CN103393439A - Needle biopsy method based on photoacoustic imaging technique - Google Patents
Needle biopsy method based on photoacoustic imaging technique Download PDFInfo
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- CN103393439A CN103393439A CN2013103672839A CN201310367283A CN103393439A CN 103393439 A CN103393439 A CN 103393439A CN 2013103672839 A CN2013103672839 A CN 2013103672839A CN 201310367283 A CN201310367283 A CN 201310367283A CN 103393439 A CN103393439 A CN 103393439A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 79
- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000013188 needle biopsy Methods 0.000 title abstract 2
- 239000012528 membrane Substances 0.000 claims abstract description 40
- 238000010521 absorption reaction Methods 0.000 claims abstract description 30
- 238000001574 biopsy Methods 0.000 claims abstract description 26
- 239000013307 optical fiber Substances 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 9
- 230000008520 organization Effects 0.000 claims description 25
- 238000005516 engineering process Methods 0.000 claims description 18
- 230000003287 optical effect Effects 0.000 claims description 17
- 238000002347 injection Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 230000002745 absorbent Effects 0.000 claims description 3
- 239000002250 absorbent Substances 0.000 claims description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
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- 238000003331 infrared imaging Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- 230000000644 propagated effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 23
- 238000010895 photoacoustic effect Methods 0.000 description 8
- 238000002059 diagnostic imaging Methods 0.000 description 3
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- 230000008901 benefit Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
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- 238000007373 indentation Methods 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
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Abstract
The invention discloses a biopsy needle based on a photoacoustic imaging technique, which comprises a needle tip wall, a laser filter membrane, incident optical fibers and laser absorption layers. The invention further provides a needle biopsy method which comprises the following steps that a target tissue image is acquired in real time by other imaging techniques; the biopsy needle is aligned with a target tissue and needled; laser is emitted into the incident optical fibers; a photoacoustic signal is acquired by an ultrasonic transducer; an imaging result of a tissue nearby the laser filter membrane at the needle tip and luminous spots at the laser absorption layers and the laser filter membrane are obtained by photoacoustic reconstruction; by combining with the other imaging techniques, the target tissue imaging result and a photoacoustic imaging result of the tissue nearby the needle tip are displayed alternately; an accurate position of the needle tip is supposed by using the luminous spots at the laser absorption layers and the laser filter membrane; and when the needle tip is accurately moved to a designated position, a target tissue sample is acquired or a drug is injected for treatment. The method can accurately acquire the position of the needle tip, reduces the needling difficulty greatly, relieves a pain of a patient, and is convenient to use and outstanding in effect.
Description
Technical field
The present invention relates to biomedical sector, particularly medical imaging and medical instruments field.
Background technology
Ultra sonic imaging development so far, has become the modern times four large medical imaging diagnostic techniques arranged side by side with X-CT, MRI, PET.It is compared with other medical imaging means, have advantages of that simple to operate, low-cost, nothing injures, AT uniqueness, be widely used in a plurality of section office such as division of cardiology, obstetrics, ophthalmology, liver, kidney, gallbladder and vascular system, especially at department of obstetrics and gynecology, the effect that can not be substituted arranged especially.
Biopsy technique, due to its unique medical diagnosis meaning, has been widely used in living tissue sampling, the Drug therapy of cone tumor and not clear kind of tumor etc. in the multiple organ such as kidney, liver, lung, mammary gland, thyroid, prostate, pancreas, testis, uterus, ovary, body surface.But utilize the biopsy technique of ultra sonic imaging means but due to the needle point image blur, often cause doctor's error in judgement, cause repeatedly puncturing, thereby to patient, brought great misery and injury.Photoacoustic imaging technology, based on optoacoustic effect, combines the high contrast features of pure optical imagery and the high-penetration depth characteristic of pure ultra sonic imaging, and the imaging of tissue of high-resolution and high-contrast can be provided.Photoacoustic imaging technology is applied in aspiration biopsy, can overcome the drawback of needle point image blur.
Summary of the invention
Goal of the invention: technical problem to be solved by this invention be for other imaging technique (as ultra sonic imaging) to the needle point image blur, a kind of method of aspiration biopsy based on photoacoustic imaging technology is provided.
In order to solve the problems of the technologies described above, the invention discloses a kind of puncture biopsy needle based on photoacoustic imaging technology, comprise needle point wall (001), laser filter membrane (002), incident optical (003), laser absorption layer (004);
Described needle point wall (001) indentation, there one side fluting, self is used to the biological tissue that punctures, and can be used for obtaining destination organization sample or injection of medicine treatment in wall, and the fluting side is used for embedding optical fiber;
Described laser filter membrane (002) is positioned at optical fiber one end at needle point place, it can allow the interior laser of particular range of wavelengths see through, and is used for producing photoacoustic signal near the tissue transmission laser needle point place, the outer laser of particular range will be absorbed by the laser filter membrane, produce than the high light acoustical signal;
Described incident optical (003) is used for propagated laser, and it is embedded in needle point wall fluting one side;
Described laser absorption layer (004) is present in specific location in optical fiber, its manufacture method is that the outer wall of incident optical in specific location ground off, then coat the laser that light absorbent (as metal films such as gold, silver) is used for absorbing this position of optical fiber, and make each laser absorption layer place produce photoacoustic signal.
The invention allows for a kind of method of aspiration biopsy based on photoacoustic imaging technology, comprise the following steps:
Step 1, utilize other imaging technique Real-time Obtaining destination organization image;
Step 2, with aim at the mark tissue and thrusting of puncture biopsy needle;
Step 3, squeeze into incident optical with laser, utilizes ultrasonic transducer to gather photoacoustic signal;
Step 4, utilize the optoacoustic reconstruction to obtain the bright spot near the imaging of tissue result of needle point place laser filter membrane and each laser absorption layer and laser filter membrane place;
Step 5,, in conjunction with other imaging technique, organize the photoacoustic imaging result near Alternation Display destination organization imaging results and needle point, utilize the bright spot at laser absorption layer and laser filter membrane place to infer the needle point accurate location;
Step 6, when needle point accurately moves to specified location, obtain destination organization sample or injection of medicine treatment.
In the present invention, preferably, other imaging technique that uses in described step 1 can be a kind of in ultra sonic imaging, infrared imaging etc.Concrete which kind of imaging technique that uses is not construed as limiting this patent.
In the present invention, preferably, described step 2 is determined the position of destination organization according to other imaging technique, chooses proper angle and position is inserted puncture biopsy needle in organism.
In the present invention, preferably, after described step 3 was squeezed into incident optical with laser, part laser was absorbed by laser absorption layer, produced optoacoustic effect, and sent photoacoustic signal; Laser in residue laser in particular range of wavelengths is squeezed into the biological tissue at needle point place via the laser filter membrane, organize absorbing laser near needle point, produces optoacoustic effect, and sends photoacoustic signal; The outer laser of particular range of wavelengths is absorbed by the laser filter membrane, also produces than the high light acoustical signal.Can use ultrasonic transducer to gather these photoacoustic signals this moment.
In the present invention, preferably, the photoacoustic signal of described step 4 to collecting, utilizing existing optoacoustic algorithm for reconstructing (algorithm etc. of suing for peace as time delay) to carry out optoacoustic rebuilds, obtain near the imaging of tissue result of laser filter membrane, and the imaging results (presenting bright spot) at each laser absorption layer and laser filter membrane place.
In the present invention, preferably, the bright spot that described step 5 utilizes a plurality of laser absorption layers and the reconstruction of laser filter membrane place to obtain is inferred the particular location of needle point, and near tissue observable needle point place, then the destination organization image that coordinates other imaging technique to obtain, mobile needle point.
In the present invention, preferably, when described step 6 accurately moves to assigned address when needle point, active somatic cell that can the extracting objects tissue, or to injection of medicine in the needle point wall, treat.
Description of drawings
Below in conjunction with the drawings and specific embodiments, the present invention is done further and illustrates, above-mentioned and/or otherwise advantage of the present invention will become apparent.
Fig. 1 is aspiration biopsy needle point structural representation provided by the invention.
Fig. 2 is the schematic diagram of piercing process.
Fig. 3 is the destination organization image schematic diagram that other imaging technique presents.
Fig. 4 is near the bright spot figure at tissue and each laser absorption layer and laser filter membrane place the needle point place that utilizes optoacoustic to rebuild to obtain.
Fig. 5 is the flow chart of this puncture biopsy needle of use provided by the invention.
The specific embodiment:
The present invention proposes a kind of method of aspiration biopsy based on photoacoustic imaging technology, at first this method is obtained the image of destination organization by other imaging technique, then laser is squeezed into optical fiber and the imaging that embeds on the needle point wall, according to imaging results, moves needle point.
As shown in Figure 1, the invention discloses a kind of puncture biopsy needle based on photoacoustic imaging technology, comprise needle point wall (001), laser filter membrane (002), incident optical (003), laser absorption layer (004).
Described needle point wall (001) indentation, there one side (right side in Fig. 1) fluting, it is fine that the fluting place embeds laser beam incident, and needle point is used for puncture biological tissue, can be used for obtaining the destination organization sample in the needle point wall or injection of medicine is treated;
Described laser filter membrane (002) is positioned at optical fiber one end at needle point place, it can allow the interior laser beam of particular range of wavelengths see through irradiation needle point place tissue, produce optoacoustic effect, send photoacoustic signal, the outer laser of particular range of wavelengths will be absorbed and produce stronger photoacoustic signal by the laser filter membrane;
Described incident optical (003) is used for squeezing into laser, and it is embedded in needle point wall fluting one side;
Described laser absorption layer (004) is present in optical fiber (with tissue, contacting a side) specific location, its manufacture method is that the outer wall of incident optical in specific location ground off, then coat light absorbent (as metal films such as gold, silver), the part laser of incident is absorbed in this position, produce optoacoustic effect, and send photoacoustic signal.Particularly, laser filter membrane and laser absorption layer uniformly-spaced can be emitted on optical fiber, thereby can infer tip position according to each imaging bright spot.
The invention also discloses a kind of method of aspiration biopsy based on photoacoustic imaging technology, comprise the following steps:
Step 1, utilize other imaging technique Real-time Obtaining destination organization image;
Step 2, with aim at the mark tissue and thrusting of puncture biopsy needle;
Step 3, squeeze into incident optical with laser, utilizes ultrasonic transducer to gather photoacoustic signal;
Step 4, utilize the optoacoustic reconstruction to obtain the bright spot near the imaging of tissue result of needle point place laser filter membrane and each laser absorption layer and laser filter membrane place;
Step 5,, in conjunction with other imaging technique, organize the photoacoustic imaging result near Alternation Display destination organization imaging results and needle point, utilize the bright spot at laser absorption layer and laser filter membrane place to infer the needle point accurate location;
Step 6, when needle point accurately moves to specified location, obtain destination organization sample or injection of medicine treatment.
In the present invention, step 1, other imaging technique that uses can be a kind of in ultra sonic imaging, infrared imaging etc.Concrete which kind of imaging technique that uses is not construed as limiting this patent.
In the present invention, step 2, utilize other imaging technique to obtain the particular location of destination organization, then chooses correct position and insert angle, and puncture biopsy needle is inserted in organism.Signal is put and inserted to equipment as shown in Figure 2, and it comprises ultrasonic transducer (005), needle point wall (006), destination organization (007), assigned address (008).The destination organization imaging results that other imaging technique presents as shown in Figure 3.
In the present invention, step 3, at first squeeze into incident optical with laser, and the laser absorption layer on optical fiber can, with the laser absorption of part incident, produce optoacoustic effect, and send photoacoustic signal; Laser in unabsorbed laser in particular range of wavelengths is squeezed into needle point adnexa tissue via the laser filter membrane, produces optoacoustic effect, sends photoacoustic signal; Laser outside particular range of wavelengths is absorbed by the laser filter membrane, also produces optoacoustic effect, sends than the high light acoustical signal.The photoacoustic signal that at this moment, can utilize the ultrasonic transducer collection to send.
In the present invention, step 4, utilize existing optoacoustic algorithm for reconstructing (algorithm etc. of suing for peace as time delay) to rebuild the photoacoustic signal that collects, obtain near the imaging results (as shown in Fig. 4 009) of organizing needle point place laser filter membrane, and the imaging results at each laser absorption layer and laser filter membrane place (presenting bright spot, as 010 indicated in Fig. 4).
In the present invention, step 5, a plurality of bright spots of utilizing the step 4 reconstruction to obtain are inferred the particular location of needle points, utilize the imaging results of needle point place tissue, the destination organization image that coordinates other imaging technique to obtain, mobile needle point.
In the present invention, step 6, photoacoustic imaging result in the destination organization imaging results of rebuilding by other imaging technique of Alternation Display and the present invention, accurately move to assigned address with needle point, this moment can the extracting objects tissue active somatic cell, or to injection of medicine in the needle point wall, treat.
Use flow process of the present invention as shown in Figure 5, comprises the following steps:
Step 1, utilize other imaging technique to obtain particular location and the image of destination organization;
Step 2, according to the position of destination organization, mobile needle point;
Step 3, squeeze into laser in incident optical, and gather the photoacoustic signal that needle point place tissue and laser absorption layer and laser filter membrane place send;
Step 4, utilize existing optoacoustic algorithm for reconstructing to carry out imaging of tissue, rebuilds the imaging results that obtains near tissue needle point, and the bright spot that presents of each laser absorption layer and laser filter membrane;
Step 5, near the image of the destination organization that obtains according to photoacoustic imaging result, other imaging technique needle point, and infer the tip position that obtains, judge whether needle point has arrived assigned address;
Step 6,, if needle point has arrived assigned address, obtain tissue sample or carry out Drug therapy, otherwise repeating above step.
The invention provides a kind of method of aspiration biopsy based on photoacoustic imaging technology; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.In addition, in the present embodiment not clear and definite each ingredient all available prior art realized.
Claims (6)
1. the puncture biopsy needle based on photoacoustic imaging technology, is characterized in that, comprises needle point wall (001), laser filter membrane (002), incident optical (003), laser absorption layer (004);
Described needle point wall (001) is used for puncture biological tissue, also can be used for obtaining destination organization sample or injection of medicine treatment, and one side fluting, be used for embedding optical fiber;
Described laser filter membrane (002) is positioned at optical fiber one end at needle point place, can allow laser in particular range of wavelengths see through and the tissue at directive tip position place in, thereby produce photoacoustic signal; Simultaneously, the outer laser of particular range of wavelengths can't penetrate filter membrane and be absorbed and produce stronger photoacoustic signal, be conducive to accurately observe the position of needle point;
Described incident optical (003) is affixed on needle point wall one side fluting place, is used for propagated laser;
The manufacture method of described laser absorption layer (004) is that the outer wall of incident optical in specific location ground off, then coat the laser that light absorbent (as metal films such as gold, silver) is used for absorbing the optical fiber specific location, make it at each laser absorption layer place, produce photoacoustic signal.
2. the method for the aspiration biopsy based on photoacoustic imaging technology, is characterized in that, comprises the following steps:
Step 1, utilize other imaging technique Real-time Obtaining destination organization image;
Step 2, with aim at the mark tissue and thrusting of puncture biopsy needle;
Step 3, squeeze into incident optical with laser, utilizes ultrasonic transducer to gather photoacoustic signal;
Step 4, utilize the optoacoustic reconstruction to obtain the bright spot near the imaging of tissue result of needle point place laser filter membrane and each laser absorption layer and laser filter membrane place;
Step 5,, in conjunction with other imaging technique, organize the photoacoustic imaging result near Alternation Display destination organization imaging results and needle point, utilize the bright spot at laser absorption layer and laser filter membrane place to infer the needle point accurate location;
Step 6, when needle point accurately moves to specified location, obtain destination organization sample or injection of medicine treatment.
3. a kind of method of aspiration biopsy based on photoacoustic imaging technology according to claim 2, is characterized in that, in described step 1, other imaging technique can be a kind of in ultra sonic imaging, infrared imaging etc.
4. a kind of method of aspiration biopsy based on photoacoustic imaging technology according to claim 2, is characterized in that, after described step 3 was squeezed into incident optical with laser, part laser was absorbed by laser absorption layer, sends photoacoustic signal; Laser in residue laser in particular range of wavelengths is squeezed into biological tissue via the laser filter membrane, organizes absorbing laser, sends photoacoustic signal; The outer laser of particular range of wavelengths is absorbed by the laser filter membrane, sends photoacoustic signal, then uses ultrasonic transducer to gather these photoacoustic signals.
5. a kind of method of aspiration biopsy based on photoacoustic imaging technology according to claim 2, it is characterized in that, the photoacoustic signal of described step 4 to collecting, utilize existing algorithm for reconstructing (algorithm etc. of suing for peace as time delay), carrying out optoacoustic rebuilds, obtain near the imaging results of organizing the laser filter membrane, and the imaging results (being bright spot) at laser absorption layer and laser filter membrane place.
6. a kind of method of aspiration biopsy based on photoacoustic imaging technology according to claim 2, it is characterized in that, the bright spot that described step 5 utilizes a plurality of laser absorption layers and the reconstruction of laser filter membrane place to obtain is inferred the particular location of needle point, the destination organization image that coordinates other imaging technique to obtain, mobile needle point.
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| CN2013103672839A CN103393439A (en) | 2013-08-22 | 2013-08-22 | Needle biopsy method based on photoacoustic imaging technique |
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| CN107923847A (en) * | 2015-08-17 | 2018-04-17 | Gpx医疗公司 | The system and method for the internal analysis of gas in human body based on laser |
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Application publication date: 20131120 |