CN103263537B - 一种治疗股骨头坏死的中药制剂 - Google Patents
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Abstract
本发明公开了一种治疗股骨头坏死的中药制剂。祖国医学将本病归属于“骨痹”、“骨蚀”的范畴。肾藏精，精生髓而充于骨，故肾之发育成长、荣枯与肾精盛衰关系密切，肾精亏虚，髓海不足，复受邪痹经络，痰血内阻是本病的病机。为此，本发明选择中药过山龙、小血藤、蛋不老、小木通、矮地茶、柘木白皮、炒杜仲、续断、龟板、竹节参、灸甘草，水煎成汤剂，经我院临床试验，总有效率达到97.7％，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗股骨头坏死的中药制剂。
背景技术
股骨头坏死是骨科领域常见的难治性疾病，严重地危害着人类健康，股骨头坏死是由于多种原因导致的股骨头局部血运不良，从而进一步缺血、坏死、骨小梁断裂、股骨头塌陷的一种病变，轻则致残，丧失劳动能力，重则瘫痪，生活不能自理，抱病终身；多年来，国内外对股骨头坏死多采用手术疗法，如人工股骨头置换术，钻孔减压术，血管植入术、骨支架术等。由于人工股骨头材料不当，加上人体自身排斥反应，致使很多患者术后出现人工股骨头松动，需重复手术，患者痛苦较大，远期疗效不佳。再加上手术指征严格等诸多因素以及费用昂贵，手术治疗不易被患者接受。
发明内容
本发明的目的是提供一种治疗股骨头坏死的中药制剂。祖国医学将本病归属于“骨痹”、“骨蚀”的范畴。肾藏精，精生髓而充于骨，故肾之发育成长，荣枯与肾精盛衰关系密切，肾精亏虚，髓海不足，复受邪痹经络，痰血内阻是本病的病机。
本发明的目的是通过以下技术方案实现的，该治疗股骨头坏死的中药制剂由以下重量份的中药制成：过山龙10-30份、小血藤5-25份、蛋不老8-15份、小木通7-20份、矮地茶14-16份、柘 木白皮9-14份、炒杜仲13-22份、续断9-18份、龟板10-15份、竹节参5-10份、炙甘草7-10份。
优选的，过山龙20份、小血藤15份、蛋不老12份、小木通14份、矮地茶15份、柘木白皮11份、炒杜仲17份、续断13份、龟板13份、竹节参7份、炙甘草8份。
制备方法按传统的制备方法水煎制成汤剂。
方中：过山龙、小血藤、蛋不老活血散瘀，消炎解毒，行气止痛，祛风湿，通经络，消坚块；矮地茶止咳化痰，祛风解毒；柘木白皮、小木通清热凉血，舒筋活络，祛湿止痛；炒杜仲、续断补肝肾，强筋骨，通血脉；龟板、竹节参滋阴潜阳，益肾健骨，滋补强壮，散淤止痛；炙甘草益气补中，清热解毒，祛痰止咳，缓解止痛。
临床资料
1、一般资料所选病例来源于2009-2010年本院治疗股骨头坏死患者260例，随机分为治疗组和对照组，治疗组130例，其中男72例、女58例。年龄：9-10岁3例，15-26岁18例27-40岁27例，41-46岁39例，47-56岁43例；对照组130例，其中男78例、女52例。年龄：9-11岁4例，16-27岁20例28-41岁26例，42-47岁37例，48-57岁43例。两组症状患者自觉症状：髋关节活动受限、活动不自如，下蹲不能或完全受限。所有患者均跋行，部分患者伴有大小腿肌肉萎缩。全部患者于治疗前均行X线检查，结果均呈不同程度的X线改变，诸如股骨头骨密度增高，骨小梁消失，骨质疏松，关节肿胀，关节间隙增宽，关节软骨下可见透明区，股骨头碎裂与塌陷，骨骺线宽而不规则等。两组年龄、性别、病情，P>0.05， 差异无显著性。
2、疗效标准治愈：髋部疼消失，下蹲起立自如，X线骨质恢复正常，患者可正常步行；显效：髋部疼痛基本消失，扔掉腋下拐杖，徒步1-2里路，X线显示骨质密度接近正常，骨小梁清晰，骨膜肿胀消失，关节腔正常；有效：髋部疼痛减轻，可徒步8-10m，能缓慢下蹲及起身，X线显示少量骨小梁，关节间隙略窄；无效：经治疗1个疗程，自觉症状及客观体征均无改善。
3、治疗方法治疗组服用本发明所述的中药制剂，每日一剂，每日分早晚二次服用；对照组采用单纯运动功能训练，两组均为一个月为一个疗程。
4、治疗结果两组治疗后疗效比较见表1。
表1两组治疗后疗效比较
两组比较具有可比性P<0.05
两组比较治疗组治愈率、总有效率，明显优于对照组，具有统计学意义P<0.05。
5、典型病例王某，女，55岁，浙江省退休工人，因用激素后致髋关节疼痛，活动受限，X线显示：骨小梁疏松，骨质破坏，显示股骨头早期坏死，此时患者髋关节不能外展和屈伸，抬腿、下蹲困难。口服上述中药制剂3个月，髋部疼痛基本消失，并可外展及屈伸，X线显示：骨小梁清晰，骨密度正常。继续服药1个月，髋部疼痛消失，活动自如、临床治愈。
具体实施方式
实施例一：称取过山龙20g、小血藤15g、蛋不老12g、小木通 14g、矮地茶15g、柘木白皮11g、炒杜仲17g、断续13g、龟板13g、竹节参7g、炙甘草8g，将上述中药水煎制成汤剂。
实施例二：称取过山龙30g、小血藤5g、蛋不老15g、小木通7g、矮地茶16g、柘木白皮9g、炒杜仲22g、断续9g、龟板15g、竹节参10g、炙甘草10g，将上述中药水煎制成汤剂。
实施例三：称取过山龙10g、小血藤25g、蛋不老8g、小木通20g、矮地茶14g、柘木白皮14g、炒杜仲13g、断续18g、龟板10g、竹节参5g、炙甘草7g，将上述中药水煎制成汤剂。
Claims (2)
1.一种治疗股骨头坏死的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：过山龙10-30份、小血藤5-25份、蛋不老8-15份、小木通7-20份、矮地茶14-16份、柘木白皮9-14份、炒杜仲13-22份、续断9-18份、龟板10-15份、竹节参5-10份、炙甘草7-10份。
2.根据权利要求1所述的一种治疗股骨头坏死的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：过山龙20份、小血藤15份、蛋不老12份、小木通14份、矮地茶15份、柘木白皮11份、炒杜仲17份、续断13份、龟板13份、竹节参7份、炙甘草8份。
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| CN102552624A (zh) * | 2011-12-30 | 2012-07-11 | 江西新和药业有限公司 | 一种治疗骨伤的药物 |
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Effective date of registration: 20170602 Address after: 17, Jiangsu 226000, Qidong City, Nantong Hai re town Patentee after: The Fifth People's Hospital of Qidong Address before: Suzhou City, Jiangsu province 215000 Industrial Park No. 6 Jinsha Road only commercial Plaza 1 building 1520 room Patentee before: Hu Yan |