CN103356463B - Peel-off type radix saposhnikoviae anti-anaphylaxis facial mask and preparation method thereof - Google Patents
Peel-off type radix saposhnikoviae anti-anaphylaxis facial mask and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a peel-off type radix saposhnikoviae anti-anaphylaxis facial mask and a preparation method thereof. The peel-off type radix saposhnikoviae anti-anaphylaxis facial mask is prepared from the following raw materials in parts by weight according to a conventional method: 10-14 parts of polyvinyl alcohol, 8-12 parts of glycerin, 0.8-1.2 parts of hydrolyzed egg white, 4-6 parts of ethanol, 6-8 parts of disodium lauroamphodipropionate, 0.8-2 parts of radix saposhnikoviae extracting solution, 0.03-0.08 part of compound preservative and 100 parts of deionized water, wherein the compound preservative comprises the following components in parts by weight: 1-3 parts of carnosic acid, 3-5 parts of antioxidants of bamboo leaves, 1-3 parts of nisin and 1-3 parts of iodopropynyl butylcarbamate. According to the peel-off type radix saposhnikoviae anti-anaphylaxis facial mask, facial skins can be deeply cleaned, facial fine wrinkles can be faded, and the skins are elastic and compact; the peel-off type radix saposhnikoviae anti-anaphylaxis facial mask has anti-allergic, anti-inflammatory and skin-calming effects.
Description
Technical field
The present invention relates to facial film and preparation method thereof, be specifically related to a kind of exfoliated Radix Saposhnikoviae antiallergic mask and preparation method thereof.
Background technology
Facial film is the important content in skin nursing, and for the regular application facial film of all kinds of skin characteristic, can make oily skin defat, thick pore is restrained, and the skin of withered gauffer recovers gloss, and the inflammation of skin sore skin is inhibited.Facial film makes skin seem salubrious after using, smooth and pure white delicacy, this is because when facial film is coated on skin, facial film and skin produce affinity, along with the drying gradually of facial film, skin temperature rise, blood circulation is accelerated, skin-tightening and tension force are strengthened, the sebum of skin secretion and moisture reverse osmosis are in horny layer, epidermis softness is unfolded, pore instinct is opened, effective ingredient in facial film infiltrates skin and is absorbed, facial film is tightly connected with skin simultaneously, when removing facial film, aging cutin on skin, in pore deep layer dirt also by while leukorrhagia, make skin totally pure and fresh.
The principle of facial film, utilize the blink covering face exactly, the air that temporary transient isolation is extraneous and pollution, improve skin temperature, the pore expansion of skin, promote sweat gland secretion and metabolism, make the oxygen content of skin increase, be conducive to the oil substances that skin gets rid of the metabolic product of epidermis cell and accumulation, the moisture in facial film infiltrates the horny layer of skin epidermis, skin becomes soft, and skin naturally light is flexible.
Along with the raising of people's quality of the life and people are to the pursuit of U.S., cosmetics kind is more and more various.At present, face mask of traditional Chinese medicine is one of beauty treatment educational circles effective whitening regime, and especially some Chinese medicine extraction liquid have the effect of good toxin expelling, speckle dispelling, reparation, skin care, also by being applied in facial film gradually.
But because facial film is liquid condition, Chinese medicine extraction liquid is easy to mould growth, a lot of face mask of traditional Chinese medicine antiseptic effects are in the market not good, and the shelf-life is short.Therefore all antiseptic can be added in a lot of face mask of traditional Chinese medicine.But a lot of antiseptic, while the microorganism such as kill bacteria, fungus, also can produce zest to skin, even causes erythema and erythra, Long Term Contact antiseptic, organism material sensitization can be increased, cause the danger of anaphylactic reaction.
