CN103251479B - Schlemm canal expansion stent - Google Patents
Schlemm canal expansion stent Download PDFInfo
- Publication number
- CN103251479B CN103251479B CN201310191751.1A CN201310191751A CN103251479B CN 103251479 B CN103251479 B CN 103251479B CN 201310191751 A CN201310191751 A CN 201310191751A CN 103251479 B CN103251479 B CN 103251479B
- Authority
- CN
- China
- Prior art keywords
- expandable stent
- schlemm
- sub
- lai mushi
- submounts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Prostheses (AREA)
Abstract
The invention discloses a Schlemm canal expansion stent which is in a one-way spiral shape. The outer diameter of the expansion stent is matched with the inner diameter of a Schlemm canal. The length of the expansion stent is matched with the length of the Schlemm canal. Or, the length of the expansion stent is matched with the length of the nidus of the Schlemm canal. The expansion stent can also be a secondary expansion stent. Or, the expansion stent is formed by connecting a plurality of secondary expansion stents in series. The Schlemm canal expansion stent is simple in structure, low in manufacturing process requirement, low in manufacturing cost, and beneficial for popularization and application. The Schlemm canal expansion stent is not only suitable for treatment of a late glaucoma patient, but also suitable for treatment of an early glaucoma patient and treatment of a secondary glaucoma patient.
Description
Technical field
The present invention relates to a kind of ophthalmic support, especially relate to a kind of Lai Mushi that executes that executes Lai Mushi pipe (Schlemm) for inserting ophthalmic and manage (Schlemm) expandable stent.
Background technology
Glaucoma is a kind of very serious public health disease, and glaucoma is a kind of optic nerve sick (optic nerve disease) more specifically, and it is not smooth that it is generally ophthalmic aqueous humor drainage, produces intraocular pressure and raises.Pressure in eyes raises, and makes optic nerve injury, and field range is dwindled.When patient exists lasting high intraocular pressure, can cause patient blind.
Eyes are hollow-core construction, comprise the transparent fluid that is called " aqueous humor ".Aqueous humor is formed in the back room of eyes with about 2.5 microlitres speed per minute by corpus ciliare.The fluid producing with suitable constant speed is again from crystalline lens process around, and enters in the anterior chamber of eyes by the pupil opening in iris.Once in anterior chamber, this fluid is discharged eyes by two different routes.In " uvea sclera (uveoscleral) " path, fluid filters between capsulociliary muscle fiber.This route account for flow out human body aqueous humor about 10.The major avenues of approach of flowing out the aqueous humor of human body is by " tubule " route, and this route relates to trabecular reticulum and Schlemm pipe (executing Lai Mushi pipe).
Trabecular reticulum and execute Lai Mushi pipe (Schlemm) junction between iris and sclera.Trabecular reticulum is the wedge structure extending around the periphery of eyes.It comprises the collagen bundle that is arranged to three-dimensional screen shape structure, and this collagen bundle aligns with the cell monolayer that is called trabecular meshwork cell.The outer wall of trabecular reticulum overlaps with the inwall of executing Lai Mushi pipe (Schlemm).Executing Lai Mushi pipe (Schlemm) is the tubular structure extending around the periphery of cornea.In adult, think execute Lai Mushi pipe (Schlemm) by every being divided into a series of independently closed end pipes.
Aqueous humor fluid is by the space between girder bundle, and cross the inwall of executing Lai Mushi pipe (Schlemm) and enter in this pipe, and by collecting conduit and enter episcleral veins system from executing a series of (about 25) that Lai Mushi pipe (Schlemm) discharges.Under normal circumstances, the generation of aqueous humor equals the discharge of aqueous humor, and intraocular pressure remains in 15 to 21mmHg scope quite consistently.In glaucoma, extremely high by the resistance of tubule outflow system.
