CN103316170B - Chinese patent medicine helpful for recovery from hepatic and gall diseases and preparation method thereof - Google Patents
Chinese patent medicine helpful for recovery from hepatic and gall diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese patent medicine helpful for recovery from hepatic and gall diseases. The Chinese patent medicine is prepared from the following raw materials: by weight, 15-28 parts of cordyceps flower, 12-19 parts of rabdosia lophanthide, 10-17 parts of gentrin knotweed, 8-14 parts of deep-fried Atractylodes macrocephala Koidz, 5-9 parts of banksia rose, 9-15 parts of radix bupleuri, 6-9 parts of dilatate microsorium herb, 12-16 parts of semen pharbitidis, 1-3 parts of wild aconite root, 2-4 parts of mountain data, 6-14 parts of cranesbill and 9-16 parts of Chinese Starjasmine stem. The medicine provided by the invention has the following advantages: during the development process of chronic liver disease- hepatic fibrosis- liver cirrhosis- liver cancer, hepatic fibrosis is the key link. If hepatic fibrosis can be prevented/reversed, most liver diseases can be treated. Thus, by the theory of homogeny of liver and gallbladder and combined treatment of liver and gallbladder, cordyceps flower is used as the monarch drug to move qi and enrich blood; rabdosia lophanthide,gentrin knotweed and deep-fried Atractylodes macrocephala Koidz are selected as ministerial drugs to regulate the function of the liver and spleen, regulate vital energy and resolve phlegm; and banksia rose, radix bupleuri and dilatate microsorium herb are used as adjuvant drugs to clear heat, nourish gallbladder, clear damp, promote dieresis, soften hardness and dissipate binds.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine that contributes to liver and gall diseases rehabilitation and preparation method thereof, belong to tcm field.
Background technology
Theory of Chinese medical science is thought, liver and gallbladder phase the exterior and the interior, and liver controlling conveyance and dispersion, secretion and excretion of bile, the gallbladder being attached to the liver, bile derives from liver and catharsis and small intestinal, and the two completes the physiological function of main catharsis jointly; On pathology, hepatopathy often has influence on gallbladder more, occurs the symptoms such as yellow disease, hypochondriac pain.And hepatitis, chronic viral hepatitis B particularly, become global public health problem, the whole world has more than 1,000,000 people to die from HBV infection and relevant disease thereof every year at present according to statistics, the direct economic loss that China causes because of hepatitis B every year reaches 50,000,000,000 yuan, but up to now chronic viral hepatitis B is still lacked to desirable Therapeutic Method and medicine, therefore how effectively to prevent and treat hepatitis B and be still 21 century by the key subjects that face and need to solve.But traditional traditional Chinese medical science formula was aspect treatment hepatopathy, gallbladder disease in the past, employing be to do things in his own way, hepatopathy treating the liver, gallbladder disease are controlled gallbladder, generally speaking effect is all not bery desirable.
Summary of the invention
The deficiency existing for prior art, technical problem to be solved by this invention is that a kind of Chinese patent medicine that contributes to liver and gall diseases rehabilitation and preparation method thereof is provided, can effectively prevent and treat and block hepatic fibrosis, improved curative effect, reduced side effect, technique is simple and easy to realize.
For solving the problems of the technologies described above, the technical scheme that the present invention takes is, a Chinese patent medicine that contributes to liver and gall diseases rehabilitation, is made by the raw material of following parts by weight: Cordyceps 15-28 part, Herba Rabdosiae Lophanthoidis 12-19 part, Rhizoma Polygoni Cuspidati 10-17 part, Rhizoma Atractylodis Macrocephalae preparata 8-14 part, Radix Aucklandiae 5-9 part, Radix Bupleuri 9-15 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 6-9 part, Semen Pharbitidis 12-16 part, Radix Aconiti Kusnezoffii Preparata 1-3 part, Fructus Choerospondiatis 2-4 part, Herba Erodii 6-14 part and Caulis Trachelospermi 9-16 part.
Optimize, the above-mentioned Chinese patent medicine that contributes to liver and gall diseases rehabilitation, is made by the raw material of following parts by weight: Cordyceps 17-22 part, Herba Rabdosiae Lophanthoidis 15-17 part, Rhizoma Polygoni Cuspidati 12-14 part, Rhizoma Atractylodis Macrocephalae preparata 10-12 part, Radix Aucklandiae 7-8 part, Radix Bupleuri 11-13 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 7-8 part, Semen Pharbitidis 14-15 part, Radix Aconiti Kusnezoffii Preparata 2-2.5 part, Fructus Choerospondiatis 3-4 part, Herba Erodii 10-12 part and Caulis Trachelospermi 12-14 part.
