
  • Packaging Of Annular Or Rod-Shaped Articles, Wearing Apparel, Cassettes, Or The Like (AREA)
  • Buffer Packaging (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Cartons (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Discharge Heating (AREA)

Abstract

A package for storing and dispensing potentially dangerous materials, such as medicament tablets or the like, said package being resistant to opening by children but readily openable by adults, particularly adults having impaired manual dexterity of their hands and/or fingers. In a particularly preferred embodiment, the package comprises a bottle (12), a collar (32) which is secured in place over the uppermost portion of the bottle (12) and a closure (52) which is secured to the finish portion of the bottle by means of complementary screw threads.

Description

Child-resistant packaging with preloaded locking mechansim
The present invention relates to a kind of improved packing of storing and distributing of being used to, if may be the packing of deletrious material during the unreasonable picked-up of splendid attire particularly.This material can be solid shape, sheet, granular, pulverous, semi-solid, paste or aqueous.
In a particularly preferred embodiment, the present invention relates to a kind of packing that is used to store and distribute medicine such as pain-killer tablet or similar tablet.
The invention still further relates to a kind of can prevent that the most of children that are in contact with it from opening it and the impaired at least to a certain extent adult of the function of hand in the packing that does not have can open it under much situation of difficult.
The invention still further relates to a kind of can the low-cost packing of making, make that wherein medicine one uses up after, just can be easily to its packing of handling.The invention further relates to the manufacture method of this packing.
Child-resistant packaging because of be good fortune be again that misfortune is well-known.It is conceived substantially and prevents that child has the packing of the material of potential danger, for example has medicine; But to adult the elderly particularly, this packing may make troubles.
Because the deterioration of health status, the elderly relies on medicine more than common people.Yet, make the old man obtain medicine with comparalive ease simply and bring to make children obtain the danger of the medicine of packaging easily, if children have obtained medicine and eaten it, may make health be subjected to heavy damage.
The problems referred to above have particularly been considered in medical industry in packaging industry usually.Relevant this problem has many reports.For example can be referring to the compound medicine bottle " of disclosed " in year in autumn in 1988 of Stout magazine version.
A kind ofly can prevent that children from opening it, and the impaired to a certain extent the elderly of the function of hand is in the packing that does not have can open it under much situation of difficult, disclosed August 14 nineteen ninety, therefore authorizing in people's such as Thornock the common known US Patent 4948002, here as with reference to data.Disclosed such packing adopts stream line pattern in above-mentioned known people's such as Thornock usually patent, in the test clause, promptly relate to children well, relate to the impaired old man of hand function again, unexpected discovery simultaneously, head board will make such shape like the spring of the vertical sponson that cooperates with the innermost lip-deep interlocking tooth of closure member shirt rim if will have, one is used for packing under the complete stack-mounted Interlock Status with closure member, will make head board like the spring that to a certain degree distortion is arranged, under the situation that does not make packing more be difficult to be opened, this child-resistant packaging is further strengthened like this by the old man.Reach this purpose, make the top of head board like the spring just have before closure member is assembled in the packing to a certain degree outwards outstanding shape usually.The actual effect of this shape is, the vertical sponson of head board so that one be assembled in closure member in the packing fully, just applies a power to innermost surface, closure member shirt rim at least to a certain extent by preload like the spring.
Therefore, the purpose of this invention is to provide a kind of improved child-resistant packaging of opening difficulty for the obvious increase of the impaired the elderly of hand function.
Another object of the present invention provides the method for making this improved packing.
In a particularly preferred embodiment, the present invention includes a kind of packing that is used to distribute potential dangerous substance, the medicine as pain-killer tablet or similar tablet.As usually authorizing in the known usually US Patent 4948002 of people such as Thornock or with PeterW.Hamilton above-mentioned, the name of Robest S.Dirksing and Reuben E.Oder is in No. 826747 U. S. applications of the co-applications of application on January 28th, 1992, generally disclosed
Be called in the child safety auxiliary device and in name in " the child safety auxiliary device that is of value to the adult that is used for storing the container of potential danger material " disclosed like that, this packing preferably includes a bottle, a lasso and a closure member of screwing on that is pressed on the bottle topmost.In the U. S. application 826747 of co-applications the child safety auxiliary device of disclosed the sort of type be with the bottle of the material of splendid attire medicine or other potential danger or container separate make and be installed on the container afterwards, or also they can be made with container is whole.Regardless of its correct profile, also no matter how it makes, lasso preferably includes head board like the spring that a pair of the top at them has vertical sponson.Closure member has the shirt rim.The shirt rim comprises a pair of sometimes as the interlocking tooth of ratchet.One installs to closure member on the bottle fully, and the interlocking tooth just can prevent from it is backed out, unless opposed head board on the lasso is forced down, makes the innermost lip-deep interlocking tooth disengagement in its part of vertically stretching out and closure member shirt rim.
According to the present invention, a kind of packing that is suitable for storing and distributing the potential danger material is provided, described packing anti-children open, and the adult opens easily, described packing is characterised in that and comprises:
(a) container that is used for the described potential danger material of splendid attire, described container has a body portion and a top end part;
(b) be used for rotatably and removably a closure member be fixed to first device on the described top end part of described container, described first device is fixed on the peripheral of described top end part and around its extension;
(c) lasso on described body portion that is fixed on described container with respect to described top end part, described lasso comprises that at least one has the head board of the top and an elastically deformable bottom, described at least one head board also comprises a vertical sponson, this vertical sponson extends upward and protrudes on the upper space of described lasso from described the top, when squeese pressure was applied on described the top of described at least one head board, described the top of described at least one head board can move inward with respect to the remainder of described lasso; With
(d) closure member, have at least one shirt rim and comprise and be used for cooperating with described first device, so that rotatably and removably described closure member is fixed to the device of second on the described container, described closure member also have described at least one shirt rim in lip-deep at least one interlocking tooth, described at least one interlocking tooth is to be shaped like this and the location, when on the described top end part that described closure member is rotatably fixed to described container, it can make the described vertical sponson skew of described at least one head board, but when rotating described closure member in opposite direction, it can stop unloads the described top end part of described closure member from described container, unless earlier described at least one head board on the described lasso is forced down, allow described vertical sponson and described at least one interlocking tooth throw off, it is characterized in that described at least one head board has a state that is not deformed, extend radially outwardly out from described top end part in the outmost surface of the described vertical sponson of this state and to be distal to the inner surface of described at least one shirt rim, in the time of like this on the described top end part that described closure member is completely fixed described container, to a certain at least degree, and described vertical sponson applies at least one preload force to the inner surface of described at least one shirt rim to described at least one head board by elastic deformation.
