CN103393572B - Preparation method of deep-submicron granule emulsion with anti-aging efficacy - Google Patents
Preparation method of deep-submicron granule emulsion with anti-aging efficacy Download PDFInfo
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Abstract
The invention relates to a preparation method of a deep-submicron granule emulsion with anti-aging efficacy, and the preparation method comprises the following steps: A, weighing a lipid material, and heating to 75-85 DEG C to obtain a liquid oil-phase; B, proportionally weighing a cistus incanus extract, a taraxacum officinale extract, decarboxy carnosine HCL and a rhodobacter sphaeroides lysate extract to obtained an anti-aging active composition; C, proportionally weighing the anti-aging active composition and the lipid material to obtain a mixed oil phase; D, weighing a composite emulsifier; E, proportionally weighing the composite emulsifier and distilled water to obtain a mixed water phase; F, mixing the mixed oil phase and the mixed water phase, and homogenizing for 15 minutes in a rotate speed of 2800 rpm at the normal temperature and under the normal pressure to obtain a premixed solution; and G, homogenizing the premixed solution by a high pressure homogenizer. The advantages of the preparation method is that: the deep-submicron granule emulsion simultaneously loaded with the cistus incanus extract, the taraxacum officinale extract, the decarboxy carnosine HCL and the rhodobacter sphaeroides lysate extract can be prepared.
Description
Technical field
The present invention relates to the preparing technical field of deep-submicron grain emulsion, particularly a kind of preparation method with the deep-submicron grain emulsion of aging resistance effect.
Background technology
Causing the extrinsic factor that human body skin is aging, is mainly that photoaging and air pollution are aging.Modern industry is day by day serious to depletion of the ozone layer, cause penetrating the uitraviolet intensity increase that atmosphere arrives at earth surface, being subject to excessive ultraviolet radiation can cause skin to occur photoaging, it is the DNA/RNA structure of destroying skin cell that its characteristic changes, collagen fiber elastic fibers organizational structure disappearance, it is easily lax that this infringement shows as skin, and wrinkle increases, and severe patient also there will be skin carcinoma symptom.Modern society's air pollution simultaneously increases the weight of, various micronic dusts, particularly other microgranule of nano-scale level, as the microgranule after cigarette combustion, motor vehicle exhaust emission micronic dust etc., its surface activity is very strong, stick on skin and easily cause free radical, make skin cell impaired, cause various skin ageing problems.
Causing the endogenous factor that human skin is aging, is mainly the saccharifying of skin collagen protein and aging, and causing collagen protein saccharifying and aging reason is mainly the gene problem of human body itself and bad living habit.The glycosylation in skin field, refers to that virtue draws reaction, and in body, too much sugar can be attached on collagen protein, makes collagen cross-linking degeneration become brown, follows the string.Skin antioxidation, refers to antioxidant content is provided, Cell protection film, avoids over oxidation, helps cell elongation life cycle.At present, improve the skin ageing problem that endogenous factor causes, the main method adopting is to help the anti-saccharifying of skin and antioxidation.
Grey Cistus flower extract (Cistus Incanus Flower Extract; No. CAS: active component 93165-04-9) is isoquercitrin (Isoquercitrin); by reducing generation and the quantity of Cell protection to the injury of antiperoxide, minimizing sunburn cell of the peroxide of ultraviolet induction, reach Cell protection DNA and antioxidative effect.The manufacturer of grey Cistus flower extract has German EVONIK company, and commodity are called TEGO Cistus.Japan Katakura Chikkarin also has grey Cistus flower extract, as merchandise sales.
In air, smog and particulate matter can bring out skin inflammation, Europe Herba Taraxaci (TARAXACUM OFFICINALE EXTRACT, No. CAS: 84775-55-3) active substance of extract is levan, can reduce the generation of scytitis factor interleukin-11-α, reduce the oxidation protein ratio of pollutant induction, improve dull-looking skin and rough texture problem that in air, smog and particulate matter cause.The manufacturer of the Europe Herba Taraxaci extract using in the present invention is French SILAB company, and commodity are called APOLLUSKIN.
