CN103263645A

CN103263645A - Gastritis and gastric ulcer treatment drug

Info

Publication number: CN103263645A
Application number: CN2013101643102A
Authority: CN
Inventors: 魏守刚; 程秀菊
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-04-19
Filing date: 2013-04-19
Publication date: 2013-08-28
Anticipated expiration: 2033-04-19
Also published as: CN103263645B

Abstract

The invention discloses a gastritis and gastric ulcer treatment drug, which is characterized by comprising the following traditional Chinese medicine components: 10-20 g of prepared rhizome of rehmannia, 5-15 g of common yam rhizome, 5-15 g of cornus, 10-20 g of dodder, 5-15 g of angelica, 5-15 g of szechwan lovage rhizome, and the like, wherein the common yam rhizome, dangshen, licorice root, cuttlebone, dried ginger and coptis chinensis are adopted as main drugs, other traditional Chinese medicines are adopted as auxiliary drugs, and various drug components complement each other so as to provide effects of efficacy increase and toxic-side effect reduction, and effectively treat abdominal pain, belching, abdominal distension, poor appetite, nausea, vomiting and other gastritis and gastric ulcer symptoms.

Description

A kind of medicine for the treatment of gastritis, gastric ulcer

Technical field

The present invention relates to the field of Chinese medicines, specifically, is a kind of medicine for the treatment of chronic gastritis, gastric ulcer.

Background technology

Chronic gastritis is that the non-specific chronic inflammatory disease with gastric mucosa is the chronic gastropathy of main pathological change, and pathological changes can be confined to the part of stomach, the whole stomach that also can permeate, and clinical often have gastric acid minimizing, appetite decline, epigastric discomfort and pain, a dyspepsia etc.Chronic gastritis does not have specificity, generally can show as loss of appetite, epigastrium has glutted feel oppressed sense and pain, feels sick, belch, become thin, diarrhoea etc.The paathogenic factor that causes chronic gastritis has the chronic lesion in acute gastritis protracted course of disease, bacterial infection, medicine irritation, improper diet, nasopharynx oral cavity, achlorhydria etc.

Gastric ulcer is modal a kind of in the peptic ulcer, mainly refers to the tissue injury that surpasses muscular layer of mucosa that gastric mucosa is caused by peptic digestion liquid autodigestion.The gastric ulcer symptom often is not true to type and can shows as upper abdominal pain and epigastric discomfort etc.Various dyspeptic symptoms can appear in overwhelming majority people, but have do not have any symptom yet, until developing complications.That its common complication mainly contains is hemorrhage, perforation, pyloric obstruction, canceration.Common gastrointestinal symptom and General Symptoms mainly contain burn feeling behind belch, acid regurgitation, big belly, the breastbone, feel sick, vomiting, poor appetite etc.Burn feeling is because cardiochalasia is felt sick, vomitted many reflection ulcer and may point out ulcer to be in active stage behind acid regurgitation and the breastbone.Frequent vomiting dyspepsia, the prompting pyloric obstruction.Part patient has autonomic nervous dysfunction's symptoms such as insomnia, hyperhidrosis.

It is big to exist toxic and side effects in the medicine to gastritis, gastric ulcer at present, the unconspicuous characteristics of therapeutic effect, for example gastropine, spasmolytic treatment chronic gastritis are used for alleviating spasmic pain, but can not take for a long time, medicine such as dexamethasone, meticorten has stimulation to gastric mucosa, can increase the weight of the state of an illness of gastric ulcer, should avoid using as far as possible.

Summary of the invention

The technical problem to be solved in the present invention is to overcome above-mentioned defective, and a kind of evident in efficacy, treatment gastritis that toxic and side effects is little, the medicine of gastric ulcer are provided.