In improved packing of the present invention or auxiliary device, at first make and have the lasso part that vertical sponson is fixed on head board like the spring above it, when being installed on packing or the auxiliary device fully with convenient closure member, under the vertical sponson unstrained condition on the head board like the spring, they also will separate than the corresponding innermost surface of closure member shirt rim.The result is, closure member is installed to the vertical sponson that makes head board like the spring and/or fixed thereon on the packing at least produce to a certain degree elastic deformation, like this, when packing or auxiliary device when being in the child safety state, vertical sponson has added load for the innermost surface of the shirt rim of closure member in advance.
Can be sure of, the vertical component of head board is given the position and lock that preload guarantee and the in-to-in of closure member shirt rim on the innermost surface of closure member shirt rim are interlocked tooth like the spring, even exceed under the situation of the given limit in the manufacturing gap, the vertical sponson that is head board like the spring is always wanted fully outwards to move, leave closure member shirt rim in-to-in interlocking tooth, so that unscrew closure member.If there is not head board preload like the spring, the skew of making the gap can reduce the amount that the vertical sponson of head board moves, thereby by reducing the degree of forcing down of spring-like head board, just can tighten closure member.
Also can be sure of, can be greatly interlock system is thrown off and unscrew the needed whole power of closure member because give the amount that adds load to obviously increasing, the injured adult of the function of hand can not feel innermost lip-deep preload power that the part of vertically stretching out on the head board like the spring is applied to the closure member shirt rim to they cause any other open difficulty.
When the obvious claimed claim that particularly points out with the present invention when this specification sheets finishes, can believe, from description, will be more readily understood the present invention below in conjunction with accompanying drawing.Wherein:
Fig. 1 is the exploded perspective sketch of a special preferred packaging of the present invention;
Fig. 2 is the section sketch of the packing after the assembling shown in Figure 1, and the line of centers of said figure is perpendicular to the retainer lug 28 of bottle 12;
Fig. 3 is and the similar section sketch of Fig. 2, but has expressed the section of crossing the retainer lug 28 of bottle 12;
Fig. 4 was the transversal surface sketch of packing shown in Figure 2 of the hatching IV-IV of Fig. 2;
Fig. 5 is the part schematic perspective view of the packing of Fig. 1, is illustrated in closure member is installed to before packing goes up the position of the vertical sponson like the spring on the head board.
Fig. 6 is the lateral plan of a particularly preferred child safety auxiliary device of the present invention;
Fig. 7 was the cross sectional drawing of auxiliary device shown in Figure 1 of the hatching I-I of Fig. 6;
Fig. 7 A was the cross-sectional view of Fig. 6 child safety auxiliary device of the hatching II-II of Fig. 6;
Fig. 8 is the cross sectional drawing that head board is in the auxiliary device shown in Figure 6 under the state of forcing down, and the view direction of said figure overlaps with the direction of analysing and observe along Fig. 6 I-I line;
Fig. 8 A is the cross-sectional view that head board is in the child safety auxiliary device of the Fig. 6 under the state of forcing down, the II-II line of the view direction of said figure and Fig. 6 to analyse and observe direction consistent;
Fig. 9 is the lateral plan of child safety auxiliary device of the present invention, and wherein, top end part and medicine bottle are molded as one; With
Fig. 9 A is the child safety auxiliary device of Fig. 9 and the cross sectional drawing of medicine bottle.
Fig. 1 represents the exploded drawings of a kind of improved child-resistant packaging 100 of the present invention.This basic packing 100 belonged in August 14 nineteen ninety authorizes disclosed substantially the sort of type in people's such as Thornock the common known US Patent 4948002, at this as bibliography of the present invention.Yet in the scope of the such packings of people such as Thornock, now disclosed content is tended to the example that indefiniteness is described.Packing 100 is specially adapted to the splendid attire medicine, as tablet for alleviating pain 20.Yet effective use of packing of the present invention never is limited to the scope of medicine base to tablet.Packing of the present invention can be used for storing and distributing almost any proemial material, no matter these materials are solid shape, sheet, granular, pulverous, partly shape, paste or aqueous admittedly.Just understand a particularly preferred embodiment of the present invention fully from the corresponding description that the angle of tablet package is done in order to be easy to.
Fig. 1 represents a bottle 12, and it is relatively good to make this bottle with common and the most cheap pain relieving medicine bottle manufactured materials polyethylene.The most handy blow molding method is made bottle 12, makes its wall thickness in about 0.015 inch to 0.050 inch scope.The bottle 12 that refers in particular to shown in Figure 1 has body portion 14, and its cross-sectional plane is general common ellipse garden shape.In a particularly preferred embodiment, the ratio of the major and minor axis in ellipse garden is about 0.7.
The preferably ellipse taper of upper shoulder part 16 of bottle 12, its cone angle is preferably between about 36 ° to 70 °.In a particularly preferred embodiment, the major axis of body portion 14 is about 1.75 inches, and minor axis is about 1.25 inches, and whole height is about 1.12 inches.The height of the truncated cone of shoulder part 16 is about 0.75 inch in this embodiment.
Above the shoulder part 16 of bottle 12 is the top end part 18 of a garden cylindricality, and in the above-described embodiments, the height of this part is about 0.5 inch.Bottle part 14, shoulder part 16 and top end part 18 these three parts preferably are centered in a common vertical central lines with one heart.