Decarboxylation carnosine HCL (DECARBOXY CARNOSINE HCL, cosmetic material Catalog Sequence Number: 3751) can reduce the formation of advanced glycation end products, reverse the collagen protein of initial stage saccharifying.The manufacturer of the decarboxylation carnosine using in the present invention is Morocco EXSYMOL company, and commodity are called ALISTIN.
The molten born of the same parents' thing of the red antibacterial of class ball extract (Rhodobacter Sphaeroides Lysate Extract) main active is that (INCI name is called lycopene Lycopene: lycopene, No. CAS: 502-65-8), can resist skin oxidation, can also imitate and suppress induced by ultraviolet irradiation collagen protein decomposition promotion collagen protein hypertrophy.Can resist skin oxidation, manufacturer is Taiwan Asia-Placific Biotech Development, Inc., and commodity are called LYCOGEN.
Mechanism for skin anti-aging, the present invention is by grey Cistus flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract carries out composite, not only there is the effect of antagonism intrinsic aging, and thering is the exogenous aging effect of antagonism, two kinds of effects are worked in coordination with and are reached comprehensive aging resistance effect.But grey Cistus flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract, their chemism is strong, poor stability, directly add in cosmetic formulations, easily oxidized and cause active matter content to reduce, product colour also can very fast flavescence, browning.Along with grey Cistus flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract is oxidized, occurs unwelcome foreign odor, causes losing its commodity value.
Deep-submicron grain emulsion, refers to the particle in emulsion, and mean diameter is at 0.25 μ m and following.Deep-submicron grain emulsion prepared by the present invention refers to the emulsion of particle diameter between 100-250 nanometer, relative grain size is at the nanoemulsions of 0-100 nanometer, its to human body permeability a little less than, can not enter human body internal circulation system, can the long period rest on skin surface, the more general nanoemulsions of safety and slow-releasing is better, stronger to the load capacity of active matter.
Summary of the invention
The technical problem to be solved in the present invention is that the preparation method of the deep-submicron grain emulsion with aging resistance effect of a kind of grey Cistus of load simultaneously flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract is provided.
For solving the problems of the technologies described above, the present invention by the following technical solutions: there is the preparation method of the deep-submicron grain emulsion of aging resistance effect, it is characterized in that: said method comprising the steps of:
A: take matrix material, be heated to 75-85 ℃, obtain liquid oil phase; Described matrix material comprises glyceryl stearate, cetearyl alcohol, spermol cetylate and Vegetable oil lipoprotein;
B: in mass ratio for the ratio of 2.5-5:2-3:1-2:1 takes grey Cistus flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract, above-mentioned four kinds of materials are mixed, obtain aging resistance active compound;
C: in mass ratio for the ratio of 0.225-0.55:1 takes aging resistance active compound and matrix material, mix homogeneously post-heating to 75-85 ℃, are stirred to aging resistance active compound and dissolve completely, obtain mixing oil phase;
D: in mass ratio for the ratio of 0.30-0.50:1 takes ceteareth-12 and ceteareth-20, form compound emulsifying agent;
E: in mass ratio for the ratio of 0.15-0.30:1 takes step D gained compound emulsifying agent and distilled water, both mix post-heating to 75-85 ℃, stir, and obtain mixing water;
F: after C step gained mixing oil phase and E step are obtained and mix water and mix, with the rotating speed homogenizing of 2800rpm 15 minutes, obtain premixed solution under room temperature, normal pressure;
G: by premixed solution under 80-150MPa pressure, 75-90 ℃ of temperature conditions, by high pressure homogenizer circulation 3500rpm homogenizing 8-15 time, in high pressure homogenizer outlet, use chiller, guarantee that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 ℃, must have the deep-submicron grain emulsion of aging resistance effect after homogenizing completes.
Further, described Vegetable oil lipoprotein is Suaeda salsa seed oil (Suaeda Salsa Seed Oil), U.S. rattan fruit oil (Sacha Inchi oil), Fructus rhois chinensis fruit oil (Sumac Fruit Oil), samara oil (Elaeagnus Mollis Diels Oil), tea-seed oil (Tea Camellia Seed Oil), hemp-seed oil (Cannabis Sativa Seed Oil), Fructus Cannabis oil (Fructus CannabisSeed Oil), granada seed oil (Punica GranatumSeed Oil), Semen Cucurbitae oil (Pumpkin Seed Oil), lycium barbarum seed oil (Lycium BarbarumSeed Oil), Semen Lini oil (LINUM USITATISSIMUM Seed Oil), a kind of in batilol (Batyl Alcohol) or their mixture.
