CN103381282A - Intelligent module for measuring pH value in drug release capsule - Google Patents
Intelligent module for measuring pH value in drug release capsule Download PDFInfo
- Publication number
- CN103381282A CN103381282A CN 201210133412 CN201210133412A CN103381282A CN 103381282 A CN103381282 A CN 103381282A CN 201210133412 CN201210133412 CN 201210133412 CN 201210133412 A CN201210133412 A CN 201210133412A CN 103381282 A CN103381282 A CN 103381282A
- Authority
- CN
- China
- Prior art keywords
- module
- value
- drug release
- sensor
- chip microcomputer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention belongs to the technical field of medical devices, and particularly relates to an intelligent module for measuring pH value in a drug release capsule. The intelligent module for measuring the pH value in the drug release capsule provided by the invention is high in accuracy and low in power consumption. The module comprises a pH sensor, a measuring circuit, an A/D converter, a singlechip, a power module and a drug release module; the structure key point is that the pH sensor, the measuring circuit, the A/D converter, the singlechip and the drug release module are connected in sequence.
Description
Technical field
The invention belongs to the medical treatment device technical field, relate in particular to pH measurement module in a kind of intelligent medicine releasing capsule.
Background technology
35 in recent years, and human body alimentary canal medicine local absorption characteristic research becomes a very active new technique of international pharmaceutical field referred to as human body medicine Absorption Study (Human Drug Absorption, HDA).It is mainly that the drug absorption characteristic of digestive tract part is studied, for the early development of new drug provides the important foundation data.As a kind of noninvasive human body medicine Absorption Study (HDA) means, digestive tract fixed point drug release pill (Site-Specific Delivery Capsule, SSDC) has obtained extensive concern and application.SSDC is a kind of typical micromachine electronics (Micro-Electro-Mechanical Systems, MEMS) system, and it can realize digestive tract noinvasive fixed point drug release, and then obtains the drug absorption curve.But normally utilize the navigation system capsule outside that capsule is located and then release in the domestic and international digestive tract fixed point drug release capsules (SSDC) of studying before, this capsule structure is complicated, need to position by external resource such as ultrasonic device, radioscopy machine etc., operating process is complicated, the large and poor accuracy of consumed energy.1972, but Matsushita improve and developed before the swallowable capsule concept that proposes, measurement pH has been proposed, the measurement capsule of the physiological parameters such as pressure.Afterwards, the SmartPiIICorporation that is positioned at the New York Buffalo has released SmartPill pH.p Capsule, can be used for pH value determination, gastric emptying time, food by small intestinal and required total time of large intestine and the food total time by needed by human body.The Bravo capsule of Medtronic company development can be adsorbed on Real-Time Monitoring and wireless transmission esophagus pH value on people's esophagus, and mainly for detection of Gastroesophageal Reflux, these capsules are that the simple pH value in digestive tract is measured.
Summary of the invention
The present invention is exactly for the problems referred to above, and pH measurement module in a kind of accuracy intelligent medicine releasing capsule high, low in energy consumption is provided.
For achieving the above object, the present invention adopts following technical scheme, the present invention includes pH sensor, measuring circuit, A/D converter, single-chip microcomputer, power module, release module, its structural feature pH sensor, measuring circuit, A/D converter, single-chip microcomputer, release module are connected successively.
As a kind of preferred version, pH sensor of the present invention adopts antimony electrode pH sensor.
As another kind of preferred version, single-chip microcomputer of the present invention adopts the PIC12F683 single-chip microcomputer.
Beneficial effect of the present invention
The mensuration that changes by pH value, can be accurately at esophagus, stomach, release is in this paper can detect esophagus comparatively accurately based on the acid-base value module in pH value intelligent medicine releasing electronic capsule micro-system with carrying out in intestinal section Three regions, the acid-base value of stomach and intestinal, the difference of the acid-base value at three places can accurately trigger medicine-releasing system.System has non-invasive, real-time, and the characteristics such as low-power consumption, and system do not need navigation system, but determine whether want release according to acid-base value, have intelligent.Wicresoft, noinvasive is the important directions of biomedical engineering development.Because capsule can be swallowed, and can diagnose and treat some digestive tract disease, so capsule system will progressively replace traditional intubate and reperfusion mode.In addition, multifunction, intellectuality is the total development trend of capsule-style medical micro-instrument.
Description of drawings
Fig. 1 is schematic block circuit diagram of the present invention;
Fig. 2 is single-chip microcomputer algorithm flow chart of the present invention.
The specific embodiment
As shown in the figure, the present invention includes pH sensor, measuring circuit, A/D converter, single-chip microcomputer, power module, release module, pH sensor, measuring circuit, A/D converter, single-chip microcomputer, release module are connected successively.
Described pH sensor adopts antimony electrode pH sensor.Antimony electrode is a kind of oxidoreduction solid electrode, can miniaturization, and cost is low, with after detected solution contacts, chemical reaction can occur when metallic antimony.