The internal diameter of top end part 18 changes with the filling speed of diameter of tablet 20 (as tablet is not circle, then gets upperlimit) and tablet 20.Specifically, the internal diameter of top end part 18 should be greatly reduces to minimum to the bridging phenomenon that makes the tablet 20 that enters from the taper feed hopper.In case choose the internal diameter of top end part 18, comprise that the truncated cone diameter topmost of shoulder part 16 has just determined thereupon that promptly, it is substantially equal to the internal diameter of top end part 18.Then determine the size of the major axis and the minor axis of body portion 14 for the folded cone angle of shoulder part 16 selections.Be about 0.375 inch pain-killer tablet 20 for diameter, the major axis dimension of body portion 14 is usually in about 1.5 inches to 2.5 inches scope.The height of selection body portion 14 guarantees to satisfy any requirement that is full of volume (overflow volume) 100 li of packings.
When adopting any suitable device for example the fabricate block of lug and screw thread can be tightened and can closure member 52 be fixed to with unscrewing on the part 18 on top of bottle 12, select especially auxiliary screw thread.
The preferably two helical pitch screw threads of screw thread 22 on the top end part 18, the pitch that each screw thread all has every half cycle is about 0.1 inch to about 0.13 inch lead angle.
Be positioned at the groove 24 at place, bottom of bottle 12 shoulder part 16 and the ring 26 of outside protrusion at place, the top that is positioned at the shoulder part 16 of bottle 12 and provide for lasso 32 to clamp structure, as shown in Figure 1.As described in will be in sufficient detail at hypomere, the retainer lug 28 that the lucky shoulder part 16 from bottle 12 below the ring 26 that outwards protrudes is stretched out can form interlocking with lasso, so that closure member 52 be subjected to lemon pine moment of torsion do the time spent prevent that lasso 32 from rotating relative to bottle 12.
Lasso 32 is the part of an injection mo(u)lding preferably, its profile such as same truncated cone, and its shape of cross section is identical with the shape of the cylindroid cross-sectional plane of the body portion 14 of bottle 12.The most handy poly-mer that enough modulus of elasticity are arranged is made lasso 32, so that head board 34 like the spring of a pair of elastically deformable is provided.In the embodiment shown in fig. 1, head board is molded like the spring, and this makes them stretch out from their bottom cantilever arms at two opposed cone flanks of lasso and remains static.Their thickness preferably equates with the thickness of lasso 32 basically, for example, and between about 0.040 inch and 0.060 inch.
The vertical sponson 36 of a protrusion above the apical margin of lasso 32 all arranged at the top of head board 34 like each spring.When above the top end part 18 that closure member is screwed to fully bottle 12, the vertical sponson 36 of head board forms interlocking with the outer skirt of closure member 52 60 innermost lip-deep teeth 62.
As seeing from the cross-sectional view of the transparent view of Fig. 5 and Fig. 4 fully aware ofly, head board is preferably molded like the spring, like this, under undeformable state, the distance that they protrude between the surface of the outermost of the vertical component above the apical margin of lasso 32 36 is X 1Square is from X 1Be a bit larger tham corresponding inner distance X 2Corresponding inner distance X 2When being assembled into packing when closure member 52 fully and going up, vertical sponson 36 and near the distance between the contact point between the relative innermost surface of the closure member shirt rim 60 of the tooth 62 of closure member.Because of distance X 1Be a bit larger tham distance X 2Closure member is assembled on the packing, when the tooth on the closure member shirt rim 60 one is crossed, the distortion that spring is produced to a certain degree like head board 34 and/or vertical sponson 36 attached to it, thereby, when closure member one was in the perfect fitting position, the outmost surface of vertical sponson 36 added a load just for the corresponding innermost surface of shirt rim 60 in advance.This load power F of the outside finger shown in the cross-sectional view of Fig. 4 1Expression.
Although distance X 1And X 2Can differ less, for example about 0.001 inch and about 0.05 inch, but beyond thoughtly be, improved packing of the present invention is because of having adopted head board like the spring that adds load, do not awarding when the injured adult of function increases the difficulty of unpacking, obviously increasing the child safety performance of packing.
A kind of packing is held in the palm, exert pressure for like the opposed spring pushing piece 34 with thumb and forefinger, tooth 62 on itself and the closure member shirt rim 60 is thrown off, thereby back out closure member 52 from this packing, to this packing, the numerical value that is applied to the corresponding innermost lip-deep preload power of closure member shirt rim 60 by vertical sponson 36 need be not big especially.For example, the pressure of having found to act on the top of head board 34 like the opposed spring can reasonably well play the effect that realizes purpose of the present invention in the scope of 0.01 pound and 2.00 pounds the time.In a particularly preferred embodiment, found to act on the preload pressure F of the top of head board 34 like two opposed springs 1When being approximately 0.25 pound,, play fabulous effect improving the child safety performance and avoiding increasing significantly aspect unpack difficult to the impaired at least to a certain extent adult of hand function.
When not understanding the real phenomenon that produces above-mentioned better effects fully, head board 34 guarantees that vertical sponson must be enough moving at least like the spring of the preload of considering in a manner described, so as to make its with closure member shirt rim 60 on tooth 62 disengagements.By its characteristic, if the outmost surface of vertical sponson 36 and the innermost total surface of closure member shirt rim 60 are to keep direct contact, head board 34 must be enough moving at least like the then opposed spring, like this, vertically sponson 36 can be crossed the innermost lip-deep interlocking tooth 62 of closure member shirt rim.
In addition, because children generally are unfamiliar with this mechanism that is used to open child-resistant packaging, can believe, has head board like the spring of the preload that to a certain degree initial anti-children force down ability, natural energy stops children's attempt that opposed head board is depressed simultaneously, and closure member 52 is screwed down.The result is that this has reduced by the people who is unfamiliar with this opening mechanism the accidental chance of opening of closure member.
Probably the more important thing is, because improved packing of the present invention is had to a certain degree impaired adult to increase for the function of the elderly or hand and opens difficulty, after opening first, adult one takes out the medicine that institute must measure, be easier to install to closure member on the packing again, and can only not allow closure member partly install on the packing, or leave packing fully.
