CN103191147A - Povidone-iodine three-component compound sterilizing-disinfecting agent - Google Patents
Povidone-iodine three-component compound sterilizing-disinfecting agent Download PDFInfo
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- CN103191147A CN103191147A CN2013101188935A CN201310118893A CN103191147A CN 103191147 A CN103191147 A CN 103191147A CN 2013101188935 A CN2013101188935 A CN 2013101188935A CN 201310118893 A CN201310118893 A CN 201310118893A CN 103191147 A CN103191147 A CN 103191147A
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Abstract
The invention discloses a povidone-iodine three-component compound sterilizing-disinfecting agent. The povidone-iodine three-component compound sterilizing-disinfecting agent disclosed by the invention is prepared from the following components in percentage by weight: 5-20% of povidone-iodine, 0.1-1% of hydroxyethyl cellulose, 0.1-1% of nonoxynol-10 and the balance of water for injection. The povidone-iodine three-component compound sterilizing-disinfecting agent disclosed by the invention can be used for producing a variety of different specifications of povidone-iodine compound prep pads, povidone-iodine compound cotton swabs, povidone-iodine compound sponge mats and povidone-iodine compound hand-washing brushes; the products are specially processed or sterilized, so that the asepsis property and the safety of the products are fully ensured; and a user can directly use the products at once after disassembling the packages, so that the cross contamination and infection of the intermediate links. The povidone-iodine three-component compound sterilizing-disinfecting agent disclosed by the invention is little in stimulation to the skin, low in toxicity and durable in function, is safe and simple to use, basically has no stimulation to the tissue and can be used for disinfecting the skin and the mucosa, for example, washing before operation, disinfecting the operation parts and wounds, washing and disinfecting the skin before and after drawing blood from artery.
Description
[technical field]
The present invention relates to a kind of medical powerful disinfectant, virus, antibacterial, fungus and mycotic spore are had stronger killing action.
[background technology]
At present, in medical treatment clinical course, the skin cleaning liquid of sterilizing usually has 3% concentration hydrogen peroxide, 70% concentration ethanol and iodine tincture, wherein iodine tincture it be that iodine is dissolved in formed liquid among the alcoholic solution of potassium iodide.Concrete using method is to dip bottled above-mentioned sterilization cleaning liquid with the cotton rod of common plastics, skin, operation and wound, injection and articles for use such as site of puncture sterilization or vessel is carried out disinfection again.In daily use, if improper use is put into sterilization cleaning liquid bottle again with used cotton rod, will cause cross infection.The disinfective action of these conventional sterilization disinfectant not only the persistent period not long, and the strain that can kill is limited, simultaneously, this class sterilization is big to tissue irritation, with clean wound, skin ulceration place, mucosal infections place, can produce pain and the damage of stimulation to the patient, patient be caused the misery that is difficult to bear.Simultaneously, it can not infiltrate deep skin effectively, more can not stop blooding.The more important thing is that these cleanout fluid or disinfectant all are uncontrolled or do not reach in the environment that GMP requires and prepare, the degree of accuracy of its composition can not get guaranteeing, and the pathogenic bacteria in the product and microorganism can not get effective control, brings very big potential safety hazard for patient or end user.
Development along with society, the raising of people's health care consciousness, people improve constantly the requirement of external disinfectant, press for that a kind of bactericidal effect is good, long sterilizing time, product safety is reliable, side effect is little, to the non-stimulated antibacterial that does not increase the weight of wound or wound pain of wound.
[summary of the invention]
The purpose of this invention is to provide the tripartite compound sterilizing disinfectant of a kind of poly-dimension cave iodine.
The tripartite compound sterilizing disinfectant of a kind of poly-dimension cave iodine, it is characterized in that: it is formulated by povidone iodine 5%-20%, ethoxy fibre, nonoxynolum-10 and water for injection, and wherein the weight percentage of each component is: povidone iodine 5%-20%; The fine 0.1%-1% of ethoxy; Nonoxynolum-10 0.1%-1%; Other are water for injection.
Embodiment one, the weight percentage of each component is: povidone iodine 11%; Hydroxyethyl-cellulose 0.1%; Nonoxynolum-10 0.2% water for injection 88.7%.
Embodiment two, the weight percentage of each component is: povidone iodine 5%; Hydroxyethyl-cellulose 0.1%; Nonoxynolum-10 0.1% water for injection 94.8%.
