CN103347491A - Cosmetic or dermatological preparations comprising a combination of polyacrylate and polyacrylamide thickeners and having a high silicone oil content - Google Patents
Cosmetic or dermatological preparations comprising a combination of polyacrylate and polyacrylamide thickeners and having a high silicone oil content Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/892—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a hydroxy group, e.g. dimethiconol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
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Abstract
The invention relates to cosmetic or dermatological sunscreen preparations comprising, in addition to one or more cyclomethicones and one or more linear organosilicon compounds, a combination of polyacrylate and polyacrylamide thickeners. Said formulations have excellent stability despite a high UV filter content, while improving the product perception of the user.
Description
Technical field
The present invention relates to comprise cosmetic or the dermatological preparations, particularly sun-screening agent of polyacrylic ester thickener and polyacrylamide thickener blend composition.Although described preparation has very high silicone oil content, but still have excellent stability and product sense organ.
Background technology
As everyone knows, the light radiation of wavelength in 280～400nm scope may be tanned with human epidermal, and the radiation of wavelength in 280～320nm scope is called UV-B, can cause erythema and skin burn, be unfavorable for forming the brown tone of nature, therefore want the filtering uv b radiation.
In addition, the UV-A radiation meeting tanning of known wavelength in 320～400nm scope may cause that skin changes, and be all the more so when very sensitive or skin suffers solar radiation continuously when skin especially.The UV-A radiation can make skin forfeiture elasticity and the wrinkle of ageing in advance occurs causing especially.This can impel erythema to form, and perhaps can strengthen this reaction at some person, even may be toxic reaction or the anaphylactoid reason that photoconduction causes.Therefore wishing also can filtering UV-A radiation.
In general, people are familiar with the optical absorption characteristics of sun-proof ray filtering material and the document record are arranged very much, particularly in most industrialized countries all relevant for the mutatis mutandis inventory that uses this type of material, this mutatis mutandis inventory has been determined quite strict standard to the document record.People are according to absorb the wide spectrum lightscreening agent that ultraviolet light is distinguished UV-B lightscreening agent, UV-A lightscreening agent and have filtration in the four corner of UV-A and UV-B in which spectral region.Suitably select uv filters and the concentration in sunscreen thereof, just can influence the shielding degree to ultraviolet light.Certainly extinction value can provide at most these materials quantitatively are added in directive guidance in the end formulation, because may cause situation about can't weigh with formula components or with the interaction of skin itself.In addition, be difficult to usually pre-estimate medium with which kind of uniformity coefficient, which kind of layer thickness distribution among the horny layer of skin and on.
Except the influence factor, uv filters is also very important for the waterproof ability of prescription in the binding ability in the skin or on the skin.Be understandable that the oil-soluble uv filters is compared with the water solublity uv filters and can better be combined on (lipophilic) skin surface, perhaps is difficult to more wash off from skin.
Usually under normalization condition, test to determine sunscreen by biological effectiveness or based on the effectiveness of the uv filters of sunscreen.
SPF (sun protection factor) LSF, it also often is called SPF (sun protection factor3) expression and uses sunscreen can prolong the sunlit time, is the erythema time threshold and the ratio that is not coated with the erythema time threshold of sunscreen that is coated with sunscreen.
Usually use IPD method (IPD=immediate pigment darkening/ pigment blackening at once) to check the UV-A barrier propterty.With measure that SPF (sun protection factor) is the same will determine a value, this value representation uses the UV-A radiation pigmentation identical with the skin of not smearing sunscreen just can occur to the skin exposure longer time how long that scribbles sunscreen.
The another kind of method of inspection of widely using in Europe is Australian Standard AS/NZS2604:1997, namely measures the absorbtivity of preparation in the UV-A scope.Preparation must absorb 90% at least to the UV-A radiation in 320～360nm scope, could satisfy standard-required.
According to the international SPF assay method regulation in (COLIPA, in May, 2006), in the human body skin upper body, measure SPF (Sun Protection Factor/ SPF (sun protection factor)).Need at least 10 experimenters to test, the meansigma methods confidence interval of result of the test must not be greater than 17%.
Definition: SPF=smears and does not smear the ratio of the minimum erythema dose (MED) on the skin of sunscreen.
MED be slight through causing after the irradiation in 16～24 hours, but the minimum UV radiation dose of obvious visible skin rubefaction (sunburn, erythema), radiation source is solar simulator, most xenon lamps that use.
The degree of depth that the ultraviolet radiation of different frequency/wavelength is invaded tissue differs the same.Therefore type of impairment also depends on wavelength.Here particularly importantly protect the UV-A ultraviolet radiation because this ultraviolet radiation (UV-A wavelength 315～400nb) is the principal element that causes skin aging.
The UVA lightscreening agent belongs to chemical sun-proof lightscreening agent.The UVA lightscreening agent can penetrate among the skin, absorbs the high energy ultraviolet radiation, and is converted into heat energy or the luminous energy that can not cause damage.Although the current detection method that does not have to generally acknowledge can be used to measure protective action in the UVA scope (comparing with the COLIPA method that is used for detecting the UVB lightscreening agent), still should pay attention to the balanced barrier propterty of UVA/UVB in practice.
In order to provide the information about the UVA barrier propterty of sunscreen product, can use in the various body and vitro trial model, and the conclusion that draws is imprinted on (the UVA barrier propterty of Australian Standard regulation on the packing material, persistency blackening index etc.), but these explanations do not have comparability each other.In view of this reason, EU Committee announced in JIUYUE in 2006 on the 22nd should make great efforts the recommendation that makes that sunscreen is safer, transparent.The recommendation proposition UVA of European Union protection should be 1/3 with the ratio of UVB barrier propterty.In the cosmetics instruction, only stipulate the UVB radiation that causes sunburn is protected before.European Union's recommendation of new issue then requires every kind of sunscreen also can protect the UVA radiation simultaneously.Consumer may think that the UVA barrier propterty rises along with the raising of spf value.For moral reason, a kind of in vitro tests method is adopted in suggestion.The Beiersdorf AG company in hamburger has developed a kind of in vitro method of measuring the UVA barrier propterty according to SPF (sun protection factor): UVA/UVB-Balance.In February, 2005, UVA/UVB-Balance announced that as DIN67502 this is first kind of official method that European Region is used to measure the UVA barrier propterty.COLIPA is also a kind of for the method for measuring the UVA barrier propterty in revision at present, because industrial quarters requires to have a kind of unified method.COLIPA is European cosmetics industry community, and main issue is about the suggestion of implementing assay method etc.UVA/UVB-Balance is the basis of method discussed herein.To carry out following modification to UVA/UVB-Balance, and it be extended to utilize ultraviolet light to carry out pre-radiation, in order to also can consider the uv filters system that some are special.Do not having to have tested product under the situation of pre-radiation up to now.Whether protective action is arranged also under the full-scale condition of effect of sunlight about this product, do not draw enlightenment.The name of this expansion measuring method is called " COLIPA Ratio ".