Iodine propilolic alcohol butyl mephenesin Carbamate (being called for short IPBC) is a kind of novel cosmetic antiseptic, there is good fungistatic effect, and good dissolubility is had in surfactant, emulsifying agent, polar solvent, therefore be widely used in resident class and drip washing class cosmetic formulations, normal and other antiseptic such as diazolidinyl urea, hydantoin with the use of.In China's cosmetics health specification and European Union's regulatory affairs, regulation IPBC limits the use of antiseptic in components of cosmetics, and in cosmetics, maximum permission working concentration is 0.05%, and can not be used for oral hygiene and lip product.But in facial film, antiseptic effect when addition is less than 0.05% is also not obvious.Therefore, there is the little and problem that antiseptic effect is poor, the shelf-life is short of consumption in the antiseptic used in current facial film.Also there are the iodine propilolic alcohol butyl mephenesin Carbamate in partial face mask or other antiseptic large usage quantities, pessimal stimulation can be produced by skin, with rear needs cleaning face, use trouble.
Radix Saposhnikoviae, belongs to perennial herb, high 30-80cm.Root is sturdy, elongated cylindrical, has branch, yellowish laurel color, and root tiltedly rises, closely isometric with stem, has thin rib.Basal leaf is grown thickly, and has the petiole of prolate, and base portion has wide sheath, slightly embraces stem; Avette or the Long Circle of blade, long 14-35cm, wide 6-8(-18) cm, two to three times pinnation, the avette or Long Circle of first time sliver, have handle, long 5-8cm, second time sliver bottom tool short handle, the narrow wedge shape of sliver is returned at end, long 2.5-5cm, wide 1-2.5cm; Change between acrogen, have wide sheath.Universal umbel is most, and be born in stem and branch top, terminal inflorescence obstructs long 2-5cm, and umbrella spoke 5-7, long 3-5cm, without hair, without phyllary; Umbellule has dead 4-10, involucel sheet 4-6, and linear or lanceolar, is about 3mm; Calyx tooth triangular shape is avette; Petal obovate, white, is about 1.5mm, without hair, tip nick, tool infolding tab.The narrow circle of diachenium or ellipse, long 4-5mm, wide 2-3mm, have verruca during children, gradually level and smooth time ripe; Have oil pipe in every rib groove, there is oil pipe in symphysis face.The florescence 8-9 month, the fruit phase 9-10 month.Within 2010, be documented in version at Chinese Pharmacopoeia.
Radix Saposhnikoviae has antiinflammatory action: get body weight 24g-26g male mice 20 and only divide equally two groups, dosage is the same, after l hour, is coated with auris dextra causes inflammation with Oleum Tiglii mixture 25ul, within 4 hours, put to death mice, weigh and observe inflammatory reaction degree.The swelling degree (13.9 ± 0.9mg) of result Radix Saposhnikoviae group is starkly lower than matched group (18.4 ± 1.2mg) (P<0.05).
Extracorporeal bacteria inhibitor test, flat band method is adopted to carry out antibacterial experiment in vitro, result Radix Saposhnikoviae has bacteriostasis to staphylococcus aureus, beta hemolytic streptococcus, Diplococcus pneumoniae and two kinds of mycetes (Penicllium chrysogenum, aspergillus versicolor) etc., and to hemophilus influenza, Bacillus typhi, Fu Shi and dysentery bacterium without bacteriostasis.
Radix Saposhnikoviae has anti-allergic effects:
To 2, the impact of the caused delayed hypersensitivity of 4-dinitrochlorobenzene (DNCB): get body weight 25-28g male mice 20 and only divide equally two groups, by 5%DNCB acetone soln 0.01ml skin of back sensitization, next day, sensitization was once again, 5 days start administration, Radix Saposhnikoviae group mice po every day Radix Saposhnikoviae 20g/kg, matched group takes consubstantiality hydrops, successive administration 7 days, auris dextra is coated with 1%DNCB acetone 0.02ml after last administration, 20 hours execution mices are got left and right auricle (diameter 8mm) and weigh, and represent the degree of delayed hypersensitivity with the difference of two auricle weight.Result Radix Saposhnikoviae group is 2.90 ± 0.45mg, is starkly lower than matched group 4.88 ± 0.78mg(P<0.05), illustrate that Radix Saposhnikoviae has the effect of the delayed hypersensitivity suppressed caused by DNCB.