At last, adopt the of the present invention improved packing of head board like the spring of preload, when the vertical sponson 36 1 on head board like the spring 34 is crossed tooth 62 on the closure member 52, just can hear that the " card takes the sound of ".This is because exactly before the tooth of crossing on the closure member shirt rim 62, the distance between the vertical sponson 36 on the spring-like head board 34 of elastically deformable has been reduced.After this, exactly before tooth 62 was crossed the edge of vertical sponson 36, the spring-like head board 34 of elastically deformable was deformed to maximum strength.Vertical sponson one is crossed tooth 62, just sends the sound that the " card is taken ", and the reason that this phenomenon occurs is, is not having under the situation of closure member, and vertical sponson will be got back to their undeformable distance X 1, distance X 1Than the inner respective distance X in closure member shirt rim 2Want big.
Installed on the top end part 18 of bottle 12 fully at closure member after, in order to turn on closure member 52 from top end part 18, two head boards 34 must be forced down, be positioned at the innermost lip-deep tooth 62 in closure member shirt rim so that the vertical sponson 36 of head board leaves.With head board 34 force down must pressure preferably arrive the inaccessible power of children greatly, and little people such as arthritis patient to medication can force down opposed head board 34 easily, simultaneously closure member 52 turned on.The preferred pressure that head board is applied is between about 0.5 pound to 5 pounds.
In addition, when closure member being installed to fully packing when going up, head board 34 preferably basically with the outmost flush of lasso 32, like this, only hold the then unlikely head board 34 that makes of whole peripheries of lasso and throw off with the tooth 62 of closure member by accident.Otherwise, must apply opposed head board by the user and urge to open pressure, just can impel packing to open.This has reduced that children only exert pressure to lasso 32 peripheries with hand and the chance of wanting closure member 52 is turned on.
Can be sure of that before the material in packing is all taken out, packing 12 will keep its function.Determine that the thickness of head board 34 like the spring and the condition of length are, the vertical sponson 36 that make initial preload or make head board and the tooth 62 of closure member are thrown off flexure stress that institute must skew the be produced yield strength less than manufacturing lasso 32 and head board 34 poly-mers.Resemble the material that polyethylene has composite bending modulus (bending moduii) and yield strength like this, usually can provide pressure by the lower limit of the scope of above-mentioned power, and resemble the such material of acrylonitrile-butadiene-styrene terpolymer (being commonly called ABS), can provide pressure by the upper limit of the scope of above-mentioned power.
As shown in Figure 4, the limit 44 of each head board sponson 36 all with the tooth of closure member in an interlocking, before head board 34 is depressed like two springs, prevent that closure member 52 from being turned on.These two surfaces contact in such a way, unless turn on before the moment of torsion applying, head board 34 has been depressed, otherwise can make head board sponson 36 inside faces that head on shirt rim 60 pushed outwards by the moment of torsion that the direction of turning on closure member 52 (direction of arrow 3) applies.Because only can prevent to throw off with the tooth 62 of closure member by applying the big moment of torsion head board sponson 36 of turning on, this feature has improved packs 100 child safety performance.
Shown in Fig. 2 and 3, lasso 32 is respectively having one to projecting inward dome ring 38 and 40 on the inside face of its foot and on the inside face of its topmost.On the nethermost surface of projecting inward dome ring 40, also has one to projecting inward flange 41 at it.As Fig. 2 and Fig. 3 generally shown in, 32 ring dome 38 of lasso fixes in the groove 24 of bottle 12, the ring 40 with inside flange 41 is stuck on the outwards outstanding ring 26 of bottle 12.As above said, one is in place lasso 32 on bottle 12, and the groove 42 on the opposite side of the ring 40 of lasso 32 just matches with retainer lug 28 on the shoulder part 16 of bottle 12, prevents that lasso 32 from rotating on bottle 12.
Closure member 52 shown in Figure 1 preferably has outer skirt 60, and the external diameter of outer skirt 60 is identical with the external diameter at the top of the frusto-conical surface of lasso 32.Two interior side-prominent teeth of 60 62 are preferably apart 180 ° from the shirt rim, tooth 62 preferably has mild inclined-plane and steep limit, in the process of the top end part 18 that closure member 52 is screwed to bottle 12, this inclined-plane just pushes inward head board 34 like the spring, one is contained in closure member 52 on the bottle 12 then when the direction of turning on is reversed fully, steep limit then with the vertical sponson interlocking of head board.
As shown in Figure 2, the bottom inside circumference of the outer skirt 60 of closure member 52 is bevelled preferably, and in the process of dress closure member, when the top of the vertical sponson 36 of head board 34 like the shirt rim begins to run into spring, the bevelled inside circumference has the effect of importing.The negative thread 56 that outside thread 22 on the top end part 18 that has on second shirt rim 54 of outer skirt 60 in-to-in closure members 52 with bottle 12 matches.
Two shirt rims closure arrangement is convenient at the inwards outstanding ring 40 of the top of lasso 32 employing than broad.Ring 40 than broad makes lasso have rigidity, thereby can easily lasso 32 be fixed on the bottle 12.
In order to obtain the excellent friction characteristic between the outside thread on the top end part 18 of the bottle 12 made at negative thread 56 and the most handy polyethylene, the most handy polypropylene is made closure member 52.Preferably place carboard or other suitable liner plate 58 in the inside of closure member 52, when installing to closure member 52 on the bottle, liner plate 58 is just sealing the top of the top end part 18 of bottle 12.Because the thickness of liner plate 58 and compressibi1ity are variable, the position of the tooth relevant with the starting point of negative thread 56 preferably, when installing to closure member 52 on the bottle fully, tooth 62 is crossed the vertical sponson 36 of head board 34 like the spring slightly.This makes the parts match tolerance that matches reduce to minimum.
Fig. 2 and Fig. 3 have represented to pack the relation between 100 replace the spare parts mutually fully aware ofly, as are in shown in the skiagraph of bottle 12, lasso 32 and closure member 52 under the complete assembled state.The cross sectional drawing of Fig. 3 is vertical with the cross sectional drawing of Fig. 2, so that more clearly represent retainer lug 28.