The inventive method is by selecting suitable matrix material, rationally control the ratio between matrix material and active matter, under specific process conditions, the grey Cistus of load simultaneously flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, four kinds of active component of the molten born of the same parents' thing of the red antibacterial of class ball extract, can effectively guarantee that four kinds of active component are covered by the solid-state lipid particles structure of deep-submicron simultaneously, can be used for alleviating skin intrinsic aging and exogenous aging simultaneously, reach the effect of comprehensive resisting age of skin.The inventive method has improved stability, transdermal characteristic and the slow-releasing of active matter by the solid-state lipid particles structure of deep-submicron grain.The present invention is by suitable matrix material, control proportioning between material simultaneously, suitable pressure, temperature and homogenization cycles are set, can obtain the deep-submicron solid particle emulsion of particle diameter within the scope of 100-250nm, good emulsion stability, be conducive to skin and absorb, can not enter body internal circulation system again, there is higher safety and slow-releasing.
The deep-submicron grain emulsion with aging resistance effect of preparing by the inventive method rotating speed be in per minute 10000 centrifuges that turn centrifugal 30 minutes not stratified; Under 45 ℃ of environment, preserve not stratified, invariant color in three months; Normal temperature storage 3 years is not stratified, has good stability.
By recruiting regular Sunlight exposure, smoking, below 35 years old, men and women each half, there is crowd in slight wrinkle, amounts to 30 examples, carries out human trial in 28 days.In for the blank cosmetics paste of test (composition see below remarks), being added with the aging resistance effect deep-submicron grain emulsion that has prepared by 10% embodiment tetra-tests.In this example, actual grey Cistus flower extract 0.30%, Europe Herba Taraxaci extract 0.50%, decarboxylation carnosine HCL 0.10%, the molten born of the same parents' thing of the red antibacterial of the class ball extract 0.10% of containing in these cosmetics, adding up to active matter total content is 1.0%, test result shows that its crease-resistant effect of compacting is better than only adding 1.0% grey Cistus flower extract, is also better than only adding 1.0% Europe Herba Taraxaci extract or only adds 1.0% decarboxylation carnosine HCL or only add the same basic components cosmetics of the molten born of the same parents' thing of the red antibacterial of 1.0% class ball extract.Meanwhile, be also better than not passing through deep sub-micron processes, and directly add the same basic components cosmetics of grey Cistus flower extract 0.30%, Europe Herba Taraxaci extract 0.50%, decarboxylation carnosine HCL 0.10%, the molten born of the same parents' thing of the red antibacterial of class ball extract 0.10%.Sooner or later get the appropriate cosmetics containing having active matter after clean face and evenly spread upon left face every day, and the cosmetics that do not add active matter are smeared by the right face.With MPA580 elasticity tester, VISIA skin analysis tester, record weekly everyone experimental data.Experimental data is as following table:
Note: sample A, interpolation grey Cistus flower extract 1.0%;
Sample B, interpolation Europe Herba Taraxaci extract 1.0%;
Sample C, interpolation decarboxylation carnosine HCL 1.0%;
Sample D, the molten born of the same parents' thing of the interpolation red antibacterial of class ball extract 1.0%;
Sample E, directly add grey Cistus flower extract 0.30%, Europe Herba Taraxaci extract 0.50%, decarboxylation carnosine HCL 0.10%, the molten born of the same parents' thing of the red antibacterial of class ball extract 0.10%;
Sample F, the deep-submicron grain emulsion that contains grey Cistus flower extract 0.30%, Europe Herba Taraxaci extract 0.50%, decarboxylation carnosine HCL 0.10%, the molten born of the same parents' thing of the red antibacterial of class ball extract 0.10% of adding.
Remarks: the formula for the blank cosmetics paste of test is as follows, adds the active matter of respective amount in this mastic, obtain test sample A, B, C, D, E, F.