The technical solution adopted in the present invention is:

A kind of medicine for the treatment of gastritis, gastric ulcer is characterized in that, described medicine is made up of following parts by weight of Chinese traditional medicine:

Radix Rehmanniae Preparata 10-20 gram, Rhizoma Dioscoreae 5-15 gram, Fructus Corni 5-15 gram, Semen Cuscutae 10-20 gram, Radix Angelicae Sinensis 5-15 gram, Rhizoma Chuanxiong 5-15 gram, Radix Astragali 25-35 gram, Ramulus Cinnamomi 8-16 gram, Herba Asari 1-5 gram, Rhizoma Atractylodis Macrocephalae preparata 10-20 gram, Radix Codonopsis 10-20 gram, Poria 10-20 gram, Radix Glycyrrhizae 2-10 gram, extra large Octopus ocellatus Gray 15-25 gram, Rhizoma Zingiberis 4-16 gram, Radix Aucklandiae 3-17 gram, Rhizoma Coptidis 1-3 gram, Radix Aconiti Lateralis Preparata 1-7 gram, Radix Saposhnikoviae 4-16 gram.

As a kind of improvement, described medicine is made up of following parts by weight of Chinese traditional medicine:

Radix Rehmanniae Preparata 15 grams, Rhizoma Dioscoreae 10 grams, Fructus Corni 10 grams, Semen Cuscutae 15 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Chuanxiong 10 grams, the Radix Astragali 30 grams, Ramulus Cinnamomi 12 grams, Herba Asari 3 grams, Rhizoma Atractylodis Macrocephalae preparata 15 grams, Radix Codonopsis 15 grams, Poria 15 grams, Radix Glycyrrhizae 6 grams, extra large Octopus ocellatus Gray 20 grams, Rhizoma Zingiberis 10 grams, the Radix Aucklandiae 10 grams, Rhizoma Coptidis 2 grams, Radix Aconiti Lateralis Preparata 4 grams, Radix Saposhnikoviae 10 grams.

Optionally, described medicine is made up of following parts by weight of Chinese traditional medicine:

Radix Rehmanniae Preparata 10 grams, Rhizoma Dioscoreae 5 grams, Fructus Corni 5 grams, Semen Cuscutae 10 grams, Radix Angelicae Sinensis 5 grams, Rhizoma Chuanxiong 5 grams, the Radix Astragali 25 grams, Ramulus Cinnamomi 8 grams, Herba Asari 1 gram, Rhizoma Atractylodis Macrocephalae preparata 10 grams, Radix Codonopsis 10 grams, Poria 10 grams, Radix Glycyrrhizae 2 grams, extra large Octopus ocellatus Gray 15 grams, Rhizoma Zingiberis 4 grams, the Radix Aucklandiae 3 grams, Rhizoma Coptidis 1 gram, Radix Aconiti Lateralis Preparata 1 gram, Radix Saposhnikoviae 4 grams.

Radix Rehmanniae Preparata 20 grams, Rhizoma Dioscoreae 15 grams, Fructus Corni 15 grams, Semen Cuscutae 20 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 15 grams, the Radix Astragali 35 grams, Ramulus Cinnamomi 16 grams, Herba Asari 5 grams, Rhizoma Atractylodis Macrocephalae preparata 20 grams, Radix Codonopsis 20 grams, Poria 20 grams, Radix Glycyrrhizae 10 grams, extra large Octopus ocellatus Gray 25 grams, Rhizoma Zingiberis 16 grams, the Radix Aucklandiae 17 grams, Rhizoma Coptidis 3 grams, Radix Aconiti Lateralis Preparata 7 grams, Radix Saposhnikoviae 16 grams.

Wherein:

But Radix Rehmanniae Preparata tonifying blood and regulating menstruation, nourishing kidney liver, tool vasa vasorum, blood sugar lowering, hypotensive activity.

Rhizoma Dioscoreae has the spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, is used for that insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung are breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst, and is one of important principal agent of the present invention.

Fructus Corni nourishing the liver and kidney, yin fluid astringing, hidroschesis, emergency treatment of collapse are applicable to diseases such as soreness of the waist and knees due to Liver and kidney two void, vertigo and tinnitus, sexual impotence, seminal emission, frequent micturition, incessant sweating due to debility.

