The specific embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1:
The present embodiment is prepared from take Herba Cistanches, Fructus Cannabis, the Radix Astragali, Rhizoma Atractylodis Macrocephalae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Radix Rehmanniae, Semen Persicae, Radix Polygoni Multiflori, Radix Scrophulariae, Radix Ophiopogonis, Semen Armeniacae Amarum, Fructus Aurantii, Cortex Magnoliae Officinalis, Radix Et Rhizoma Rhei as crude drug.The every clothes of its component (% by weight) are Herba Cistanches 7.3, Fructus Cannabis 9.7, the Radix Astragali 11.8, Rhizoma Atractylodis Macrocephalae 7.5, Radix Gentianae Macrophyllae 9.7, Radix Angelicae Sinensis 9.8, Radix Rehmanniae 5.9, Semen Persicae 8.6, Radix Polygoni Multiflori 6.5, Radix Scrophulariae 0.6, Radix Ophiopogonis 4.2, Semen Armeniacae Amarum 4.1, Fructus Aurantii 5.2, Cortex Magnoliae Officinalis 3.9, Radix Et Rhizoma Rhei 5.2.Get above-mentioned 15 flavor Chinese herbal medicine gross weight 216g, at room temperature 15 flavor Chinese herbal medicine are added the 800-1000 milliliter of purifying waste water, soaked 5-6 hour, then boil with high heat slow fire and decoct about 100-120 minute, 210 milliliters of the filtrates removed slag to get, medicinal residues add water 200-300 milliliter again, decoct 30-40 minute, remove slag to get 90 milliliters of filtrates to get 300 milliliters of medicine juice altogether, and namely system is used for the treatment of mixed hemorrhoid postoperative relieving constipation pain relieving decoction.Pack in the aseptic vial, seal bottle cap is for subsequent use.Every day potion divide sooner or later 2 times oral, each 150 milliliters of warm medicine soup of (medicine) being taken before meal took for 1 week continuously.
Therapeutic Principle of the present invention:
Mixed hemorrhoid postoperative imbalance of YIN and YANG, QI and blood deficiency, qi depression to blood stasis, large intestine conduction mistake department, and cause constipation.Theory of Chinese medical science is thought, the kidney controlling urination and defecation, if deficiency of kidney yin then intestinal lose and to moisten fosterly, dry stool is unfavorable; If insufficiency of kidney-YANG, then intestinal loses warmly, conducts unablely, defecates not all right.The deficiency of vital energy and blood deficiency two diseases are also deposited, and the deficiency of vital energy can not be taken the photograph blood, and blood deficiency can not carrier gas, causes insufficiency of the spleen unable transporting, and the large intestine conduction is weak, and the blood deficiency and depleted fluid dryness of the intestine forms the constipation of QI and blood deficiency.The postoperative venation is impaired, qi depression to blood stasis, and hematogenous blockage, intestinal network stasis blocking, the function of intestinal canal imbalance causes difficulty in defecation row.Its Therapeutic Principle should be: warming YANG YIN nourishing, qi-supplementing, blood-engendering, blood-activating analgetic, loosening bowel to relieve constipation.
Herba Cistanches of the present invention, sweet, salty temperature enters the kidney large intestine channel, the gas of sweet energy spleen reinforcing kidney, salty can hard masses softening and resolving, kidney and spleen invigorating, loosening bowel to relieve constipation is the key medicine of loosening bowel to relieve constipation, " book on Chinese herbal medicine converges and wants ": " be the agent of flat benefits; temperature and not hot, mend and not high, warm and not dry, sliding and do not let out, therefore name is calmly arranged."; Fructus Cannabis, sweet, flat, return spleen, large intestine channel, matter profit greasiness, energy loosening bowel to relieve constipation, can moisten tonify deficiency again, and " medicineization justice " " the body profit can be gone dry for Fructus Cannabis, energy intestine moistening, the depressed constipation of patent large intestine; all old blood is uninteresting, and puerperal, QI and blood had some setbacks, and vigour is multiple after being ill, or can not the operator all control a little less than reporting." the two kidney and spleen invigorating, loosening bowel to relieve constipation is monarch drug altogether.Pharmacological research shows, Herba Cistanches can significantly improve the mouse small intestine advance rate, shortens the relieving constipation time, simultaneously the moisture content of large intestine is absorbed with obvious inhibitory action; Fructus Cannabis can stimulate intestinal mucosa, and secretion is increased, and wriggling is accelerated, and reduces large intestinal absorption moisture, and discharge function is arranged. because of its fatty Chuck Steak, therefore be emollient laxative.