In primary open-angle glaucoma (this primary open-angle glaucoma is modal glaucoma form), think that abnormal resistance is the outside and the inwall of executing Lai Mushi pipe (Schlemm) along trabecular reticulum.Primary open-angle glaucoma accounts for whole glaucomatous about 60 percent.The glaucoma of other form (for example angle sealing glaucoma and supervention glaucoma) also relates to by executing the stream that of Lai Mushi pipe (Schlemm) path and reducing, but resistance increment is due to other reason, such as machinery obstruction, inflammation remains, cell obstruction etc.
Owing to increasing resistance, will accumulate aqueous humor fluid, because aqueous humor can not be discharged fast enough.When fluid accumulation, the intraocular pressure in eyes (IOP) raises.The IOP raising, by the neural axon in compression optic nerve, also may affect the blood vessel of optic nerve is supplied with.Optic nerve sends vision to brain from eyes.Feasible glaucoma treatment method only reduces intraocular pressure at present.
Glaucomatous clinical treatment adopts progressively mode.Drug therapy normally the first treatment is selected.Can be topical or oral administration, the effect of these medicines be to reduce aqueous humor generation, or they are for increasing discharge.Current obtainable medicine has a lot of serious side effect, comprising: congestive heart disease, rapid breathing, hypertension, depression, nephrolith, aplastic anemia, sexual dysfunction and death.The compliance of medicine is subject matter, and according to estimates, the glaucoma patients that surpasses half is not followed their orthochronous dosage, thereby causes the fluctuation of intraocular pressure, causes optic nerve injury and defect of visual field.
When under medication, when reducing intra-ocular pressure power, conventionally carry out laser trabeculoplasty.In laser trabeculoplasty, the heat energy being produced by laser is applied on a plurality of discontinuity poinies in trabecular reticulum.It is believed that, laser energy stimulates the metabolism of trabecular meshwork cell in some way, and changes the extracellular material in trabecular reticulum.In about patient of 80 percent, flow of aqueous humor output increases, and IOP reduces.But, this effect can not continue the long period conventionally, and 50 percent patient developed into high pressure in 5 years.Laser surgery can not be reused conventionally.In addition, laser trabeculoplasty transplantation can not effectively be treated the primary open-angle glaucoma lower than the patient of 50 years old, can not effectively treat angle sealing glaucoma and a lot of supervention glaucomas.When laser trabeculoplasty transplantation can not fully reduce pressure, will carry out trabeculectomy so.By trabeculectomy, at sclera and anterior chamber region, form hole, this hole can make aqueous humor leave eyes by optional route.
It is trabeculectomy that glaucoma patient carries out processing mode the most conventionally, and this art formula can form artificial aqueous humor outflow pathway.Yet trabeculectomy can form the paralysed trace of scleral flap, make the artificial aqueous humor forming flow out pathway closure, thereby cause that intraocular pressure raises again, particularly for child and early youth.Successfully carrying out in the eyes of trabeculectomy at first, after operation, in three to five years, 80 percent will lose efficacy owing to filtering the paralysed trace of passage.Trabeculectomy has produced the path that makes aqueous humor go out ocular surface.Meanwhile, it has produced and has made conventionally to live in the path that ocular surface and superciliary antibacterial enter eyes.When this thing happens, may be called the interior eye infections of interior ophthalmia.Endophthalmitis causes permanent and larger vision loss conventionally.
In addition, existing aqueous humor drainage device also can form aqueous humor outflow pathway and reduce intraocular pressure.Aqueous humor drainage device is to be silicone tube, and one end of this silicone tube is arranged on plastics (polypropylene or other synthetic) plate.For aqueous humor part flow arrangement, in conjunctiva, form otch, thereby expose sclera.Plastic plate is sewn in eyes posterior face, conventionally crossing the line line.The hole of through thickness is formed in eyes at edge place by pin conventionally.Pipe inserts in eyes by this hole.The outside of pipe is covered by donor sclera or pericardium.Put back to conjunctiva, and closure of incisions tightly.Aqueous humor part flow arrangement has a lot of complication.The wall that thickens of the scar tissue forming around plastic plate provides certain resistance to outflow, reducing restriction eyes pressure in a lot of eyes.In a lot of eyes, because it is also unrestricted to flow through the fluid stream of pipe, therefore form hypotonia.Absorbable stitching thread on a lot of doctor's surrounding tube subsystems, and wait for that this stitching thread dissolves after operation, this time is enough to form scar cell around plate.Some device is included in the pressure sensitive valve in pipe, but these valves can not be worked well.Operation is carried out in posterior orbit, and a lot of patients form eye muscle imbalance and diplopia after operation.For the aqueous humor part flow arrangement of prior art, produced and made antibacterial enter the passage in eyes, and may produce endophthalmitis.