Under 45 ℃ of environment, place three months, the aging resistance effect deep-submicron grain emulsion of embodiment 1 to embodiment 5 below, appearance color is unchanged, with the standard sample comparison that is kept at 5 ℃ of cryostates, without obviously outward appearance and color change.With Ma Erwen particle diameter tester, measure, its aging resistance deep-submicron grain emulsion mean diameter is also without significant change.
The aging resistance effect deep-submicron grain emulsion of preparing by the inventive method, its gross activity thing mass ratio in deep-submicron grain emulsion can reach 3.5-11.0%, under room temperature, viscosity is less than 1500cps, can coldly join and join in cosmetic formulations, easy to use in aging resistance effect cosmetics.
The particle diameter of aging resistance effect deep-submicron grain emulsion prepared by the present invention can be controlled at 100-250nm, and this particle diameter microgranule relative size is larger, can not penetrate in human body internal circulation system, and safety is higher.Its solid-state lipid particles structure pro-skin simultaneously, low viscosity, aqueous dispersion, easy to use, can effectively strengthen the stability of its active substance containing.It is simple and convenient that this method also has preparation process, constant product quality, and large-scale industrial is produced the advantages such as convenient.
In sum, the inventive method has the following advantages: the deep-submicron grain emulsion with aging resistance effect that can prepare the grey Cistus of load simultaneously flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract, alleviate skin intrinsic aging and exogenous aging, reach comprehensive aging resistance effect, emulsion-stabilizing invariant color, facilitates cold joining to join in cosmetic formulations.
The specific embodiment
embodiment mono-:
A preparation method with the deep-submicron grain emulsion of aging resistance effect, adopts following steps:
A. take 25.0g oleostearin acid esters, cetearyl alcohol, spermol cetylate, common seepweed seeds oil, U.S. rattan fruit oil (2:1:2:1:2) mixture in beaker, 75 ℃ of heating in water bath, obtain liquid oil phase;
B. in the ratio of 4:2.5:1.5:1, take 4.0g grey Cistus flower extract, 2.5g Europe Herba Taraxaci extract, 1.5g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.0 red antibacterial of g class ball extract, they are joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 75 ℃;
Ceteareth-20=0.5:1) and 144.35g distilled water C. get ratio that emulsifying agent and distilled water mass ratio are 0.15: 1 and take 21.65g (ceteareth-12:, put into beaker, be heated to 75 ℃, stir and obtain liquid water;
D. the liquid water that the mixing oil phase that B step is obtained and C step obtain with the rotating speed homogenizing of 2800rpm 15 minutes, obtains premixed solution under room temperature, normal pressure;
E. by premixed solution under 80MPa pressure, 80 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 8 times, in high pressure homogenizer outlet, use chiller, controlling high pressure homogenizer outlet section mixeding liquid temperature is 75 ℃, obtains deep-submicron grain emulsion after homogenizing completes.
The high temperature deep-submicron grain emulsion obtaining is quickly cooled to room temperature, can add 0.15% DMDM hydantoin antiseptic, stir, obtain the aging resistance deep-submicron grain emulsion containing 4.0g grey Cistus flower extract, 2.5g Europe Herba Taraxaci extract, 1.5g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.0 red antibacterial of g class ball extract that mean diameter is about 180nm, aging resistance active matter total content is 4.5%.
embodiment bis-:
A preparation method with the deep-submicron grain emulsion of aging resistance effect, adopts following steps:
A. take 30.0g oleostearin acid esters, cetearyl alcohol, spermol cetylate, Fructus rhois chinensis fruit oil, samara oil (2:1:1:1:2) mixture are in beaker, and 80 ℃ of heating in water bath, obtain liquid oil phase;
B. in the ratio of 3.3:2.3:1.3:1, take 5.0g grey Cistus flower extract, 3.5g Europe Herba Taraxaci extract, 2.0g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.5 red antibacterial of g class ball extract, they are joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 75 ℃;
Ceteareth-20=0.3:1) and 131.67g distilled water C. get ratio that emulsifying agent and distilled water mass ratio are 0.2: 1 and take 26.33g (ceteareth-12:, put into beaker, be heated to 75 ℃, stir and obtain liquid water;
D. the liquid water that the mixing oil phase that B step is obtained and C step obtain with the rotating speed homogenizing of 2800rpm 15 minutes, obtains premixed solution under room temperature, normal pressure;
E. by premixed solution under 100MPa pressure, 85 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 15 times, in high pressure homogenizer outlet, use chiller, controlling high pressure homogenizer outlet section mixeding liquid temperature is 75 ℃, obtains deep-submicron grain emulsion after homogenizing completes.