This means that UVA lightscreening agent and the ratio of the consumption of UVB lightscreening agent are 1: 3, and the UVA barrier propterty improves along with the rising of sun-proof performance.The recommendation proposition UVA of European Union protection should be 1/3 with the ratio of UVB barrier propterty.The name of this measuring method is called " COLIPA Ratio ".The expression formula of COLIPA Ratio is as follows
COLIPA Ratio is for the standard of measuring the UVA barrier propterty.
Existingly under the prior art condition manyly reach disclosing of higher ultraviolet protection performance about stable.
EP887069A2, EP0887068A2 and EP935959A2 all disclose a kind of UV-A-Boosting that realizes by synthetic bees wax or natural Cera Flava.
Boosting here represents to compare with the preparation that does not contain Cera Flava and can promote sun-proof performance.
EP1965871A2 disclose UV-ABalance greater than 35, contain the make-up preparation of one or more merocyanines.
Sunscreen formulas on sale on the market has only the addition that improves ultraviolet ray filtering material could realize sufficient ultraviolet protection performance usually.
And the content that improves ultraviolet ray filtering material can cause preparation to be unfavorable for skin, tarnish and viscous, be difficult to smear, is difficult to more preparation, and primary be not have long-time stability.
Be desirable to provide the preparation that the ultraviolet filtering agent content remains unchanged, sun-proof performance makes moderate progress, and other effect of preparation can not affect adversely.
Advantageously, also consider the demand to higher sun-proof performance, and do not lose the product sense organ.
Thickening agent is to regulate the auxiliary agent that make-up preparation or dermatological preparations make it to have suitable product denseness and proper flow dynamic characteristic, and it preferably is used in emulsion and contains among the cleaning product of surfactant.
The material grouping of thickening agent can roughly be divided into natural thickener (as starch, gelatin, alginate), modified natural material (as cellulose ether or hydroxyethyl-cellulose) and synthetic fully polymer (for example polyacrylate).
Known natural thickener or modification thickening agent comprise polysaccharide, xanthan gum, cellulose ether and other cellulose derivative (as carboxymethyl cellulose, hydroxyethyl-cellulose), gelatin, starch and starch derivatives, sodium alginate, fatty acid polyethylene glycol ester, agar, traganth or dextrin and their mixture.Known other thickening agent is all based on silicate or modification Alumina (as bentonite or Strese Hofmann's hectorite .) or its derivant.
Polyacrylic ester thickener for example is the polyacrylate that is selected from Carbopole, and for example Carbopole of 980,981,1382,2020,2984,3128,5984 types, and Permulen TR1, TR2 are independent or combined separately.
Carbopol3128 is acrylate/C10-30 alkyl acrylate cross-linked polymer, be C10-30 alkyl acrylate and acrylic acid, methacrylic acid and their copolymer of one or more monomers of monoesters, copolymer forms branching with allyl ether sucrose or tetramethylolmethane allyl ether.。
In WO2006134038A1, Permulen TR1 and Carbopol3128 are called preferred gel former and structure-forming agent, these gel formers and structure-forming agent have the fabulous characteristics of emulsification property on the one hand, but also can cause very strong shear thinning rheological behavior on the other hand, just can form a kind of structure very strong, that still under shear action, still can destroy suddenly.
Also can use anion or cation-modified product (anion and PAMC) as the polyacrylamide thickening agent, for example make acrylamide and acrylic acid sodium or acrylic acid quaternary ammonium carry out copolyreaction and obtain, its structure is as follows:
Polyacrylamide/C13-14 isoparaffin/laureth 7) or Simulgel600 (CTFA title: acrylamide/acryloyl group dimethyl sodium taurocholate copolymer/2-Methylpentadecane/Polyoxyethylene Sorbitan Monooleate) known polyacrylamide is the horizontal cross-linked copolymer of SEPPIC company, and trade name is Sepigel305 (CTFA title:.
Also have the SEPIPLUS265 of SEPPIC company in addition, this is a kind of acrylamide that mixes with polyisobutylene and polysorbate-20/ammonium acrylate copolymer.
The make-up preparation that comprises Sepiplus265 for example for by document US 20070237735A1 known, as anti-aging product Nutri35/50, comprise that content is the glycerol of 2 weight %, polyglycereol-4 stearate and other the common cosmetic composition that content is 3 weight %.
EP1752133A1 has described polyacrylamide, especially for the Sepiplus265 in the hair conditioner.
Owing to must design each make-up preparation according to purposes, effective ingredient and application form and packing, therefore not have unified available thickening agent, but must select and be used in combination unique thickening agent all the time, in order to meet corresponding requirement.
The cosmetic field technical staff often can face when selecting thickening agent and will guarantee preparation stability and will consider problem aspect the sense organ.
Summary of the invention
The present invention will address this problem exactly, that is, provide a kind of stable, have make-up preparation or a dermatological preparations of comfortable product sense organ simultaneously.
The combined sunscreen formulas of the organosilicon of high-load (＞5%) and very high sun-proof lightscreening agent consumption (＞10%) is difficult to keep stable, usually will show typical stability problem (for example oil is separated out or elutriation goes out, even occurs being separated) through after 1～3 month resting period.
Another object of the present invention is improved these weak points exactly.
Surprisingly, polyacrylamide thickening agent (preferably Sepiplus265) and acrylate thickening agent and powder stock are used in combination, can form and be combined with high organosilicon content (＞5%), high sun-proof lightscreening agent consumption (＞10%) and can in 6～24 months time, keeping stable prescription under the various storage temperatures.
The present invention is a kind of make-up preparation or dermatological preparations, and it comprises
A) one or more are based on the thickening agent of polyacrylate,
B) one or more are based on the thickening agent of polyacrylamide,
C) one or more Cyclomethicone and one or more straight chain organo-silicon compound, and
D) one or more ultraviolet ray filtering materials in case of necessity.
