CN103263651A - Fresh ginger essential oil and mixed cyclodextrin inclusion compound and preparation method thereof - Google Patents
Fresh ginger essential oil and mixed cyclodextrin inclusion compound and preparation method thereof Download PDFInfo
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- CN103263651A CN103263651A CN2013101988682A CN201310198868A CN103263651A CN 103263651 A CN103263651 A CN 103263651A CN 2013101988682 A CN2013101988682 A CN 2013101988682A CN 201310198868 A CN201310198868 A CN 201310198868A CN 103263651 A CN103263651 A CN 103263651A
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Abstract
The invention belongs to the field of a medical technology and particularly relates to a fresh ginger essential oil and mixed cyclodextrin inclusion compound and a preparation method of the fresh ginger essential oil and mixed cyclodextrin inclusion compound. The invention provides a technical scheme of carrying out inclusion on a mixture of alpha-cyclodextrin and beta-cyclodextrin and fresh ginger essential oil in water, so that the inclusion rate is improved, the solubility and the stability are increased and an organic solvent used in a production process is avoided.
Description
Technical field
The present invention relates to medical technical field, particularly a kind of ginger essential oil and hybrid ring cyclodextrin inclusion compound and preparation method thereof.
Background technology
Rhizoma Zingiberis Recens is the tuber stem of ginger, Chang Zuowei flavouring agent and Chinese medicine.Ginger essential oil is the Rhizoma Zingiberis Recens main component, is a kind of faint yellow liquid that the peculiar acid of Rhizoma Zingiberis Recens is arranged to yellow clarification that extracts by the way of distillation.Ginger essential oil can be used for the treatment of effects such as fracture, rheumatism sexually transmitted disease (STD), arthritis, stasis of blood flu and influenza, cough, skin wound, carbuncle, regurgitation are felt sick, skin pain.But the highly volatile loss of ginger essential oil and the shortcoming of oxidation deterioration have had a strong impact on the inconvenience of ginger essential oil at aspects such as preparation processing, storage, transportations.And cyclodextrin mainly is stable in medical applications,, effect such as prevent from volatilizing that gentle slow release is put.
Cyclodextrin is the product that the cyclodextrin transglucosylase acts on starch, be by six above glucoses with α-1, the member cyclic oligosaccharides of 4-glycosidic bond link is made of six, seven and eight glucose molecules respectively, is the molecule of relative flexibility.Cyclodextrin has very unique space structure-molecule and becomes awl column or coniform garland, many rotatable keys and hydroxyl are arranged, in a cavity is arranged, cavity has unique inclusion function, can form the inclusion conjugate with many kinds of materials, so cyclodextrin has been widely used in fields such as food, medicine, cosmetics as good stable agent, emulsifying agent, correctives, eliminating smell agent, antioxidant.
Have bibliographical information that ginger essential oil is made clathrate with the beta-schardinger dextrin-inclusion, but its clathrate dissolubility low (＜9g/L).
At present, main component zingiberene, zingiberol, zingiberone in the overseas utilization oil of ginger, develop a kind of protecting the liver arranged, the drinks of the fatty effect of burning.A kind of good water solubility of demand, antioxidation, the Rhizoma Zingiberis Recens extract that volatility is stable, cycloheptaamylose and oil of ginger clathrate can't satisfy the demand of this series products.(dissolubility: 25 ℃ in 12.7g/100g water), (dissolubility: 25 ℃ in 1.85g/100g water) its dissolubility exceeds 6.8 times to the contrast cycloheptaamylose so we adopt cyclohexaamylose.Therefore can satisfy the demand of beverage products, consider that simultaneously composition is complicated in the oil of ginger, have some bigger molecules, therefore will add a certain amount of cycloheptaamylose.
In order better to bring into play the effect of ginger essential oil, solve the shortcoming of ginger essential oil highly volatile and oxidation deterioration, improve its stability, we adopt hybrid ring dextrin (alpha-cyclodextrin and beta-schardinger dextrin-are formed) that ginger essential oil is carried out inclusion.The hybrid ring dextrin has been gathered the advantage of alpha-cyclodextrin and beta-schardinger dextrin-, is more suitable for the material of inclusion molecular size difference, complicated component.In the inclusion process, we do not add ethanol and participate in inclusion, have avoided bringing into of other harmful substances, have simplified operation sequence, improve safety, the suitability for industrialized production of being more convenient for.
Summary of the invention
The object of the present invention is to provide a kind of antioxidation that strengthens ginger essential oil, heat resistanceheat resistant to decompose and improve the ginger essential oil of its utilization rate and hybrid ring cyclodextrin inclusion compound of different proportion and preparation method thereof.
A first aspect of the present invention provides the clathrate of a kind of ginger essential oil and hybrid ring dextrin.Described clathrate is by the hybrid ring dextrin of 9-18 part, and the ginger essential oil of 1-2 part (except specifying, the proportioning among the application, umber all are that benchmark calculates with weight) is prepared from.
Preferably, described clathrate is by 9 parts hybrid ring dextrin, and 1 part ginger essential oil is prepared from.
Described hybrid ring dextrin refers to the mixture of alpha-cyclodextrin, beta-schardinger dextrin-and gamma-cyclodextrin.Preferably, described hybrid ring dextrin is made up of 1-3 part alpha-cyclodextrin and 1 part of beta-schardinger dextrin-, best, described hybrid ring dextrin is by 2 parts of alpha-cyclodextrins and 1 part of beta-schardinger dextrin-.
In a second aspect of the present invention, provide the preparation method of the clathrate of a kind of ginger essential oil and hybrid ring dextrin:
(1) gets 9-18 part hybrid ring dextrin and mix with 70-80 part pure water, be heated to 60-70 ℃ of dissolving, be cooled to 50-60 ℃ and obtain mixing the cyclodextrin saturated solution;
(2) 1-2 part ginger essential oil is slowly joined in the above-mentioned mixing ring-type dextrin in aqueous solution, carry out the high-speed stirred enclose with cutter, system temperature is incubated between 45-60 ℃, is cooled to room temperature behind the shearing 60-80min;
(3) ginger essential oil inclusion complex in solution spray drying is obtained product.
The present invention compared with prior art has following advantage:
(1) uses the mixture of alpha-cyclodextrin and beta-schardinger dextrin-to replace beta-schardinger dextrin-ginger essential oil is carried out enclose, improved inclusion rate, increased dissolubility and stability.
(2) ginger essential oil and hybrid ring dextrin are carried out enclose in pure water, do not need to introduce the ethanol that uses in the prior art; In food and medicine under the overall situation of strict control organic solvent residual, production technology does not with an organic solvent have huge advantage undoubtedly current.
(3) the present invention is compared with prior art simple to operate, and working condition is easy to control, and the inclusion rate height is easy to realize suitability for industrialized production.
The specific embodiment
Embodiment 1: the determining of the best proportioning of alpha-cyclodextrin and beta-schardinger dextrin-
Select two kinds of different proportionings of alpha-cyclodextrin and beta-schardinger dextrin-, through repeatedly experiment, the hybrid ring dextrin that will contain different proportion carries out enclose at identical temperature, enclose under the time, select the proportioning of alpha-cyclodextrin and beta-schardinger dextrin-the best according to the height of inclusion rate.Draw the data in the form 1 by experiment:
The best proportioning of table 1 alpha-cyclodextrin and beta-schardinger dextrin-is determined table
Cyclodextrin cyclodextrin is called for short CD.
As can be seen by weight when the hybrid ring dextrin is made up of 2 parts of alpha-cyclodextrins and 1 part of beta-schardinger dextrin-, the inclusion rate of ginger essential oil is the highest from experimental result.
Embodiment 2
10 parts in hybrid ring dextrin (alpha-cyclodextrin and beta-schardinger dextrin-proportioning are 2:1), 75 parts in water, be heated to 70 ℃ and make hybrid ring dextrin saturated aqueous solution, after being cooled to 60 ℃, dropwise adding 1 part of ginger essential oil and carry out enclose under stirring with 5000r/min with cutter, system temperature is incubated about 50 ℃, shear after 70 minutes to clathrate carry out microscopy qualified after, be cooled to room temperature, ginger essential oil inclusion complex in solution spray drying is obtained product, the inclusion rate of ginger essential oil is 92.3%.
Embodiment 3
9 parts in hybrid ring dextrin (alpha-cyclodextrin and beta-schardinger dextrin-proportioning are 2:1), 70 parts in water, be heated to 60 ℃ and make hybrid ring dextrin saturated aqueous solution, after being cooled to 50 ℃, dropwise adding 1 part of ginger essential oil and carry out enclose under stirring with 5000r/min with cutter, system temperature is incubated about 55 ℃, shear after 80 minutes to clathrate carry out microscopy qualified after, be cooled to room temperature, ginger essential oil inclusion complex in solution spray drying is obtained product, the inclusion rate of ginger essential oil is 94.8%.
Embodiment 4
16 parts in hybrid ring dextrin (alpha-cyclodextrin and beta-schardinger dextrin-proportioning are 2:1), 80 parts in water, be heated to 70 ℃ and make hybrid ring dextrin saturated aqueous solution, after being cooled to 60 ℃, dropwise adding 2 parts of ginger essential oils and carry out enclose under stirring with 5000r/min with cutter, system temperature is incubated about 60 ℃, shear after 60 minutes to clathrate carry out microscopy qualified after, be cooled to room temperature, ginger essential oil inclusion complex in solution spray drying is obtained product, the inclusion rate of ginger essential oil is 84.1%.
Claims (6)
1. a ginger essential oil and hybrid ring cyclodextrin inclusion compound is characterized in that described hybrid ring dextrin refers to the mixture of alpha-cyclodextrin and beta-schardinger dextrin-.
2. ginger essential oil as claimed in claim 1 and hybrid ring cyclodextrin inclusion compound is characterized in that described clathrate is prepared from by the hybrid ring dextrin of 9-18 part and the ginger essential oil of 1-2 part.
3. ginger essential oil as claimed in claim 2 and hybrid ring cyclodextrin inclusion compound is characterized in that described clathrate is prepared from by 9 parts hybrid ring dextrin and 1 part ginger essential oil.
4. ginger essential oil as claimed in claim 1 and hybrid ring cyclodextrin inclusion compound is characterized in that described hybrid ring dextrin is made up of 1-3 part alpha-cyclodextrin and 1 part of beta-schardinger dextrin-.
5. ginger essential oil as claimed in claim 4 and hybrid ring cyclodextrin inclusion compound is characterized in that described hybrid ring dextrin is prepared from by 2 parts of alpha-cyclodextrins and 1 part of beta-schardinger dextrin-to form.
One kind prepare as each described ginger essential oil of claim 1-5 with mix Preparation methods of cyclodextrin inclusion complexes, it is characterized in that comprising the steps:
(1) gets 9-18 part hybrid ring dextrin and mix with 70-80 part pure water, be heated to 60-70 ℃ of dissolving, be cooled to 50-60 ℃ and obtain mixing the cyclodextrin saturated solution;
(2) 1-2 part ginger essential oil is slowly joined in the above-mentioned mixing ring-type dextrin in aqueous solution, carry out the high-speed stirred enclose with cutter, system temperature is incubated between 45-60 ℃, is cooled to room temperature behind the shearing 60-80min;
(3) ginger essential oil inclusion complex in solution spray drying is obtained product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103910911A (en) * | 2014-03-27 | 2014-07-09 | 华侨大学 | Preparation method of long-acting antibacterial edible film with sustained release effect |
| CN105169410A (en) * | 2015-11-04 | 2015-12-23 | 南京美凯生物科技有限公司 | Ginger essential oil cyclodextrin inclusion compound and preparation method thereof |
| CN106110276A (en) * | 2016-08-24 | 2016-11-16 | 南京财经大学 | A kind of have the complex improving functional gastrointestinal disorder effect |
Citations (3)
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| CN1229809A (en) * | 1999-02-03 | 1999-09-29 | 中国科学院广州化学研究所 | Prepn. of cassia oil and beta-cyclodextrin indusion compound |
| WO2003057133A2 (en) * | 2002-01-10 | 2003-07-17 | Lupin Limited | Herbal composition for treating various disorders including psoriasis, a process for preparation thereof and method for treatment of such disorders |
| CN101501052A (en) * | 2006-06-13 | 2009-08-05 | 嘉吉公司 | Large-particle cyclodextrin inclusion complexes and methods of preparing same |
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2013
- 2013-05-25 CN CN2013101988682A patent/CN103263651A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1229809A (en) * | 1999-02-03 | 1999-09-29 | 中国科学院广州化学研究所 | Prepn. of cassia oil and beta-cyclodextrin indusion compound |
| WO2003057133A2 (en) * | 2002-01-10 | 2003-07-17 | Lupin Limited | Herbal composition for treating various disorders including psoriasis, a process for preparation thereof and method for treatment of such disorders |
| CN101501052A (en) * | 2006-06-13 | 2009-08-05 | 嘉吉公司 | Large-particle cyclodextrin inclusion complexes and methods of preparing same |
Non-Patent Citations (4)
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| 吴秋燕等: "叶黄素浸膏的环糊精包合作用研究", 《食品工业科技》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103910911A (en) * | 2014-03-27 | 2014-07-09 | 华侨大学 | Preparation method of long-acting antibacterial edible film with sustained release effect |
| CN103910911B (en) * | 2014-03-27 | 2016-10-05 | 华侨大学 | A kind of preparation method of the long acting antibiotic edible film having slow releasing function |
| CN105169410A (en) * | 2015-11-04 | 2015-12-23 | 南京美凯生物科技有限公司 | Ginger essential oil cyclodextrin inclusion compound and preparation method thereof |
| CN106110276A (en) * | 2016-08-24 | 2016-11-16 | 南京财经大学 | A kind of have the complex improving functional gastrointestinal disorder effect |
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