Impact on sensitized guinea pig isolated tracheal, ileum smooth muscle anaphylaxis are shunk: get body weight 250g-350g Cavia porcellus 10, in every guinea pig intraperitoneal injection 5% egg protein 1ml, two back legs respectively inject 0.4ml sensitization simultaneously, carry out the shrinkage test of guinea-pig isolated trachea ileum smooth muscle anaphylaxis after 4 weeks.As a result, airway constriction (2.8 ± 0.5mm), obviously reduces than controlled trial (7.8 ± 0.7mm).Ileum contraction result of the test, 10 sections of ileum contraction height are that 31.8 ± 4.3mm obviously reduces than matched group 10 sections of ileum contraction height (42.4 ± 5.2mm).
Summary of the invention
For above shortcomings in prior art, one of technical problem to be solved by this invention provides a kind of exfoliated Radix Saposhnikoviae antiallergic mask.
Two of technical problem to be solved by this invention provides the preparation method of above-mentioned exfoliated Radix Saposhnikoviae antiallergic mask.
The present invention seeks to be achieved through the following technical solutions:
A kind of exfoliated Radix Saposhnikoviae antiallergic mask, is prepared from according to a conventional method by the raw material of following weight parts:
10-14 part polyvinyl alcohol, 8-12 part glycerol, 0.8-1.2 part hydrolysis Ovum Gallus domesticus album, 4-6 part ethanol, 6-8 part lauroyl both sexes base disodium beclomethasone, 0.8-2 part Radix Saposhnikoviae extracting solution, 0.03-0.08 part compound preservative, 100 parts of deionized waters.
Wherein, described compound preservative, is made up of by weight following component: 1-3 part carnosic acid, 3-5 part AOB, 1-3 part nisin, 1-3 part iodine propilolic alcohol butyl mephenesin Carbamate.
By carnosic acid, AOB, nisin and iodine propilolic alcohol butyl mephenesin Carbamate simple agitation mix homogeneously, described compound preservative can be obtained.
Described exfoliated Radix Saposhnikoviae antiallergic mask can adopt industry conventional method to be prepared from.
Further, present invention also offers a kind of preparation method of exfoliated Radix Saposhnikoviae antiallergic mask, be made up of following step:
Polyvinyl alcohol is added in deionized water, be heated to 70-90 DEG C, dissolve, be cooled to 45-55 DEG C, add glycerol, hydrolysis Ovum Gallus domesticus album, ethanol, the stirring of lauroyl both sexes base disodium beclomethasone, be cooled to 40 DEG C, add Radix Saposhnikoviae extracting solution and compound preservative, stir, described exfoliated Radix Saposhnikoviae antiallergic mask can be obtained.
Concrete, in the present invention:
Described polyvinyl alcohol can select cosmetics-stage polyvinyl alcohol, specifically can select if the trade mark is the polyvinyl alcohol of PVA1788, PVA1799 or PVA2488.
Glycerol, has another name called: propylene glycol, English name: Glycerin, molecular formula C
3h
8o
3.
Hydrolysis Ovum Gallus domesticus album, No. CAS: 73049-73-7, HYDROLYZED ALBUMEN.Containing the mineral multiple nutritional components such as protein, methionine and vitamin, phosphorus, ferrum, potassium, magnesium, sodium, silicon in hydrolysis Ovum Gallus domesticus album.Composition and the human body of the gal4 amino acid in Ovum Gallus domesticus album are closest, and biological value is also the highest.Ovum Gallus domesticus album also has heat-clearing and toxic substances removing, antiinflammatory, the effect of protection skin and enhancing skin immune function controlling.