Fig. 4 is the cross sectional drawing that the hatching IV-IV along Fig. 2 cuts open, and it is clearly expressed, and after installing to closure member on the bottle fully, the tooth 62 on the shirt rim 60 of closure member 52 is how with vertical sponson 36 interlockings of spring-like head board 34.
Just as known to those skilled in the art, in conjunction with head board 34 like the spring of the described preload of embodiment of the packing of Fig. 1 of the present invention, can be applied to equally and be to grant people such as Thornock August 14 nineteen ninety, and by the embodiment of the present invention in these common known US Patent 4948002 disclosed many other packings of quoting.
Certainly, give that the ad hoc approach of head board preload will be adjusted to be fit to the particular envelope structure like the spring of elastically deformable.For example, in a particularly preferred embodiment of the present invention, head board 34 is directly molded like the spring of elastically deformable, like this, before installing to closure member 52 on the packing, the top of head board 34 exceeds the outmost surface of lasso 32 slightly like the spring.Closure member 52 installed to makes the elastic deformation that head board 34 produces to a certain degree like the spring on the packing, therefore, be under the stack-mounted state in packing, like the spring the top of head board 34 in fact with the outmost flush of lasso 32.
For these embodiment that between head board like the spring and lasso, adopt the bonded assembly lasso as the simple hinge, the supplemental support that is used for the innermost surface of head board is in use given spring-like resistance can stretch out to a certain degree, like this, before installing to closure member on the packing, lasso relatively makes head board outside slightly.
With being used for making vertical sponson 36 to give the specific manufacture method of the shape of head board like the spring of elastically deformable of corresponding innermost surperficial preload of closure member shirt rim 60 is not conclusive.
As this specification sheets point out already, if necessary, the present invention also can be implemented in best mode with Petex W.Hamilton, the name of Robext S.Dirhsing and Renben E.Oder in No. 826747, the U. S. application of the co-applications of on January 28th, 1992 application and name be called " be used for storing the potential danger material container be of value to general disclosed the sort of child safety auxiliary device among the adult child safety auxiliary device ".In No. 826747, the U. S. application of co-applications the child safety auxiliary device of disclosed the sort of type be with the bottle of the material of splendid attire medicine or other potential danger or container separate make and be installed on the container afterwards, or also can be with them with bottle or container is whole makes.
Fig. 6 is illustrated in the lateral plan of the preferred child safety annex 2100 of general disclosed the sort of type in No. 826747, the common known U. S. application of co-applications, and said annex further embodies the present invention.Auxiliary device 2100 is specially adapted to distribute for example cylindrical vial or the liquid medicine bottle commonly used of tablet of pharmaceutical products.Yet, if necessary, can utilize to have the container that the section vertical with its longitudinal axis is non-circular section, for example elliptic jet, rectangular cross section or the like are implemented the present invention.Auxiliary device 2100 comprises top end part 2001 and closure member 2002, top end part 2001 and closure member 2002 the most handy polypropylene, polystyrene, polycarbonate or similar material injection molded.Top end part 2001 comprises clamping ring 2004 and thin-walled circle or lasso 2005.Although lasso shown in Figure 6 has circular cross section usually, if necessary, can adopt other section form, for example oval-shaped, cantilever head board (following detailed description) is positioned at two opposite ends of transverse.Dome 2003 on the clamping ring 2004 is used for auxiliary device 2100 is fixed to drug packaging (not drawing).Slotted 2006 on the thin-walled circle 2005, thus a pair of opposed cantilever head board 2007 formed, as shown in Figure 7.
Fig. 7 is the cross sectional drawing of the auxiliary device 2100 cut open of the hatching I-I by Fig. 6.Closure member closes circle and comprises rotationally and removably closure member 2002 is installed to first on the top end part 2001 device.In an illustrated embodiment, first device is included in the screw 2009 on the outermost surfaces of screw collar 2010.Closure member 2002 comprises that being used for removably closure member being installed to rotationally closure member closes second device that said first device on the circle cooperates.In the embodiment of Fig. 7, second device is included in the innermost lip-deep screw thread 2018 of the screw collar 2017 of closure member 2002.Although any suitable detouchable closing appliance for example combination of bead and screw thread all can be used to rotationally and removably closure member 2002 installed on the top end part 2001, the screw thread 2009 and 2018 of corresponding cooperation shown in Figure 7 is particularly preferred.
Screw thread 2009 on the outside face of screw collar 2010 is double-threaded screw preferably.The spiral shell square of screw thread 2009 and 2018 of matching is preferably, and closure member 2002 rotations just can be installed on the top end part 2001 for about 180 ° fully.
Lasso 2005, screw collar 2010 and clamping ring 2004 preferably are molded as one, and generally want mutually with one heart.The top of head board 2007 all has a vertical sponson 2008 of giving prominence on the plane of the apical margin of thin-walled circle 2005 like each spring.When closure member 2002 being screwed to top end fully dividing on 2001, innermost lip-deep tooth 2015 interlockings of vertical sponson 2008 and the interlock ring 2016 of closure member 2002.When closure member 2002 was screwed to top end part 2001, the annular groove 2011 that forms between the innermost surface of lasso 2005 and screw collar 2010 held screw collar 2017.
Closure member 2002 is being installed in the process of top end part 2001, tooth 2015 must turn over vertical sponson 2008.Yet vertical sponson 2008 overslaugh teeth 2015 rotate, thereby make inwardly deflection flexibly of head board 2007.The guide ramp on the plane on the tooth 2015 makes this deflection be easy to produce.Guiding face is tilted gradually inwards, like this, can prevent that closure member 2002 is installed to the moment of torsion that repeats to apply required on the top end part 2001 fully to be increased suddenly.If necessary, usually shown in the section of Fig. 7 A and Fig. 8 A, the mating surfaces of vertical sponson 2008 also can be made the bevelled surface, closure member 2002 be installed to the moment of torsion that repeats to apply required on the top end part of auxiliary device 2100 fully so that reduce.After these two features help to guarantee that the user unpacks, can suitably closure member be refilled on the child-resistant packaging.
Continuous rotation closure member 2002 makes tooth 2015 cross vertical sponson 2008, thereby makes vertical sponson 2008 and head board 2007 flexibly get back to the blocking shown in Fig. 7 and the 7A.Top end part 2001 is molded, and like this, vertical sponson 2008 has the unrestricted maximum outside diameter bigger slightly than the internal diameter of closure member interlock ring 2016.In this case, shown in Fig. 7 A, after closure member 2002 is installed fully, make vertical sponson 2008 give the inside face preload of interlock ring 2016 on the top end part 2001 just closure member 2002 installed to.
The screw thread 2009 and 2018 relevant with vertical sponson 2008 and tooth 2015 is to be provided with like this, tooth 2015 is crossed vertical component 2008 formation lockings and is almost installed to generation simultaneously on the top end part 2001 fully with closure member 2002, in this position, sealing flange 2020 preferably contacts with the conical surface 2025 of top end part, so that form sealing.Because screw thread 2009 is Unitarily molded with the top end part 2001 of the conical surface 2025 that comprises integrally formed head board 2007, vertical sponson 2008 and top end part, simultaneously, screw thread 2018 is to form single-piece with the closure member 2002 that comprises tooth 2015 and sealing flange 2020, so above-mentioned requirements is easy to realize.
Fig. 7 A is the cross sectional drawing of the auxiliary device 2100 cut open of the hatching II-II along Fig. 6.Because head board 2007 is in the position shown in Fig. 7 and Fig. 7 A, the limit 2030 of vertical sponson 2008 can stop rotating counterclockwise of tooth 2015, prevents to press the anticlockwise motion closure member shown in the arrow " T ", and attempt is opened auxiliary device again.
The gap of the groove 2011 between the inside face of the outside face of screw collar 2017 and head board 2007 is shown in the size " X " among Fig. 7.This gap provides condition to bias internal for head board 2007 fully from position shown in Figure 7.When the user forces down head board 2007 and during the loosening torque that closure member 2002 applied by the direction of arrow " T " simultaneously, vertical head board 2008 can be crossed tooth 2015.
Fig. 8 is the view of the auxiliary device 2100 cut open at the hatching I-I place that is suitable for Fig. 6 mutually, and different is head board 2007 is to bias internal.In order after closure member is assembled fully, to turn on closure member 2002 from top end part 2001, must apply enough pressure for relative head board 2007 with hand by the direction of arrow " P " indication among Fig. 8, like this, release pull 2007 vertical sponsons 2008 just with innermost lip-deep tooth 2015 disengagements of the interlock ring 2016 of closure member 2002.Head board 2007 is forced down required pressure preferably to be difficult to reach to children greatly, little people to medication is the arthritis patient for example, can easily opposed head board 2007 be forced down, apply loosening torque for closure member 2002 by the direction of the arrow " T " among Fig. 8 A simultaneously.Being applied to can provide child safety on the head board 2007, but do not give the impaired adult of hand function bring the preferred pressure " P " of much difficulties be determined to be in about 0.5 pound in about 5 pounds scope.
In addition, when with closure member 2002 installation in position, head board 2007 preferably flushes with the outside face of thin-walled circle or lasso 2005 basically, like this, when closure member 2002 is applied loosening torque, merely hold the periphery and the extruding of lasso, unlikely two the vertical sponsons 2008 of opposed head board 2007 that make are thrown off by accident with tooth 2015.Otherwise, when opening process begins, must apply the short pressure of opening to opposed head board 2007 by the user, and want continuously closure member 2002 to be applied loosening torque simultaneously, just can impel packing to open.This has reduced children and only with hand the periphery of lasso 2005 has been exerted pressure and want chance that closure member 2002 turned on.
Fig. 8 A is the cross sectional drawing of the auxiliary device 2100 cut open at the hatching II-II place corresponding to Fig. 6, and different is expression state shown in Figure 8 auxiliary device 2100 down, i.e. release is pulled 2007 and has been offset inwards.So vertical sponson has moved on to the tooth 2015 that no longer stops on the interlock ring 2016 and has done the position that rotates counterclockwise by the direction of arrow " T " indication.At this moment, the user of child-resistant packaging just can further rotate closure member 2002 by anticlockwise direction, makes it upwards move on to the top of vertical sponson 2008, and the screw thread 2009 and 2018 on screw collar 2010 and the screw collar 2017 is disengaged.This makes closure member 2002 leave top end part 2001 fully.
Fig. 9 is the side partial cross-sectional of another alternative embodiment of child safety auxiliary device of the present invention.Yet as from Fig. 9 and 9A saw, the top end part 2501 and the medicine bottle 2550 of child safety auxiliary device 2500 are molded into one becomes a part.Closure member 2502 demonstrates in Fig. 9 with top end part 2501 and does not fit together.The part of thin-walled circle 2505 demonstrates by partial cutaway, and has exposed the groove 2511 of the screw collar 2517 that hold closure member 2502.Thin-walled circle or lasso 2505 have been cut off by slit 2506, form suspended wall head board 2507 like a pair of opposed spring.Head board 2507 has the vertical sponson of giving prominence on the plane of the upper surface of thin-walled circle 2,505 2508.
Fig. 9 A represents to be in the child safety auxiliary device 2500 of complete assembled state and the cross sectional drawing of bottle 2550 and closure member 2502, and said figure was that opposed head board 2507 is cut open.The clamping ring 2504 of auxiliary device be molded into one with the top of medicine bottle 2550 bottom.On the outmost surface of screw collar 2510 and the innermost lip-deep screw thread 2509 and 2518 that matches of screw collar 2517 closure member 2502 is fixed on the top end part 2501 respectively.Vertical sponson 2508 is interlocked with the innermost lip-deep tooth 2515 of interlock ring 2516.As the embodiment of Fig. 6-8A, molded top end parts 2501, the maximum free external diameter that vertical sponson 2508 is had, it is a bit larger tham the internal diameter of closure member interlock ring 2516.Usually, the using method of child safety auxiliary device 2500 is identical with the using method of child safety auxiliary device 2100.
Can be sure of,, be bound to understand the advantage that the structure of structure, auxiliary device of disclosed packing in this manual and technological process and manufacture method and they are had by top description.Certainly, to one skilled in the art, obviously, under the situation of principle of the present invention and scope, can do multiple change to its shape, structure and assembling, all these modification within the scope of the present invention all are included in the claim of the present invention.