Most of problem of existing glaucoma treatment device and processing is because aqueous humor is discharged to ocular surface from inside ofeye.Therefore, need to more meet physiological system, to increase from anterior chamber to the aqueous humor fluid expulsion of executing in Lai Mushi pipe (Schlemm).In most of glaucoma patients, resistance problem is to execute between Lai Mushi pipe (Schlemm) and anterior chamber.When executing Lai Mushi pipe (Schlemm) chamber, occur narrowly or while subsiding, can cause aqueous humor drainage obstacle, thereby intraocular pressure raises, and causes glaucoma.
In December, 2012 19 Patent Office of the People's Republic of China disclose the applicant's a patent application, and publication number is: CN102824238A, denomination of invention is: a kind of Lai Mushi pipe (Schlemm) expandable stent and assembly thereof executed.The expandable stent of this Patent Application Publication be by tinsel through circumferential skewing repeatedly, axially the formed curve of inflection forms, described curve is to consist of coaxial right-handed screw ring and backpitch ring alternate and that put.Such expandable stent has less prepackage diameter and good submissive performance, but structure is comparatively complicated, and manufacture process requirement is higher, and manufacturing cost is slightly high.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Lai Mushi of executing pipe (Schlemm) expandable stent, this expandable stent, and simple in structure, manufacture process requirement is lower, and manufacturing cost is lower, is conducive to apply.
In order to solve the problems of the technologies described above, the Lai Mushi of executing pipe (Schlemm) expandable stent of the present invention is one-way spiral shape; The external diameter of described expandable stent adapts with the internal diameter of executing Lai Mushi pipe (Schlemm); The length of described expandable stent adapts with the pipe range of executing Lai Mushi pipe (Schlemm), or the length of described expandable stent adapts with the focus length of executing Lai Mushi pipe (Schlemm).
Described expandable stent is a support that is long one-way spiral shape; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is 3 ~ 15mm.
The external diameter of described support is 200um; The length of this support is 40mm; The screw pitch of this support is 10mm.
Described expandable stent is a sub-expandable stent, or, by a plurality of sub-expandable stent serial connections, formed; Described in each, sub-expandable stent is a submounts that is short one-way spiral shape; The external diameter of this submounts is 150 ~ 250um; The length of this submounts is 1 ~ 6mm; The screw pitch of this submounts is 0.1 ~ 1mm.
The external diameter of this submounts is 200um; The length of this submounts is 3mm; The screw pitch of this submounts is 0.2 ~ 0.5mm.
Described a plurality of sub-expandable stent is integrated part; Or the two ends of sub-expandable stent are provided with and expand head or be bent into earhole described in each, a plurality of described sub-expandable stents form expandable stent by suture by described head or the described earhole serial connection of expanding.
Described sub-expandable stent has 2 ~ 15.
Described sub-expandable stent has 2 ~ 5; Described in each, the two ends of sub-expandable stent are respectively equipped with suture, and the suture of every one end is from the close-by examples to those far off passed the axial center hole of all sub-expandable stents of this end successively.
The filament coiling that described expandable stent is made by elastomeric material forms; The diameter of described filament is 20 ~ 100um.
Described elastomeric material is Nitinol, Stainless steel 316 L or cochrome; The surface of described expandable stent scribbles medicine layer, and described medicine layer comprises fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine.
