CN103191215A

CN103191215A - Eye drops for treating conjunctivitis

Info

Publication number: CN103191215A
Application number: CN2013101178187A
Authority: CN
Inventors: 高蓉; 张岚; 田军政
Original assignee: 高蓉
Priority date: 2013-04-07
Filing date: 2013-04-07
Publication date: 2013-07-10
Anticipated expiration: 2033-04-07
Also published as: CN103191215B

Abstract

The invention relates to eye drops for treating conjunctivitis, which have the effect of treating the conjunctivitis by washing eyes to achieve anti-inflammatory treatment. The eye drops for treating the conjunctivitis are the externally applied eye drops which are prepared from the following traditional Chinese medicine raw materials: 13-17 parts of common jujube bark, 13-17 parts of mulberry bark, 8-12 parts of herb of ramose scouring rush, 8-12 parts of swordlike atractylodes rhizome, 10-14 parts of chrysanthemum and 8-12 parts of feather cockscomb seed. According to the invention, 319 patients (408 eyes) with the acute conjunctivitis in a group are observed after being subjected to conjunctival sac washing treatment with the eye drops disclosed by the invention so that the eye drops are proved to have significant curative effects against acute bacterial conjunctivitis.

Description

The medicament for the eyes for the treatment of conjunctivitis

Technical field

The invention belongs to human drugs manufacturing technology field, particularly treat the medicament for the eyes of conjunctivitis.

Background technology

Conjunctivitis (conjunctivitis) is the commonly encountered diseases of ophthalmology, but its sickness rate is not determined at present as yet.Because most of conjunctiva directly contacts with extraneous, therefore be subjected to easily infectious in the surrounding (as antibacterial, virus, and chlamydia etc.) and the stimulation of non-infectious factor (wound, chemical substance and physical factor etc.), and the blood vessel of conjunctiva and lymphoid tissue are abundant, and self and extraneous antigen make its sensitization easily.Be commonly called as pink eye disease.

Conjunctivitis is ephemeral infectious disease, occurs in summer and autumn well, and infectiousness is extremely strong, but normal outbreak of epidemic.Conjunctivitis itself is general and not serious to eyesight influence, but when its inflammation involves cornea or leads to complications, can cause the infringement of vision, even blind.In addition, though what big defect is conjunctivitis be not, conjunctivitis is not the sole cause of " eye hyperemia ".Eye hyperemia also will consider it is other disease of eye except conjunctivitis, as the alert news of ophthalmics such as the broken skin of cornea, iritis, glaucoma, corneal ulcer or inside ofeye inflammation, and cannot general idea.

Present treatment means has:

1, flushing conjunctival sac: when in the conjunctival sac secretions being arranged, wash, its effect mainly is cleaning, and used abluent should be nonirritant, the dust head is normal saline, 2% ~ 3% boric acid solution or 1: 5000 ~ 1: 10000 mercuric chloride (or potassium permanganate) solution, washes with undine.Flushing liquor must have suitable temperature.During flushing, the upset eyelid, the flushing conjunctival surface with face about the finger push, also is rushed out the secretions of fornix simultaneously, and head turns to homonymy simultaneously, avoids the flushing liquor person who lives in exile to branch hole.

2, local application: 1. antibacterials or antiviral eye drop: according to etiological diagnosis, select corresponding medicine.2. eye ointment: the drug level height of eye ointment, long action time is applicable to be coated with before sleeping.3. caustic: caustic has very strong sterilizing power, simultaneously also corrode conjunctiva textura epidermoidea and cause necrosis, as silver nitrate, directly smear the affected part during application, can't touch cornea, 0.5 ~ 1% silver nitrate commonly used, the eyelid that will overturn during eye drip, with the eye drop on palpebral conjunctiva, stop a moment behind the eye drip slightly, namely use normal saline flushing. or dip in a small amount of medicinal liquid with cotton swab, be applied to the palpebral conjunctiva surface, use normal saline flushing immediately.For the many persons of acute stage secretions, effect is fine, but can not prolonged application.

3, whole body therapeutic: for serious conjunctivitis, as gonococcal conjunctivitis, trachoma etc., need to treat in conjunction with systemic administration

In above-mentioned Therapeutic Method, especially will be less because give with topical treatment, simple and convenient the most frequently used, but used medicine as long as purpose is antiinflammatory, easily causes recurrence for conjunctivitis based on Western medicine.

Summary of the invention

The present invention seeks to invent a kind of medicament for the eyes for the treatment of conjunctivitis, reach the effect that anti-inflammatory treatment is treated conjunctivitis by cleaning eye.

The medicament for the eyes for the treatment of conjunctivitis, it makes the external medicament for the eyes with following raw material of Chinese medicine:

Cortex Jujubae 13-17, Cortex Mori 13-17, Herba Equiseti Hiemalis 8-12, Rhizoma Atractylodis 8-12, Flos Chrysanthemi 10-14, Semen Celosiae 8-12.

The preferential recommendation made the external medicament for the eyes with following raw material of Chinese medicine: Cortex Jujubae 15, Cortex Mori 15, Herba Equiseti Hiemalis 10, Rhizoma Atractylodis 0, Flos Chrysanthemi 12, Semen Celosiae 10.

Each component effect of the present invention is as follows:

Cortex Jujubae---stop blooding, make eye bright, control dysentery antidiarrheal, relieving cough and expelling phlegm;

Cortex Mori---eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema;

Herba Equiseti Hiemalis---dispelling wind heat, nebula removing film;

Rhizoma Atractylodis---expelling wind and dampness, invigorating the spleen to arrest diarrhea, cold expelling, block removing make eye bright;

Flos Chrysanthemi---dispelling wind and heat pathogens, suppressing the hyperactive liver make eye bright;

Semen Celosiae---liver heat removing and eyesight improving, nebula removing are used for the liver-heat conjunctival congestion, the nebula of looking unfamiliar film, blurring of vision, dizziness due to liver-fire.

The present invention adopts Cortex Jujubae, Semen Celosiae, Flos Chrysanthemi to make eye bright; It is cold to adopt Herba Equiseti Hiemalis, Rhizoma Atractylodis to dispel the wind, and uses the Cortex Mori inducing diuresis to remove edema again, totally has the inflammation-dimishing and eye brightening effect, and conjunctivitis is had better therapeutic effect.

The present invention treats with collyrium irrigation of conjunctival sac of the present invention by observation group's 319 examples (408) acute conjunctivitis patient.Prove that collyrium of the present invention is evident in efficacy to acute bacterial conjunctivitis by the flushing of sacculation film.

The specific embodiment

Prescription 1: Cortex Jujubae 15, Cortex Mori 15, Herba Equiseti Hiemalis 10, Rhizoma Atractylodis 0, Flos Chrysanthemi 12, Semen Celosiae 10.

Prescription 2: Cortex Jujubae 13, Cortex Mori 17, Herba Equiseti Hiemalis 8, Rhizoma Atractylodis 12, Flos Chrysanthemi 10, Semen Celosiae 12

Prescription 3: Cortex Jujubae 17, Cortex Mori 13, Herba Equiseti Hiemalis 12, Rhizoma Atractylodis 8, Flos Chrysanthemi 14, Semen Celosiae 8.

Above-mentioned prescription drug cleans the back extracting solution and makes external medicament for the eyes water preparation.

Embodiment of the invention treatment conjunctivitis 319 examples (408) clinical report

1 data and method

1.1 diagnosis and observation index, standards of grading diagnostic criteria are decided according to national higher medical universities and colleges' teaching materials " ophthalmology " and " ophthalmology pandect ".Morbidity is anxious, and the course of disease is short; Consciously shed tears, foreign body sensation, burning sensation or the pain etc. of itching.Conjunctival congestion, secretions is many.Is mucus earlier, after be purulence, subconjunctival hemorrhage can take place.Cytolgical examination is polynucleosis.Observation index and standards of grading: observe patient's ophthalmalgia, shed tears, secretions, eyelid redness, totally 6 of palpebral conjunctiva hyperemia, bulbar conjunctiva hyperemia are divided into 0,1 according to the degree difference, 2,3 fens 4 grades.

1.2 physical data observation group is conjunctivitis 319 examples (408), the course of disease 1～2 day is all made a definite diagnosis through the cytolgical examination of conjunctiva scraping blade before the medication, does not use the other drug treatment.

1.3 Therapeutic Method observation group adds in the 500ml normal saline solution the about 100ml of irrigation of conjunctival sac eyes, every day 2 times with preparation of the present invention (according to prescription 1 preparation) 20ml.3 days courses for the treatment of, to observe eye symptom and sign and change, scoring every day record 1 time finishes the back and judge curative effect the course for the treatment of.Follow up a case by regular visits to after January.

2 results

2.1 the criterion of therapeutical effect recovery from illness: symptom and sign all disappears; Produce effects: symptomatology disappears or the cardinal symptom sign disappears; Effectively: the cardinal symptom sign disappears substantially; Invalid: the each side symptom and sign does not have improvement.

2.2 curative effect statistics

Fully recover 301 cure rate 74%; 59 of produce effects, effective 45, invalid 3, total effective rate 99%.

Treat the back cardinal symptom simultaneously: the pain of itching, shed tears, secretions, the eyelid redness, palpebral conjunctiva hyperemia, bulbar conjunctiva hyperemia etc. are basic to disappear.

Participate in following up a case by regular visits to 290 examples (people) after one month and have only 3 examples that symptomatic recurrence was arranged, do not take to treat measure spontaneous recovery, all the other patients do not see symptomatic recurrence.

3, conclusion

The present invention totally has the inflammation-dimishing and eye brightening effect, and is evident in efficacy to acute bacterial conjunctivitis by the flushing of sacculation film.

Claims

1. treat the medicament for the eyes of conjunctivitis, it is characterized in that making the external medicament for the eyes with following raw material of Chinese medicine:

2. the medicament for the eyes for the treatment of conjunctivitis according to claim 1 is characterized in that making the external medicament for the eyes with following raw material of Chinese medicine: Cortex Jujubae 15, Cortex Mori 15, Herba Equiseti Hiemalis 10, Rhizoma Atractylodis 0, Flos Chrysanthemi 12, Semen Celosiae 10.