Claims (22)

1. packing that is suitable for storing and distributing the potential danger material, described packing anti-children open, and the adult opens easily, described packing comprises:
(a) container that is used for the described potential danger material of splendid attire, described container has a body portion and a top end part;
(b) be used for rotatably and removably a closure member be fixed to first device on the described top end part of described container, described first device is fixed on the peripheral of described top end part and around its extension;
(c) lasso on described body portion that is fixed on described container with respect to described top end part, described lasso comprises that at least one has the head board of the top and an elastically deformable bottom, described at least one head board also comprises a vertical sponson, this vertical sponson extends upward and protrudes on the upper space of described lasso from described the top, when squeese pressure was applied on described the top of described at least one head board, described the top of described at least one head board can move inward with respect to the remainder of described lasso; With
(d) closure member, have at least one shirt rim and comprise and be used for cooperating with described first device, so that rotatably and removably described closure member is fixed to the device of second on the described container, described closure member also have described at least one shirt rim in lip-deep at least one interlocking tooth, described at least one interlocking tooth is to be shaped like this and the location, when on the described top end part that described closure member is rotatably fixed to described container, it can make the described vertical sponson skew of described at least one head board, but when rotating described closure member in opposite direction, it can stop unloads the described top end part of described closure member from described container, unless earlier described at least one head board on the described lasso is forced down, allow described vertical sponson and described at least one interlocking tooth throw off, it is characterized in that described at least one head board has a state that is not deformed, the outmost surface of the described vertical sponson of this state from described top end part extend radially outwardly out be distal to the inner surface of at least one shirt rim, in the time of like this on the described top end part that described closure member is completely fixed described container, to a certain at least degree, and described vertical sponson applies at least one preload force to the inner surface of described at least one shirt rim to described at least one ejecting plate by elastic deformation.
2. packing as claimed in claim 1, it is characterized in that described body portion and described top end part partly are connected to each other by the shoulder of assembling to the direction of the part on described top, and described at least one interlocking tooth so is shaped and the location, promptly when on the described top end part that described closure member is installed to described container, it can make the described vertical sponson skew of described at least one head board, but it can stop the described top end part of described closure member from described container unloaded, unless earlier described at least one head board on the described lasso is forced down.
3. packing as claimed in claim 1, it is characterized in that described lasso comprises a pair of spring-like head board that is positioned at apart about 180 ° elastically deformable on the described lasso periphery, and described closure member also have a pair of be positioned at described at least one shirt rim in lip-deep apart about 180 ° interlocking tooth.
4. child safety auxiliary device that is used for the described device of claim 1, described child safety auxiliary device is characterised in that and comprises:
(a) top end part with closure member mounting ring, the closure member mounting ring comprises and is used for rotationally and removably a closure member is fixed on first on the described closure member mounting ring installing, first device is positioned at least one surface of closure member mounting ring, be used for described top end part is fixed to device on the described container, with the annular collar that is coaxial line substantially with described closure member mounting ring, this annular collar is also cut off by at least one pair of slit, thereby form the cantilever head board of at least one elastically deformable, this head board has basically the consistent surface profile that exposes of outer surface profile with the neighbouring part of described annular collar, when being held with the described annular collar of box lunch, minimizing is to its accidental chance of forcing down, described at least one head board has the top and bottom, described at least one head board also comprises vertical sponson, it extends upward and protrudes on the upper space of described annular collar from described the top, when a squeese pressure affacts described the top of described at least one head board, described the top of described at least one head board can move inward with respect to the remainder of described annular collar and
(b) closure member with first shirt rim and second shirt rim, have at least one surface of first shirt rim and second installing of being used for rotationally and removably described closure member being fixed to that described first device on the described closure member mounting ring on the described top end part matches, second shirt rim is in the outside of first shirt rim, described closure member also have at least one described second shirt rim in lip-deep interlocking tooth, described at least one interlocking tooth has been this shaping and location, promptly when described closure member being rotatably fixed on the described closure member mounting ring, it can make the described vertical sponson skew of described at least one head board, but it can stop described closure member is unloaded from described closure member mounting ring when rotating described closure member in opposite direction, unless earlier described at least one head board on the described annular collar is forced down, allow described vertical sponson and described at least one interlocking tooth throw off, described at least one head board has a state that is not deformed, at this state, the outmost surface of described vertical sponson extends radially outwardly out from described top end part and is distal to the inner surface of described second shirt rim, like this when described closure member being completely fixed on the described closure member mounting ring, described at least one head board is applied at least one preload force to a certain at least degree and described vertical sponson to the inner surface of described second shirt rim by elastic deformation.
5. by the described child safety auxiliary device of claim 4, it is characterized in that, be used for the erecting device that described top end part is fixed on the described container is comprised an auxiliary circle, it has the anchor fitting that cooperates with respective fixation device on the described container, after being assembled to described child safety auxiliary device on the described container fully, can prevent that particularly children separate described child safety auxiliary device with described container like this.
6. by the described child safety auxiliary device of claim 5, it is characterized in that, when being attached to the described top end part of described container with being maintained fixed, described anchor fitting allows described child safety auxiliary device to be not limited to 360 ° rotation with respect to described container around the central longitudinal axis by described child safety auxiliary device, thereby further stops children to open the child safety auxiliary device and obtain material in the described container.
7. by the described child safety auxiliary device of claim 4, it is characterized in that, the described top end part of described child safety auxiliary device for good and all is fixed on the described container.
8. by the described child safety auxiliary device of claim 7, it is characterized in that, by the described top end part of described child safety auxiliary device and described integral container is molded and the described top end part of child safety auxiliary device for good and all is fixed on the described container.
9. by the described child safety auxiliary device of claim 4, it is characterized in that, be used for rotationally and described first and second devices that removably described closure member are fixed on the described closure member mounting ring comprise the screw thread that matches, wherein said annular collar comprises two pairs of slits, thereby form a pair of head board, and described closure member comprises a pair of opposed tooth with opposed elastically deformable of vertical sponson.
