CN103217324B - Biochip sample application instrument - Google Patents
Biochip sample application instrument Download PDFInfo
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- CN103217324B CN103217324B CN201310122855.7A CN201310122855A CN103217324B CN 103217324 B CN103217324 B CN 103217324B CN 201310122855 A CN201310122855 A CN 201310122855A CN 103217324 B CN103217324 B CN 103217324B
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- syringe needle
- plc
- sample application
- travelling mechanism
- electric pump
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Abstract
The invention provides a biochip sample application instrument. The technical scheme is as follows: the biochip sample application instrument comprises a bracket, wherein the bracket is provided with an X-directional operation mechanism with a servo motor, a Y-directional operation mechanism and a Z-directional operation mechanism; the Z-directional operation mechanism is provided with a needle head fixing seat with a needle head; the bracket is provided with a sample application platform; and the bracket at one side of the sample application platform is provided with a sample box fixing seat, an ultrasonic washing and drying box and an electronic stroboscopic shooting device. The sample application instrument disclosed by the scheme can accurately finish sample application; and the needle head can be rapidly and conveniently washed and dried.
Description
Technical field
What the present invention relates to is a kind of point sample instrument for biochip.
Background technology
In the prior art, known technology is that biochip is at new drug development, the field such as medical diagnosis on disease and clinical monitoring is widely used, point sample instrument is exactly the device carrier for micro-biological sample to be transferred to biochip according to predetermined mode being formed microarray, present point sample instrument is mostly direct to be laid on sample application platform by biochip carrier, relative sliding can be produced like this between carrier and platform, and, Component Vectors (as cellulose membrane) itself is with electrostatic, little projection can be produced after tiling, affect the effect of point sample, during cleaning syringe needle, syringe needle is stretched in cleaning box, cleaned to syringe needle by flowing freely of water in cleaning box, because the flow velocity of water is limited, can not clean thoroughly to syringe needle, this is the weak point existing for prior art.
Summary of the invention
Object of the present invention is exactly for the deficiency existing for prior art, and provides a kind of technical scheme of biochip point sample instrument, the point sample instrument of the program, can complete point sample accurately, clean quickly and easily syringe needle, dry.
This programme is achieved by the following technical measures: a kind of biochip point sample instrument, comprise support, described support is provided with X with servomotor to travelling mechanism, Y-direction travelling mechanism and Z-direction travelling mechanism, the feature of this programme is: described Z-direction travelling mechanism is provided with the syringe needle holder with syringe needle, described support is provided with sample application platform, the support of sample application platform side is provided with sample box holder, ultrasonic cleaning drying box and electronic stroboscopic camera arrangement.
Described sample application platform comprises the paralell be fixed on support, and paralell top is fixed with panel, and described panel is provided with multiple hole, is provided with cavity between described panel and paralell, has an air pump by pipeline and cavity connects.
Described electronic stroboscopic camera arrangement is connected with a PLC, described PLC is connected with described servomotor, described PLC is also connected with the electric pump case for fixing electric pump, described electric pump case is respectively by pipeline and syringe needle, washer bottle is connected with devil liquor recovery bottle, described ultrasonic cleaning drying box is connected with devil liquor recovery bottle by pipeline, described ultrasonic cleaning drying box is connected with PLC, described PLC and upper control machine connect, liquid level sensor is provided with in described washer bottle, described liquid level sensor is connected with described PLC, described PLC is connected with air pump, one is also had to be communicated with electric pump case by pipeline for liquid bottle.
Described ultrasonic cleaning drying box comprises cleaning area and dry section, the syringe needle hole for cleaning syringe needle is provided with in cleaning area, described syringe needle hole is communicated with electric pump case, and described syringe needle hole is communicated with devil liquor recovery bottle, and the box body of described dry section is provided with multiple strip groove.
The beneficial effect of this programme can be learnt according to describing of such scheme, owing to having X in this scenario to travelling mechanism, Y-direction travelling mechanism and Z-direction travelling mechanism, Z-direction travelling mechanism is provided with the syringe needle holder with syringe needle, syringe needle can be driven to carry out titration to the position set; The panel of sample application platform there is multiple hole, there is an air pump by pipeline and cavity connects, like this when biochip carrier laid by panel, the air in cavity can be extracted out generation negative pressure with air pump, make biochip carrier smooth be layered on panel, can not bubble be produced; Syringe needle hole and strip groove on ultrasonic cleaning drying box, ultrasonic cleaning can be carried out to syringe needle by syringe needle hole, syringe needle hole is communicated with electric pump case, therefore in syringe needle hole, water flow velocity is fast, just can clean thoroughly to syringe needle in conjunction with ultrasound wave, syringe needle is connected with electric pump case by pipeline, electric pump case can supply water to syringe needle, needle wall is cleaned, strip groove can place dry paper, during dry syringe needle, owing to there being strip groove, syringe needle would not be touched disconnected, provide cost savings to enterprise, can also prevent the residual liquid of syringe needle end from affecting point sample effect; Electronic stroboscopic camera arrangement can by the dropping liquid situation of electronic capture syringe needle, and when ensure that point sample, drop evenly drips; PLC is connected with electric pump case, electronic stroboscopic camera arrangement, servomotor etc., control accordingly, control electric pump to ultrasonic cleaning drying box water supply cleaning syringe needle, control electronic stroboscopic camera arrangement to take pictures to syringe needle, when after needle aspirate sample, utilize electric stroboscopic lamp to take pictures to syringe needle, whether evenly observe sample titration, evenly, again point sample is carried out to biochip carrier; PLC also controls the electric pump in electric pump case, makes needle aspirate sample; Be provided with liquid level sensor in washer bottle, when liquid level is lower, liquid level sensor is to PLC signal, and PLC controls electric pump by the liquid suction washer bottle in standby liquid bottle.As can be seen here, compared with prior art, have outstanding substantive distinguishing features and significant progress, its beneficial effect implemented also is apparent in the present invention.
Accompanying drawing explanation
Fig. 1 is the structural representation of the specific embodiment of the invention.
Fig. 2 be the specific embodiment of the invention electrical principle block diagram.
In figure, 1 is support, and 2 is that X is to travelling mechanism, 3 is Y-direction travelling mechanism, and 4 is Z-direction travelling mechanism, and 5 is syringe needle holder, 6 is syringe needle, and 7 is sample box holder, and 8 is ultrasonic cleaning drying box, 9 is electronic stroboscopic camera arrangement, 10 is paralell, and 11 is the orbit of Y-direction travelling mechanism, and 12 is hole, 13 is air pump, 14 is electric pump case, and 15 is washer bottle, and 16 is standby liquid bottle, 17 is liquid level sensor, 18 is cleaning area, and 19 is dry section, and 20 is devil liquor recovery bottle, 21 is PLC, and 22 is servomotor.
Embodiment
For the technical characterstic of this programme can be clearly demonstrated, below by an embodiment, and in conjunction with its accompanying drawing, this programme is set forth.
Can be found out by accompanying drawing, the biochip point sample instrument of this programme, comprise support 1, described support 1 is provided with X with servomotor 22 to travelling mechanism 2, Y-direction travelling mechanism 3 and Z-direction travelling mechanism, described Z-direction travelling mechanism 2 is provided with the syringe needle holder 5 with syringe needle 6, described support 1 is provided with sample application platform, the support 1 of sample application platform side is provided with sample box holder 7, ultrasonic cleaning drying box 8 and electronic stroboscopic camera arrangement 9.
Described sample application platform comprises the paralell 10 be fixed on support 1, paralell 10 top is fixed with panel, described panel is provided with multiple hole 12, cavity is provided with between described panel and paralell 10, have an air pump 13 by pipeline and cavity connects, when sample application platform is laid biochip carrier, the air in cavity can siphon away by air pump 13, produce negative pressure, make smooth being layered on sample application platform of biochip carrier.
Described electronic stroboscopic camera arrangement 9 is connected with a PLC 21, described PLC 21 is connected with described servomotor 22, described PLC 21 is also connected with the electric pump case 14 for fixing electric pump, described electric pump case 14 is respectively by pipeline and syringe needle 6, washer bottle 15 is connected with devil liquor recovery bottle 20, described ultrasonic cleaning drying box 8 is connected with devil liquor recovery bottle 20 by pipeline, described ultrasonic cleaning drying box 8 is connected with PLC 21, during cleaning syringe needle, PLC 21 just can control the ultrasonic generator vibration in ultrasonic cleaning drying box 8, simultaneously, the electric pump that PLC 21 also controls in electric pump case 14 supplies water to syringe needle 6 and syringe needle hole, be beneficial to the cleaning of syringe needle 6, described PLC 21 connects with upper control machine, liquid level sensor 17 is provided with in described washer bottle 15, described liquid level sensor 17 is connected with described PLC 21, described PLC 21 is connected with air pump 13, one is also had to be communicated with electric pump case 14 by pipeline for liquid bottle 16.
Described ultrasonic cleaning drying box 8 comprises cleaning area 18 and dry section 19, the syringe needle hole for cleaning syringe needle 6 is provided with in cleaning area 18, described syringe needle hole is communicated with electric pump case 14, described syringe needle hole is communicated with devil liquor recovery bottle 20, and the box body in described drying 19 district is provided with multiple strip groove.
The present invention is not limited in above-mentioned embodiment, the change that those of ordinary skill in the art make in essential scope of the present invention, remodeling, interpolation or replacement, also should belong to protection scope of the present invention.
Claims (3)
1. a biochip point sample instrument, comprise support, described support is provided with X with servomotor to travelling mechanism, Y-direction travelling mechanism and Z-direction travelling mechanism, it is characterized in that: described Z-direction travelling mechanism is provided with the syringe needle holder with syringe needle, described support is provided with sample application platform, the support of sample application platform side is provided with sample box holder, ultrasonic cleaning drying box and electronic stroboscopic camera arrangement, described sample application platform comprises the paralell be fixed on support, the both sides of paralell are provided with the orbit of Y-direction travelling mechanism, paralell top is fixed with panel, described panel is provided with multiple hole, cavity is provided with between described panel and paralell, there is an air pump by pipeline and cavity connects.
2. biochip point sample instrument according to claim 1, it is characterized in that: described electronic stroboscopic camera arrangement is connected with a PLC, described PLC is connected with described servomotor, described PLC is also connected with the electric pump case for fixing electric pump, described electric pump case is respectively by pipeline and syringe needle, washer bottle is connected with devil liquor recovery bottle, described ultrasonic cleaning drying box is connected with devil liquor recovery bottle by pipeline, described ultrasonic cleaning drying box is connected with PLC, described PLC and upper control machine connect, liquid level sensor is provided with in described washer bottle, described liquid level sensor is connected with described PLC, described PLC is connected with air pump.
3. biochip point sample instrument according to claim 2, it is characterized in that: described ultrasonic cleaning drying box comprises cleaning area and dry section, the syringe needle hole for cleaning syringe needle is provided with in cleaning area, described syringe needle hole is communicated with electric pump case, described syringe needle hole is communicated with devil liquor recovery bottle, and the box body of described dry section is provided with multiple strip groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122855.7A CN103217324B (en) | 2013-04-10 | 2013-04-10 | Biochip sample application instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122855.7A CN103217324B (en) | 2013-04-10 | 2013-04-10 | Biochip sample application instrument |
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| Publication Number | Publication Date |
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| CN103217324A CN103217324A (en) | 2013-07-24 |
| CN103217324B true CN103217324B (en) | 2015-06-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310122855.7A Active CN103217324B (en) | 2013-04-10 | 2013-04-10 | Biochip sample application instrument |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103398885B (en) * | 2013-07-31 | 2015-11-04 | 重庆大学 | A kind of spot sample device for the preparation of biological test |
| CN103712956B (en) * | 2014-01-15 | 2016-05-11 | 中国科学院化学研究所 | A kind of microarray spot sample device |