Semen Cuscutae has the effect of the solid tire of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, spleen invigorating, cures mainly lumbago tinnitus, impotence and seminal emission, quenches one's thirst, sterile, enuresis incontinence, stranguria with turbid discharge leukorrhagia, the head is dim, lack of appetite is had loose bowels, frequent fetal movement.

Radix Angelicae Sinensis have enrich blood invigorate blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation, be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Rhizoma Chuanxiong has the effect of activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain, controls that air-cooled headache revolves that dizzy, hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.

The Radix Astragali has the effect of the gas of enriching blood, liver and kidney tonifying, adjusting immunity of organism.

Ramulus Cinnamomi has the effect of expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI, main air tremble with fear exterior syndrome, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea, lump in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria are used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Herba Asari have dispel the wind, cold expelling, Hang Shui, the effect of having one's ideas straightened out, can control diseases such as air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.

The effect of Rhizoma Atractylodis Macrocephalae preparata invigorating the spleen to arrest diarrhea is for diarrhea due to hypofunction of the spleen, chronic dysentery, women's diseases such as pouring band nebulousurine.

Radix Codonopsis has the effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, being used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat quenches one's thirst etc., modern pharmacology studies have shown that Radix Codonopsis has the effect of the gastrointestinal motility dysfunction of correction pathological state, antiulcer, enhancing human body immunity power, is one of important principal agent of the present invention.

Poria has promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, the anticancer effect that relieves internal heat, and contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.

Radix Glycyrrhizae has the effect of QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription, the anxious pain of main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swell and ache, infantile carbuncle, drug intoxication, alimentary toxicosis, be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, the present invention mainly utilizes the effect of Radix Glycyrrhizae treatment weakness of the spleen and stomach to alleviate gastric ulcer patient's stomach discomfort.

The sea Octopus ocellatus Gray has astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, holds back the effect of skin ulcer, be used for that Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia are had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation, external treatment bleeding due to trauma, the many pus of skin ulcer are one of important principal agents of the present invention.

Rhizoma Zingiberis has that warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the effect of dampness expectorant, warming the lung to resolve fluid-retention, and digestive system and ulcer is had certain inhibitory action, and the present invention mainly utilizes Rhizoma Zingiberis to the inhibitory action treatment gastric ulcer of digestive system and ulcer.

Radix Aucklandiae fragrance row looses, and can rise and can fall, and is used for promoting the circulation of QI to relieve pain, soothing the liver, the spleen invigorating of regulating the flow of vital energy disappears stagnant.

Rhizoma Coptidis has the effect of heat clearing and damp drying, eliminating fire and detoxication, have pharmacologically actives such as antibiotic, antitumor and arrhythmia, also have antibiotic, blood sugar lowering, antitumor, protection gastric mucosa isoreactivity, be used for that damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood are told nosebleed, conjunctival congestion, have a toothache, quenched one's thirst, the carbuncle furuncle; External treatment eczema, eczema, auditory meatus are suppurated, and are one of important principal agents of the present invention.

Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, mend that fire is supporing yang, the effect of dispersing cold for relieving pain, is used for the faint disease of contrary, cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldness vomiting and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, carbuncle of yin nature skin infection and all chronic diseaseses of excess of YIN gram sun, loss of YANG due to profuse perspiration, vomiting and diarrhoea.

Radix Saposhnikoviae has expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic effect.

The present invention is principal agent with Rhizoma Dioscoreae, Radix Codonopsis, Radix Glycyrrhizae, extra large Octopus ocellatus Gray, Rhizoma Zingiberis, Rhizoma Coptidis, other Chinese medicines are accessory drugs, the each component medicine complements each other, play the enhancement drug effect, reduce the effect of toxic and side effects, effectively treat stomachache, belch, abdominal distention, inappetence, feel sick, multiple gastritis, gastric ulcer symptom such as vomiting.