10. by any one the described packing in the claim 1,2 and 3, it is characterized in that the vertical sponson of the head board of each described opposed elastically deformable gives described preload force that described closure member shirt rim applies between about 0.01 pound and about 2 pounds.
11. by any one the described packing in the claim 1,2 and 3, it is characterized in that, the head board of each the described elastically deformable on the described lasso was connected on the described lasso in connecting by means of a cantilever bottom of it, therefore the head board of each described elastically deformable all bears the described pressure of the upper end that acts on it, and this pressure is to produce by being connected the elasticity beam action that is risen by it with the cantilever of the remainder of described lasso.
12. any one the described packing by in the claim 1,2 and 3 is characterized in that, described first and second devices that are used for removably described closure member being fixed on the described top end part of described container comprise the screw thread that matches.
13. by any one the described packing in the claim 1,2 and 3, it is characterized in that, by means of described lasso being fixed with respect to described container at least one groove on described container or the described lasso and at least one the protruding circle that matches on another described container or described lasso.
14. by the described packing of claim 13, it is characterized in that, also comprise at least one groove that matches on retainer lug on the container and the part that matches at described lasso, thereby, force down at the head board that does not have elder generation with each described elastically deformable, allow under the situation that interlocking tooth on the shirt rim of vertical sponson of each described head board and described closure member throws off, when loosening torque being affacted on the described closure member, can prevent that described lasso from rotating relative to described container.
15. by claim 1, the described packing of in 2 and 3 any one, it is characterized in that, the shirt rim of described closure member in lip-deep described interlocking tooth have the cammed surfaces that a radius reduces gradually, when on the described top end part that described closure member is installed to described container, this interlocking tooth is offset the vertical sponson of the head board of described elastically deformable gradually, but, interlocking tooth one is crossed the described vertical sponson of described head board, just immediately described vertical sponson is blocked backward towards its indeformable position, thereby, provide sound signal to the user, show that this packing has had anti-children's characteristic in the use afterwards.
16. by the described packing of claim 15, it is characterized in that, described interlocking tooth on the vertical sponson of the head board of described elastically deformable and the shirt rim of described closure member has mating surfaces, do not having under the situation about earlier the top of described head board being forced down, if described closure member is applied loosening torque, mating surfaces can make described tooth and described vertical sponson more step up lock mutually.
17. any one the described packing by in the claim 1,2 and 3 is characterized in that the described closure member shirt rim with described interlocking tooth comprises an outermost shirt rim.
18., it is characterized in that the vertical sponson of the head board of each described opposed elastically deformable gives described preload force that described closure member shirt rim applies between about 0.01 pound and about 2 pounds by the described child safety auxiliary device of claim 4.
19. by the described child safety auxiliary device of claim 4, it is characterized in that, the head board of each the described elastically deformable on the described lasso was connected on the described lasso in connecting by means of a cantilever bottom of it, therefore the head board of each described elastically deformable all bears the described pressure of the upper end that acts on it, and this pressure is to produce by being connected the elasticity beam action that is risen by it with the cantilever of the remainder of described lasso.
20., it is characterized in that described first and second devices that are used for removably described closure member being fixed on the described top end part of described container comprise the screw thread that matches by the described child safety auxiliary device of claim 4.
21. by the described child safety auxiliary device of claim 4, it is characterized in that, the shirt rim of described closure member in lip-deep described interlocking tooth have the cammed surfaces that a radius reduces gradually, when on the described top end part that described closure member is installed to described container, this interlocking tooth is offset the vertical sponson of the head board of described elastically deformable gradually, but, interlocking tooth one is crossed the described vertical sponson of described head board, just immediately described vertical sponson is blocked backward towards its indeformable position, thereby, provide sound signal to the user, show that this packing has had anti-children's characteristic in the use afterwards.
22. by the described child safety auxiliary device of claim 21, it is characterized in that, described interlocking tooth on the vertical sponson of the head board of described elastically deformable and the shirt rim of described closure member has mating surfaces, do not having under the situation about earlier the top of described head board being forced down, if described closure member is applied loosening torque, mating surfaces can make described tooth and described vertical sponson more step up lock mutually.
CN92111072.3A 1991-10-07 1992-08-29 Child-resistant package having preloaded locking mechansim Expired - Fee Related CN1034007C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77272991A 1991-10-07 1991-10-07
US772,729 1991-10-07
US88265992A 1992-05-13 1992-05-13
US882,659 1992-05-13

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CN1034007C true CN1034007C (en) 1997-02-12

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JP (1) JP2815703B2 (en)
CN (1) CN1034007C (en)
AT (1) ATE134579T1 (en)
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CA (1) CA2120713C (en)
DE (1) DE69208676T2 (en)
DK (1) DK0606261T3 (en)
EG (1) EG19617A (en)
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GR (1) GR3019158T3 (en)
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MA (1) MA22636A1 (en)
MX (1) MX9205009A (en)
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MA22636A1 (en) 1993-04-01
DE69208676T2 (en) 1996-10-02
MY110040A (en) 1997-11-29
AU665962B2 (en) 1996-01-25
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TW217381B (en) 1993-12-11
CN1071635A (en) 1993-05-05
JP2815703B2 (en) 1998-10-27
NZ244156A (en) 1995-08-28
DK0606261T3 (en) 1996-05-20
CA2120713C (en) 1999-01-19
CA2120713A1 (en) 1993-04-15
GR3019158T3 (en) 1996-05-31
HK1006162A1 (en) 1999-02-12
SG50464A1 (en) 1998-07-20
AU2547492A (en) 1993-05-03
PT8588T (en) 1993-05-31
EP0606261A1 (en) 1994-07-20
JPH06511218A (en) 1994-12-15
DE69208676D1 (en) 1996-04-04
WO1993007071A1 (en) 1993-04-15
TR27036A (en) 1994-10-10
ATE134579T1 (en) 1996-03-15
PT8588U (en) 1995-12-29
ES2083762T3 (en) 1996-04-16
MX9205009A (en) 1993-05-01
EG19617A (en) 1995-07-27

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