Embodiment three, the weight percentage of each component is: povidone iodine 20%; Hydroxyethyl-cellulose 1%; Nonoxynolum-10 1% water for injection 78%.
In component of the present invention:
Povidone iodine claims povidone iodine, Iodophors again, it is recorded the sterile products into American Pharmacopeia, British Pharmacopoeia, Japanese Pharmacopoeia and the Pharmacopoeia of the People's Republic of China present unique while, be incorporated into again in the national essential drugs catalogue in 9 years, and go through can be used on the directly disinfectant of use of health care, human body.It is generally acknowledge in the world efficient, wide spectrum, and nontoxic antibacterial, it has extremely strong sterilizing power and fungicidal spectrum widely.It has stronger killing action to staphylococcus aureus, gonococcus, bacillus pyocyaneus, treponema pallidum, hepatitis B virus, HIV (human immunodeficiency virus), trichomonas vaginitis, spore etc., in the in vitro tests that common clinically antibacterial is carried out, almost there is not a kind of antibacterial not to be killed.
Hydroxyethyl-cellulose is as a kind of surfactant of nonionic, except having thickening, suspension, bonding, floatingization, film forming, dispersion, water conservation and providing the protective colloid action, also has following character:
1, HEC dissolves in hot water or cold water, and high temperature or boil does not precipitate, and makes it have large-scale dissolubility and viscosity characteristics and non-hot gelation;
2, nonionic own can with on a large scale in other water-soluble polymers, surfactant, salt coexistence is a kind of good colloid thickening agent that contains the high concentration electrolyte solution;
3, water holding capacity exceeds one times than methylcellulose, has flow adjustment preferably;
4, to compare dispersibility the poorest for the dispersibility of HEC and the methylcellulose of generally acknowledging and hydroxypropyl emthylcellulose, but the protecting colloid ability is the strongest.
Nonoxynolum-the 10th, a kind of surface activity medicine, has the spermicide function, this material is that commercial product the present invention detects through the antibacterial test laboratory, it has stronger killing action to have biocidal efficacies to 25 kinds of antibacterials, virus, fungus, mycete, spore etc., meet U.S. FDA GLP standard, compared with common medicine antibacterial such as ethanol, its bactericidal effect is quicker, more efficient, before being embodied in clinical operation especially, use is in the sterilization pretreatment of doctors and patients wound, have characteristics such as low toxicity, efficient, slow release, can guarantee working long hours of medical operating.For traditional sterile products, povidone iodine is gentleer, and range of application is more extensive.70% the medicinal alcohol wound of can directly sterilizing, but it stimulates the pain and the damage ordinary person that produce to be difficult to bear, and iodine tincture can discharge iodine equally and sterilize, but because the strong oxidizing property of iodine, often skin and medicated clothing are produced very strong corrosivity, be difficult to clean in case be infected with.And the povidone iodine product does not stimulate skin, mucosa etc. when discharging the elemental iodine sterilization, and release time is long simultaneously, effect is lasting, because the chemical characteristic of povidone iodine makes its easier cleaning when being infected with skin and medicated clothing, for user has solved a lot of unnecessary worries.
The present invention is a kind of disinfection sanitizer of new high-efficiency, concentration is that 0.7%～10% solution can discharge 1.8～24ppm free-iodine in water, Oxidation by the latter plays killing action to microorganism, the killing effect of antibacterial is better than Xian Bitai, and bacterial spore is had certain lethality.This medicine all has significant killing action to Candida albicans, golden grape bacterium, escherichia coli, bacillus subtilis etc.; With similar with compound iodine solution, the iodine tincture of concentration, but its toxicity only is 1/4～1/9 of compound iodine solution, iodine tincture to the sterilizing time of bacillus pyocyaneus, Candida albicans.The poly-dimension of compound recipe cave iodine compound recipe has no side effect, and is cheap, has a defencive function to mucocutaneous, and its anti-STD effect obviously is better than JIEERYIN and potassium permanganate solution.In solvent, discharge iodine gradually, play a kind of slow releasing function, to keep the sterilizing power of long period.Its powerful bactericidal mechanism is the active group of oxidation pathogen oleo stock albumen, and can be combined with the amino of protein and make its degeneration, thereby hundreds of antibacterial, virus etc. such as pathogen such as killing bacteria, spore, fungus, virus and protozoon have quick killing action effectively.This product is the first-selected Cidex-7 that is directly used in human body skin, mucosa at present both at home and abroad.It is strong to have sterilizing power, and bactericidal range is wide, and zest is minimum, characteristics such as xanthochromia is light, easy cleaning, the irritated reaction of nothing.