The high temperature deep-submicron grain emulsion obtaining is quickly cooled to room temperature, can add the imidazolidinyl urea of 0.15% methyl hydroxybenzoate and 0.15% as antiseptic, stir, obtain the aging resistance deep-submicron grain emulsion containing 5.0g grey Cistus flower extract, 3.5g Europe Herba Taraxaci extract, 2.0g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.5 red antibacterial of g class ball extract that mean diameter is about 200nm, aging resistance active matter total content is 6.0%.
embodiment tri-:
A preparation method with the deep-submicron grain emulsion of aging resistance effect, adopts following steps:
A. take 35.0g oleostearin acid esters, cetearyl alcohol, spermol cetylate, tea-seed oil, hemp-seed oil (1:1:2:1:2) mixture in beaker, 80 ℃ of heating in water bath, obtain liquid oil phase;
B. in the ratio of 2.5:2:1.5:1, take 2.5g grey Cistus flower extract, 2.0g Europe Herba Taraxaci extract, 1.5g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.0 red antibacterial of g class ball extract, they are joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 75 ℃;
Ceteareth-20=0.4:1) and 126.4g distilled water C. get ratio that emulsifying agent and distilled water mass ratio are 0.25: 1 and take 31.6g (ceteareth-12:, put into beaker, be heated to 75 ℃, stir and obtain liquid water;
D. the liquid water that the mixing oil phase that B step is obtained and C step obtain with the rotating speed homogenizing of 2800rpm 15 minutes, obtains premixed solution under room temperature, normal pressure;
E. by premixed solution under 150MPa pressure, 90 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 10 times, in high pressure homogenizer outlet, use chiller, controlling high pressure homogenizer outlet section mixeding liquid temperature is 85 ℃, obtains deep-submicron grain emulsion after homogenizing completes.
The high temperature deep-submicron grain emulsion obtaining is quickly cooled to room temperature, can add the imidazolidinyl urea of 0.20% methyl hydroxybenzoate and 0.10% as antiseptic, stir, obtain the aging resistance deep-submicron grain emulsion containing 5.0g grey Cistus flower extract, 3.5g Europe Herba Taraxaci extract, 2.0g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.5 red antibacterial of g class ball extract that mean diameter is about 100nm, aging resistance active matter total content is 3.5%.
embodiment tetra-:
A preparation method with the deep-submicron grain emulsion of aging resistance effect, adopts following steps:
A. take 40.0g oleostearin acid esters, cetearyl alcohol, spermol cetylate, Fructus Cannabis oil, granada seed oil, Semen Cucurbitae oil (2:2:1:2:1:1) mixture are in beaker, and 75 ℃ of heating in water bath, obtain liquid oil phase;
B. in the ratio of 3:5:1:1, take 6.0g grey Cistus flower extract, 10.0g Europe Herba Taraxaci extract, 2.0g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 2.0 red antibacterial of g class ball extract, they are joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 75 ℃;
Ceteareth-20=0.6:1) and 109.37g distilled water C. get ratio that emulsifying agent and distilled water mass ratio are 0.28: 1 and take 30.63g (ceteareth-12:, put into beaker, be heated to 75 ℃, stir and obtain liquid water;
D. the liquid water that the mixing oil phase that B step is obtained and C step obtain with the rotating speed homogenizing of 2800rpm 15 minutes, obtains premixed solution under room temperature, normal pressure;
E. by premixed solution under 100MPa pressure, 90 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 10 times, in high pressure homogenizer outlet, use chiller, controlling high pressure homogenizer outlet section mixeding liquid temperature is 90 ℃, obtains deep-submicron grain emulsion after homogenizing completes.