The preparation that preparation of the present invention is identical with the ultraviolet filtering agent content is compared and has been improved stability of formulation.Stability improves and shows especially and improved storage stability.
Carried out stress test at stability of formulation of the present invention.
Carry out stress test reaching in resting period of 360 days under various environmental condition (high temperature, low temperature and room temperature).Then carry out the sense organ assessment to stablizing sample.Observe pH value and viscosity or denseness in time of 180 days reaching in addition.
But preparation of the present invention is except being different from prior art, also have good product sense organ simultaneously, and the ultraviolet protection performance is unrestricted.
The COLIPA Ratio of preparation of the present invention and LSF and SPF do not change, perhaps even be higher than the same preparation that does not contain thickener blend composition of the present invention.
Method according to Sensory Spectrum company is carried out the sense organ test to the experimenter, and described in example, the product sense organ of preparation of the present invention is compared with the preparation that does not use thickener blend composition and made moderate progress.
Detailed description about this method, can consult Civille, G.V. (1991) Tactile Properties of Skin Care Products-Descriptive Analysis.Cosmet.Toiletries, 106,83-88 and ASTM Standard Practice for Descriptive Skinfeel Analysis of Creams and Lotions/Designation E1490-03.
Thickening agent based on polyacrylate of the present invention can be regarded as acrylate and acrylate cross linked polymer especially.
Be that the chemical nature of these acrylate of Carbopol is referred to as " carbomere " (carbomer) according to USP-NF (American Pharmacopeia), European Pharmacopoeia, British Pharmacopoeia, united states drug NK (USAN) and international cosmetic composition term (INCI) with trade name.
Japanese Pharmacopoeia is called the Carbopol homopolymer " carboxyvinyl polymer " (carboxy vinyl polymer) and " carboxy polymethylene " (carboxyl polymethylene).Italy's pharmacopeia is called Carbopol934P " carboxy polymethylene " (carboxyl polymethylene), and Deutscher Arzneibucs is called Carbopol980NF " polyacrylic acid " (polyacrylic acid).
USP-NF is called " carbomer " (carbomer) with the Carbopol copolymer of Carbopol1342NF and 1382 and so on, and INCI also is called it " acrylate/C10-C30 alkyl acrylate cross-linked polymer ".
For example can select the acrylate cross linked polymer of Pemulen TR1 by name on sale on the market and TR2, Carbopol1342,1382, ETD2020, Ultrez21 (Lubrizol Advanced Materials) and on the market Carbopol954 by name, 5984,980 on sale, 981 and 7 or Carbopol2984 as the thickening agent based on polyacrylate.
Can select acrylate/C10-30 alkyl acrylate cross-linked polymer as Carbomer3128 or Pemulen TR1 as polyacrylic ester thickener especially.
The polyacrylic ester thickener particularly content of acrylate/C10-30 alkyl acrylate cross-linked polymer is selected for use: with respect to 0.01～1.0 weight % of preparation gross mass, preferably in 0.2～0.7 weight % scope.
Preferably select for use acrylamide/ammonium acrylate copolymer as the polyacrylamide thickening agent.
The thickening agent based on polyacrylamide that this class that can buy is on the market preferably used is Sepiplus265.
Acrylamide/ammonium acrylate the copolymer that mixes with polyisobutylene, polysorbate-20, the smooth isostearate of Pyrusussuriensis and water is provided in Sepiplus265.
Other on the market polyamide thickening agent on sale the Sepiplus250 (containing mineral oil and polysorbate-20) of Seppic company and the Bozepole CV of Clariant company are for example arranged.
In order to obtain better operability, mostly just be present among the mixture that contains described solvent PIB etc. based on the thickening agent of polyacrylamide, in order to for example prevent from forming dust.
The content of polyacrylamide thickening agent, particularly acrylamide/ammonium acrylate copolymer is preferably selected for use: with respect to the preparation gross mass be 0.1～4 weight %, particularly in 0.3～2 weight % scope, select.
Preferably with the polyacrylamide thickening agent, particularly acrylamide/ammonium acrylate copolymer (Sepiplus265) be selected from polyacrylate, be used in combination with one or both different thickening agents that are selected from acrylate cross linked polymer more precisely.
Preferred do not use more or other thickening agent.
In addition, advantageously, preparation comprises one or more powder stocks.
The drying solid that people will be applied to grind superfinely in the cosmetic industry is called powder.Decide on applicable cases, the dust carrier material is by silicate (Pulvis Talci and Kaolin), carbonate (magnesium carbonate or calcium carbonate), oxide (zinc oxide, titanium dioxide), organic zinc salt and magnesium salt (stearate, laruate and hendecane hydrochlorate) or sugar derivatives constitute.The powder stock that is selected from sugar derivatives for example has starch and/or starch derivatives or cyclodextrin and/or cyclodextrin derivative.
Known starch powder for example has PASELLI EASYGEL, tapioca, acetyl acid or adipic acid substituted starch, hydroxypropyl starch, N-octenyl succinate substituted starch, corn starch, 2-hydroxypropyl ether modified starch and hydroxypropyl starch phosphate ester.
Tapioca starch or tapioca are a kind of nearly tasteless starch of making behind manioc root (Maninot esculenta crantz.) dry processing.
Known cyclodextrin have a-, β-, y-and HP-.
Preferred powder stock is methyl methacrylate cross linked polymer, poly methyl silsesquioxane, tapioca, PASELLI EASYGEL, nylon, polyamide-5, starch ocentyl succinic aluminum and acrylonitrile-methacrylonitrile-methylmethacrylate copolymer.
Though methyl methacrylate cross linked polymer powder also is a kind of polymer, owing to its chemical constitution does not have thickening characteristic.
Powder stock is preferably selected in 0.5～4 weight % scope with respect to the content of preparation gross mass.
It is particularly advantageous selecting methyl methacrylate cross linked polymer, poly methyl silsesquioxane, tapioca and PASELLI EASYGEL.
These powder stocks with respect to the consumption of preparation gross mass particularly between 0.5～3 weight %.
According to of the present invention, especially preferably use methyl methacrylate cross linked polymer and/or poly methyl silsesquioxane as powder stock.
As the restriction of preferred raw material, and then the preferred total content of selecting powder stock in the content range of appointment, perhaps only the preferred powder powder stock is present among the preparation with the content range of appointment.