The specific embodiment

The present invention is further illustrated below in conjunction with embodiment, and following this embodiment only for explanation the present invention to the present invention without limits.

Embodiment 1: a kind of medicine for the treatment of gastritis, gastric ulcer, and described medicine is made up of following parts by weight of Chinese traditional medicine:

Embodiment 2: a kind of medicine for the treatment of gastritis, gastric ulcer, and described medicine is made up of following parts by weight of Chinese traditional medicine:

Embodiment 3: a kind of medicine for the treatment of gastritis, gastric ulcer, and described medicine is made up of following parts by weight of Chinese traditional medicine:

In addition, the step of making decoct in above-described embodiment is: selection by weight, soak 30 minutes, decoct 1 hour, filtering medicinal residues and obtain the medicinal liquid decoct.Once-a-day, take before the sleep after the supper, five days is a course for the treatment of, and can fully recover general two to five courses for the treatment of.

For safety and the curative effect that guarantees medicine of the present invention, use medicine of the present invention that treatment gastritis, gastric ulcer have been carried out observation of curative effect clinically.

One, to treating the observation of curative effect of chronic gastritis

200 routine chronic gastritis patients are divided into four groups at random, and wherein age 18-58 year, the course of disease is the shortest 2 months, and is the longest 7 years, every group of 50 routine patients.Matched group 50 routine patients, oral gentamicin sheet, each 2, every day 3 times; The treatment group has three groups, is respectively 3 groups of 2 groups of 1 group of embodiment, embodiment and embodiment, and every group is respectively 50 routine patients, gives the decoct among the embodiment of the invention 1, embodiment 2, the embodiment 3 respectively.Treatment time all is decided to be 20 days, and treatment finishes back check gastroscope statistics curative effect.

" new Chinese medicine clinical guidance principle " gastroscope diagnostic criteria that diagnostic criteria was promulgated with reference to Ministry of Public Health in 1993: mucus increases, and is attached to difficult drop-off on the mucosa, and stigma lamellar or wire are rubescent, edema, and rotten to the corn, pleat face mucosal abrasion often have white fur.

" the new Chinese medicine clinical guidance principle " that curative effect determinate standard adopts Ministry of Public Health to promulgate in 1993:

Recovery from illness: symptom, sign disappear, and chronic inflammatory disease reaches slightly under the gastroscope, and bile reflux disappears;

Produce effects: symptom disappears substantially, and the chronic inflammatory disease degree takes a turn for the better under the gastroscope, and bile reflux reduces more than 2/3;

Effectively: doing well,improving, the mucosa infection scope is dwindled more than 1/2 under the gastroscope, and the chronic inflammatory disease degree alleviates, and bile reflux reduces more than 1/2;

Invalid: as not reach effective standard or deterioration person on the contrary.

Therapeutic outcome sees Table 1.

Table 1

This a kind of its treatment gastritis cure rate of medicine for the treatment of gastritis, gastric ulcer is significantly higher than the matched group medicine, and side effect is little.

Two, to treating the observation of curative effect of gastric ulcer

80 routine gastric ulcer patients are divided into 3 groups of matched group, 2 groups of 1 group of embodiment, embodiment and embodiment, every group of 20 examples, matched group ranitidine, 1 150mg, every day 2 times at random; 3 groups of 2 groups of 1 group of embodiment, embodiment, embodiment be the decoct among oral embodiment 1, embodiment 2 and the embodiment 3 respectively, 1 time 1 dose, every day 3 times, two groups for the treatment of times all were decided to be for 4 weeks, treatment finishes back check gastroscope statistics curative effect.

" the medicine for digestive system clinical research guideline " that diagnostic criteria was promulgated with reference to Ministry of Public Health in 1993, syndrome of heat in the stomach: burning pain in the epigastrium, mouthful happiness is thirsty, desire for cold drinks, acid regurgitation.Gingival swelling and pain, dry stool yellowish urine, red tongue with yellow fur.Syndrome of cold in the stomach: stomachache with cool feeling, the pain gesture is acute, cold reviewing gently, the vomiting clear water, tongue is thick in vain.The blood stasis gastric abscess: gastralgia such as acupuncture, fix and do not move tenderness, purplish tongue.The dyspepsia card: gastral cavilty distension pain, acid regurgitation, sour is smelly dirty under rushing down, and thick fur is turbid.

