CN103372247B - Medical grade syringe filters and injection filter preparation methods - Google Patents
Medical grade syringe filters and injection filter preparation methods Download PDFInfo
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- CN103372247B CN103372247B CN201210132075.6A CN201210132075A CN103372247B CN 103372247 B CN103372247 B CN 103372247B CN 201210132075 A CN201210132075 A CN 201210132075A CN 103372247 B CN103372247 B CN 103372247B
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Abstract
The invention discloses the preparation method of a kind of medical needle filter and injection filter.Its step comprises: 1. the making of filter cabinet metal die, and through the upper and lower supporting shell of injection molding machine of plastic injection mo(u)lding filter; 2. the cutting of the hydrophilic microporous filter membrane of identical appearance size; 3., in the corresponding finished product filter air steam vent position of hydrophilic diaphragm, spot printing is on a small quantity containing the organic solvent of hydrophobicity silicon composition, and by Technology for Heating Processing, evaporation of organic solvent, causes silicon component deposition in the restricted area of diaphragm small areas; 4. use ultrasonic welding process, filter membrane after treatment, be clipped in upper and lower supporting cabinet inner, welding fabrication.In welding position, to during correspondence, in the filter membrane of silicon component deposition process, the position of silicon composition must be suitable with plastics kit steam vent position.After the syringe filters made through present invention process and injection filter pack, then through Co 60 gamma ray radiation sterilization, can medical procedure be used in, filter the solid impurity in injecting drug use.This invention product is compared containing lid small pieces hydrophobic membrane filtration diaphragm than traditional hydrophilic syringe filters or injection filter, is manufacturing in flow process, can omit hydrophobic air permeable diaphragm in the cost of the extra soldered flow process of hydrophilic filter membrane main body diaphragm and time.
Description
Technical field:
The present invention relates to a kind of semi permeable hydrophilic microporous filter membrane, particularly aperture and be encompassed in microporous filter membrane between 0.01 micron to 10 microns, and make there is microporous filter membrane syringe filters and the injection filter that little property region is dredged in aerofluxus.
Summary of the invention:
At medical field, when intravenous injection medicinal liquid is in patient, injection filter need be used, finally block larger particles impurity medicinal liquid enter the security personnel's step before human body to do.In operating process, because injection enters the approach of patient's vein, be driving force by medicinal liquid from body weight, although the filter membrane essence in injection filter is hydrophilic, but due to adhesive force factor, because of the tiny air bubble that Transport Vibration produces in injection, hydrophilic filter membrane surface can be accumulated in.After the injection flow process operating time extends, this builds up phenomenon accumulation and gradually forms larger air bubble.Injection medical personnel must use to pat and flick or other modes, make air bubble depart from filter membrane surface, enter hydrophobic membrane filtration steam vent position and get rid of its air bubble.
Syringe filters or injection filter manufacturing firm traditionally, when designing this filter, considers that use 2 kinds of microporous filter membrane are with assembled filters to be, reach the object that filter can filter water liquid medicine, also can get rid of the problem of medicinal liquid hollow bubble simultaneously.That is, first filter manufacturing firm is welded on hydrophobic micropore filter membrane on the cabinet of reserved aperture, and then being welded on another supporting cabinet hydrophilic filter filter membrane entirety.Finally these two shells are welded mutually and be assembled into finished product.
The present invention gets rid of the loaded down with trivial details welding step of traditional two steps, does not use the welding in advance of hydrophobicity aerofluxus filter membrane, and directly uses hydrophilic filters film welding procedure, only before filter membrane welding, filter membrane body does a hydrophobicity processing procedure in advance.First processing procedure prepares the alcoholic solution that 1% to 10% contains hydrophobicity silicon composition, uses dropper syringe needle to take 0.01 milliliter of above-mentioned solution to 0.1 ml volumes, drips to the hydrophilic filter membrane surface of assigned address through capillary theory.Because the surface tension value of this solution is much smaller than hydrophilic filter membrane surface tension value, the silicon composition alcoholic solution of trace is absorbed by hydrophilic filter membrane completely, and forms the stain point of circular area.Through heating process 30 DEG C to 40 DEG C about 10 seconds to 40 seconds, volatilized alcohol solvent completely, causes the hydrophilic filter membrane crossing region through the process of silicon composition alcoholic solution, have hydrophobic property.This filter membrane can make the filtration raw material of syringe filters or injection filter as follow-up assembling.In syringe filters and injection filter number of assembling steps, the filter membrane after above-mentioned process, location is positioned in the middle of the shell of plastic filter up and down in advance after plastic process completion.The filter membrane of water repellent region must be corresponded to plastic filter reserved steam vent position during location, after filter set installs into, to cross when liquid uses the air bubble of accumulation can be discharged smoothly in reality.