Lauroyl both sexes base disodium beclomethasone, CAS accession number: 68929-04-4, English name: DISODIUMLAUROAMPHODIPROPIONATE, amphoteric surfactant, zest is low, good foaming power, good salt tolerance.
Radix Saposhnikoviae extracting solution of the present invention can pass through commercially available and obtain.Also following method can be adopted to prepare and obtain: after Radix Saposhnikoviae is pulverized, add the deionized water of 6-10 times of weight, soak 1-3 hour, ultrasonic extraction, 10-15 minute, filter, centrifugal, discard precipitation by supernatant concentration, obtained Radix Saposhnikoviae extracting solution.Preferably, after concentrated, controlling Radix Saposhnikoviae extracting solution density is 1.02-1.10g/cm
3.
Carnosic acid, molecular formula: C
20h
28o
4, No. CAS: 3650--09-7, source: Labiatae Rosmarinus plant rosemary Rosmarinus officinalis L.
AOB, No. CNS: 04.019, English name: antioxidant of bamboo leaves.That AOB extracts from the tender leaf of Phyllostachys (phyllostachys) bamboo, with flavone and phenolic compound to be effective ingredient natural, nutrition, multi-functional food antioxidant.
Nisin, also claims nisin, English name: Nisin, a kind of polypeptide be made up of 34 aminoacid synthesized by streptococcus acidi lactici metabolism, molecular formula C
143h
228o
37n
42s
7molecular weight is 3348, and nisin is made up of water-wet side and hydrophobic side, is typical surfactant, efficient, nontoxic biological antiseptic, be widely used at present milk and milk products, fermented beverage, filling food, vegetable protein food, meat and its products anticorrosion.
Iodine propilolic alcohol butyl mephenesin Carbamate, English name: 3-Iodo-2-propynyl butylcarbamate, is abbreviated as IPBC, No. CAS: 55406-53-6, molecular formula: C
8h
12iNO
2, molecular weight is 281.10.
The present invention uses carnosic acid, AOB, nisin and iodine propilolic alcohol butyl mephenesin Carbamate composite as antiseptic, and antiseptic effect is significantly improved, the long shelf-life of facial film.And, use Compositional antiseptic agent, greatly reduce the consumption of iodine propilolic alcohol butyl mephenesin Carbamate, the consumption of iodine propilolic alcohol butyl mephenesin Carbamate is made to control below 0.03%, meet the IPBC specified in China's cosmetics health specification and European Union's regulatory affairs and limit the use of antiseptic in components of cosmetics, in cosmetics, maximum permission working concentration is 0.05%.Carnosic acid, AOB, nisin are nontoxic biological antiseptic, be widely used in food service industry, be diverted to cosmetic mask in the present invention, ill effect can't be brought to human body or skin, and harmful effect can not be produced to the stability of facial film.
The using method of exfoliated Radix Saposhnikoviae antiallergic mask of the present invention is: before using facial film, first deeply clean facial, again facial film is coated on face, after 15-25 minute, facial film active substance is absorbed by the skin, and moisture evaporates, thin film is formed gradually at face, this thin film is peeled off from face, the dirt on skin of face, scurf also stick on thin film in company with and be eliminated, face seems clean, smooth.
Exfoliated Radix Saposhnikoviae antiallergic mask of the present invention, can deep layer cleaning skin of face, and desalination facial lines, makes elasticity of skin compact, and water profit is plentiful.Continue to use, skin water profit is flexible, reproduces youthful vigor.
Exfoliated Radix Saposhnikoviae antiallergic mask of the present invention, has antiallergic, antiinflammatory action, effect of Lavender Extract.
Exfoliated Radix Saposhnikoviae antiallergic mask of the present invention, adopt the antiseptic that carnosic acid, AOB, nisin, iodine propilolic alcohol butyl mephenesin Carbamate are composite, shelf life of products is long, and can not produce harmful effect to skin.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Take each raw material according to embodiment 1 data corresponding in table 1, by carnosic acid, AOB, nisin and iodine propilolic alcohol butyl mephenesin Carbamate simple agitation mix homogeneously, described compound preservative can be obtained.