" the medicine for digestive system clinical research guideline " that curative effect determinate standard was promulgated with reference to Ministry of Public Health in 1993

Recovery from illness: transference cure, ulcer healing of focus under the gastroscope, it is normal that the pathological changes mucosa recovers;

Produce effects: symptom disappears substantially, and the ulcer focus heals substantially under the gastroscope, and the pathological changes mucous membrane tissue still has mild inflammation;

Effectively: the primary and secondary symptom partly disappears, healing of focus 〉=50%;

Invalid: the primary and secondary symptom is improved entirely, ulcer healing of focus≤50%.

Therapeutic outcome sees Table 2.

Table 2

This a kind of its treatment gastric ulcer cure rate of medicine for the treatment of gastritis, gastric ulcer is significantly higher than matched group medicine, non-evident effect.

Model case:

Liu, the woman, 44 years old, high school teachers, gastralgia for many years, patient's emaciated physique, shallow complexion, gastral cavilty portion causalgia, the feed postemphasis, thirsty, dry stool, tart flavour food is advanced in happiness, the red tongue tongue is few, thready and stringy pulse.Gastroscopy is diagnosed as chronic atrophic gastritis, superficial gastritis acute active stage, companion's intestinal epithelial metaplasia.Integrative therapy for many years, the state of an illness repeatedly, nothing is clearly better, and adopts Drug therapy of the present invention, after three courses for the treatment of, above-mentioned symptom disappears, appetite is as usual, weight increase, consolidate 1 course for the treatment of of continuing to take medicine, recovery from illness is followed up a case by regular visits to and was not had recurrence in 1 year.

Zhang, man, 38 years old, the company clerk, patient's readme getting up early feeling of repletion, the sense of early expanding after the meal is even more serious, the companion retches, the time vomitus is arranged, body weight obviously alleviates over nearly 1 year, constipation, Western medicine diagnose is chronic gastritis, obeys how secondary western medicine and does not have and be clearly better, and adopts medicine of the present invention, after two courses for the treatment of, feeling of repletion alleviates to some extent, the retch transference cure, and constipation makes moderate progress, successively take medicine five courses for the treatment of, above-mentioned symptom all disappears, and defecates once a day 4.5 kilograms of weight increase, consolidate course for the treatment of of medication again, follow up a case by regular visits to and do not have recurrence in 1 year.

Money, man, 29 years old, IT company procedure person, patient's readme medical history 3 years, the gastral cavilty distension, belch, appetite is poor, sternal rib pain, irritability, above-mentioned symptom obviously increases the weight of when quarrelling with the people, the gastroscopy chronic superficial gastritis, western medical treatment does not have and is clearly better, and adopts medicine of the present invention, and after the course for the treatment of, above-mentioned symptom alleviates, after two courses for the treatment of, above-mentioned symptom disappears substantially, the random thoughts sternal rib pain, continue to take medicine after the course for the treatment of, physical recovery health is followed up a case by regular visits to after 1 year and is not had recurrence.

Claims

1. a medicine for the treatment of gastritis, gastric ulcer is characterized in that, described medicine is made up of following parts by weight of Chinese traditional medicine:

2. a kind of medicine for the treatment of gastritis, gastric ulcer according to claim 1 is characterized in that described medicine is made up of following parts by weight of Chinese traditional medicine:

3. a kind of medicine for the treatment of gastritis, gastric ulcer according to claim 1 is characterized in that described medicine is made up of following parts by weight of Chinese traditional medicine:

4. a kind of medicine for the treatment of gastritis, gastric ulcer according to claim 1 is characterized in that described medicine is made up of following parts by weight of Chinese traditional medicine: