CN103254209A - Process method for preparing artemether by using artemisinin - Google Patents
Process method for preparing artemether by using artemisinin Download PDFInfo
- Publication number
- CN103254209A CN103254209A CN2013101631887A CN201310163188A CN103254209A CN 103254209 A CN103254209 A CN 103254209A CN 2013101631887 A CN2013101631887 A CN 2013101631887A CN 201310163188 A CN201310163188 A CN 201310163188A CN 103254209 A CN103254209 A CN 103254209A
- Authority
- CN
- China
- Prior art keywords
- artemether
- parts
- weights
- artemisinin
- methyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a process method for preparing artemether by using artemisinin. The process method comprises the following five process steps of: step a, effectively hydrogenating artemisinin; step b, further etherifying the artemisinin; step c, carrying out decoloration treatment on the paste obtained in the step b; and step d, controlling the temperature and crystallizing in a centrifugal mode so as to obtain a rough artemether product. The process has simple and practical steps; in the step e, a fine artemether product can be obtained through refining; effective components can be obtained to the maximum extent through the process, and the waste of the effective components is prevented. The process is comprehensive and simple and convenient to operate; and the total yield is increased by 4%.
Description
Technical field
The present invention relates to Artemether production technique field, relate in particular to the processing method that a kind of Artemisinin prepares Artemether.
Background technology
Artemisinin, Artemether are all for malaria treatment, and Artemisinin is converted into Artemether through structure of modification, and the Artemether antimalarial effect is better, use safer.
Dihydroarteannuin is converted into the visible patent of Artemether and reports for work, but this invention relates to crucial two steps, and the one, Artemisinin prepares dihydroarteannuin, and the 2nd, dihydroarteannuin transforms Artemether.
By patent retrieval, there is following patented technology scheme:
Patent 1:
Application number: 200910038509.4, the applying date: 2009-04-09, the applicant: Guangzhou Si Weisen Science and Technology Ltd., open day is 2010-10-13.The invention discloses a kind of is raw material one kettle way stereospecific synthesis of beta-artemether with the Artemisinin.In methylene dichloride alkaline aqueous solution system, with sodium borohydride as reductive agent, tert.-butoxy Al catalysts, the dihydroarteannuin that obtains of reduction.Tell water, add methyl alcohol and sodium pyrosulfate, aluminum perchlorate, nickelous perchlorate etc. as the methyl-etherified catalyst for reaction, room temperature reaction 2h obtains β-Artemether productive rate and is up to 85%, and the Artemether overall yield is up to 93.5%.
Patent 2:
Application number: 201210237077.1, the applying date: 2012-07-10, the applicant: Liu Zhiqiang, open day is 2012-10-17.The invention discloses the method for a kind of β of preparation-Artemether, may further comprise the steps: (1) Artemisinin is under the effect of reductive agent, and reaction generates dihydroarteannuin; (2) dihydroarteannuin and tosic acid reaction generates β-Artemether; (3) refining: in step (2) gained Artemether crude product, adding weight is equivalent to methyl alcohol, ethanol, ethylene glycol or the Virahol of 2～4 times of Artemether crude product weight, is warming up to 35-45 ℃ of dissolving, is down to room temperature under the agitation condition earlier, be down to 0-5 ℃ again, crystallization 3～5 hours; Filter, earlier with 0-5 ℃ of freezing methyl alcohol, ethanol, ethylene glycol or washed with isopropyl alcohol, used washings weight is equivalent to 0.5-1 times of filter cake weight with the gained filter cake, under 35-45 ℃, dry to constant weight again.
Patent 3:
Application number: 201210184711.X, the applying date: 2012-06-06, the applicant: Kunming Medicine Group Stock Co., Ltd, open day is 2012-10-03.The invention discloses a kind of method that dihydroartemisin ether derivant is converted into dihydroarteannuin, dihydroartemisin ether derivant or dihydroarteannuin etherification reaction mother liquor are mixed with the ether hydrolysing agent, 0 ~ 80 ℃ of reaction 1 ~ 24h, solid collected by filtration is refining namely; Wherein the solute of ether hydrolysing agent compares ≧ 1 with the Mo Er of dihydroartemisin ether derivant, with the Mo Er ratio ≧ 1 of solute in the etherification reaction mother liquor.The method of the invention can be converted into dihydroarteannuin with dihydroartemisin ether derivant, be applicable to simultaneously and change compounds such as antimalarial active is low in the dihydroarteannuin etherification reaction mother liquor α-Artemether, α-arteether into dihydroarteannuin, the dihydroarteannuin yield height, the purity height that obtain are suitable for large-scale industrial production.
Patent in the documents does not disclose the technical scheme of this patent, can not destroy the novelty of this patent, and the combination of above documents simultaneously can not destroy the creativeness of this patent.
Summary of the invention
Technical problem to be solved by this invention is to realize that Artemisinin is to the suitability for industrialized production of Artemether; Optimize technology; Operate easier, quality is more reliable and yield has improved 4% than traditional method.
For realizing above purpose, the technical solution used in the present invention: a kind of Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get the methyl alcohol of 10 parts of weights, cool-8 ~-1 ℃; Get the methylene dichloride that 2 parts of heavy Artemisinins are dissolved in 3 parts of weights, pour in the above-described methyl alcohol, keeping temperature is-8 ~-1 ℃; Gradation adds the Calcium Chloride Powder Anhydrous of 0.54 part of heavy POTASSIUM BOROHYDRIDE and 0.34 part of weight, and 1～4 ℃ of reaction process control temperature does not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the methylene dichloride of 8 parts of weights, cool to-8 ~-3 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4 parts of heavy methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 30～32 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH6～7 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste;
Step c: in paste, add the methyl alcohol of 12 parts of weights, stirring and dissolving, the gac of 0.2 part of weight of adding keeps 20-40 ℃ of decolouring 20-40 minute, filters, and collects filtrate;
Steps d: drip the distilled water of 6.6 parts of weights in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is 20 parts of weights of methanol aqueous solution of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
Under preferable performance, in the described step of hydrogenation, the methyl alcohol of pre-standby 10 parts of weights, above-described cooling-4 ~-2 ℃; Above-described maintenance temperature is-4 ~-2 ℃; The methylene dichloride of 8 parts of weights that described continuation drops into cools to-6 ~-4 ℃.
Under preferable performance, in the described step of hydrogenation, the methyl alcohol of pre-standby 10 parts of weights, above-described cooling-3 ℃; Above-described maintenance temperature is-3 ℃; The methylene dichloride of 8 parts of weights that described continuation drops into cools to-5 ℃.
Under preferable performance, before the processing step of the recovery dichloromethane extraction liquid described in the described step b, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the methylene dichloride of 4 parts of weights.
Beneficial effect of the present invention: 1, can realize the hydrogenation of Artemisinin by step a efficiently.2, can further realize etherificate to Artemisinin by step b.3, can realize among the step c the paste that step b the obtains processing of decolouring.4, in the steps d to temperature controlling, can crystallization obtain the Artemether crude product by centrifugal, this processing step is simple, practical.5, can make with extra care by step e and obtain the Artemether elaboration.6, under preferable performance, before the processing step of the recovery dichloromethane extraction liquid described in the described step b, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the methylene dichloride of 4 parts of weights.Adopt this technology farthest to obtain effective constituent, prevented the waste of effective constituent.Technology of the present invention is comprehensive, and is easy and simple to handle, and total recovery improves 4%.
Embodiment
In order to make those skilled in the art understand technical scheme of the present invention better, describe the present invention below in conjunction with specific embodiment, the description of this part only is exemplary and explanatory, should any restriction not arranged to protection scope of the present invention.
Embodiment 1:
A kind of Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get 10kg methyl alcohol, cool-8 ℃; Get the 2kg Artemisinin and be dissolved in the 3kg methylene dichloride, pour in the above-described methyl alcohol, keeping temperature is-8 ℃; Gradation adds 0.54kg POTASSIUM BOROHYDRIDE and 0.34kg Calcium Chloride Powder Anhydrous, and 1 ℃ of reaction process control temperature does not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the 8kg methylene dichloride, cool to-8 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4kg methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 30 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH6 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste;
Step c: add 12kg methyl alcohol in paste, stirring and dissolving adds the 0.2kg gac, keeps 20 ℃ of decolourings 20 minutes, filters, and collects filtrate;
Steps d: drip 6.6kg distilled water in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is the methanol aqueous solution 20kg of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
Can access following beneficial effect by embodiment 1: 1, can realize the hydrogenation of Artemisinin efficiently by step a.2, can further realize etherificate to Artemisinin by step b.3, can realize among the step c the paste that step b the obtains processing of decolouring.4, in the steps d to temperature controlling, can crystallization obtain the Artemether crude product by centrifugal, this processing step is simple, practical.5, can make with extra care by step e and obtain the Artemether elaboration.Technology of the present invention is comprehensive, and is easy and simple to handle, and total recovery improves 4%.
Embodiment 2:
A kind of Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get 10kg methyl alcohol, cool-4 ℃; Get the 2kg Artemisinin and be dissolved in the 3kg methylene dichloride, pour in the above-described methyl alcohol, keeping temperature is-4 ℃; Gradation adds 0.54kg POTASSIUM BOROHYDRIDE and 0.34kg Calcium Chloride Powder Anhydrous, and 4 ℃ of reaction process control temperature do not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the 8kg methylene dichloride, cool to-6 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4kg methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 32 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH7 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste;
Step c: add 12kg methyl alcohol in paste, stirring and dissolving adds the 0.2kg gac, keeps 40 ℃ of decolourings 40 minutes, filters, and collects filtrate;
Steps d: drip 6.6kg distilled water in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is the methanol aqueous solution 20kg of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
Can access following beneficial effect by embodiment 2: 1, can realize the hydrogenation of Artemisinin efficiently by step a.2, can further realize etherificate to Artemisinin by step b.3, can realize among the step c the paste that step b the obtains processing of decolouring.4, in the steps d to temperature controlling, can crystallization obtain the Artemether crude product by centrifugal, this processing step is simple, practical.5, can make with extra care by step e and obtain the Artemether elaboration.Technology of the present invention is comprehensive, and is easy and simple to handle, and total recovery improves 4%.
Embodiment 3:
A kind of Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get 10kg methyl alcohol, cool-3 ℃; Get the 2kg Artemisinin and be dissolved in the 3kg methylene dichloride, pour in the above-described methyl alcohol, keeping temperature is-3 ℃; Gradation adds 0.54kg POTASSIUM BOROHYDRIDE and 0.34kg Calcium Chloride Powder Anhydrous, and 2 ℃ of reaction process control temperature do not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the 8kg methylene dichloride, cool to-5 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4kg methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 31 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH7 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste; Before the processing step of described recovery dichloromethane extraction liquid, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the 4kg methylene dichloride;
Step c: add 12kg methyl alcohol in paste, stirring and dissolving adds the 0.2kg gac, keeps 30 ℃ of decolourings 30 minutes, filters, and collects filtrate;
Steps d: drip 6.6kg distilled water in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is the methanol aqueous solution 20kg of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
Can access following beneficial effect by embodiment 3: 1, can realize the hydrogenation of Artemisinin efficiently by step a.2, can further realize etherificate to Artemisinin by step b.3, can realize among the step c the paste that step b the obtains processing of decolouring.4, in the steps d to temperature controlling, can crystallization obtain the Artemether crude product by centrifugal, this processing step is simple, practical.5, can make with extra care by step e and obtain the Artemether elaboration.6, under preferable performance, before the processing step of the recovery dichloromethane extraction liquid described in the described step b, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the methylene dichloride of 4kg; Adopt this technology farthest to obtain effective constituent, prevented the waste of effective constituent.Technology of the present invention is comprehensive, and is easy and simple to handle, and total recovery improves 4%.
Embodiment 4:
A kind of Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get 10kg methyl alcohol, cool-2 ℃; Get the 2kg Artemisinin and be dissolved in the 3kg methylene dichloride, pour in the above-described methyl alcohol, keeping temperature is-2 ℃; Gradation adds 0.54kg POTASSIUM BOROHYDRIDE and 0.34kg Calcium Chloride Powder Anhydrous, and 2 ℃ of reaction process control temperature do not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the 8kg methylene dichloride, cool to-4 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4kg methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 30 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH7 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste;
Step c: add 12kg methyl alcohol in paste, stirring and dissolving adds the 0.2kg gac, keeps 40 ℃ of decolourings 20 minutes, filters, and collects filtrate;
Steps d: drip 6.6kg distilled water in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is the methanol aqueous solution 20kg of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
Can access following beneficial effect by embodiment 4: 1, can realize the hydrogenation of Artemisinin efficiently by step a.2, can further realize etherificate to Artemisinin by step b.3, can realize among the step c the paste that step b the obtains processing of decolouring.4, in the steps d to temperature controlling, can crystallization obtain the Artemether crude product by centrifugal, this processing step is simple, practical.5, can make with extra care by step e and obtain the Artemether elaboration.Technology of the present invention is comprehensive, and is easy and simple to handle, and total recovery improves 4%.