Described single-chip microcomputer adopts the PIC12F683 single-chip microcomputer.in order to save electric weight, single-chip microcomputer adopts interval sampling, every the 5s once sampling, after single-chip microcomputer is started working, system is to input, output port, AD converter, and intervalometer initializes, then enter little power consumption resting state, at this moment, enumerator T1 begins timing, timing is to 5s, single-chip microcomputer wakes up from resting state, A/D converter in sheet begins the pH value in digestive tract is sampled, and sampled value is at this moment compared with the front value of adopting of 5s, if both differences are certain numerical value, in the numerical range of this numerical value set program in single-chip microcomputer, assert that capsule has reached preposition at this moment, trigger release, if both differences are not within setting scope, return, enter resting state, sample after dormancy 5s next time.Flow chart is seen Fig. 2.
Above content is the further description of the present invention being done in conjunction with concrete preferred implementation; can not assert that concrete enforcement of the present invention is confined to these explanations; for the general technical staff of the technical field of the invention; without departing from the inventive concept of the premise; can also make some simple deduction or replace, all should be considered as belonging to the definite protection domain of claims that the present invention submits to.
Claims (3)
1. pH measurement module in intelligent medicine releasing capsule, comprise pH sensor, measuring circuit, A/D converter, single-chip microcomputer, power module, release module, it is characterized in that pH sensor, measuring circuit, A/D converter, single-chip microcomputer, release module are connected successively.
2. pH measurement module in intelligent medicine releasing capsule according to claim 1, is characterized in that described pH sensor adopts antimony electrode pH sensor.
3. pH measurement module in intelligent medicine releasing capsule according to claim 1, is characterized in that described single-chip microcomputer adopts the PIC12F683 single-chip microcomputer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210133412 CN103381282A (en) | 2012-05-02 | 2012-05-02 | Intelligent module for measuring pH value in drug release capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210133412 CN103381282A (en) | 2012-05-02 | 2012-05-02 | Intelligent module for measuring pH value in drug release capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103381282A true CN103381282A (en) | 2013-11-06 |
Family
ID=49489342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210133412 Pending CN103381282A (en) | 2012-05-02 | 2012-05-02 | Intelligent module for measuring pH value in drug release capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103381282A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107041727A (en) * | 2017-05-26 | 2017-08-15 | 杭州师范大学 | A kind of intelligent radio capsule and its control method |
| CN111760177A (en) * | 2020-06-16 | 2020-10-13 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery and control method thereof |
-
2012
- 2012-05-02 CN CN 201210133412 patent/CN103381282A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107041727A (en) * | 2017-05-26 | 2017-08-15 | 杭州师范大学 | A kind of intelligent radio capsule and its control method |
| CN111760177A (en) * | 2020-06-16 | 2020-10-13 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery and control method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101378751B1 (en) | Positioning system, apparatus and method for esophageal ph value wireless monitoring | |
| JP2012511961A (en) | Judgment of digestive tract function using portable visceral electrical recording system and method using the same | |
| CN102781323A (en) | Body parameter sensor and monitor interface | |
| Miley et al. | Video capsule endoscopy and ingestible electronics: emerging trends in sensors, circuits, materials, telemetry, optics, and rapid reading software | |
| CN103079453A (en) | Swallowable capsule for monitoring a condition | |
| CN205433706U (en) | Noninvasive glucose monitoring based on finger detects | |
| CN101406410A (en) | System of non-invasive in vivo minitype device fixed in esophagus | |
| US8840551B2 (en) | Tethering capsule system | |
| CN104970757A (en) | Implantable wireless gastroenteric function detection system and usage method thereof | |
| CN105740633A (en) | Health management method and system | |
| CN102743169A (en) | Multifunctional acupuncture point detection device and method | |
| CN104055525A (en) | Implantable type low-consumption wireless blood glucose monitor | |
| CN101108122A (en) | Permanent magnetism positioning type non-invasive 24-hour monitoring system for gastrointestinal tract PH value | |
| CN103381282A (en) | Intelligent module for measuring pH value in drug release capsule | |
| CN101828907B (en) | Implanted micro physio-parameter detection system | |
| CN206414261U (en) | Tele-medicine wrist-watch | |
| CN104107036A (en) | Household portable monitoring device for sleep apnea | |
| CN104188673B (en) | A kind of lingualis pressure transducer and facing model | |
| CN207228689U (en) | Health examination cabin | |
| CN203873726U (en) | Implanted type wireless gastroenteric function detection system | |
| US20090137947A1 (en) | System and method of wireless physiological signal integration | |
| CN106236108A (en) | Intelligence Wicresoft blood glucose continuous monitor system | |
| CN102178527B (en) | Wireless recorder for detecting human gastrointestinal motility | |
| CN201088779Y (en) | Multifunctional body temperature monitoring stomach tube | |
| CN211022740U (en) | Wireless heart sound signal acquisition device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131106 |