Lipid refers to oils and fats and is similar to the material of oils and fats.Lipid is mainly as softening (emollient) composition of cosmetics, and conduct is stored in the horny layer lipid between the keratinocyte.It can make skin have the ability that stores moisture.Except nursing factors, it is in order to guarantee to improve the spreading property on skin that lipid is joined in the make-up preparation, and the sensory characteristic that improves preparation.For those reasons, in many make-up preparations, all added volatile silicone oil.For those reasons, Cyclomethicone can be joined among the make-up preparation especially.
Cyclomethicone, INCI name are called octamethylcy-clotetrasiloxane (Octamethylcyclotetrasiloxane), have following general formula, wherein I=3-6
For example Cyclomethicone/decamethylcyclopentaandoxane (D5) or Cyclomethicone/ten diformazan basic rings, six siloxanes (D6) can be provided.Can use these mixture separately, perhaps in corresponding preparation used as volatility organo-silicon compound (Cosmet.Toiletries107, No.5,27[1992]).
The high molecular polydiorganosiloxanepolyurea that is known as silica gel all belongs to and contains organosilyl oil.Silica gel has for example just been described in US4152416.High molecular means that molal weight is about 200000～1000000g/mol.
Known silica gel is polyphosphazene polymer dimethyl siloxane (INCI title: polydimethylsiloxane (Dimethicone)), for example Dow Corning company is with title DC200 product sold, polyphenyl methyl siloxane (INCI title: polyphenylene trimethicone (Phenyl Trimethicone)), the product DC556Fluid of Dow Corning company for example, organosilicon glycol copolymer (INCI title: dimethicone copolyol (Dimethicone Copolyol)), for example product DC190 and the DC193 of Dow Corning company, the ester of organosilicon glycol copolymer and partial ester, for example Fanning is with trade name Fancorsil LIM product sold (INCI title: the white Limnanthes Alba Seed Oil acid esters of dimethicone copolyol (Dimethicone Copolyol Meadowfoamate)), have terminal hydroxy group polydimethylsiloxane (the INCI title: polydimethylsiloxane end alcohol (Dimethiconol)), for example product DC1401 and the Q2-1403 of Dow Corning company.
Other the known silica gel that is used for cosmetic applications for example has SE30, SE33, SE54 and the SE76 of General Electric company.
Also have the silica gel of Dow Corning company in addition, name is called Dow
1501Fluid (D5, polydimethylsiloxane end alcohol); Dow
1503Fluid (polydimethylsiloxane, polydimethylsiloxane end alcohol), Dow
CB1556Fluid (polyphenylene trimethicone, polydimethylsiloxane end alcohol) and Dow
BY25-320 (C13-16 isoparaffin, polydimethylsiloxane).Equally also known, the mixture of organosilicon liquid and the volatile silicone oils such as Cyclomethicone and silica gel is used in the make-up preparation.
According to the organosilicon of use of the present invention preferably by sector of breakdown volatility lightweight cyclic compound and less, the heavier straight chain organo-silicon compound of content of Cyclomethicone (D5/D6), the polydimethylsiloxane that for example has 20 above siloxane units, perhaps silica gel (for example DC1501Fluid) constitutes.
Cyclic compound can produce comfortable skin sense, and fabulous spreading property is arranged, and the soft and smooth sensation of silkiness is just arranged when spreading upon product on the skin immediately.Straight chain compound also produces the soft and smooth residue of silkiness can allow consumer feel nursing role at skin after 5 of spread product minutes or longer time the last time.
According to of the present invention, preferred Cyclomethicone is 2.0～12.0 weight % with respect to the consumption of prescription gross weight, is preferably 4.0～7.0 weight %.
According to of the present invention, preferred straight chain organo-silicon compound are 0.5～2.5 weight % with respect to the consumption of prescription gross weight, are preferably 1.0～2.0 weight %.
The total content of organosilicon phase is between 3.5～12.5 weight % with respect to the total formulation weight amount in the prescription, preferably between 4.0～10.0 weight %, especially preferably is higher than 5 weight %, especially between 5.0～7.5 weight %.
According to of the present invention, in view of the skin sense advantageously, the ratio of Cyclomethicone and long-chain straight chain organo-silicon compound should be between 10: 1～1: 1, preferably between 5: 1～2: 1.In other words, in preferable range in the general formula of the present invention the content of cyclic compound double the straight chain organosilicon all the time at least.
Long-chain refers to that the silicon atom number is greater than 20.
The Evaluation criterion of ultraviolet protection performance of the present invention for example is SPF (sun protection factor) (LSF or SPF).
Make-up preparation of the present invention and dermatological preparations can not stay the impression of greasy or viscosity at skin, and be fabulous with skin-friendliness, although and more surprisingly silicone oil content and ultraviolet filtering agent content are higher, still have good stable.
Ultraviolet ray filtering material is based on the pyrrolotriazine derivatives of following structure
This material is known already, and for example EP-A-775 698, EP-A-0 878 469 and EP-A-1 027881 just describe to some extent to this.
C in view of the triazine matrix of these chemical compounds
3Axle is well imagined not only and can symmetry be replaced, and can asymmetricly replace.The s-triazine that symmetry replaces has three identical substituent R
1, R
2And R
3, the Striazine derivative of asymmetric replacement then has destruction C
3The different substituents of symmetry.All the time will be asymmetric with the C of triazine matrix in the present invention
3Axle be interpreted as " asymmetric ", unless mention other saying.
Below also asymmetric replacement Striazine derivative of the present invention is called pyrrolotriazine derivatives.
Therefore pyrrolotriazine derivatives of the present invention for example is this type of pyrrolotriazine derivatives described in the EP-A-775 698:
And/or
Be favourable with general formula or disclosed all Bisresorcinyltriazines of concrete structure formula in meaning of the present invention in this patent documentation.
Very particularly advantageously be from the branching of 1～18 carbon atom and non-branching alkyl, to select R for use
4And R
5Advantageously, also can use the silyloxy substituted alkyl.
Advantageously, A
1Aromatics five-membered ring or the hexatomic ring of the homoannular or heterocycle of a replacement of expression.
