CN103393783B - Composition containing resveratrol and application - Google Patents
Composition containing resveratrol and application Download PDFInfo
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- CN103393783B CN103393783B CN201310324972.1A CN201310324972A CN103393783B CN 103393783 B CN103393783 B CN 103393783B CN 201310324972 A CN201310324972 A CN 201310324972A CN 103393783 B CN103393783 B CN 103393783B
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Abstract
The invention discloses a composition containing resveratrol and an application. The composition comprises the following components in parts by weight: 100-300 parts of resveratrol, 80-200 parts of rose-boot extracts and 80-250 parts of red date extracts. Through experimental verification, the composition containing resveratrol has stronger functions of resisting fatigue, enhancing resistance, resisting bacteria and diminishing inflammation and dispelling the wind to relieve pain. The composition can quickly remove the symptoms of gout patients, such as ache, joint extension inflexibility and the like, is low in cost, has short courses of treatment, takes an effect quickly, does not have toxic or side effect, and has long-term and stable curative effects after healing.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of composition and method of making the same containing resveratrol.
Background technology
A kind of disease of gout to be urate deposition cause in joint capsule, synovial bursa, cartilage, sclerotin, kidney, subcutaneous and other tissue corresponding disease damage and inflammatory.Dark red for main manifestations with have an intense pain swelling or local pyrexia, color of the leather of Minor articulus clinically, increase the hereditary for its biochemical indicia-kind of purine metabolic disturbance with urate in blood.Gout is distributed in all over the world, by race, diet, drink, the multifactor impact such as professional, environment and schooling.In recent years along with the change with diet style that improves constantly of living standards of the people, the sickness rate of gout rises to some extent.The prevalence of European and American areas gout is 0.2% ~ 1.7%.China general population prevalence about 1.14%, wherein Taiwan and In The Area of Qingdao are gout districts occurred frequently, more than 18 years old Taiwan aborigines' prevalence about 11.7%.The generation of gout is relevant to sex and age, is more common in middle-aged and elderly people, accounts for 90%, and the onset peak age is 40 ~ 50 years old, and M-F is about 20:1.
At present, the therapeutic modality conventional for gout takes western medicine, but Western medicine is temporary relief of symptoms, can not effect a radical cure, and there is various toxic and side effects, and medical expense is higher simultaneously.Therefore natural plant composition is utilized to its pathogenic characteristic determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs day by day by people are paid close attention to.
Resveratrol is the Natural antioxidant be present in plant, be mainly derived from the plants such as Fructus Vitis viniferae, Rhizoma Polygoni Cuspidati, Semen arachidis hypogaeae, Fructus Mori, mainly through removing or suppressing free radical to generate, the mechanisms play antioxidations such as anti-lipid peroxidation, adjustment antioxidation related enzyme activity.There is the effect of stronger antibacterial, antiinflammatory; Meanwhile, resveratrol has stronger enhancing human immunization, improves immunity, to promote physical recovery.Resveratrol has the wind action for the treatment of pain, but its structural instability, in blood, the holdup time is shorter, is used alone the persistence of impact effect.
The applicating history of Radix Rhodiolae is long, and before more than 2,000 year, the people of Qinghai-Tibet Platean is just used as medicine with it, with building body, and the impact of opposing poor environment.Among the people being commonly used to is decocted water or steeps in wine, to banish fatigue or to resist mountain area cold.Simultaneously and diseases prevention is healthy and strong and nourishing lengthens one's life.There is magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting.
Fructus Jujubae: Li Shizhen (1518-1593 A.D.) is said in Compendium of Material Medica: Fructus Jujubae sweet in the mouth, warm in nature, can invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, be used for the treatment of diseases such as " insufficiency of the spleen weak, anorexia and loose stool, deficiency of qi and blood ".Normal food Fructus Jujubae can treat physical weakness, neurasthenia, incoordination between the spleen and stomach, dyspepsia, epersalgia cough, anemia are become thin, and nourishing the liver preventing cancer function is particularly outstanding, has saying of " solar eclipse three Fructus Jujubaes, at the age of one hundred years old bear one's age well ".
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of compositions containing resveratrol is provided.
Second object of the present invention is to provide a kind of purposes of the compositions containing resveratrol.
Technical scheme of the present invention is summarized as follows:
A compositions containing resveratrol, comprises following component: resveratrol 100-300 part by weight; Radix Rhodiolae extract 80-200 part; Fructus Jujubae extract 80-250 part.
Preferred: resveratrol is 150-250 part; Radix Rhodiolae extract 100-160 part; Fructus Jujubae extract 100-200 part.
Above-mentioned a kind of compositions containing resveratrol is preparing the purposes of anti-gout drugs.
By verification experimental verification, a kind of compositions containing resveratrol of the present invention has stronger resisting fatigue, builds up resistance, the effect of anti-inflammation, wind-expelling pain-stopping.For the patient of gout, can Rapid reversal ache, the symptom such as joint joint stuffiness, and cost is low, short treating period, instant effect, have no side effect, more after curative effect steady in a long-term.
Detailed description of the invention
Raw material of the present invention:
Resveratrol (content 90%-98%), Radix Rhodiolae extract (Determination of Salidroside 2%-10%), Fructus Jujubae extract (crude polysaccharides content 10%-40%)
Resveratrol, Radix Rhodiolae extract and Fructus Jujubae extract are purchased from Jianfeng Natural Product R&D Development Co., Ltd., Tianjin.
Disclosing of the source of above-mentioned raw materials, only understand the present invention better to enable those skilled in the art to, but do not impose any restrictions the present invention, the above-mentioned raw materials meeting other source of resveratrol, Radix Rhodiolae extract and Fructus Jujubae extract content requirement may be used to the present invention.
Resveratrol (content 90%), Radix Rhodiolae extract (Determination of Salidroside is 3%), Fructus Jujubae extract (crude polysaccharides content 10%) in each embodiment
Embodiment 1
A preparation method for compositions containing resveratrol, comprises the steps:
(1) take: resveratrol 100g; Radix Rhodiolae extract 80g; Fructus Jujubae extract 80g;
(2) mix homogeneously, adds lactose 100g, dextrin 180g, magnesium stearate 20g, is the ethanol water granule processed in right amount of 60%, is pressed into 1000, tablet by volumetric concentration.
Embodiment 2
A preparation method for compositions containing resveratrol, comprises the steps:
(1) take: resveratrol 120g; Radix Rhodiolae extract 100g; Fructus Jujubae extract 100g;
(2) mix homogeneously, adds starch 180g, magnesium stearate 20g, and mixing, makes capsule 1000.
Embodiment 3
A preparation method for compositions containing resveratrol, comprises the steps:
(1) take: resveratrol 150g; Radix Rhodiolae extract 120g; Fructus Jujubae extract 130g;
(2) mix homogeneously, adds starch 100g, magnesium stearate 20g, and mixing, makes capsule 1000.
Embodiment 4
A preparation method for compositions containing resveratrol, comprises the steps:
(1) take: resveratrol 180g; Radix Rhodiolae extract 150g; Fructus Jujubae extract 170g;
(2) mix homogeneously, adds lactose 100g, dextrin 150g, magnesium stearate 30g, mixing, is 60% by volumetric concentration
Ethanol water makes granule.
Embodiment 5
A preparation method for compositions containing resveratrol, comprises the steps:
(1) take: resveratrol 250g; Radix Rhodiolae extract 160g; Fructus Jujubae extract 200g;
(2) mix homogeneously, adds lactose 120g, dextrin 100g, magnesium stearate 30g, and mixing, makes granule with the ethanol water that volumetric concentration is 60%.
Embodiment 6
A preparation method for compositions containing resveratrol, comprises the steps:
(1) take: resveratrol 300g; Radix Rhodiolae extract 200g; Fructus Jujubae extract 250g;
(2) mix homogeneously, adds lactose 200g, dextrin 100g, magnesium stearate 50g, and mixing, makes granule with the ethanol water that volumetric concentration is 60%.
Experiment effect:
1, clinical case: patient with gout 50 example, male 48 example, women 2 example.Age distribution is in 25-70 year.
2, instructions of taking: patient per takes tablet prepared by embodiment 1, takes 3 every day, each serving with four, bfore meals, warm water delivery service.
3, observation index
(1) Level of Serum Uric Acid: before treatment and treatment after two weeks morning take a blood sample on an empty stomach with phosphotungstic acid colorimetry survey Level of Serum Uric Acid.
(2) erythrocyte sedimentation rate and routine blood test, liver function and renal function: survey once respectively at drawing blood on an empty stomach before medication and after taking medicine two weeks.
(3) change of joint, treatment front and back intensity of anomaly integration: work out clinical observation table, the change that investigation records patient articular pain, arthroncus and joint motion are limited respectively before and after treatment, and be converted into respective integration.
4, efficacy determination doctor trained in Western medicine curative effect determinate standard: the curative effect determinate standard ［ 1 ］ worked out with reference to " guideline of clinical investigations of new Chinese medicine treatment gout ", divide level Four, specific as follows: (1) fully recovers: symptom disappears completely, joint function recovery is normal, blood uric acid is less than 380 μm of ol/L, and erythrocyte sedimentation rate, numeration of leukocyte drop to normal level; (2) effective: cardinal symptom disappears, and function of joint is recovered substantially, and blood uric acid is less than 416 μm of ol/L, and erythrocyte sedimentation rate, numeration of leukocyte return to normal level substantially; (3) effective: cardinal symptom disappears substantially, and function of joint makes moderate progress, and blood uric acid, erythrocyte sedimentation rate, numeration of leukocyte etc. decline to some extent; (4) invalid: to compare with before treatment, each side is all without improvement.
5, the course for the treatment of and principle of medication: 2 weeks be a course for the treatment of, takes 3 courses for the treatment of.