Polyvinyl alcohol is added in deionized water, be heated to 70-90 DEG C, dissolve, be cooled to 45-55 DEG C, add glycerol, hydrolysis Ovum Gallus domesticus album, ethanol, the stirring of lauroyl both sexes base disodium beclomethasone, be cooled to 40 DEG C, add Radix Saposhnikoviae extracting solution and compound preservative, stir, described exfoliated Radix Saposhnikoviae antiallergic mask can be obtained.
Wherein, the Radix Saposhnikoviae extracting solution in embodiment 1 and comparative example 1-5 adopts following method to be prepared from: after Radix Saposhnikoviae is pulverized, add the deionized water of 8 times of weight, soak 2 hours, ultrasonic extraction, 12 minutes, filters, centrifugal, discard precipitation by supernatant concentration, after concentrated, obtained density is 1.06g/cm
3radix Saposhnikoviae extracting solution.
Table 1: face pack prescription list position: kilogram
| Embodiment 1 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | |
| Deionized water | 100 | 100 | 100 | 100 | 100 | 100 |
| PVA-124 88 | 12 | 12 | 12 | 12 | 12 | 12 |
| Glycerol | 10 | 10 | 10 | 10 | 10 | 10 |
| Hydrolysis Ovum Gallus domesticus album | 1 | 1 | 1 | 1 | 1 | 1 |
| Ethanol | 5 | 5 | 5 | 5 | 5 | 5 |
| Lauroyl both sexes base disodium beclomethasone | 7 | 7 | 7 | 7 | 7 | 7 |
| Radix Saposhnikoviae extracting solution | 1 | 1 | 1 | 1 | 1 | 1 |
| Carnosic acid | 0.01 | / | / | / | / | / |
| AOB | 0.02 | 0.02 | 0.02 | 0.03 | / | / |
| Nisin | 0.01 | 0.01 | 0.02 | 0.01 | / | / |
| Iodine propilolic alcohol butyl mephenesin Carbamate | 0.01 | 0.02 | 0.01 | 0.01 | / | / |
| Methyl parahydroxybenzoate | / | / | / | / | 0.05 | / |
Comparative example 1
Each raw material is taken according to comparative example 1 data corresponding in table 1.The method described in embodiment 1 is adopted to prepare the exfoliated Radix Saposhnikoviae antiallergic mask of comparative example 1.
Comparative example 2
Each raw material is taken according to comparative example 2 data corresponding in table 1.The method described in embodiment 1 is adopted to prepare the exfoliated Radix Saposhnikoviae antiallergic mask of comparative example 2.
Comparative example 3
Each raw material is taken according to comparative example 3 data corresponding in table 1.The method described in embodiment 1 is adopted to prepare the exfoliated Radix Saposhnikoviae antiallergic mask of comparative example 3.
Comparative example 4
Each raw material is taken according to comparative example 4 data corresponding in table 1.The method described in embodiment 1 is adopted to prepare the exfoliated Radix Saposhnikoviae antiallergic mask of comparative example 4.
Comparative example 5
Take each component according to comparative example 5 data corresponding in table 1, adopt method described in embodiment 1, namely obtain the exfoliated Radix Saposhnikoviae antiallergic mask of comparative example 5.
Test case 1
Respectively by the exfoliated Radix Saposhnikoviae antiallergic mask that embodiment 1 and comparative example 1-5 obtain, carry out fill with dark brown vial, open wide bottle cap, under being placed in ambient temperature 40 DEG C, relative humidity 85% environment, continuous observation is also tested, and concrete outcome sees the following form.Detect microorganism level, concrete test item, detection method and examination criteria carry out according to QB/T2872-2007.
| Observe phenomena | |
| Embodiment 1 | No abnormality seen after 60 days, pure in smell |
| Comparative example 1 | After 50 days, occur mildew, microorganism exceeds standard, and gives out unhappy abnormal smells from the patient |
| Comparative example 2 | After 40 days, occur mildew, microorganism exceeds standard, and gives out unhappy abnormal smells from the patient |
| Comparative example 3 | After 40 days, occur mildew, microorganism exceeds standard, and gives out unhappy abnormal smells from the patient |
| Comparative example 4 | After 40 days, occur mildew, microorganism exceeds standard, and gives out unhappy abnormal smells from the patient |
| Comparative example 5 | After 5 days, occur mildew, microorganism exceeds standard, and gives out unhappy abnormal smells from the patient |
The antiseptic methyl parahydroxybenzoate used in comparative example 4 is one of the most frequently used cosmetics preservative in this area.Belong to antiseptic phenols, generally effective to mycete, yeast, antibacterial, there is the effect suppressing growth of microorganism, the shelf-life (under test condition of the present invention 40 days shelf-lifves) of cosmetics is effectively extended after adding, but long-term this antiseptic of excessive use, Diazolidinyl Urea epidermis cell, causes epidermis transition aging.
Can significantly be drawn by test data, the embodiment of the present invention 1 uses carnosic acid, AOB, nisin and the composite Synergistic of iodine propilolic alcohol butyl mephenesin Carbamate, and antiseptic effect (under test condition of the present invention 60 days shelf-lifves) is obviously better than comparative example 1-3 and only adopts AOB, nisin and iodine propilolic alcohol butyl mephenesin Carbamate three composite (under test condition of the present invention less than 50 days shelf-life).
The accelerated test of facial film under opening is placed in ambient temperature 40 DEG C, relative humidity 85% environment of the embodiment of the present invention 1, can reach 60 days antiseptic effects, the long shelf-life of facial film, and shady and cool dry its shelf-life of place far surpasses 3 years in sealed states in conversion.
Test case 2
With CorneometerCM820 moisture of skin measuring instrument, carry out measurement skin surface moisture at tested position, tested position is respectively the abundant forehead of sebaceous gland.Operating ambient temperature is 22-24 DEG C, and relative humidity is 46%-55%, and the unit of skin moisture content is au (arbitraryunit).Use the female consumer forehead skin of the embodiment of the present invention 1 to test to one, concrete data see the following form.
| Before using, au | After using, au | Use latter 1 hour, au | |
| Embodiment 1 | 37.4 | 81.0 | 76.6 |
The above; be only the specific embodiment of the present invention; but protection scope of the present invention is not limited thereto; any those of ordinary skill in the art are in the technical scope disclosed by the present invention; the change can expected without creative work or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should limit with claims is as the criterion.
Claims (2)
1. an exfoliated Radix Saposhnikoviae antiallergic mask, it is characterized in that, be prepared from according to a conventional method by the raw material of following weight parts: 10-14 part polyvinyl alcohol, 8-12 part glycerol, 0.8-1.2 part hydrolysis Ovum Gallus domesticus album, 4-6 part ethanol, 6-8 part lauroyl both sexes base disodium beclomethasone, 0.8-2 part Radix Saposhnikoviae extracting solution, 0.03-0.08 part compound preservative, 100 parts of deionized waters;
Described compound preservative is made up of by weight following component: 1-3 part carnosic acid, 3-5 part AOB, 1-3 part nisin, 1-3 part iodine propilolic alcohol butyl mephenesin Carbamate.
2. the preparation method of exfoliated Radix Saposhnikoviae antiallergic mask as claimed in claim 1, it is characterized in that, be made up of following step: polyvinyl alcohol is added in deionized water, be heated to 70-90 DEG C, dissolve, be cooled to 45-55 DEG C, add glycerol, hydrolysis Ovum Gallus domesticus album, ethanol, the stirring of lauroyl both sexes base disodium beclomethasone, be cooled to 40 DEG C, add Radix Saposhnikoviae extracting solution and compound preservative, stir.
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