The present invention compared with prior art has following beneficial effect:
1, the technical program executes owing to having adopted the technological means that Lai Mushi pipe (Schlemm) expandable stent is one-way spiral shape, so this expandable stent is simple in structure, manufacture process requirement is lower, and manufacturing cost is lower, is conducive to apply.The schlemm pipe holder of this patent design can be expanded the schlemm tube chamber subsiding lastingly, promotes aqueous humor to flow into collector tube from the schlemm tube chamber of lasting expansion, thereby reduces intraocular pressure, reaches the glaucomatous object for the treatment of.
2, the technical program is a support that is long one-way spiral shape owing to having adopted expandable stent; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is the technological means of 3 ~ 15mm, so, can support all sidedly executing Lai Mushi pipe (Schlemm), be applicable to the CR Critical patient treatment of glaucoma.
3, the technical program is 200um owing to having adopted the external diameter of described support; The length of this support is 40mm; The screw pitch of this support is the technological means of 10mm, so, applicable to the CR Critical patient treatment of most of glaucomas.
4, the technical program is the technological means of a sub-expandable stent owing to having adopted expandable stent, so, can carry out the treatment of local lesion to executing Lai Mushi pipe (Schlemm).When the technological means that has adopted a plurality of sub-expandable stent serial connections to form, can treat for executing a plurality of local lesions in Lai Mushi pipe (Schlemm).Owing to having adopted each sub-expandable stent, be a submounts that is short one-way spiral shape again; The external diameter of submounts is 150 ~ 250um; The length of submounts is 1-6mm; The screw pitch of submounts is the technological means of 0.1 ~ 1mm, so, be applicable to the patient treatment lighter to glaucoma.
5, the technical program is 200um owing to having adopted the external diameter of this submounts; The length of this submounts is 3mm; The screw pitch of this submounts is the technological means of 0.2 ~ 0.5mm, so, applicable to the patient treatment lighter to most of glaucomas.
6, the technical program is owing to having adopted a plurality of sub-expandable stents to be integrated part, or, the two ends of each sub-expandable stent are provided with expands head or is bent into earhole, a plurality of sub-expandable stents form the technological means of expandable stent by suture by expanding head or earhole serial connection, so, can produce multiple different expandable stent, be applicable to different patient demands.
7, the technical program is owing to having adopted the technological means of 2 ~ 15 sub-expandable stents, so, can meet the needs to common glaucoma patient treatment.
8, the technical program is owing to having adopted described sub-expandable stent to have 2 ~ 5; The two ends of each sub-expandable stent are respectively equipped with suture, the suture of every one end is from the close-by examples to those far off successively through the technological means of the axial center hole of all sub-expandable stents of this end, so, when expandable stent, insert and execute after Lai Mushi pipe (Schlemm), the position that is conducive to adjust respectively each sub-expandable stent, its therapeutic effect is better.
9, the technical program is because the filament coiling that has adopted expandable stent to be made by elastomeric material forms, and the technological means that the diameter of filament is 20 ~ 100um, so expandable stent not only has enough elasticity, and has enough rigidity.
10, the technical program is Nitinol owing to having adopted elastomeric material, and the technological means of Stainless steel 316 L or cochrome, so expandable stent is durable in use.Again owing to having adopted the surface of expandable stent to scribble medicine layer, medicine layer comprises the technological means of fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine, so, can prevent support again narrow or endotheliocyte at rack surface, assemble.Can expand lastingly the schlemm tube chamber subsiding, promote aqueous humor to flow into collector tube from the schlemm tube chamber of lasting expansion, thereby reduce intraocular pressure, reach the glaucomatous object for the treatment of.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, the present invention is further described in detail.
Fig. 1 is the structural representation that the present invention executes Lai Mushi pipe (Schlemm) expandable stent the first embodiment.
Fig. 2 is the structural representation that the present invention executes Lai Mushi pipe (Schlemm) expandable stent the second embodiment.
Fig. 3 is intended to the improved structure of Lai Mushi pipe (Schlemm) expandable stent of executing in Fig. 2.
Fig. 4 is intended to the another kind of improved structure of Lai Mushi pipe (Schlemm) expandable stent of executing in Fig. 2.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
As shown in Figure 1, the Lai Mushi of executing pipe (Schlemm) expandable stent 1 of the present invention is one-way spiral shape; The external diameter of described expandable stent 1 adapts with the internal diameter of executing Lai Mushi pipe (Schlemm); The length of described expandable stent 1 adapts with the pipe range of executing Lai Mushi pipe (Schlemm).
Present embodiment executes owing to having adopted the technological means that Lai Mushi pipe (Schlemm) expandable stent is one-way spiral shape, so this expandable stent is simple in structure, manufacture process requirement is lower, and manufacturing cost is lower, is conducive to apply.Again owing to having adopted the external diameter of expandable stent to adapt with the internal diameter of executing Lai Mushi pipe (Schlemm); The technological means that the length of expandable stent and the pipe range of executing Lai Mushi pipe (Schlemm) adapt, so, can support treatment to executing the total length of Lai Mushi pipe (Schlemm).When technological means that the length that has adopted expandable stent and the focus length of executing Lai Mushi pipe (Schlemm) adapt, can support treatment to executing the part of Lai Mushi pipe (Schlemm).
As a kind of improvement of present embodiment, as shown in Figure 1, described expandable stent 1 is a support that is long one-way spiral shape; 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is 3 ~ 15mm.
Present embodiment is a support that is long one-way spiral shape owing to having adopted expandable stent; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is the technological means of 3 ~ 15mm, so, can support all sidedly executing Lai Mushi pipe (Schlemm), be applicable to the CR Critical patient treatment of glaucoma.。
As present embodiment, further improve, the external diameter of described support is 200um; The length of this support is 40mm; The screw pitch of this support is 10mm.
Present embodiment is 200um owing to having adopted the external diameter of support; The length of this support is 40mm; The screw pitch of this support is the technological means of 10mm, so, applicable to the CR Critical patient treatment of most of glaucomas.
As the second embodiment, as shown in Figure 2, described expandable stent 1 is a sub-expandable stent 11.Be preferably, the length of sub-expandable stent adapts with the length of executing Lai Mushi pipe (Schlemm) focus.
Present embodiment is the technological means of a sub-expandable stent owing to having adopted expandable stent, so, can carry out the treatment of local lesion to executing Lai Mushi pipe (Schlemm).
As a kind of improvement of present embodiment, as shown in Figure 3, described expandable stent 1 is formed by a plurality of sub-expandable stent 11 serial connections; Described in each, sub-expandable stent 11 is a submounts that is short one-way spiral shape; The external diameter of this submounts is 150 ~ 250um; The length of this submounts is 1 ~ 6mm; The screw pitch of this submounts is 0.1 ~ 1mm.
Present embodiment, due to the technological means that has adopted a plurality of sub-expandable stent serial connections to form, can be treated for executing a plurality of local lesions in Lai Mushi pipe (Schlemm).Owing to having adopted each sub-expandable stent, be a submounts that is short one-way spiral shape again; The external diameter of support is 150 ~ 250um; The length of submounts is 1-6mm; The screw pitch of submounts is the technological means of 0.1 ~ 1mm, so, be applicable to the patient treatment lighter to glaucoma.
As present embodiment, further improve, the external diameter of described support is 200um; The length of submounts is 3mm; The screw pitch of submounts is 0.2 ~ 0.5mm.
Present embodiment is 200um owing to having adopted the external diameter of support; The length of submounts is 3mm; The screw pitch of submounts is the technological means of 0.2 ~ 0.5mm, so, applicable to the patient treatment lighter to most of glaucomas.
As a kind of improvement of present embodiment, described a plurality of sub-expandable stents 11 are integrated part (referring to Fig. 3); Certainly, also can be described in each the two ends of sub-expandable stent 11 be respectively equipped with expand a 4(referring to Fig. 2 and Fig. 4) or be bent into earhole 3(referring to Fig. 1 and Fig. 3), a plurality of described sub-expandable stents 11 by suture 5 by described expand 4 or described earhole 3 serial connections form expandable stents 1.
Present embodiment is owing to having adopted a plurality of sub-expandable stents to be integrated part, or, the two ends of each sub-expandable stent are provided with expands head or is bent into earhole, a plurality of sub-expandable stents form the technological means of expandable stent by suture by expanding head or earhole serial connection, so, can produce multiple different expandable stent, be applicable to different patient demands.
As present embodiment, further improve, described sub-expandable stent 11 has 2-15.
Present embodiment is owing to having adopted the technological means of 2-15 sub-expandable stent, so, be applicable to common glaucomatous patient treatment.
As present embodiment, further improve, as shown in Figure 4, described sub-expandable stent 11 has 4; Described in each, the two ends of sub-expandable stent 11 are respectively equipped with suture 5, and the suture 5 of every one end is from the close-by examples to those far off passed the axial center hole 6 of all sub-expandable stent 11 of this end successively.
Present embodiment is owing to having adopted the two ends of each sub-expandable stent to be respectively equipped with suture, the suture of every one end is from the close-by examples to those far off successively through the technological means of the axial center hole of all sub-expandable stents of this end, so, the position that is conducive to adjust respectively each sub-expandable stent, its therapeutic effect is better.Certainly, the sub-expandable stent in present embodiment can be also 2,3 or 5.
As present embodiment, further improve again, the filament coiling that described expandable stent 1 is made by elastomeric material forms; The diameter of described filament is 20 ~ 100um.
Present embodiment is because the filament coiling that has adopted expandable stent to be made by elastomeric material forms, and the technological means that the diameter that the diameter of filament is described filament is 20 ~ 100um, so expandable stent not only has enough elasticity, and has enough rigidity.
As present embodiment, also further improve, the diameter of described filament is 50um.
Present embodiment is owing to having adopted the technological means that the diameter of filament is 20 ~ 100um, so the rigidity of expandable stent is best.
As present embodiment, further improve, described elastomeric material is Nitinol, Stainless steel 316 L or cochrome.
Present embodiment is Nitinol owing to having adopted elastomeric material, and the technological means of Stainless steel 316 L or cochrome, so expandable stent is durable in use.Again owing to having adopted the surface of expandable stent to scribble a kind of special material, comprise fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine, so, can prevent support again narrow or endotheliocyte at rack surface, assemble.
Fluorouracil (5-FU) and ametycin (MMC) are antiproliferative class medicines conventional in operation for glaucoma, these two kinds of medicines all can prevent that endotheliocyte and fibroblast are in the gathering of rack surface, thus can prevent from having expanded to execute Lai Mushi pipe (schlemm) tube chamber again narrow.
Rapamycin antiproliferative effect has been widely used in the coating of coronary stent, with Lai Mushi pipe (schlemm) tube chamber of executing that prevents from having expanded, forms restenosis.The support that is coated with rapamycin can make restenosis rate lower, can prevent that endotheliocyte and fibroblast are in the gathering of rack surface, thereby prevents that the Lai Mushi that executes having expanded manages (schlemm) tube chamber restenosis, can reduce the probability of repeat surgery.
Claims (8)
1. execute Lai Mushi pipe (Schlemm) expandable stent, described expandable stent is one-way spiral shape; The external diameter of described expandable stent adapts with the internal diameter of executing Lai Mushi pipe (Schlemm); The length of described expandable stent adapts with the focus length of executing Lai Mushi pipe (Schlemm); Described expandable stent is formed by a plurality of sub-expandable stent serial connections; Described in each, the two ends of sub-expandable stent are respectively equipped with suture, it is characterized in that: the suture of every one end is from the close-by examples to those far off passed the axial center hole of all sub-expandable stents of this end successively.
2. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 1, is characterized in that: described in each, sub-expandable stent is a submounts that is short one-way spiral shape; The external diameter of this submounts is 150 ~ 250um; The length of this submounts is 1 ~ 6mm; The screw pitch of this submounts is 0.1 ~ 1mm.
3. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 2, is characterized in that: the external diameter of this submounts is 200um; The length of this submounts is 3mm; The screw pitch of this submounts is 0.2 ~ 0.5mm.
4. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 2, is characterized in that: described in each, the two ends of sub-expandable stent are provided with and expand head or be bent into earhole.
5. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 4, is characterized in that: described sub-expandable stent has 2 ~ 15.
6. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 5, is characterized in that: described sub-expandable stent has 2 ~ 5.
7. according to the Lai Mushi that executes one of claim 1 to 6 Suo Shu, manage (Schlemm) expandable stent, it is characterized in that: the filament coiling that described expandable stent is made by elastomeric material forms; The diameter of described filament is 20 ~ 100um.
8. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 7, is characterized in that: described elastomeric material is Nitinol, Stainless steel 316 L or cochrome; The surface of described expandable stent scribbles medicine layer, and described medicine layer comprises fluorouracil (5-FU), ametycin (MMC) or rapamycin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310191751.1A CN103251479B (en) | 2013-05-22 | 2013-05-22 | Schlemm canal expansion stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310191751.1A CN103251479B (en) | 2013-05-22 | 2013-05-22 | Schlemm canal expansion stent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103251479A CN103251479A (en) | 2013-08-21 |
| CN103251479B true CN103251479B (en) | 2014-10-29 |
Family
ID=48955928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310191751.1A Expired - Fee Related CN103251479B (en) | 2013-05-22 | 2013-05-22 | Schlemm canal expansion stent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103251479B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769433A (en) * | 2016-01-08 | 2016-07-20 | 王素常 | Screw type Schlemm tube stent |
| CN105726203A (en) * | 2016-02-04 | 2016-07-06 | 张绍丹 | Schlemm tube probing and flushing support sleeve and use method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0898947A3 (en) * | 1997-08-15 | 1999-09-08 | GRIESHABER & CO. AG SCHAFFHAUSEN | Method and apparatus to improve the outflow of the aqueous humor of an eye |
| US20040193262A1 (en) * | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
| BRPI0519087B8 (en) * | 2004-12-16 | 2021-06-22 | Iscience Interventional Corp | instrument for inserting an implant into the schlemm's canal of the eye |
| US8657776B2 (en) * | 2011-06-14 | 2014-02-25 | Ivantis, Inc. | Ocular implants for delivery into the eye |
-
2013
- 2013-05-22 CN CN201310191751.1A patent/CN103251479B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103251479A (en) | 2013-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102824238B (en) | Schlemm tube expansion bracket and combined body thereof | |
| CN102481404B (en) | Ocular implants | |
| US20200085620A1 (en) | Methods and apparatus for treating glaucoma | |
| JP3703721B2 (en) | Shunt device for treating glaucoma | |
| JP5524841B2 (en) | Lacrimal implant and related methods | |
| CN101998846B (en) | Devices and methods for opening fluid passageways | |
| JP5406840B2 (en) | Intraocular graft | |
| US11707383B2 (en) | Inner drainage biomimetic stent for glaucoma and use thereof | |
| US20090082862A1 (en) | Ocular Implant Architectures | |
| KR20040036912A (en) | Improved shunt device and method for treating glaucoma | |
| CN108743016A (en) | A kind of miniature part flow arrangement of the glaucoma of structurally variable | |
| JP6825761B2 (en) | Drainage device for controlling intraocular pressure in glaucoma | |
| WO2022268143A1 (en) | Aqueous humor drainage device implantable in eye of glaucoma patient | |
| WO2023155565A1 (en) | Corneal path one-way aqueous humor drainage device | |
| CN103251479B (en) | Schlemm canal expansion stent | |
| CN106963543A (en) | Conduction type flexible miniature support and medicine equipment | |
| CN105434103A (en) | Miniature glaucoma drainage implant device and system | |
| US9259310B2 (en) | Device and method for ciliary muscle compression for increasing the amplitude of accommodation | |
| CN205434069U (en) | Device and system are implanted in miniature glaucoma drainage | |
| CN207168636U (en) | Conduction type flexible miniature support and medicine equipment | |
| CN114795652A (en) | Ocular implant and system thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141029 Termination date: 20190522 |