CN1033936A - The preparation method of rifampicin eye ointment - Google Patents
The preparation method of rifampicin eye ointment Download PDFInfo
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- CN1033936A CN1033936A CN 87108236 CN87108236A CN1033936A CN 1033936 A CN1033936 A CN 1033936A CN 87108236 CN87108236 CN 87108236 CN 87108236 A CN87108236 A CN 87108236A CN 1033936 A CN1033936 A CN 1033936A
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- rifampicin
- eye ointment
- preparation
- dissolving
- ointment
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Abstract
The present invention is a kind of preparation method of broad-spectrum antibiotic rifampicin eye ointment.It is to add antioxidant vitamin e1 part for 90～99 parts by white oil and the mixed substrate of vaseline, go into jar and be heated to 5～70 ℃, make its dissolving, splash into 0.5～5 part of the chloroformic solution of rifampicin again, the final vacuum that stirs decompression, till the chloroform emptying, last machine pressing mold promptly gets the soft capsule eye ointment.Rifampicin eye ointment of the present invention is nontoxic, have no side effect, non-stimulated, it has special curative effect to tuberculous keratitis and sand holes.
Description
The present invention relates to a kind of preparation method of broad-spectrum antibiotic ointment, particularly rifampicin eye ointment.
Rifampicin is one of the widest antibiotics of modern antimicrobial spectrum, and it has powerful sterilizing ability.Injure the application of field of ophthalmology outside, existing a lot of report.Rifampicin has powerful kill capability to Gram-positive and gram negative bacteria, and the outer ophthalmic disease due to the general antibacterial is had better curative effect, particularly tuberculous keratitis and serious symptom sand holes is had unique curative effect.But rifampicin eye ointment does not still have report at present both at home and abroad, and only Heilongjiang Province's health personnel administration institute drop pill type eyedrops of rifaldazine has been applied to clinical.Drop pill type eyedrops of rifaldazine is with a kind of buffer drop pill to be dissolved, and its solution can only keep for two weeks.Stability is very poor, and is that the existing molten use of existing usefulness is extremely inconvenient.Provide a kind of rifampicin dissolving eye ointment complete, good stability the real necessity that belongs to for this reason.
The object of the present invention is to provide a kind of preparation method of broad-spectrum antibiotic ointment, particularly rifampicin eye ointment.It has dissolving fully, good stability, sterilizing power is strong, nontoxic, have no side effect, non-stimulated, technology is simple, and is easy to use, is easy to the spongaion that numerous people is accepted.
The object of the present invention is achieved like this: get substrate that the vaseline of 40～70% white oil and 30～60% forms and add in 0.2～5 part of tank filling of antioxidant for 90～110 parts and be heated to 5～70 ℃, make its dissolving, and then splash into 0.2～5 part of the chloroformic solution (its ratio is 1: 2～20) of rifampicin.Stir while dripping, treat even final vacuum decompression, till the chloroform emptying.It is 0.15～0.3 soft capsule rifampicin eye ointment that last machine pressing mold promptly gets every weight.Substrate is the pharmacopeia defined, the antioxidant vitamin E is a kind of defying age antioxidation class medicine, it is fabulous to the effect of ointment type preparation stabilization, chloroformic solution is the best solvent of rifampicin, under the condition of uniform temperature through stirring cooling again through vacuum decompression, chloroform fully emptying die nontoxic, have no side effect, non-stimulated.Rifampicin eye ointment is better than the medicament for the eyes of other method preparation.Has the not available advantage of drop pill type eyedrops of rifaldazine.
Advantage of the present invention:
1, rifampicin eye ointment, dissolving is complete, and good stability can keep stablizing 1～2 year.
2, cream is longer in the local action time than water, and therapeutic effect is good, and particularly tuberculous keratitis and sand holes have special curative effect.
3, carry, easy to use, cut off soft capsule and can use.
4, every next capsule has prevented the disadvantage that continuous use pollutes.
5, technology is simple, makes the microgranule rifampicin pressing mold that promptly is available on the machine.Reduce the preparation and the packing of buffer, be convenient to produce in enormous quantities.
6, soft capsule is convenient to packing and transportation.
7, with low cost, be easy to apply.
Embodiment:
Embodiment of the present invention realize by the following method:
1, the mixed substrate 99.6% of vaseline of getting 40% white oil and 60% adds vitamin E 0.2%, in the tank filling, is heated to 5～70 ℃, make its dissolving, splash into the chloroformic solution (its ratio is 1: 4) 0.2% of rifampicin again, stir, treat that evenly the machine pressing mold is gone up promptly in the back while dripping.
2, get the mixed substrate 98.5% of 56% white oil and 44% vaseline, add vitamin e1 %, tinning is heated to 5～70 ℃, make its dissolving, splash into the chloroformic solution (its ratio is 1: 10) 0.5% of rifampicin again, stir while splashing into, treat evenly after, vacuum decompression is until the chloroform emptying, and last machine pressing mold promptly.
3, get 70% white oil and 30% the mixed substrate 90% of vaseline, be heated to 5～70 ℃ in adding vitamin E 5% tank filling, make its dissolving, splash into the chloroformic solution (its ratio is 1: 20) 5% of rifampicin again, stir while dripping, treat that evenly the machine pressing mold is gone up promptly in the back.
Every heavily is the soft capsule of 0.15～0.3 gram.
Claims (2)
1, a kind of broad-spectrum antibiotic ointment, the preparation method of rifampicin eye ointment particularly, it is characterized in that: get 90～110 parts of substrate that the vaseline of 40～70% white oil and 30～60% forms and add 0.2～5 part of tinning of antioxidant and be heated to 5～70 ℃ and make its dissolving, splash into 0.2～5 part of the chloroformic solution (its ratio is 1: 2～20) of rifampicin again, stir while splashing into, treat evenly after, vacuum decompression, till the chloroform emptying, last machine pressing mold promptly.
2, preparation method according to claim 1 is characterized in that: antioxidant is preferentially selected vitamin E for use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87108236 CN1020252C (en) | 1987-12-26 | 1987-12-26 | Prepn. of rifampin eye ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87108236 CN1020252C (en) | 1987-12-26 | 1987-12-26 | Prepn. of rifampin eye ointment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1033936A true CN1033936A (en) | 1989-07-19 |
| CN1020252C CN1020252C (en) | 1993-04-14 |
Family
ID=4816429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 87108236 Expired - Fee Related CN1020252C (en) | 1987-12-26 | 1987-12-26 | Prepn. of rifampin eye ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1020252C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054741C (en) * | 1995-10-09 | 2000-07-26 | 康孟喆 | Medicinal composite for eyes |
| JP2022137176A (en) * | 2014-07-21 | 2022-09-21 | エーエムディー セラピューティックス エルエルシー | Ophthalmic composition of rifamycin, and use of the same |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100463693C (en) * | 2004-09-17 | 2009-02-25 | 深圳市海王英特龙生物技术股份有限公司 | Interferon oculentum |
-
1987
- 1987-12-26 CN CN 87108236 patent/CN1020252C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054741C (en) * | 1995-10-09 | 2000-07-26 | 康孟喆 | Medicinal composite for eyes |
| JP2022137176A (en) * | 2014-07-21 | 2022-09-21 | エーエムディー セラピューティックス エルエルシー | Ophthalmic composition of rifamycin, and use of the same |
| US11850213B2 (en) | 2014-07-21 | 2023-12-26 | Amd Therapeutics Llc | Ophthalmic compositions of rifamycins and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1020252C (en) | 1993-04-14 |
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| C14 | Grant of patent or utility model | ||
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