Embodiment 5:
A kind of Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get 10kg methyl alcohol, cool-1 ℃; Get the 2kg Artemisinin and be dissolved in the 3kg methylene dichloride, pour in the above-described methyl alcohol, keeping temperature is-1 ℃; Gradation adds 0.54kg POTASSIUM BOROHYDRIDE and 0.34kg Calcium Chloride Powder Anhydrous, and 4 ℃ of reaction process control temperature do not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the 8kg methylene dichloride, cool to-3 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4kg methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 30 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH6.5 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste; Before the processing step of described recovery dichloromethane extraction liquid, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the 4kg methylene dichloride;
Step c: add 12kg methyl alcohol in paste, stirring and dissolving adds the 0.2kg gac, keeps 20 ℃ of decolourings 40 minutes, filters, and collects filtrate;
Steps d: drip 6.6kg distilled water in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is the methanol aqueous solution 20kg of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
Can access following beneficial effect by embodiment 5: 1, can realize the hydrogenation of Artemisinin efficiently by step a.2, can further realize etherificate to Artemisinin by step b.3, can realize among the step c the paste that step b the obtains processing of decolouring.4, in the steps d to temperature controlling, can crystallization obtain the Artemether crude product by centrifugal, this processing step is simple, practical.5, can make with extra care by step e and obtain the Artemether elaboration.6, under preferable performance, before the processing step of the recovery dichloromethane extraction liquid described in the described step b, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the methylene dichloride of 4kg; Adopt this technology farthest to obtain effective constituent, prevented the waste of effective constituent.Technology of the present invention is comprehensive, and is easy and simple to handle, and total recovery improves 4%.
Need to prove, in this article, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thereby make and comprise which key element process, method, article or the equipment of a series of key elements not only comprise, but also comprise other key elements of clearly not listing, or also be included as the intrinsic key element of this process, method, article or equipment.Do not having under the situation of more restrictions, the key element that is limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment that comprises key element and also have other identical element.
Used specific case herein principle of the present invention and embodiment are set forth, the explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.The above only is preferred implementation of the present invention, should be understood that, because the finiteness of literal expression, and objectively there is unlimited concrete structure, for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also make some improvement, retouching or variation, also above-mentioned technical characterictic can be made up by rights; These improve retouching, change or combination, or directly apply to other occasion without improving the design that will invent and technical scheme, all should be considered as protection scope of the present invention.
Claims (4)
1. an Artemisinin prepares the processing method of Artemether, it is characterized in that comprising following processing step:
Step a: get the methyl alcohol of 10 parts of weights, cool-8 ~-1 ℃; Get the methylene dichloride that 2 parts of heavy Artemisinins are dissolved in 3 parts of weights, pour in the above-described methyl alcohol, keeping temperature is-8 ~-1 ℃; Gradation adds the Calcium Chloride Powder Anhydrous of 0.54 part of heavy POTASSIUM BOROHYDRIDE and 0.34 part of weight, and 1～4 ℃ of reaction process control temperature does not have crystalline particle in mixed solution, and reaction finishes; Continue to drop into the methylene dichloride of 8 parts of weights, cool to-8 ~-3 ℃; Be that 2.5% hydrochloric acid soln is regulated PH3 with massfraction; Reaction finishes and appends dichloromethane extraction, collects dichloromethane extraction liquid;
Step b: add 1.4 parts of heavy methyl alcohol, the concentrated hydrochloric acid 0.1L more than 37% in dichloromethane extraction liquid, the control temperature of reaction is at 30～32 ℃, and the reaction times is 5 hours; Reaction is finished, and regulates PH6～7 with 5% sodium bicarbonate, and standing demix divides and gets dichloromethane extraction liquid layer and upper solution, reclaims dichloromethane extraction liquid, gets paste;
Step c: in paste, add the methyl alcohol of 12 parts of weights, stirring and dissolving, the gac of 0.2 part of weight of adding keeps 20-40 ℃ of decolouring 20-40 minute, filters, and collects filtrate;
Steps d: drip the distilled water of 6.6 parts of weights in filtrate, stir, the control temperature is not higher than 30 ℃, drips and finishes cooling below 5 ℃, and is centrifugal, gets crude product;
Step e: it is 20 parts of weights of methanol aqueous solution of 3:6 that the Artemether crude product adds mass ratio, the secondary of pulling an oar, and centrifugal, drying namely gets Artemether.
2. a kind of Artemisinin according to claim 1 prepares the processing method of Artemether, it is characterized in that in described step of hydrogenation, the methyl alcohol of pre-standby 10 parts of weights, above-described cooling-4 ~-2 ℃; Above-described maintenance temperature is-4 ~-2 ℃; The methylene dichloride of 8 parts of weights that described continuation drops into cools to-6 ~-4 ℃.
3. a kind of Artemisinin according to claim 2 prepares the processing method of Artemether, it is characterized in that in described step of hydrogenation, the methyl alcohol of pre-standby 10 parts of weights, above-described cooling-3 ℃; Above-described maintenance temperature is-3 ℃; The methylene dichloride of 8 parts of weights that described continuation drops into cools to-5 ℃.
4. a kind of Artemisinin according to claim 1 prepares the processing method of Artemether, it is characterized in that before the processing step of the recovery dichloromethane extraction liquid described in the described step b, extract upper solution secondary behind the standing demix, combined dichloromethane liquid respectively with the methylene dichloride of 4 parts of weights.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310163188.7A CN103254209B (en) | 2013-05-07 | 2013-05-07 | A kind of Artemisinin prepares the processing method of Artemether |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310163188.7A CN103254209B (en) | 2013-05-07 | 2013-05-07 | A kind of Artemisinin prepares the processing method of Artemether |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103254209A true CN103254209A (en) | 2013-08-21 |
| CN103254209B CN103254209B (en) | 2015-09-23 |
Family
ID=48958470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310163188.7A Active CN103254209B (en) | 2013-05-07 | 2013-05-07 | A kind of Artemisinin prepares the processing method of Artemether |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103254209B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030181513A1 (en) * | 2002-03-25 | 2003-09-25 | Council Of Scientific & Industrial Research | Single pot conversion of artemisinin into artemether |
| CN101857599A (en) * | 2009-04-09 | 2010-10-13 | 广州斯威森科技有限公司 | Industrial stereospecific synthesis of beta-artemether by using artemisinin as raw material |
| CN102731523A (en) * | 2012-07-10 | 2012-10-17 | 刘志强 | Preparation method of beta-artemether |
-
2013
- 2013-05-07 CN CN201310163188.7A patent/CN103254209B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030181513A1 (en) * | 2002-03-25 | 2003-09-25 | Council Of Scientific & Industrial Research | Single pot conversion of artemisinin into artemether |
| CN101857599A (en) * | 2009-04-09 | 2010-10-13 | 广州斯威森科技有限公司 | Industrial stereospecific synthesis of beta-artemether by using artemisinin as raw material |
| CN102731523A (en) * | 2012-07-10 | 2012-10-17 | 刘志强 | Preparation method of beta-artemether |
Non-Patent Citations (3)
| Title |
|---|
| 李雪芳，等: "β-蒿甲醚的合成工艺研究", 《化学与生物工程》 * |
| 李雪芳，等: "双氢青蒿素醚化法制备蒿甲醚的工艺优化", 《实验科学与技术》 * |
| 谢莹，等: "青蒿中青蒿素的提取分离及蒿甲醚的制备", 《中国药业》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103254209B (en) | 2015-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102249998A (en) | Method for preparing cisatracurium besylate | |
| CN103570508B (en) | Total synthesis method of trans-resveratrol | |
| CN102731523B (en) | Preparation method of beta-artemether | |
| CN103601735B (en) | A kind of method of mosictin of purifying | |
| CN107216298A (en) | A kind of preparation method of butylphenyl phthaleine | |
| CN103641780B (en) | A kind of method of purifying isoquinoline from coal tar crude product | |
| CN101838249A (en) | Method for preparing high-purity guaiacol glycidyl ether | |
| CN103254209A (en) | Process method for preparing artemether by using artemisinin | |
| CN106622070A (en) | Method for continuously preparing melatonin by using microreactor | |
| CN107235943A (en) | A kind of preparation method of high purity butylene phthalide | |
| CN103755533A (en) | Method for synthesizing anethole by taking estragole oil as raw material | |
| CN103232415A (en) | Eperisone hydrochloride production method | |
| CN103787918A (en) | Production technology for synthesizing bromoxynil | |
| CN104292197B (en) | A kind of synthetic method of Envidor | |
| CN100564384C (en) | A kind of preparation method of Iodotrimethylsilane | |
| CN101486705B (en) | Preparation of Azelnidipine alpha crystal form | |
| CN101270028B (en) | purification process of alpha-methylnaphthalene | |
| CN103772188B (en) | The preparation method of R-(+)-α-Cyclo hexyl mandelic acid | |
| CN103012071A (en) | Method for extracting and purifying resveratrol from peanut meal | |
| CN101468943B (en) | Preparation technique of 1,6-dimethoxynaphthalene | |
| CN101239947A (en) | Method for preparing cryptotanshinone | |
| CN109516908A (en) | The method of purification and its application of 1,1,3- trichloroacetone | |
| CN108047080A (en) | A kind of synthetic method of isopropyl hydrazine | |
| CN104276980B (en) | Clean production technology of 2-cyan-4'-methyl diphenyl | |
| CN108191697A (en) | A kind of method of synthetic isopropyl hydrazine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |