CN103202852B - Medicine used for burns and scalds - Google Patents
Medicine used for burns and scalds Download PDFInfo
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- CN103202852B CN103202852B CN201310136632.6A CN201310136632A CN103202852B CN 103202852 B CN103202852 B CN 103202852B CN 201310136632 A CN201310136632 A CN 201310136632A CN 103202852 B CN103202852 B CN 103202852B
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- misgurni anguillicaudati
- mucus
- medicine
- scalds
- burn
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Abstract
The invention relates to the field of medicines, and particularly relates to a medicine used for burns and scalds. The secreted mucus on the surfaces of loaches is collected, a total polysaccharide mixture or an active polysaccharide mixture in the secreted mucus is extracted and dried to prepare particles; and the polysaccharide particles are dissolved in water to form a sticky substance, or medicines for treating burns and scalds can be added in the mucus, and the mucus is coated on the surfaces of the burn wounds and scald wounds, so as to achieve the purposes of moisturizing, inhibiting bacteria, ventilating and providing nutrition for the wounds. The medicine used for burns and scalds disclosed by the invention has the characteristics that the biological characteristics of the secreted mucus on the skins of loaches is adequately utilized; the healing of the wounds can be promoted; and in particularly, the medicine is low in cost and free from generating any adverse reaction.
Description
Technical field
The present invention relates to field of medicaments, a kind of by extracting the material obtained in Misgurni anguillicaudati epidermis mucus and the pharmaceutical formulation made specifically.
Background technology
Misgurni anguillicaudati system Cobitidae animal, meat or entirety can be used as medicine, and record and " Chinese medicine voluminous dictionary ".Its major function is invigorating the spleen and replenishing QI, protects the liver except Huang, heat-clearing and toxic substances removing, dissolving lump and resolving mass, the conventional treatment of its mucus carbuncle, otitis media among the people, external application for curing breast carcinoma, osteomyelitis etc. are smashed to pieces with live loacs, evident in efficacy, be also used to the diseases such as treatment infectious hepatitis, diabetes, hyperglycemia modern age.
Misgurnus anguillicaudatus polysaccharides is that the one extracted from Misgurni anguillicaudati mucus is dissociated active polysaccharide, it has been generally acknowledged that the biological function of Misgurnus anguillicaudatus polysaccharides comprises:
1. the liver protection effect of Misgurnus anguillicaudatus polysaccharides
Misgurni anguillicaudati has and protects the liver except yellow, and effect of heat-clearing and toxic substances removing is among the people with Misgurni anguillicaudati loose treatment icterohepatitis, has report Misgurni anguillicaudati and floral leaf thereof to have many-sided inhibitory action (volume the 4th phase Chinese medicine journal calendar year 2001 the 29th) to Experimental Hepatic Damage.Pituita Misgurni anguillicaudati has the active component of liver protection effect, and through animal experiment study, the experimental injury of Misgurnus anguillicaudatus polysaccharides to mouse liver has obvious inhibitory action.
2. the antioxidation of Misgurnus anguillicaudatus polysaccharides
Someone adopts (phase Acta Biochimica et Biophysica Sinica calendar year 2001 the 32nd 215 ~ 218 pages) chemoluminescence method and spectrophotography in number of chemical simulated system, study the effect of Misgurnus anguillicaudatus polysaccharides cleaning active oxygen, confirm that Misgurnus anguillicaudatus polysaccharides has direct scavenging action to various active oxygen, propose Misgurnus anguillicaudatus polysaccharides and the effect in antitumor, anti-aging, anti-inflammatory, Adjust-blood lipid etc. can need exploitation further.
The skin that burn causes for heating power, chemical substance, electric energy, lonizing radiation etc., the mucosa even infringement of deep tissue, wherein skin heat injury is the most common.The year number of the infected of China's burn is about 2,000 ten thousand people, and every year because of the death toll of unexpected injury, burn is only second to vehicle accident.The treatment of burn mainly adopts the method for Chinese medicine or Western medicine, and its western medicines in treatment mainly uses antibiotics to avoid wound infection.Chinese medicine and preparation for treating burn thereof are a kind of more satisfactory therapeutic modalities.
After burn causes, promoting wound healing and preventing wound infection is two keys for the treatment of, and keeps the nutrition supply of the aseptic of wound, breathability and wound site particularly important.Usually there is malnutrition, immunologic hypofunction and infection in burn patients, three's reciprocal causation simultaneously.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of medicine for burn and scald is provided.
The object of the invention is to be achieved through the following technical solutions:
For a medicine for burn and scald, comprise Misgurnus anguillicaudatus polysaccharides.
The medicine also comprising conventional therapy burn and scald becomes pharmaceutical composition.
Described conventional burn and scald medicine is chlortetracycline or Oleum Radix Arnebiae (Oleum Radix Lithospermi).
The extracting method of described Misgurnus anguillicaudatus polysaccharides is: clear water raises Misgurni anguillicaudati, and every 12 ~ 24 hours with multilamellar filtered through gauze raising clear water, filtrate collected by test tube, freezen protective; By gel filtration chromatography, extract the component of mucus middle-molecular-weihydroxyethyl between 2000 ~ 30000, then become powder through-20 ~-50 DEG C of lyophilizations or be spray dried to granule to preserve.
Described Misgurni anguillicaudati is Misgurnus mizolepis (Gunther)., Inner Mongol Misgurni anguillicaudati, cyan Misgurni anguillicaudati, intend Misgurni anguillicaudati, the body surface such as Misgurni anguillicaudati can produce mucus in two colors Misgurni anguillicaudati.
The using method of described medicine: be dissolved in pure water by Misgurnus anguillicaudatus polysaccharides dry powder, uses after regulating viscosity to 1 × 10-3 Pas ~ 0.1 Pas.
Add burn and scald medicine in Misgurnus anguillicaudatus polysaccharides dry powder, then regulate viscosity.
The described use for burn and scald medicine directly medicaments uniformity is coated in burn and scald wound surface, do not produce flowing be advisable with whole wound coverage surface.In use procedure, can cover the gauze that clear water or medicine infiltrate at polysaccharide dressing surface, moisturizing, antifouling, the drug of topical application, after 3 hours ~ 5 days, by polysaccharide dressing clean water, applies again, until cure.
Compared with prior art, good effect of the present invention is:
(1) the present invention draws materials easily, with low cost, and the course of processing is simple, can be used for large-scale production.Make full use of Misgurni anguillicaudati epidermis biological characteristic slimy, can promote wound healing, especially material is natural, with low cost and do not produce any untoward reaction.
(2) the present invention takes full advantage of the biological activitys such as Misgurnus anguillicaudatus polysaccharides antibiotic property, non-oxidizability, water solublity, anti-inflammatory, medicine of the present invention, not only can keep the breathability of wound, can also moisturizing, sterilize, nutrition, energy be provided, solve the difficult problems such as traditional burn medicine cannot suppress bacterial wound to grow, airtight, easy drying.No matter to enriching burn and scald medicine, or making full use of and the no pollution of environment Misgurni anguillicaudati resource, all there is major contribution.
(3) meanwhile, Misgurnus anguillicaudatus polysaccharides is decomposed into as free monosaccharide, for burned part provides nutrient, promotes the growth of new skin.
Accompanying drawing explanation
Fig. 1: mice healing every day number accounts for total number percentage ratio.
Fig. 2: account for total number percentage ratio without cicatrix mice number.
Detailed description of the invention
embodiment 1
Misgurnus anguillicaudatus polysaccharides extracts: clear water raises Misgurni anguillicaudati, every 12 ~ 24 hours with multilamellar filtered through gauze raising clear water, filtrate collected by test tube, by gel filtration chromatography purification, extract the component of mucus middle-molecular-weihydroxyethyl between 2000 ~ 30000, then become powder through-20 ~-50 DEG C of lyophilizations or be spray dried to granule to preserve.
Polysaccharide is dissolved in pure water, forms the glutinous thick liquid of stickiness between the Pas of 1 × 10-3 Pas ~ 0.1, test for white mice.
Adopt Aegerita duthiei, get 2 groups of healthy Kunming white mice, body weight 20 ± 10g, back subtracts hair and fixes, under waking state, high steam causes body surface area 10% ~ 20% to scald, experimental group Misgurnus anguillicaudatus polysaccharides class burn medicine process wound after wound, matched group normal saline process.Every process in 12 hours once, wound healing situation is observed every day.
Finally, as shown in Figure 1, 2, fast with the experimental mice wound healing speed ratio matched group of Misgurnus anguillicaudatus polysaccharides class burn medicine process wound, stay scar few, illustrates that Misgurnus anguillicaudatus polysaccharides class burn medicine is respond well to burn treating, reach the object for the treatment of empyrosis.
embodiment 2
When adjusting mucus, in mucus, 10:1 adds commercially available chlortetracycline unguentum (the hydrochloric chlortetracycline of every 1g unguentum is about 0.005g) in mass ratio, and matched group is normal saline, and all the other steps are with embodiment 1.
Result shows that 15 days healing rate exceed matched group 50%, remained scar ratio fewer than matched group 62%.
embodiment 3
When adjusting mucus, in mucus, 5:1 adds Oleum Radix Arnebiae (Oleum Radix Lithospermi) in mass ratio, and matched group is normal saline, and all the other steps are with embodiment 1.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, without departing from the inventive concept of the premise; can also make some improvements and modifications, these improvements and modifications also should be considered within the scope of protection of the present invention.
Claims (3)
1. the application of Misgurnus anguillicaudatus polysaccharides in preparation treatment burn and scald medicine.
2. apply as claimed in claim 1, it is characterized in that the extracting method of described Misgurnus anguillicaudatus polysaccharides is: clear water raises Misgurni anguillicaudati, every 12 ~ 24 hours with multilamellar filtered through gauze raising clear water, filtrate collected by test tube, freezen protective; By gel filtration chromatography, extract the component of mucus middle-molecular-weihydroxyethyl between 2000 ~ 30000, then become powder through-20 ~-50 DEG C of lyophilizations or be spray dried to granule to preserve.
3. apply as claimed in claim 2, it is characterized in that described Misgurni anguillicaudati is Misgurni anguillicaudati in Misgurnus mizolepis (Gunther)., Inner Mongol Misgurni anguillicaudati, cyan Misgurni anguillicaudati, plan Misgurni anguillicaudati, two colors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310136632.6A CN103202852B (en) | 2013-04-19 | 2013-04-19 | Medicine used for burns and scalds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310136632.6A CN103202852B (en) | 2013-04-19 | 2013-04-19 | Medicine used for burns and scalds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103202852A CN103202852A (en) | 2013-07-17 |
| CN103202852B true CN103202852B (en) | 2015-07-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310136632.6A Expired - Fee Related CN103202852B (en) | 2013-04-19 | 2013-04-19 | Medicine used for burns and scalds |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103202852B (en) |
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2013
- 2013-04-19 CN CN201310136632.6A patent/CN103202852B/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 泥鳅多糖对化学性肝损伤的保护作用;钦传光;《中医药学报》;20011231;第29卷(第4期);31-32 * |
| 泥鳅多糖对实验性糖尿病小鼠血糖血脂的影响;钦传光 等;《中国药理学与毒理学杂志》;20020430;第16卷(第2期);124-127 * |
| 泥鳅多糖抗炎作用的实验研究;钦传光 等;《中国药理学通报》;20011231;第17卷(第6期);715-716 * |
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|---|---|
| CN103202852A (en) | 2013-07-17 |
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Granted publication date: 20150701 Termination date: 20160419 |