CN103396322A - Preparation method of o-biphenylmethylamine hydrochloride - Google Patents
Preparation method of o-biphenylmethylamine hydrochloride Download PDFInfo
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- CN103396322A CN103396322A CN2013102796660A CN201310279666A CN103396322A CN 103396322 A CN103396322 A CN 103396322A CN 2013102796660 A CN2013102796660 A CN 2013102796660A CN 201310279666 A CN201310279666 A CN 201310279666A CN 103396322 A CN103396322 A CN 103396322A
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- hydrochloric acid
- hydrochloride
- preparation
- concentrated hydrochloric
- biphenylmethylamine
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Abstract
The invention relates to a preparation method of o-biphenylmethylamine hydrochloride, which comprises the following steps: heating distilled water to 70-90 DEG C, adding concentrated hydrochloric acid and o-tolidine, completely dissolving, adding metastannic acid and activated carbon for decolorization, filtering, adding concentrated hydrochloric acid into the filtrate for salt precipitation, cooling to precipitate the crystal, filtering out the crystal, drying by filtration, and drying at 80 DEG C to obtain the o-biphenylmethylamine hydrochloride. The synthesis method using water-soluble hydrochloride is universal, easy to implement and simple to operate, and has the advantages of accessible raw materials and short period.
Description
Technical field
The invention belongs to the chemical reagent field, relate to a kind of indicator, especially a kind of preparation method of adjacent biphenyl methylamine hydrochloride.
Background technology:
Acid base indicator is often referred to a class material that is accompanied by colour-change along with the change of pH, is the indispensable chemical substance of chemistry and analysis field, and this tell-tale variation is actual is the result of a kind of " tautomer " structural changes.
This tautomer has the character of conjugate acid-base pair, is in each other a kind of equilibrium state.The pH value just can affect their balance while changing, and balance moves and be attended by the change of structure, the mutual conversion of acid or the alkali formula of proton occurred losing or obtaining, and namely we study the pH indicator to the indicator of this moment.
In actual applications, wish that usually the color change interval of indicator is narrower good, even pH value of solution has less variation also can make indicator produce sharp variation like this.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of preparation method of adjacent biphenyl methylamine hydrochloride is provided, the present invention selects the more common easy row of the synthetic method of water-soluble sodium salt, and raw material is easy to get, and the cycle is short, and is easy and simple to handle.
The present invention solves its technical problem and takes following technical scheme to realize:
A kind of preparation method of adjacent biphenyl methylamine hydrochloride, step is as follows:
Distilled water is heated to 70-90 ℃, then adds concentrated hydrochloric acid, o-tolidine, after dissolving fully, add metastannic acid and activated carbon decolorizing, filter after decolouring, enriching hydrochloric acid is saltoutd in filtrate,, through cooling crystallization, filters out crystallization, be filtered dry,, in 80 ℃ of dryings, obtain adjacent biphenyl methylamine hydrochloride.
And described concentrated hydrochloric acid: the o-tolidine mass ratio is 1-2:1.
Advantage of the present invention and beneficial effect are:
1, the adjacent biphenyl methylamine hydrochloride of the present invention's preparation claims that again the adjacent biphenyl methylamines of two hydrochloric acid (C14H16N2.2HCLmol285.22) are water insoluble, is insoluble to alcohol.Organic synthesis, measure the Micro Amounts of Chlorine in water.
2, the present invention selects the more common easy row of synthetic method of water-soluble hydrochloride salt, and raw material is easy to get, and the cycle is short, and is easy and simple to handle.
Embodiment
Be further described below in conjunction with embodiment, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
A kind of preparation method of adjacent biphenyl methylamine hydrochloride, step is as follows:
100L distilled water is heated to 70-90 ℃, then add 20L concentrated hydrochloric acid (37% and more than), 20kg o-tolidine, after dissolving fully, add a small amount of metastannic acid (1-5kg), gac (1-5kg), filter after making decolouring, add the 20L concentrated hydrochloric acid and saltout in filtrate, through cooling crystallization, filter out crystallization, be filtered dry,, in 80 ℃ of dryings, obtain finished product.
Wherein, concentrated hydrochloric acid: o-tolidine=2:1
Attention: the present invention is a process for preparing hydrochloride, but needs a large amount of hydrochloric acid, notes anticorrosion and the hydrochloric acid gas overflowing.
The unsuitable excess Temperature of oven dry, otherwise lose hydrogenchloride.
Claims (2)
1. the preparation method of an adjacent biphenyl methylamine hydrochloride, it is characterized in that: step is as follows:
Distilled water is heated to 70-90 ℃, then adds concentrated hydrochloric acid, o-tolidine, after dissolving fully, add metastannic acid and activated carbon decolorizing, filter after decolouring, enriching hydrochloric acid is saltoutd in filtrate,, through cooling crystallization, filters out crystallization, be filtered dry,, in 80 ℃ of dryings, obtain adjacent biphenyl methylamine hydrochloride.
2. the preparation method of adjacent biphenyl methylamine hydrochloride according to claim 1, it is characterized in that: described concentrated hydrochloric acid: the o-tolidine mass ratio is 1-2:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102796660A CN103396322A (en) | 2013-07-05 | 2013-07-05 | Preparation method of o-biphenylmethylamine hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102796660A CN103396322A (en) | 2013-07-05 | 2013-07-05 | Preparation method of o-biphenylmethylamine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103396322A true CN103396322A (en) | 2013-11-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013102796660A Pending CN103396322A (en) | 2013-07-05 | 2013-07-05 | Preparation method of o-biphenylmethylamine hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103396322A (en) |
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2013
- 2013-07-05 CN CN2013102796660A patent/CN103396322A/en active Pending
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131120 |