Behind filter membrane location, fold outside upper and lower plastics, use ultrasonic welding process, upper and lower cabinet and middle filter membrane, integrate shaped type has welded.
Claims (3)
1. the preparation method of medical grade syringe filters and injection filter, is characterized in that: comprise the following steps successively:
1.1 open metallo-plastic injection mold processed, point mold and bed die two pair, and mold leaves perforate at its edge, and as plastics injection-moulded plastic part steam vent, patrix has inlet pore, and counterdie has liquid outlet pore;
Metal die has been prepared in 1.2 uses 1.1, lower casing spare and accessory parts on injection-moulded plastic filter, spare and accessory parts divide filter housing, and proximal edge place leaves perforate as filter exhaust hole, upper plastic filter shell has liquid inlet pipe hole, and lower plastic filter has liquid outlet pore;
1.3 configuration 0.1% weight ratios contain the alcoholic solution of hydrophobicity silicon composition to 10% weight ratio, this solution is got 0.01 milliliter to 0.1 ml volumes, through tubule or needle tubing conduction pattern, drop in hydrophilic microporous filter membrane surface, solution is absorbed completely by hydrophilic filter membrane, form a circular stain speckle, again through 40 DEG C to 50 DEG C heat treatment mode volatilization alcohol solvents, liquid stain speckle is disappeared, and remaining silicon uniform composition covers in filter element finite region, the surface of all holes;
Microporous filter membrane diaphragm in 1.4 1.3 after process, is smoothly sandwiched in the middle of plastic filter shell and lower plastic filter shell, and use ultrasonic welding process, completes integrate shaped type filter packaging technology;
Syringe filters after 1.5 assemblings or injection filter, use medical grade polypropylene plastics pocket, carry out seal welding, re-use Co 60 radioactive source and carry out sterilization process.
2. the preparation method of medical grade syringe filters as claimed in claim 1 and injection filter, is characterized in that: hydrophilic microporous filter membrane aperture is 0.03 micron, 0.1 micron, 0.2 micron, 0.45 micron, 0.65 micron, 0.8 micron, 1.2 microns or 5.03 microns.
3. the preparation method of medical grade syringe filters as claimed in claim 1 and injection filter, is characterized in that: hydrophilic microporous filter membrane material is nylon 6.6, nylon 4.6, polyether sulfone or cellulose mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210132075.6A CN103372247B (en) | 2012-04-28 | 2012-04-28 | Medical grade syringe filters and injection filter preparation methods |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210132075.6A CN103372247B (en) | 2012-04-28 | 2012-04-28 | Medical grade syringe filters and injection filter preparation methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103372247A CN103372247A (en) | 2013-10-30 |
| CN103372247B true CN103372247B (en) | 2016-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210132075.6A Active CN103372247B (en) | 2012-04-28 | 2012-04-28 | Medical grade syringe filters and injection filter preparation methods |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566435B (en) * | 2013-11-14 | 2015-05-13 | 迈得医疗工业设备股份有限公司 | Process of assembling medical filter |
| CN106926410B (en) * | 2017-04-05 | 2019-03-22 | 北京凯利尔医疗科技有限公司 | Filter for transfusion production technology |
| CN112277333A (en) * | 2019-07-25 | 2021-01-29 | 江苏正迈过滤技术有限公司 | Medical filter and production method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091876A (en) * | 2007-05-18 | 2007-12-26 | 亚美滤膜（南通）有限公司 | Method for producing composite type semi permeable hydrophilic filter membrane |
| CN101239208A (en) * | 2007-11-13 | 2008-08-13 | 浙江伏尔特医疗器械有限公司 | Precision liquid medicine filter and manufacturing method thereof |
| CN101837247A (en) * | 2010-06-03 | 2010-09-22 | 武汉智迅创源科技发展股份有限公司 | Liquid medicine filtering membrane and preparation method thereof |
| CN202173637U (en) * | 2011-06-24 | 2012-03-28 | 上海双鸽实业有限公司 | Precise infusion system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01135361A (en) * | 1987-11-20 | 1989-05-29 | Nissho Corp | Small filter and its manufacture |
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- 2012-04-28 CN CN201210132075.6A patent/CN103372247B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091876A (en) * | 2007-05-18 | 2007-12-26 | 亚美滤膜（南通）有限公司 | Method for producing composite type semi permeable hydrophilic filter membrane |
| CN101239208A (en) * | 2007-11-13 | 2008-08-13 | 浙江伏尔特医疗器械有限公司 | Precision liquid medicine filter and manufacturing method thereof |
| CN101837247A (en) * | 2010-06-03 | 2010-09-22 | 武汉智迅创源科技发展股份有限公司 | Liquid medicine filtering membrane and preparation method thereof |
| CN202173637U (en) * | 2011-06-24 | 2012-03-28 | 上海双鸽实业有限公司 | Precise infusion system |
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| CN103372247A (en) | 2013-10-30 |
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