On meaning of the present invention, very particularly advantageous is following asymmetric replacement s-triazine:
R wherein
6Represent a hydrogen atom or branching or the non-branching alkyl with 1～10 carbon atom, particularly CIBA-Chemikalien GmbH is with trade name
2 of S sale, 4-pair-{ [4-(2-ethyl-hexyloxy)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines (INCI: asymmetric triazine (Aniso Triazin)), have following structure:
The particularly advantageous asymmetric replacement pyrrolotriazine derivatives of the another kind of the present invention dioctyl amide-based small triazinone that to be Sigma3V company sell with trade name UVASORB HEB (INCI: dioctyl amide-based small triazinone (Dioctylbutamidotriazone)), it is characterized in that following structural formula:
And then on meaning of the present invention advantageously:
2,4-pair-[4-(3-sulfonic group)-2-hydroxyl-propoxyl group)-the 2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines sodium salt,
2,4-pair-{ [4-(3-(2-propoxyl group)-2-hydroxyl-propoxyl group)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines,
2,4-pair-{ [4-(2-ethyl-hexyloxy)-2-hydroxyl]-phenyl }-6-[4-(2-methoxy ethyl-carboxyl)-phenylamino]-1,3,5-triazines,
2,4-pair-{ [4-(3-(2-propoxyl group)-2-hydroxyl-propoxyl group)-2-hydroxyl]-phenyl }-6-[4-(ethyl carboxyl)-phenylamino]-1,3,5-triazines,
2,4-pair-{ [4-(2-ethyl-hexyloxy)-2-hydroxyl]-phenyl }-6-(1-methyl-pyrroles-2-yl)-1,3,5-triazines,
2,4-pair-{ [4-three (trimethylsiloxy-silicyl propoxyl group)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines,
2,4-pair-{ [4-(2-methylpropenyl oxygen base)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines, and
2,4-pair-[4-(1 ', 1 ', 1 ', 3 ', 5 ' 5 ', 5 '-seven methyl silicane oxygen base-2-methyl-propoxyl group)-the 2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines.
Advantageously, asymmetric replacement Striazine derivative of the present invention is joined among the oil phase of make up prescription or department of dermatologry prescription.
Other UV-A ray filtering material of the component of preparation of the present invention (a) is phenylene-1,4-pair-(2-benzimidazolyl)-3,3 '-5,5 '-tetrasulfonic acid
And other salt, preferably corresponding sodium salt, potassium salt or triethanolamine salt, particularly phenylene-1,4-is two-(2-benzimidazolyl)-3,3 '-5,5 '-tetrasulfonic acid disodium salt
The INCI name is called phenyl bisbenzimidazole tetrasulfonic acid ester disodium (Bisimidazylate), for example can be to Haarmann; The product that trade name is Neo Heliopan AP is buied by Reimer company.
At least a ultraviolet ray filtering material of component (a) can also be 2,2 '-methylene-two-(6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)-phenol) [INCI: two octyl group triazoles (Bisoctyltriazol)], its chemical structural formula is
Can buy trade name to CIBA-Chemikalien GmbH company is
The product of M.
Particularly advantageously be, at least 2 kinds of described ultraviolet ray filtering materials used altogether that combination examples is as follows:
2,4-pair-{ [4-(2-ethyl-hexyloxy)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines and phenylene-1,4-pair-(2-benzimidazolyl)-3,3 '-5,5 '-tetrasulfonic acid disodium salt;
Phenylene-1,4-is two-(2-benzimidazolyl)-3,3 '-5,5 '-tetrasulfonic acid disodium salt and 2,2 '-methylene-two-(6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)-phenol) or
2,4-pair-{ [4-(2-ethyl-hexyloxy)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines and 2,2 '-methylene-two-(6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)-phenol).
Another embodiment of the invention comprises 2,4-pair-{ [4-(2-ethyl-hexyloxy)-2-hydroxyl]-phenyl }-6-(4-methoxyphenyl)-1,3,5-triazines
Phenylene-1,4-pair-(2-benzimidazolyl)-3,3 '-5,5 '-tetrasulfonic acid disodium salt
With 2,2 '-methylene-two-(6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)-phenol)
Jointly as ultraviolet ray filtering material.
The following stated is other the common ultraviolet ray filtering material that is used in the preparation of the present invention:
Favourable oil-soluble UV-B lightscreening agent for example has:
-3-benzylidene camphor derivatives, preferably Merck company is with 3-(4-methylbenzene methylene) Camphora [INCI:4-UVINUL MBC95 (4-Methylbenzylidene Camphor)] and/or the 3-benzylidene Camphora of trade name Eusolex6300 sale;
-4-aminobenzoic acid derivative, 4-(dimethylamino)-benzoic acid (2-ethyl-oneself) ester preferably, 4-(dimethylamino) amyl benzoate;
-cinnamate, 4-methoxy cinnamic acid (2-ethyl oneself) ester preferably, 4-methoxy cinnamic acid isopentyl ester;
-salicylate, salicylic acid (2-ethyl oneself) ester preferably, salicylic acid (4-isopropyl benzyl) ester, salicylic acid ester in the high Meng,
-benzophenone derivates, 2-hydroxyl-4-methoxy benzophenone preferably, 2-hydroxyl-4-methoxyl group-4 '-the methyldiphenyl ketone, 2,2 '-dihydroxy-4-methoxy benzophenone;
-toluenyl malonic ester, 4-methoxyl group benzal malonic acid two (2-ethyl oneself) ester preferably,
-with respect to the axisymmetric pyrrolotriazine derivatives of the C3 of triazine matrix, preferably BASF AG is with trade name
T150 sell 4,4 ', 4 " (1,3,5-triazines-2,4,6-three basic three imino groups)-three-benzoic acid-three (2-ethyl oneself-ester) [INCI: octyl triazone (Octyl Triazone)],
-benzotriazole derivatives, preferably 2,2 '-methylene-two-(6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)-phenol)
-and be combined in uv filters on the polymer.
Favourable water solublity UV-B ray filtering material for example has:
The salt of 2-Phenylbenzimidazole-5-sulfonic acid, for example its sodium salt, potassium salt or its triethanolamine salt, and sulfonic acid itself;
The sulfonic acid of 3-benzylidene Camphora, 4-(2-oxo-3-bornylene (bornylidene) methyl) benzenesulfonic acid for example, 2-methyl 5-(2-oxo-3-bornylene methyl) sulfonic acid and salt thereof.
Can be used in other common UV-A lightscreening agent in the preparation of the present invention for example has the derivant of dibenzoyl methane, 1-(4 '-tert-butyl-phenyl)-3-(4 '-methoxyphenyl) propane-1 particularly, 3-diketone and 1-phenyl-3-(4 '-isopropyl phenyl) propane-1, the 3-diketone.Favourable UV-A ray filtering material also has Givaudan company with trade name
1789 and Merck company with trade name
9020 4-(tert-butyl group)-4 '-methoxy dibenzoyl methane (the CAS-accession number: 70356-09-1) of selling.
Further advantageously 1,4-two (2-oxo-10-sulfo group-3-bornylene methyl)-benzene and salt thereof (corresponding 10-sulfate radical chemical compound particularly, particularly corresponding sodium salt, potassium salt or triethanolamine salt), be also referred to as benzene-1,4-two (2-oxo-3-bornylene methyl isophthalic acid 0-sulfonic acid) has following structure:
Not only be conducive to absorb the UV-A radiation, and the ray filtering material that is conducive to absorb uv b radiation is exactly so-called wide spectrum lightscreening agent, for example have 2,2 '-methylene-two-(6-(2H-benzotriazole-2-yl)-4-(1,1,3, the 3-tetramethyl butyl)-phenol) or 2-(2H-benzotriazole-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl 1-[(trimethyl silyl) oxygen base] the disiloxane base] propyl group]-phenol (CAS accession number: 155633-54-8), the INCI name is called drometrizole trisiloxanes (Drometrizole Trisiloxane), and chemical structural formula is as follows:
Also have some salicyclic acid derivatives to be suitable as ultraviolet ray filtering material in addition, for example salicylic acid-4-isopropyl benzyl ester (4-Isopropylbenzylsalicylat), salicylic acid-2-Octyl Nitrite (=ethylhexyl salicylate (Octylsalicylat)), salicylic acid ester in the high Meng.
Another kind of favourable sun-proof ray filtering material in the use of the present invention is that BASF AG is with title
The 2-cyano group-3 that N539 sells, 3-diphenylacrylate Octyl Nitrite (Ethylhexyl-2-cyano-3,3-diphenylacrylat) (octocrilene (Octocrylen)) has following structure:
In addition, if preparation of the present invention is so that make-up preparation or the dermatological preparations form of oil-containing do not exist, as the form of preferred existence, contain a water and at least a ultraviolet ray filtering material that at room temperature is in a liquid state as another mutually, then preparation of the present invention can also contain the following ultraviolet ray filtering material that at room temperature is in a liquid state.
Advantageously, the ultraviolet ray filtering material that is in a liquid state under the room temperature is salicylic acid ester in the high Meng, 2-cyano group-3, the ester of 3-diphenylacrylate-2-Octyl Nitrite, 2 hydroxybenzoic acid-2-Octyl Nitrite (2-Ethylhexyl-2-hydroxybenzoat) and cinnamic acid, preferably 4-methoxy cinnamic acid (the 2-ethyl is own) ester (4-
(2-ethylhexyl) ester) and 4-methoxy cinnamic acid isopentyl ester.
Salicylic acid ester in the high Meng (INCI: homosalate (Homosalate)) have following structure:
Ethylhexyl salicylate (INCI: for example be Haarmann ﹠amp ethylhexyl salicylate (Octyl Salicylate)); Reimer company has following structure with trade name Neo Heliopan OS product sold:
4-methoxy cinnamic acid (the 2-ethyl is own) ester (4-methoxy cinnamic acid-2-Octyl Nitrite, INCI: octyl methoxycinnamate (Octyl Methoxycinnamate)) for example be Hoffmann-La Roche company with trade name Parsol MCX product sold, have following structure:
4-methoxy cinnamic acid isopentyl ester (4-methoxy cinnamic acid isopentyl ester (Isopentyl-4-methoxycinnamat), INCI: for example be Haarmann ﹠amp iso-amyl p-methoxycinnamate (Isoamyl p-Methoxycinnamate)); Reimer company has following structure with trade name Neo Heliopan E1000 product sold:
Of the present inventionly be preferably selected from according to the determined uv filters as the UVA lightscreening agent of COLIPA Ratio:
4-(tert-butyl group)-4 '-methoxy dibenzoyl methane (avobenzone (Parsol1789, Eusolex9020, Escalol517)) for example
2-(4 '-lignocaine 2 '-hydroxy benzoyl)-hexyl-benzoate
Benzophenone-3
Octocrilene (trade name=Uvinul N539)
The drometrizole trisiloxanes
Di-2-ethylhexylphosphine oxide-benzotriazole base tetramethyl butyl phenol (Bisoctrizole)
Polysiloxanes-15 (trade name=Parsol SLX)
Titanium dioxide (organosilicon coating)
Zinc oxide (organosilicon coating)
Water solublity UVA lightscreening agent:
Phenylene-1,4-pair-(2-benzimidazolyl)-3,3 '-5,5 '-tetrasulfonate
The Terephthalidene Dicamphor Sulfonic Acid
Phenyl bisbenzimidazole tetrasulfonic acid disodium
4-dicyano methylene-2,6-dimethyl-1, the single sodium salt of 4-dihydropyridine-N-(ethyoxyl sulfuric acid)
2,4,6-three-(diphenyl)-1,3,5-triazines
Particularly preferred uv filters should be selected from: octocrilene, homosalate, ethylhexyl salicylate (ethylhexyl salicylate), PAROSOL 1789, titanium dioxide, Phenylbenzimidazolesulfonic acid, the own oxy phenol anisyl of two-ethyl triazine
Polysiloxanes-15, lignocaine oxybenzene formoxyl hexyl-benzoate and benzophenone-3.
Higher ultraviolet filtering agent content means that the ultraviolet protection material is higher than 10 weight % with respect to the content of preparation gross mass, preferably selects 15～40 weight % for use, especially preferably selects content between 20～35 weight % for use.
If the spf value of preparation is 30, then to preferably include the content with respect to the preparation gross mass be the ultraviolet ray filtering material of 20～30 weight % to preparation.If the spf value of preparation is 50, then to preferably include the content with respect to the preparation gross mass be the ultraviolet ray filtering material of 25～35 weight % to preparation.
In make-up preparation or the dermatological preparations as one or more ultraviolet ray filtering materials of preferred uv filters with respect to total consumption of total formulation weight amount between 15～40 weight %, preferably between 20～35 weight %.
Inventory according to above-mentioned common ultraviolet ray filtering material used in the present invention is also nonrestrictive certainly.
Uv filters can improve, promote the sun-proof performance of cosmetic or dermatological preparations.Although these preparations are owing to contained uv filters itself has the ultraviolet protection performance, but still can under the situation that does not improve the ultraviolet filtering agent content, improve this sun-proof performance by adding thickener blend composition.Because material of the present invention can promote sun-proof performance, therefore it can be called Booster, SPF-Booster, and also " lifting " sun-proof performance be called Boosting or SPF-Boosting.
In addition, advantageously, these preparations comprise that also one or more content with respect to the preparation gross mass are 1～10 weight %, are preferably 2～7.5 weight %, are preferably the emollient of 2.5～5 weight % especially.
The wetting agent of preferentially selecting for use is glycerol.
Other particularly preferred emollient is propylene glycol and butanediol.
1,2-alkane glycol particularly 1,2-pentanediol, 1,2-hexanediol and 1,2-ethohexadiol also are preferred emollient.The latter with respect to the consumption of preparation gross mass in 0.1～2 weight % scope, preferably in 0.2～1 weight % scope, in 0.3～0.75 weight % scope.
Skin moisture is the term that is derived from cosmetic industry.Healthy skin has natural moisture content.Have only when people's skin is unusual in view of drying property exists, the skin moisture of shortage just can work.Except the disease reason, age and the pigmentation of human body skin are also played a role.Moisture factor (for example carbamide) plays an important role to the moisture content of skin, can provide these Moisture factor to skin by skin care item.
Human body skin does not need supplementary means to keep nature moisture content usually, but unsound life style, dry air (especially at solarium and the indoor of heating installation arranged), environmental effect, pressure and sun tan for a long time still can cause and lose moisture content.Long and hot bath in a tub and remain in the forfeiture that detergent in the clothes also can cause the important component of skin water resin system.Can use emollient cream to prevent skin to become dry.Skin-wetting soap also can make oils and fats come back on the skin with the detergent that is substantially free of soap.It is Paint Gloss, more soft that skin will become.Here the clean skin product (pH value of skin=5.5) that can not destroy skin natural acidic protective layer are used in special recommendation.
Can't can not use air humidifier to support healthy skin moisture at some as in the dwelling house that ventilates usually because environmental condition is good yet.
Can after make-up preparation or dermatological preparations are smeared or be distributed on the skin surface, reduce horny layer moisture loss (be also referred to as transepidermal water loss (TEWL)/through the epidermis dehydration) and/or be conducive to increase the horny layer hydration material or mixture be called wetting agent, be also referred to as emollient.Favourable emollient for example is glycerol, lanoline and ester thereof, lanonol, sorbitol, lactic acid and salt thereof, 2-pyrrolidone-5-carboxylic acid and salt thereof and carbamide on meaning of the present invention.Other wetting agent for example is the macromolecule wetting agent, can be selected from water solublity and/or can expand in water and/or can be by the polysaccharide of water-setting gel.Particularly advantageous is hyaluronic acid, chitosan and/or a kind of polysaccharide that is rich in fucose for example, and " chemical abstracts " of this polysaccharide (Chemical Abstracts) accession number is 178463-23-5, for example can buy name from SOLABIAS.A. company and be called
1000 product.
Shortcoming up to now is that the wetting agent of high-load can cause the skin protection breast to have unacceptable denseness and user and undesired viscosity in the emulsion.
Thickening agent combination of the present invention also can be tackled this disadvantage.
Advantageously, pharmaceutical formulation is equally based on a kind of emulsion.
The application form of preparation of the present invention for example has: solution, and suspension, emulsion, the PIT emulsion, paste, ointment, gel, cream, emulsion, powder, soap contains detergent, oil, aerosol and the spray of surfactant.Other application form for example has shower rod, shampoo and shower room.Common carrier mass, adjuvant arbitrarily can be in preparation, added, also other effective ingredient can be added in case of necessity.
One or more polyacrylic ester thickeners of the present invention, particularly acrylate/C10-30 alkyl acrylate cross-linked polymer and compositions one or more polyacrylamide thickening agents, particularly acrylamide/ammonium acrylate copolymer, that comprise one or more Cyclomethicone and one or more straight chain organo-silicon compound are fit to sun-proof performance stable and lifting cosmetic sun-screening agent or dermatological preparations.
In addition, one or more polyacrylic ester thickeners of the present invention, particularly acrylate/C10-30 alkyl acrylate cross-linked polymer and one or more polyacrylamide thickening agents, particularly acrylamide/ammonium acrylate copolymer, comprise that the compositions of one or more Cyclomethicone and one or more straight chain organo-silicon compound can also be used to improving the product sense organ of cosmetic sun-screening agent or department of dermatologry sun-screening agent, the ultraviolet filtering agent content of described sun-screening agent is greater than 10 weight %.
In order to improve its product sense organ, sun-proof performance and to improve storage stability simultaneously, particularly advantageously, make-up preparation or dermatological preparations comprise: content is acrylate/C10-30 alkyl acrylate cross-linked polymer of 0.2～0.7 weight %; 0.3 the acrylamide of～2 weight %/ammonium acrylate copolymer; One or more uv filters, described lightscreening agent are selected from octocrilene, homosalate, salicylic acid-2-Octyl Nitrite, PAROSOL 1789, titanium dioxide, Phenylbenzimidazolesulfonic acid, the own oxy phenol anisyl of two-ethyl triazine, polysiloxanes-15, lignocaine oxybenzene formoxyl hexyl-benzoate, benzophenone-3; And one or more powder stocks, described powder stock is selected from methyl methacrylate cross linked polymer, poly methyl silsesquioxane, tapioca, PASELLI EASYGEL, nylon, polyamide-5, starch ocentyl succinic aluminum, acrylonitrile-methacrylonitrile-methylmethacrylate copolymer and one or more Cyclomethicone and one or more straight chain organo-silicon compound.
The specific embodiment
Following example can be set forth preparation of the present invention.The content of appointment is the percentage by weight with respect to the preparation gross mass.
Example
Claims (13)
1. make-up preparation or dermatological preparations comprise
A) one or more are based on the thickening agent of polyacrylate,
B) one or more are based on the thickening agent of polyacrylamide,
C) one or more Cyclomethicone and one or more straight chain organo-silicon compound, and
D) one or more ultraviolet ray filtering materials in case of necessity.
2. preparation according to claim 1 is characterized in that, a.) in 0.01～1.0 weight % scope, preferably select polyacrylic ester thickener with respect to the content of preparation gross mass in 0.2～0.7 weight % scope.
3. preparation according to claim 1 and 2 is characterized in that, b.) in 0.1～4 weight % scope, the special polyacrylamide thickening agent of selecting in 0.3～2 weight % scope is with respect to the content of preparation gross mass.
4. each described preparation in requiring according to aforesaid right is characterized in that, a.) selects one or more acrylate/C10-30 alkyl acrylate cross-linked polymer as polyacrylic ester thickener.
5. each described preparation in requiring according to aforesaid right is characterized in that, b.) selects one or more acrylamides/ammonium acrylate copolymer as the polyacrylamide thickening agent.
6. each described preparation in requiring according to aforesaid right, it comprises one or more powder stocks.
7. preparation according to claim 6, it is characterized in that, described powder stock is selected from group methyl methacrylate cross linked polymer, poly methyl silsesquioxane, tapioca, PASELLI EASYGEL, nylon, polyamide-5, starch ocentyl succinic aluminum and acrylonitrile-methacrylonitrile-methylmethacrylate copolymer, particularly methyl methacrylate cross linked polymer and/or poly methyl silsesquioxane.
8. according to claim 6 or 7 described preparations, it is characterized in that, in 0.5～4 weight % scope, the special powder stock of selecting in 0.5～3 weight % scope is with respect to the content of preparation gross mass.
9. each described preparation in requiring according to aforesaid right; it is characterized in that, from group octocrilene, homosalate, salicylic acid-2-Octyl Nitrite, PAROSOL 1789, titanium dioxide, Phenylbenzimidazolesulfonic acid, the own oxy phenol anisyl of two-ethyl triazine, polysiloxanes-15, lignocaine oxybenzene formoxyl hexyl-benzoate and benzophenone-3, select for use one or more materials as uv filters.
10. each described preparation in requiring according to aforesaid right, it comprises one or more emollient.
11. according to each described preparation in the aforesaid right requirement, it is characterized in that the ratio of Cyclomethicone and straight chain organo-silicon compound is between 10: 1～1: 1, preferably between 5: 1～2: 1.
12. one or more polyacrylic ester thickeners, particularly acrylate/C10-30 alkyl acrylate cross-linked polymer and compositions one or more polyacrylamide thickening agents, particularly acrylamide/ammonium acrylate copolymer, that comprise one or more Cyclomethicone and one or more straight chain organo-silicon compound is used for stable and promotes the purposes of the sun-proof performance of make-up preparation or dermatological preparations.
13. one or more polyacrylic ester thickeners, the purposes of the product sense organ that is used for improving the make-up preparation that comprises one or more uv filters or dermatological preparations of acrylate/C10-30 alkyl acrylate cross-linked polymer and compositions one or more polyacrylamide thickening agents, particularly acrylamide/ammonium acrylate copolymer, that comprise one or more Cyclomethicone and one or more straight chain organo-silicon compound particularly.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010063894.3 | 2010-12-22 | ||
| DE102010063894A DE102010063894A1 (en) | 2010-12-22 | 2010-12-22 | High silicone oil cosmetic or dermatological sunscreens comprising a combination of polyacrylate and polyacrylamide thickener |
| PCT/EP2011/072545 WO2012084598A2 (en) | 2010-12-22 | 2011-12-13 | Cosmetic or dermatological preparations having a high silicone oil content, comprising a combination of polyacrylate and polyacrylamide thickener |
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| CN103347491A true CN103347491A (en) | 2013-10-09 |
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| CN2011800622860A Pending CN103347491A (en) | 2010-12-22 | 2011-12-13 | Cosmetic or dermatological preparations comprising a combination of polyacrylate and polyacrylamide thickeners and having a high silicone oil content |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2654709A2 (en) |
| CN (1) | CN103347491A (en) |
| BR (1) | BR112013016012A2 (en) |
| DE (1) | DE102010063894A1 (en) |
| WO (1) | WO2012084598A2 (en) |
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| CN112752561A (en) * | 2018-09-29 | 2021-05-04 | 拜尔斯道夫股份有限公司 | Cosmetic formulations with unique sensory characteristics and appealing appearance |
| CN114641273A (en) * | 2019-11-21 | 2022-06-17 | 陶氏环球技术有限责任公司 | Personal care compositions comprising multistage polymers |
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| DE102012200074A1 (en) * | 2012-01-04 | 2013-07-04 | Beiersdorf Ag | Lightweight, waterproof cosmetic preparation |
| WO2020041543A1 (en) | 2018-08-23 | 2020-02-27 | The Procter & Gamble Company | Skin care composition |
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| DE102005028364A1 (en) | 2005-06-16 | 2006-12-28 | Beiersdorf Ag | Multifunctional bottle |
| EP1752133A1 (en) | 2005-08-11 | 2007-02-14 | Wella Aktiengesellschaft | Use of polymeric thickeners in hair treating compositions, method and composition |
| DE102005059738A1 (en) | 2005-12-13 | 2007-06-14 | Beiersdorf Ag | Merocyanine-containing sunscreens with high UV-A balance |
| US20070237735A1 (en) | 2006-03-31 | 2007-10-11 | Laboratoires Dermo-Cosmetik Inc. | Anti-aging composition, kit and method of use |
-
2010
- 2010-12-22 DE DE102010063894A patent/DE102010063894A1/en not_active Ceased
-
2011
- 2011-12-13 WO PCT/EP2011/072545 patent/WO2012084598A2/en active Application Filing
- 2011-12-13 CN CN2011800622860A patent/CN103347491A/en active Pending
- 2011-12-13 BR BR112013016012A patent/BR112013016012A2/en not_active IP Right Cessation
- 2011-12-13 EP EP11801678.1A patent/EP2654709A2/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1310237A2 (en) * | 2001-11-09 | 2003-05-14 | Beiersdorf AG | Cosmetic and dermatological sunscreen formulations comprising hydroxybenzophenones and acrylamide polymers |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112752561A (en) * | 2018-09-29 | 2021-05-04 | 拜尔斯道夫股份有限公司 | Cosmetic formulations with unique sensory characteristics and appealing appearance |
| CN114641273A (en) * | 2019-11-21 | 2022-06-17 | 陶氏环球技术有限责任公司 | Personal care compositions comprising multistage polymers |
| CN114641273B (en) * | 2019-11-21 | 2023-12-05 | 陶氏环球技术有限责任公司 | Personal care compositions comprising multistage polymers |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013016012A2 (en) | 2018-12-11 |
| WO2012084598A2 (en) | 2012-06-28 |
| WO2012084598A3 (en) | 2012-09-07 |
| EP2654709A2 (en) | 2013-10-30 |
| DE102010063894A1 (en) | 2012-06-28 |
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