Optimize, the above-mentioned Chinese patent medicine that contributes to liver and gall diseases rehabilitation, is made by the raw material of following parts by weight: 9 parts of 15 parts of Cordyceps, 12 parts of Herba Rabdosiae Lophanthoidiss, 10 parts of Rhizoma Polygoni Cuspidati, 8 parts of Rhizoma Atractylodis Macrocephalae preparatas, 5 parts of the Radix Aucklandiae, 9 parts of Radix Bupleuri, 6 parts of Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), 12 parts of Semen Pharbitidiss, 2 parts of Radix Aconiti Kusnezoffii Preparatas, 3 parts of Fructus Choerospondiatis, 6 parts of Herba Erodiis and Caulis Trachelospermis.
Contribute to a manufacture method for the Chinese patent medicine of liver and gall diseases rehabilitation, by following steps, made:
(1) getting Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Pharbitidis, Radix Aconiti Kusnezoffii Preparata, Fructus Choerospondiatis, Herba Erodii and Caulis Trachelospermi pulverizes;
(2) by adding 150 parts of water after Cordyceps, Herba Rabdosiae Lophanthoidis, Rhizoma Polygoni Cuspidati, Rhizoma Atractylodis Macrocephalae preparata, the Radix Aucklandiae and Radix Bupleuri mixing, decoct after 2.5 hours, take out medicinal liquid standby;
(3) will in the medicinal residues of step (2), add the water of 100 parts, decoct 2.5 hours, take out medicinal liquid;
(4) medicinal liquid step (2) and step (3) being obtained carries out mix and blend;
(5) mixture step (4) being completed carries out oven drying at low temperature 5 hours at the temperature of 60 degrees Celsius, obtains drug extract;
(6) medicated powder that adds step (1) to obtain in drug extract step (5) being obtained, is uniformly mixed, and makes pill.
Drug use result of the present invention shows, there is following advantage: the present invention proposes employing and comprise that multiple effective Chinese patent medicine new compositions produces more favorably effect with synergism, in the evolution by chronic hepatopathy-hepatic fibrosis-liver cirrhosis-hepatocarcinoma, hepatic fibrosis is crucial, if can stop/reverse hepatic fibrosis, just can treat most hepatopathy.So the present invention is with liver and gall homology, liver and gall and control as theory, employing Cordyceps is monarch drug, and its circulation of qi promoting is enriched blood; Selecting Herba Rabdosiae Lophanthoidis, Rhizoma Polygoni Cuspidati and Rhizoma Atractylodis Macrocephalae preparata is ministerial drug, makes its regulating the liver and spleen, regulating the flow of vital energy paralysis; With the Radix Aucklandiae, Radix Bupleuri, Fructus Choerospondiatis, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), be adjuvant drug, make its clearing heat secreting bile, promoting diuresis to eliminate damp pathogen, hard masses softening and resolving; With Semen Pharbitidis, Herba Erodii and Caulis Trachelospermi, make medicine; Play altogether full side, makes its effect that reaches conditioning liver board, regulating the flow of vital energy paralysis, liver heat removing function of gallbladder promoting, liver and gall and control, and can effectively prevent and treat and block hepatic fibrosis, has improved curative effect, has reduced side effect, and technique is simple and easy to realize.
The specific embodiment
Embodiment 1
The present invention is a kind of Chinese patent medicine that contributes to liver and gall diseases rehabilitation, by the raw material of following parts by weight, is made: 9 parts of 15 parts of Cordyceps, 12 parts of Herba Rabdosiae Lophanthoidiss, 10 parts of Rhizoma Polygoni Cuspidati, 8 parts of Rhizoma Atractylodis Macrocephalae preparatas, 5 parts of the Radix Aucklandiae, 9 parts of Radix Bupleuri, 6 parts of Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), 12 parts of Semen Pharbitidiss, 2 parts of Radix Aconiti Kusnezoffii Preparatas, 2 parts of Fructus Choerospondiatis, 6 parts of Herba Erodiis and Caulis Trachelospermis.In above-mentioned formula, also can add 1.5 parts of 1 part, Flos Carthami and Concha Ostreaes, effect is better.
