CN103269725B - 放射性缀合法 - Google Patents

放射性缀合法 Download PDF

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Publication number
CN103269725B
CN103269725B CN201180057989.4A CN201180057989A CN103269725B CN 103269725 B CN103269725 B CN 103269725B CN 201180057989 A CN201180057989 A CN 201180057989A CN 103269725 B CN103269725 B CN 103269725B
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China
Prior art keywords
peptide
formula
cys
compound
btm
Prior art date
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CN201180057989.4A
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English (en)
Chinese (zh)
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CN103269725A (zh
Inventor
B.因德雷福尔
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GE Healthcare Ltd
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GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1020314.9A external-priority patent/GB201020314D0/en
Priority claimed from GBGB1106593.5A external-priority patent/GB201106593D0/en
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Priority to CN201510440109.1A priority Critical patent/CN104984372B/zh
Publication of CN103269725A publication Critical patent/CN103269725A/zh
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Publication of CN103269725B publication Critical patent/CN103269725B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201180057989.4A 2010-12-01 2011-12-01 放射性缀合法 Active CN103269725B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510440109.1A CN104984372B (zh) 2010-12-01 2011-12-01 放射性缀合法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1020314.9A GB201020314D0 (en) 2010-12-01 2010-12-01 Apoptosis pet imaging agents
GB1020314.9 2010-12-01
US201161476805P 2011-04-19 2011-04-19
US61/476805 2011-04-19
GBGB1106593.5A GB201106593D0 (en) 2011-04-19 2011-04-19 Radioconjugation method
GB1106593.5 2011-04-19
PCT/EP2011/071506 WO2012072736A2 (en) 2010-12-01 2011-12-01 Radioconjugation method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510440109.1A Division CN104984372B (zh) 2010-12-01 2011-12-01 放射性缀合法

Publications (2)

Publication Number Publication Date
CN103269725A CN103269725A (zh) 2013-08-28
CN103269725B true CN103269725B (zh) 2015-09-23

Family

ID=45063153

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201180057989.4A Active CN103269725B (zh) 2010-12-01 2011-12-01 放射性缀合法
CN201510440109.1A Active CN104984372B (zh) 2010-12-01 2011-12-01 放射性缀合法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510440109.1A Active CN104984372B (zh) 2010-12-01 2011-12-01 放射性缀合法

Country Status (12)

Country Link
US (2) US9493504B2 (https=)
EP (2) EP2646060B1 (https=)
JP (1) JP6231882B2 (https=)
KR (1) KR20130119957A (https=)
CN (2) CN103269725B (https=)
AU (1) AU2011334881A1 (https=)
BR (1) BR112013013283A2 (https=)
CA (1) CA2819347A1 (https=)
ES (2) ES2675102T3 (https=)
MX (1) MX2013006202A (https=)
RU (1) RU2013122649A (https=)
WO (1) WO2012072736A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2819347A1 (en) * 2010-12-01 2012-06-07 Ge Healthcare Limited Radioconjugation method
GB201314936D0 (en) * 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322451D0 (en) * 2013-12-18 2014-02-05 Ge Healthcare Ltd Purification method and compositions
GB201322456D0 (en) * 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
AU2019212849B2 (en) * 2018-01-26 2024-02-29 F. Hoffmann-La Roche Ag Radiolabelled oligonucleotides and process for their preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1758925A (zh) * 2003-03-13 2006-04-12 安盛药业有限公司 生物活性载体的放射氟化方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
CA2556169C (en) * 2004-01-29 2011-11-22 Andrew Lees Use of amino-oxy functional groups in the preparation of vaccines
GB0420365D0 (en) 2004-09-14 2004-10-13 Hammersmith Imanet Ltd Radiolabelled insulin
GB0420344D0 (en) 2004-09-14 2004-10-13 Amersham Plc Diagnostic compounds
WO2008075966A2 (en) 2006-12-18 2008-06-26 Ge Healthcare As Synthesis of a radiofluorinated peptide using photolabile protecting groups
US8216548B2 (en) * 2006-12-28 2012-07-10 Ge Healthcare As Radiofluorination methods
US8545809B2 (en) * 2007-01-11 2013-10-01 Immunomedics, Inc. Methods and compositions for improved 18F labeling of proteins, peptides and other molecules
US20080274046A1 (en) * 2007-02-20 2008-11-06 Christian Prenant Radiolabelling
GB0803477D0 (en) * 2008-02-26 2008-04-02 Ge Healthcare As Therapy selection method
CA2819347A1 (en) * 2010-12-01 2012-06-07 Ge Healthcare Limited Radioconjugation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1758925A (zh) * 2003-03-13 2006-04-12 安盛药业有限公司 生物活性载体的放射氟化方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
1-Ethoxyethylidene, a New Group for the Stepwise SPPS of Aminooxyacetic Acid Containing Peptides;Ste´phanie Foillard et al.;《J. Org. Chem.》;20080104;第73卷;第983-991页 *
Electronic Generators for the Production of Positron-Emitter Labeled Radiopharmaceuticals Where Would PET Be Without Them?;N Satyamurthy et al.;《Clinical Positron Imaging》;19991001;第2卷(第5期);第233-253页 *

Also Published As

Publication number Publication date
EP3395373B1 (en) 2022-10-19
EP2646060B1 (en) 2018-05-30
RU2013122649A (ru) 2015-01-10
CA2819347A1 (en) 2012-06-07
CN104984372A (zh) 2015-10-21
ES2929507T3 (es) 2022-11-29
EP2646060A2 (en) 2013-10-09
WO2012072736A3 (en) 2012-10-18
JP6231882B2 (ja) 2017-11-15
CN104984372B (zh) 2018-11-09
US9493504B2 (en) 2016-11-15
MX2013006202A (es) 2013-07-29
EP3395373A1 (en) 2018-10-31
AU2011334881A1 (en) 2013-06-06
KR20130119957A (ko) 2013-11-01
JP2014500883A (ja) 2014-01-16
US20130259803A1 (en) 2013-10-03
ES2675102T3 (es) 2018-07-06
WO2012072736A2 (en) 2012-06-07
CN103269725A (zh) 2013-08-28
US20170044080A1 (en) 2017-02-16
BR112013013283A2 (pt) 2016-11-22

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