The high temperature deep-submicron grain emulsion obtaining is quickly cooled to room temperature, can add 0.6% phenoxyethanol antiseptic, stir, obtain the aging resistance deep-submicron grain emulsion containing 4.0g grey Cistus flower extract, 2.5g Europe Herba Taraxaci extract, 1.5g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 1.0 red antibacterial of g class ball extract that mean diameter is about 220nm, aging resistance active matter total content is 10.0%.
embodiment five:
A preparation method with the deep-submicron grain emulsion of aging resistance effect, adopts following steps:
A. take 40.0g oleostearin acid esters, cetearyl alcohol, spermol cetylate, lycium barbarum seed oil, Semen Lini oil, batilol (2:1:2:1:1:1) mixture are in beaker, and 85 ℃ of heating in water bath, obtain liquid oil phase;
B. in the ratio of 5:3:2:1, take 10.0g grey Cistus flower extract, 6.0g Europe Herba Taraxaci extract, 4.0g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 2.0 red antibacterial of g class ball extract, they are joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 75 ℃;
Ceteareth-20=0.45:1) and 106.15g distilled water C. get ratio that emulsifying agent and distilled water mass ratio are 0.3: 1 and take 31.85g (ceteareth-12:, put into beaker, be heated to 75 ℃, stir and obtain liquid water;
D. the liquid water that mixing oil phase B step being obtained and C step obtain with the rotating speed homogenizing of 2800rpm 15 minutes, obtains premixed solution under room temperature, normal pressure;
E. by premixed solution under 130MPa pressure, 90 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 15 times, in high pressure homogenizer outlet, use chiller, controlling high pressure homogenizer outlet section mixeding liquid temperature is 82 ℃, obtains deep-submicron grain emulsion after homogenizing completes.
The high temperature deep-submicron grain emulsion obtaining is quickly cooled to room temperature, can add two (methylol) imidazolidinyl antiseptic of 0.3%, stir, obtain the aging resistance deep-submicron grain emulsion containing 10.0g grey Cistus flower extract, 6.50g Europe Herba Taraxaci extract, 4.0g decarboxylation carnosine HCL, the molten born of the same parents' thing of the 2.0 red antibacterial of g class ball extract that mean diameter is about 250nm, aging resistance active matter total content is 11.0%.
Claims (2)
1. the preparation method with the deep-submicron grain emulsion of aging resistance effect, is characterized in that: said method comprising the steps of:
A: take matrix material, be heated to 75-85 ℃, obtain liquid oil phase; Described matrix material is glyceryl stearate, cetearyl alcohol, spermol cetylate and Vegetable oil lipoprotein;
B: in mass ratio for the ratio of 2.5-5:2-3:1-2:1 takes grey Cistus flower extract, Europe Herba Taraxaci extract, decarboxylation carnosine HCL, the molten born of the same parents' thing of the red antibacterial of class ball extract, above-mentioned four kinds of materials are mixed, obtain aging resistance active compound;
C: in mass ratio for the ratio of 0.225-0.55:1 takes aging resistance active compound and liquid oil phase, mix homogeneously post-heating to 75-85 ℃, are stirred to aging resistance active compound and dissolve completely, obtain mixing oil phase;
D: in mass ratio for the ratio of 0.30-0.50:1 takes ceteareth-12 and ceteareth-20, form compound emulsifying agent;
E: in mass ratio for the ratio of 0.15-0.30:1 takes step D gained compound emulsifying agent and distilled water, both mix post-heating to 75-85 ℃, stir, and obtain mixing water;
F: after C step gained mixing oil phase and E step gained mixing water are mixed, with the rotating speed homogenizing of 2800rpm 15 minutes, obtain premixed solution under room temperature, normal pressure;
G: by premixed solution under 80-150MPa pressure, 75-90 ℃ of temperature conditions, by high pressure homogenizer circulation 3500rpm homogenizing 8-15 time, in high pressure homogenizer outlet, use chiller, guarantee that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 ℃, must have the deep-submicron grain emulsion of aging resistance effect after homogenizing completes.
2. the preparation method with the deep-submicron grain emulsion of aging resistance effect according to claim 1, is characterized in that: described Vegetable oil lipoprotein is a kind of in Suaeda salsa seed oil, U.S. rattan fruit oil, Fructus rhois chinensis fruit oil, samara oil, tea-seed oil, hemp-seed oil, Fructus Cannabis oil, granada seed oil, Semen Cucurbitae oil, lycium barbarum seed oil, Semen Lini oil or their mixture.
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| CN103393572A (en) | 2013-11-20 |
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