CN103230385A - 一种经皮给药系统的制备方法 - Google Patents
一种经皮给药系统的制备方法 Download PDFInfo
- Publication number
- CN103230385A CN103230385A CN2013101589733A CN201310158973A CN103230385A CN 103230385 A CN103230385 A CN 103230385A CN 2013101589733 A CN2013101589733 A CN 2013101589733A CN 201310158973 A CN201310158973 A CN 201310158973A CN 103230385 A CN103230385 A CN 103230385A
- Authority
- CN
- China
- Prior art keywords
- solution
- delivery system
- preparation
- pha
- transdermal delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000013271 transdermal drug delivery Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 32
- 229940079593 drug Drugs 0.000 claims abstract description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- 230000037317 transdermal delivery Effects 0.000 claims description 33
- 229920000298 Cellophane Polymers 0.000 claims description 7
- 229960001760 dimethyl sulfoxide Drugs 0.000 claims description 7
- 241000589776 Pseudomonas putida Species 0.000 claims description 5
- 125000000129 anionic group Chemical group 0.000 claims description 5
- 239000007795 chemical reaction product Substances 0.000 claims description 5
- 125000002091 cationic group Chemical group 0.000 claims description 3
- 239000011521 glass Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 4
- 239000000853 adhesive Substances 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 244000005700 microbiome Species 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 abstract 6
- 229920000903 polyhydroxyalkanoate Polymers 0.000 abstract 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 238000002834 transmittance Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 241000271532 Crotalus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008337 systemic blood flow Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013101589733A CN103230385A (zh) | 2013-05-02 | 2013-05-02 | 一种经皮给药系统的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013101589733A CN103230385A (zh) | 2013-05-02 | 2013-05-02 | 一种经皮给药系统的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103230385A true CN103230385A (zh) | 2013-08-07 |
Family
ID=48878505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2013101589733A Pending CN103230385A (zh) | 2013-05-02 | 2013-05-02 | 一种经皮给药系统的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103230385A (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101845414A (zh) * | 2010-04-28 | 2010-09-29 | 清华大学 | 一种制备羟基脂肪酸酯均聚物的方法及其专用菌 |
-
2013
- 2013-05-02 CN CN2013101589733A patent/CN103230385A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101845414A (zh) * | 2010-04-28 | 2010-09-29 | 清华大学 | 一种制备羟基脂肪酸酯均聚物的方法及其专用菌 |
Non-Patent Citations (2)
Title |
---|
ZHIOXIONG WANG: "《Novel Transdermal Drug Delivery System with Polyhydroxyalkanoate and Starburst Polyamidoamine Dendrimer》", 《JOURNALO F BIOSCIENCAEN D BIOENGINEERING》 * |
王志雄: "《用聚羟基脂肪酸化合物替代中药软膏剂基质可行性探讨》", 《中华中医药杂志(原中国医药学报)》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Garg et al. | Comprehensive review on additives of topical dosage forms for drug delivery | |
Trovatti et al. | Biocellulose membranes as supports for dermal release of lidocaine | |
US11058793B2 (en) | Adhesive containing microparticles | |
Rasool et al. | Development and evaluation of ibuprofen transdermal gel formulations | |
Del Olmo et al. | Wound healing and antibacterial chitosan-genipin hydrogels with controlled drug delivery for synergistic anti-inflammatory activity | |
Padhi et al. | Development of highly biocompatible Gelatin & i-Carrageenan based composite hydrogels: In depth physiochemical analysis for biomedical applications | |
CN103520007A (zh) | 皮肤活性因子类柔性纳米脂质体及其制备方法和应用 | |
Chai et al. | Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair | |
Ribeiro et al. | Nanohybrid hydrogels designed for transbuccal anesthesia | |
Guan et al. | Manufacture of pH-and HAase-responsive hydrogels with on-demand and continuous antibacterial activity for full-thickness wound healing | |
Han et al. | Hyaluronic acid and chitosan-based injectable and self-healing hydrogel with inherent antibacterial and antioxidant bioactivities | |
CN105477647A (zh) | 石墨烯量子点/壳聚糖干凝胶的制备并应用于荧光成像和药物缓释 | |
CN103265732A (zh) | 壳聚糖-乙基纤维素共混膜及其制备方法、共混凝胶 | |
Amiel et al. | Designed sponges based on chitosan and cyclodextrin polymer for a local release of ciprofloxacin in diabetic foot infections | |
CN115066521A (zh) | 基于天然聚合物的贴片产品 | |
CN104606680A (zh) | 一种负载药物的γ-聚谷氨酸水凝胶的制备方法 | |
Wang et al. | PEG-α-CD/AM/liposome@ amoxicillin double network hydrogel wound dressing—Multiple barriers for long-term drug release | |
Boateng et al. | Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules. | |
Gatabi et al. | Green preparation, characterization, evaluation of anti-melanogenesis effect and in vitro/in vivo safety profile of kojic acid hydrogel as skin lightener formulation | |
CN102657602B (zh) | 3,5-二羟基-4-异丙基二苯乙烯壳聚糖凝胶剂及其制备方法 | |
WO2014062538A1 (en) | Polysaccharide-containing hydrogels, compositions, articles, and methods | |
Balavigneswaran et al. | Mussel-inspired adhesive hydrogels based on Laponite-confined dopamine polymerization as a transdermal patch | |
Manna et al. | Recent update on alginate based promising transdermal drug delivery systems | |
Songkroh et al. | In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction | |
CN106390179A (zh) | 一种具有防粘连止血功能的聚氨酯海绵敷料及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI MEDICAL INSTRUMENTATION COLLEGE Free format text: FORMER OWNER: WANG ZHIXIONG Effective date: 20130904 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200010 HUANGPU, SHANGHAI TO: 200093 YANGPU, SHANGHAI |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20130904 Address after: 200093 No. 101, Yingkou Road, Shanghai Applicant after: Shanghai Medical Instrumentation College Address before: 200010 room 6, No. 1586, Lane 402, Zhongshan South Road, Shanghai, Huangpu District Applicant before: Wang Zhixiong |
|
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Wang Zhixiong Inventor after: Jiu Weiwei Inventor after: Yu Qianqian Inventor before: Wang Zhixiong |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: WANG ZHIXIONG TO: WANG ZHIXIONG MIAO WEIWEI YU QIANQIAN |
|
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130807 |