Contribute to a manufacture method for the Chinese patent medicine of liver and gall diseases rehabilitation, by following steps, made:
(1) getting Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Pharbitidis, Radix Aconiti Kusnezoffii Preparata, Fructus Choerospondiatis, Herba Erodii and Caulis Trachelospermi pulverizes;
(2) by adding 150 parts of water after Cordyceps, Herba Rabdosiae Lophanthoidis, Rhizoma Polygoni Cuspidati, Rhizoma Atractylodis Macrocephalae preparata, the Radix Aucklandiae and Radix Bupleuri mixing, decoct after 2.5 hours, take out medicinal liquid standby;
(3) will in the medicinal residues of step (2), add the water of 100 parts, decoct 2.5 hours, take out medicinal liquid;
(4) medicinal liquid step (2) and step (3) being obtained carries out mix and blend;
(5) mixture step (4) being completed carries out oven drying at low temperature 5 hours at the temperature of 60 degrees Celsius, obtains drug extract;
(6) medicated powder that adds step (1) to obtain in drug extract step (5) being obtained, is uniformly mixed, and makes pill.
This tests the Chinese medicine experience compound recipe that Chinese patent medicine used is the treatment gout found out from liver, gallbladder opinion control.Wherein: Cordyceps has and braces up energy and delay senility, anoxia enduring, blood fat reducing, antibacterial and detoxicating, tranquillizing and allaying excitement, regulates immunity, relievings asthma and eliminates the phlegm, and antitumaous effect, strengthens cardiovascular, blood, liver, renal function.Herba Rabdosiae Lophanthoidis has clearing away heat-damp and promoting diuresis, removing heat from blood scattered silt, and in addition, through repetition test, under certain condition, Herba Rabdosiae Lophanthoidis also has the great ability of killing hepatitis B virus; Rhizoma Polygoni Cuspidati nature and flavor micro-hardship that is slightly cold, returns liver, gallbladder, lung meridian, has the effect of heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm, and Rhizoma Atractylodis Macrocephalae preparata is the decoction pieces after medical material Rhizoma Atractylodis Macrocephalae Preparation process, and the Rhizoma Atractylodis Macrocephalae is fried the used time, fries to pitchy, is called Rhizoma Atractylodis Macrocephalae preparata.Radix Bupleuri: the sapogenin that Radix Bupleuri mainly contains saikoside and answers in contrast.Bupleurum falcatum root is about 2.8% containing total saikosaponin, and separated saponin has a, b, c, d4 kind, and sapogenin has 7 kinds, i.e. Saikogenin A, B, C, D, E, F, G.A, B, C, D are not true property sapogenin according to inferring, but in course of reaction the secondary product by Saikogenin E, F, G and reagent reacting respectively.Saikoside a, d are one of main effective ingredient of Radix Bupleuri.In addition, Radix Bupleuri also contains rutin, volatile oil (for bupleurumol bupleurmol), fatty oil (for glyceride such as oleic acid, linoleic acid, Palmic acid, stearic acid), hitodesterol, adonistal, triterpenoid saponin glucose etc.Radix Bupeuri Scorzonerfolii. herb is containing compositions such as isorhamnetin, Quercetin, isoquercitin, globulariacitrin and narcissins, the contained flavonoid substance of stem and leaf of Radix Bupleuri and Radix Bupeuri Scorzonerfolii. is kaempferitrin and kaempferol-7-frangulin, the twice that B. kunmingense Y. Li et S. L. Pan is Radix Bupleuri containing saponin amount.The Radix Bupleuri kind of being used as medicine is more, difference to some extent between each kind of its composition, and having summed up saikoside class is main component, has in addition volatile oil polyacetylene constituents, coumarin, lignans, flavones ingredient, plant sterol constituents and other organic acid composition.This invention overcomes and adopts a kind of Chinese medicine or other compositionss compared with the defect of present composition poor effect, and therapeutic effect is more stable simultaneously, has no side effect, without medicine Drug resistance.
The present invention has obvious bacteriostasis (body is interior, external), antiinflammatory action, analgesic activity and sharp liver and gall effect, and is obviously being better than positive drug Xiaoyanlidan capsules aspect antibacterial, analgesia, sharp liver and gall.Give continuous 180 days of rat gavage every day, its high dose 21.4g/kg reaches 50 times of quantity, to rat general status, blood, routine urinalysis, the equal non-toxic reaction of hepatic and renal function and main organs, show that the heavy dose of prolonged application of Chinese medicine preparation of the present invention reacts without overt toxicity, its usual amounts of clinical practice is safe.
Case: Li patient, man, 30 years old, suffered from hepatic ascites before 4 years, the symptoms such as belly swelling, appetite decline, complexion dark, insomnia.Liver cirrhosis once multiple relapse through failing to respond to any medical treatment, through using the Chinese medicine of the present embodiment, first the course for the treatment of patient take 3-4 time every day.After taking continuously 10 days, tympanites obviously disappears, appetite is recovered normally, complexion approaches ordinary person.
Second the course for the treatment of continuous use after 25 days, on inspection, liver function is normal, muscle power, complexion return to normal person's level, appetite increases, body weight increases 10KG, can participate in normal physical work.Through supervise investigation, over 4 years without recurrence sign.
Embodiment 2
The present invention is a kind of Chinese patent medicine that contributes to liver and gall diseases rehabilitation, by the raw material of following parts by weight, is made: 16 parts of 28 parts of Cordyceps, 119 parts of Herba Rabdosiae Lophanthoidiss, 17 parts of Rhizoma Polygoni Cuspidati, 14 parts of Rhizoma Atractylodis Macrocephalae preparatas, 9 parts of the Radix Aucklandiae, 15 parts of Radix Bupleuri, 9 parts of Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), 16 parts of Semen Pharbitidiss, 1 part of Radix Aconiti Kusnezoffii Preparata, 4 parts of Fructus Choerospondiatis, 14 parts of Herba Erodiis and Caulis Trachelospermis.
Contribute to a manufacture method for the Chinese patent medicine of liver and gall diseases rehabilitation, by following steps, made:
(1) getting Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Pharbitidis, Radix Aconiti Kusnezoffii Preparata, Fructus Choerospondiatis, Herba Erodii and Caulis Trachelospermi pulverizes;
(2) by adding 150 parts of water after Cordyceps, Herba Rabdosiae Lophanthoidis, Rhizoma Polygoni Cuspidati, Rhizoma Atractylodis Macrocephalae preparata, the Radix Aucklandiae and Radix Bupleuri mixing, decoct after 2.5 hours, take out medicinal liquid standby;
(3) will in the medicinal residues of step (2), add the water of 100 parts, decoct 2.5 hours, take out medicinal liquid;
(4) medicinal liquid step (2) and step (3) being obtained carries out mix and blend;
(5) mixture step (4) being completed carries out oven drying at low temperature 5 hours at the temperature of 60 degrees Celsius, obtains drug extract;
(6) medicated powder that adds step (1) to obtain in drug extract step (5) being obtained, is uniformly mixed, and makes pill.
King's surname patient, man, 45 years old, suffering from liver cirrhosis, ascites before 3 years, splenectomy, appetite decline, complexion dark, myasthenia of limbs, weight loss, lost work capacity.Through using the Chinese medicine of the present embodiment, first the course for the treatment of patient take 3-4 time every day.After taking continuously 15 days, appetite, sleep are normal, and complexion is clearly better, and muscle power is significantly strengthened, and body weight has to a certain degree to be increased, and feel before taking medicine and are clearly better.Second the course for the treatment of continuous use after February, on inspection, liver function is normal, muscle power, complexion return to normal person's level, can participate in normal physical work.Through supervise investigation, over 3 years without recurrence sign.
Embodiment 3
The present invention is a kind of Chinese patent medicine that contributes to liver and gall diseases rehabilitation, by the raw material of following parts by weight, is made: 12 parts of 20 parts of Cordyceps, 15 parts of Herba Rabdosiae Lophanthoidiss, 11 parts of Rhizoma Polygoni Cuspidati, 10 parts of Rhizoma Atractylodis Macrocephalae preparatas, 8 parts of the Radix Aucklandiae, 12 parts of Radix Bupleuri, 8 parts of Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), 13 parts of Semen Pharbitidiss, 3 parts of Radix Aconiti Kusnezoffii Preparatas, 3 parts of Fructus Choerospondiatis, 8 parts of Herba Erodiis and Caulis Trachelospermis.
Contribute to a manufacture method for the Chinese patent medicine of liver and gall diseases rehabilitation, by following steps, made:
(1) getting Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Pharbitidis, Radix Aconiti Kusnezoffii Preparata, Fructus Choerospondiatis, Herba Erodii and Caulis Trachelospermi pulverizes;
(2) by adding 150 parts of water after Cordyceps, Herba Rabdosiae Lophanthoidis, Rhizoma Polygoni Cuspidati, Rhizoma Atractylodis Macrocephalae preparata, the Radix Aucklandiae and Radix Bupleuri mixing, decoct after 2.5 hours, take out medicinal liquid standby;
(3) will in the medicinal residues of step (2), add the water of 100 parts, decoct 2.5 hours, take out medicinal liquid;
(4) medicinal liquid step (2) and step (3) being obtained carries out mix and blend;
(5) mixture step (4) being completed carries out oven drying at low temperature 5 hours at the temperature of 60 degrees Celsius, obtains drug extract;
(6) medicated powder that adds step (1) to obtain in drug extract step (5) being obtained, is uniformly mixed, and makes pill.
Certainly, above-mentioned explanation is not limitation of the present invention, and the present invention is also not limited to above-mentioned giving an example; those skilled in the art; in essential scope of the present invention, the variation of making, remodeling, interpolation or replacement, all should belong to protection scope of the present invention.
Claims (4)
1. a Chinese patent medicine that contributes to liver and gall diseases rehabilitation, is characterized in that: the raw material by following parts by weight is made: Cordyceps 15-28 part, Herba Rabdosiae Lophanthoidis 12-19 part, Rhizoma Polygoni Cuspidati 10-17 part, Rhizoma Atractylodis Macrocephalae preparata 8-14 part, Radix Aucklandiae 5-9 part, Radix Bupleuri 9-15 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 6-9 part, Semen Pharbitidis 12-16 part, Radix Aconiti Kusnezoffii Preparata 1-3 part, Fructus Choerospondiatis 2-4 part, Herba Erodii 6-14 part and Caulis Trachelospermi 9-16 part.
2. the Chinese patent medicine that contributes to liver and gall diseases rehabilitation according to claim 1, is characterized in that: the raw material by following parts by weight is made: Cordyceps 17-22 part, Herba Rabdosiae Lophanthoidis 15-17 part, Rhizoma Polygoni Cuspidati 12-14 part, Rhizoma Atractylodis Macrocephalae preparata 10-12 part, Radix Aucklandiae 7-8 part, Radix Bupleuri 11-13 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 7-8 part, Semen Pharbitidis 14-15 part, Radix Aconiti Kusnezoffii Preparata 2-2.5 part, Fructus Choerospondiatis 3-4 part, Herba Erodii 10-12 part and Caulis Trachelospermi 12-14 part.
3. the Chinese patent medicine that contributes to liver and gall diseases rehabilitation according to claim 1, is characterized in that: the raw material by following parts by weight is made: 9 parts of 15 parts of Cordyceps, 12 parts of Herba Rabdosiae Lophanthoidiss, 10 parts of Rhizoma Polygoni Cuspidati, 8 parts of Rhizoma Atractylodis Macrocephalae preparatas, 5 parts of the Radix Aucklandiae, 9 parts of Radix Bupleuri, 6 parts of Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), 12 parts of Semen Pharbitidiss, 2 parts of Radix Aconiti Kusnezoffii Preparatas, 3 parts of Fructus Choerospondiatis, 6 parts of Herba Erodiis and Caulis Trachelospermis.
4. a manufacture method for the Chinese patent medicine that contributes to liver and gall diseases rehabilitation of any one in claim 1-3, is characterized in that: by following steps, made:
(1) getting Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Pharbitidis, Radix Aconiti Kusnezoffii Preparata, Fructus Choerospondiatis, Herba Erodii and Caulis Trachelospermi pulverizes;
(2) by adding 150 parts of water after Cordyceps, Herba Rabdosiae Lophanthoidis, Rhizoma Polygoni Cuspidati, Rhizoma Atractylodis Macrocephalae preparata, the Radix Aucklandiae and Radix Bupleuri mixing, decoct after 2.5 hours, take out medicinal liquid standby;
(3) will in the medicinal residues of step (2), add the water of 100 parts, decoct 2.5 hours, take out medicinal liquid;
(4) medicinal liquid step (2) and step (3) being obtained carries out mix and blend;
(5) mixture step (4) being completed carries out oven drying at low temperature 5 hours at the temperature of 60 degrees Celsius, obtains drug extract;
(6) medicated powder that adds step (1) to obtain in drug extract step (5) being obtained, is uniformly mixed, and makes pill.
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| CN201310298451.3A CN103316170B (en) | 2013-07-17 | 2013-07-17 | Chinese patent medicine helpful for recovery from hepatic and gall diseases and preparation method thereof |
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| CN201310298451.3A CN103316170B (en) | 2013-07-17 | 2013-07-17 | Chinese patent medicine helpful for recovery from hepatic and gall diseases and preparation method thereof |
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| CN1047317C (en) * | 1993-01-01 | 1999-12-15 | 广东省翁源县青云山保健食品厂 | Herb of linearstripe Rabdosia drink |
| CN1122721A (en) * | 1994-11-11 | 1996-05-22 | 王君 | Yin-Yang regulating liver function bag |
| CN101124932A (en) * | 2007-06-08 | 2008-02-20 | 李运乃 | Decoction preparation for treating viral hepatitis associated with fatty liver diseases |
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