The Radix Astragali is joined the Rhizoma Atractylodis Macrocephalae, air making-up and spleen enlivening, and invigorating the spleen and replenishing QI, gas is capable then just logical.When give the credit to arrogate to oneself enrich blood, invigorate blood circulation, pain relieving, intestine moistening; Semen Persicae can blood circulation promoting and blood stasis dispelling, and loosening bowel to relieve constipation, its bitter in the mouth of Radix Gentianae Macrophyllae fall and can rush down sharp two and just lead damp and hot going out, it has certain antihistaminic effect modern pharmacological research, and capillary percolation is obviously reduced, and the painful effect in town is arranged, the three share, and the merit of blood stasis dispelling, pain relieving, relieving constipation is arranged.Be ministerial drug altogether.
Radix Rehmanniae have promote the production of body fluid, moisturize, the merit of laxation, the Radix Polygoni Multiflori life is rushed down lower with laxation, Rhizoma Atractylodis Macrocephalae is adjusted gastrointestinal motility function, antiulcer, is protected the liver, enhancing body, Yin-nourishing and body fluid promoting increased liquid and sailed a boat Radix Scrophulariae, Radix Ophiopogonis.All medicines are with controlling the warm property of monarch drug with can the YIN nourishing intestine moistening helping again.The intestine moistening of Semen Armeniacae Amarum lung qi dispersing, Fructus Aurantii harmonizing the functional activities of vital QI, Papillary play the effect of carrying kettle Xie Gai." ancient Chinese medical classics essential ideas " pointed out, and " the reason stool must be transferred lung qi also.″
Cortex Magnoliae Officinalis is regulated the flow of vital energy, and Radix Et Rhizoma Rhei rushes down lower, for making medicine.Modern pharmacological research, Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause the quickening of saliva, gastric secretion, gastrointestinal peristalsis, it is the anthracene glycoside that Radix Et Rhizoma Rhei rushes down lower effective ingredient, mainly is Sennosides, and site of action is mainly at large intestine, can increase enterokinesia and suppress the enteral moisture absorption, promote defecation.
All medicines can impel the character of stool towards middle sexual development with joint efforts, and the soft stool that namely is shaped is soft sausage shape.Such excrement matter neither can cause burning sensation of the anus, hemorrhage, severe pain as the thick excrement of hard, also can not resemble to embed wound surface the water sample loose stool and bring out infection, has avoided using the drawback of charthartic
Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the present invention, but each raw material also the embodiment that mixes of the listed ratio of according to the form below (percentage by weight) realize.Its processing technique is identical with embodiment 1.
Below in conjunction with the clinical trial that my institute (In Shandong Weihai institute of traditional Chinese medicine) carries out the present invention is done further, describes in detail:
1, case is selected: this organizes 60 examples, male 31 examples, women 29 examples, age 21-75 year, 45 years old mean age, course of disease 1-20, average 9.3 years.
2, Therapeutic Method: early, late twice (medicine) being taken before meal, each oral one bag, the front beginning of sleeping evening of postoperative first day is oral, to the postoperative end of taking medicine in the 7th day.
3. symptom score quantitative criteria
Draft voluntarily with reference to " People's Republic of China's standard disease of tcm diagnosis and criterion of therapeutical effect " (State Administration of Traditional Chinese Medicine's January nineteen ninety-five) and " guideline of clinical investigations of new Chinese medicine treatment constipation ".
<1 〉. in conjunction with clinical observation to mixed hemorrhoid postoperative defecation situation, the cardinal symptom standards of grading of certainly intending difficulty in defecation row are as follows:
(1) defecation is along no situation
Defecation was smooth and easy in 0 minute
1 minute defecation slightly has and has some setbacks, still can Self-discharged
Defecation had some setbacks in 2 minutes, and awareness of defecation and rectal tenesmus sense are obvious, can not Self-discharged, need the glycerin intervention
Defecation had some setbacks in 3 minutes, and it is strong that awareness of defecation and anus heavily fall sense, can not Self-discharged, need the coloclysis intervention
(2) defecation (t) consuming time
0 minute t≤5min
1 minute 5min<t≤10min
2 minutes 10min<t≤20min (or by glycerin intervention defecation)
3 minutes t>20min (or by coloclysis intervention defecation)
(3) stool character
0 minute quality, shape, amount are all normal
1 sub-prime is sticky, and is shapeless, and amount less or medium
2 sub-primes are slightly dried, the bar column, and amount is less or medium
3 sub-primes are stiff, and ball is block, and amount is few; Just matter is thin as watery
<2 〉. in conjunction with clinical observation, certainly intend occur together pain, bleeding standards of grading of postoperative defecation as follows:
(1) pain situation
0 minute without pain
Pain was slight in 1 minute
Pain was acute in 2 minutes, needed oral analgesic
3 minutes pain endurables need the injection analgesic
4, diagnostic criteria:
(1) diagnostic criteria of mixed hemorrhoid: by the knot anorectum surgery of surgery branch of Chinese Medical Association group, anorectal disease Professional Committee of China Association of Traditional Chinese Medicine, the sick Professional Committee of CAIM (Chinese Association Of Integrative Medicine) knot anorectum " the hemorrhoid clinical diagnosis and treatment guide " formulated is discussed with reference in JIUYUE, 2006
(2) mixed hemorrhoid postoperative difficulty in defecation row and the diagnostic criteria of suffering from diarrhoea
Mixed hemorrhoid postoperative difficulty in defecation row's diagnostic criteria draft voluntarily into: judge defecation cardinal symptom integration (M) 〉=1 according to the symptom integral method; And according to the integration difference postoperative difficulty in defecation row is divided into slight, moderate, severe:
Slight 1 minute≤M≤3 minutes
4 minutes≤M of moderate≤6 minutes
7 minutes≤M of severe≤9 minutes
Defecation cardinal symptom integration (M)=defecation is along no situation integration+defecation integration consuming time+stool character integration
The diagnostic criteria of diarrhoea: defecation frequency increases (>3 times/days), and the feces amount increases (>200g/ day), excrement matter thin (water content>85%).
5, criterion of therapeutical effect:
" People's Republic of China's Chinese medicine industry standard tcm internal medicine Illnesses Diagnoses criterion of therapeutical effect " ZY/T001.1-94 according to State Administration of Traditional Chinese Medicine's issue in 1994
Efficacy assessment standard is as follows from intending:
(1). therapeutic index: use the n value representation
(2). the clinical efficacy evaluation criteria:
Cure: every transference cure, n=100%
Produce effects: the front integration minimizing for the treatment of after the treatment, n 〉=66.7%
Effectively: the front integration minimizing for the treatment of after the treatment, 33.3%≤n<66.7%
Invalid: the unchanged or minimizing of integration but n<33.3% before the treatment after the treatment
6, therapeutic outcome: the present invention treats 60 examples, and postoperative was taken medicine 7 days, cured 24 examples, effective 35 examples, invalid 1 example, cure rate 40%, effective percentage 58.3%, inefficiency 1.7%, total effective rate 98.3%.