| CN104826673B (en) * | 2015-03-16 | 2017-06-23 | 中国科学院微生物研究所 | Write two dimension Microfluidic droplet array device, purposes and its application method |
| CN108931415B (en) * | 2017-05-23 | 2021-02-19 | 北京诚智光辉科技有限公司 | Cell film-making dyeing all-in-one with wiper mechanism |
| CN107478476A (en) * | 2017-07-31 | 2017-12-15 | 成都博奥晶芯生物科技有限公司 | A kind of dish-style chip point sample instrument and its application method |
| GB2566111B (en) | 2017-09-05 | 2022-07-13 | Arrayjet Ltd | Method and device for producing a printed microarray and verifying the same |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3350774A (en) * | 1966-04-25 | 1967-11-07 | Lockheed Aircraft Corp | Sealant applying apparatus |
| CN2566258Y (en) * | 2002-08-29 | 2003-08-13 | 中国科学院电工研究所 | Biological chip specimen tester |
| CN1447118A (en) * | 2002-03-21 | 2003-10-08 | 中国科学院生物化学与细胞生物学研究所 | Intelligence biochip point sample instrument |
| CN201096780Y (en) * | 2007-06-26 | 2008-08-06 | 上海裕隆生物科技有限公司 | A biologic chip sampling platform |
| CN102637018A (en) * | 2012-04-10 | 2012-08-15 | 无锡国盛精密模具有限公司 | Double-closed-loop feedback positioning control system of sample applicator and control method |
| CN202511840U (en) * | 2012-04-09 | 2012-10-31 | 无锡国盛精密模具有限公司 | Liquid level detection device for biological chip sampler |
| CN202512117U (en) * | 2012-04-09 | 2012-10-31 | 无锡国盛精密模具有限公司 | Self-locking type slide mounting plate for biochip microarrayer |
| CN202555539U (en) * | 2012-04-09 | 2012-11-28 | 无锡国盛精密模具有限公司 | Automatic liquid-renewal ultrasonic cleaning cup for biochip spotter |
| CN202693392U (en) * | 2012-07-17 | 2013-01-23 | 上海聚阵生物科技有限公司 | Biochip spotting instrument |
| CN203275155U (en) * | 2013-04-10 | 2013-11-06 | 上海裕隆生物科技有限公司 | Biochip sample applicator |
-
2013
- 2013-04-10 CN CN201310122855.7A patent/CN103217324B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3350774A (en) * | 1966-04-25 | 1967-11-07 | Lockheed Aircraft Corp | Sealant applying apparatus |
| CN1447118A (en) * | 2002-03-21 | 2003-10-08 | 中国科学院生物化学与细胞生物学研究所 | Intelligence biochip point sample instrument |
| CN2566258Y (en) * | 2002-08-29 | 2003-08-13 | 中国科学院电工研究所 | Biological chip specimen tester |
| CN201096780Y (en) * | 2007-06-26 | 2008-08-06 | 上海裕隆生物科技有限公司 | A biologic chip sampling platform |
| CN202511840U (en) * | 2012-04-09 | 2012-10-31 | 无锡国盛精密模具有限公司 | Liquid level detection device for biological chip sampler |
| CN202512117U (en) * | 2012-04-09 | 2012-10-31 | 无锡国盛精密模具有限公司 | Self-locking type slide mounting plate for biochip microarrayer |
| CN202555539U (en) * | 2012-04-09 | 2012-11-28 | 无锡国盛精密模具有限公司 | Automatic liquid-renewal ultrasonic cleaning cup for biochip spotter |
| CN102637018A (en) * | 2012-04-10 | 2012-08-15 | 无锡国盛精密模具有限公司 | Double-closed-loop feedback positioning control system of sample applicator and control method |
| CN202693392U (en) * | 2012-07-17 | 2013-01-23 | 上海聚阵生物科技有限公司 | Biochip spotting instrument |
| CN203275155U (en) * | 2013-04-10 | 2013-11-06 | 上海裕隆生物科技有限公司 | Biochip sample applicator |
Non-Patent Citations (1)
| Title |
|---|
| 点样仪液滴频闪观测系统研制;周律等;《计算机应用》;20101231;第30卷(第12期);第3411页左栏及图2和图4 * |
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| Publication number | Publication date |
|---|---|
| CN103217324A (en) | 2013-07-24 |
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| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20130724 Assignee: Shanghai Lingang Financial Leasing Co.,Ltd. Assignor: Shanghai Yulong Biotech Co.,Ltd. Contract record no.: X2022980015555 Denomination of invention: A biochip spotter Granted publication date: 20150617 License type: Exclusive License Record date: 20220919 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A biochip spotter Effective date of registration: 20220920 Granted publication date: 20150617 Pledgee: Shanghai Lingang Financial Leasing Co.,Ltd. Pledgor: Shanghai Yulong Biotech Co.,Ltd. Registration number: Y2022980015779 |