6, clinical observation: after taking compositions of the present invention, the symptoms such as patient aches, swelling can improve very soon, after generally taking a course for the treatment of, ache, swelling, the symptom such as joint joint stuffiness can obviously improve, general patient takes 2-3 the course for the treatment of and can fully recover.
7, concrete therapeutic outcome:
After applying the treatment of this compositions, recovery from illness patient 42 example, accounts for 84%; Effective 8 examples, account for 16%; Effective percentage is 100%.
Through experiment, a kind of compositions containing resveratrol prepared by embodiment 2-embodiment 6, it is similar to embodiment 1 to the therapeutic effect of patient with gout.
Model case:
Example 1: Liu, man, 62 years old.Patient obtains gout 3 years, trick redness and swelling of joints, time serious, hold fist and all feels painstaking, foot difficulty in walking.Once took western medicine, because gastrointestinal irritability is large, drug withdrawal of having to, takes compositions of the present invention (prepared by embodiment 1), takes 3 every day, each serving with four, bfore meals, warm water delivery service always.After the course for the treatment of, the state of an illness is clearly better, and has taken 3 courses for the treatment of, and patient fully recovers, and through following up a case by regular visits to, does not recur so far.
Example 2: Zhao, man 48 years old.Suffer from gout two-and-a-half years, knee joint and toe redness, difficulty in walking, after especially suffering from cold and overworking, not only knee and toe congestion and swelling pain increase the weight of, and also can feel general joint pain, overwhelmed with sorrow time serious.Patient takes colchicine and the treatment of some hormone medicines always, but the state of an illness is never controlled, and is respite symptom once time serious, and moreover, the intestines and stomach of patient is obtained panesthesia's distension and fullness in the abdomen by medicine irritation, has a meal and namely feels indigestion.After taking a course for the treatment of of compositions of the present invention (usage and dosage is with example 1), knee joint and the toe swelling of patient obviously alleviate, and gastrointestinal function obviously strengthens, and starting has appetite, after take to 3 courses for the treatment of, patient fully recovers, and follows up a case by regular visits to and do not recur so far.
The Radix Rhodiolae extract added in prescription of the present invention and Fructus Jujubae extract by invigorating the spleen and replenishing QI, building up resistance promotes the rehabilitation of body, thus play the effect of anti-inflammation, and good stability, action time is lasting, like this, by three combination of components together, the effect complemented each other has been given full play to, improve curative effect, and safety is without any side effects.
Claims (3)
1. the compositions containing resveratrol, is characterized in that medicinal raw material is by weight: resveratrol 100-300 part; Radix Rhodiolae extract 80-200 part; Fructus Jujubae extract 80-250 part, described Resveratrol content is 90%, Determination of Salidroside is 3% in Radix Rhodiolae extract, crude polysaccharides content is 10% in Fructus Jujubae extract.
2. the compositions containing resveratrol according to claim 1, is characterized in that described resveratrol is 150-250 part; Radix Rhodiolae extract 100-160 part; Fructus Jujubae extract 100-200 part.
3. a kind of compositions containing resveratrol of claim 1 or 2 is preparing the purposes of anti-gout drugs.
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| CN105767329A (en) * | 2016-04-13 | 2016-07-20 | 严绍章 | Anti-fatigue functional beverage and preparing method thereof |
| CN112189849A (en) * | 2020-10-28 | 2021-01-08 | 无锡市世纪生物工程有限公司 | Uric acid reducing composition and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380114A (en) * | 2008-10-29 | 2009-03-11 | 通化腾龙保健品有限公司 | Pushenkang health products |
| CN102166302A (en) * | 2011-03-31 | 2011-08-31 | 王一军 | Metabolism-compensation method for treating rheumatic osteoarthritis and proportioning and preparing process of preparation thereof |
| CN102432620A (en) * | 2011-09-09 | 2012-05-02 | 南京大学 | Resveratrol tetramer compound, its preparation method and application |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380114A (en) * | 2008-10-29 | 2009-03-11 | 通化腾龙保健品有限公司 | Pushenkang health products |
| CN102166302A (en) * | 2011-03-31 | 2011-08-31 | 王一军 | Metabolism-compensation method for treating rheumatic osteoarthritis and proportioning and preparing process of preparation thereof |
| CN102432620A (en) * | 2011-09-09 | 2012-05-02 | 南京大学 | Resveratrol tetramer compound, its preparation method and application |
Non-Patent Citations (1)
| Title |
|---|
| 陈仁寿.红景天.《新编临床中药学》.科学出版社,2011,(第1版), * |
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Effective date of registration: 20150916 Address after: 300457, Tianjin economic and Technological Development Zone, Huang Hai Road No. 276 Taida small and medium enterprises Park 6 Patentee after: TIANJIN KANGSHI BIOTECHNOLOGY CO., LTD. Address before: 300457, Tianjin Binhai New Area Economic and Technological Development Zone fourth, 80 Avenue, Tian Da Science and Technology Park, block B9 Patentee before: JF-Pharmaland Technology Development Co., Ltd. |