The present invention can be used for producing the poly-dimension cave iodine compound recipe wiping sheet of various different sizes, the cotton rod of poly-dimension cave iodine compound recipe, poly-dimension cave iodine compound recipe foam-rubber cushion and poly-dimension cave iodine compound recipe hand scub brush etc., these products all pass through special handling or sterilization, aseptic and the safety of product have fully been guaranteed, can directly use after user is unpacked, avoid cross-contamination and the infection of intermediate link.The present invention is little to skin irritation, and toxicity is low, and effect is lasting, uses safe, easy.To organizing basic nonirritant, be used for the sterilization of skin and mucosa, as perform the operation preceding cleaning, operative site and wound disinfection, the skin cleaning of tremulous pulse blood drawing front and back and sterilization.
Concrete side executes mode:
Illustrate preparation method of the present invention below:
Formulation components and percentage by weight such as the following table of the tripartite compound sterilizing disinfectant of poly-dimension cave iodine of the present invention,
Preparation procedure is formulated as example with 100 kilograms, and concrete operations are as follows:
The first step is opened the hand hole cover of 100L Agitation Tank, takes by weighing during injection water 25kg adds jar, closes hand hole cover; Open the stirring power supply, rotating speed is transferred to 50r/min, begin to stir; Take by weighing povidone iodine 11kg and put into povidone iodine special stainless steel bucket, slowly join in the Agitation Tank by hopper, pick up counting and stirred 1-1.5 hour;
Second step, take by weighing hydroxyethyl-cellulose 0.1kg and put into the beaker of 5000ml, taking by weighing injection water 25kg again adds in the hydroxyethyl-cellulose special stainless steel bucket, with agitator the injection water in the hydroxyethyl-cellulose special stainless steel bucket is stirred (rotating speed transfers to 1450r/min gradually), regularly 25-30 minute, slowly add hydroxyethyl-cellulose in the injection water, stir after 25-35 minute, close agitator, the solution that stirs is poured in the 250L Agitation Tank, open and stir power supply, the adjusting rotating speed is 50r/min, pick up counting, stir and stop after 3-5 hour stirring, left standstill again 7-9 hour;
The 3rd step took by weighing the beaker that nonoxynolum-10 0.2kg puts into 5000ml, stirred into uniform milky with Glass rod; The injection water that takes by weighing 2kg then adds in the beaker of 5000ml, and continuing to be stirred to solution is uniform state; Seal standby with preservative film;
The 4th step was added to above-mentioned second step and the 3rd solution that goes on foot in the Agitation Tank of the first step, added about 36.7kg injection water again to the graduation mark of Agitation Tank 100kg, restir 20-30 minute.
Preparation method for the tripartite compound sterilizing disinfectant of poly-dimension cave iodine of variable concentrations is all identical with last example.
Claims (5)
1. one kind is gathered the tripartite compound sterilizing disinfectant of dimension cave iodine, and it is characterized in that: it is formulated by povidone iodine 5%-20%, ethoxy fibre, nonoxynolum-10 and water for injection, and wherein the weight percentage of each component is: povidone iodine 5%-20%; The fine 0.1%-1% of ethoxy; Nonoxynolum-10 0.1%-1%; Other are water for injection.
2. according to the tripartite compound sterilizing disinfectant of the described poly-dimension cave iodine of claim 1, it is characterized in that: the weight percentage of each component is: povidone iodine 11%; Hydroxyethyl-cellulose 0.1%; Nonoxynolum-10 0.2% water for injection 88.7%.
3. according to the tripartite compound sterilizing disinfectant of the described poly-dimension cave iodine of claim 1, it is characterized in that: the weight percentage of each component is: povidone iodine 5%; Hydroxyethyl-cellulose 0.1%; Nonoxynolum-10 0.1% water for injection 94.8%.
4. according to the tripartite compound sterilizing disinfectant of the described poly-dimension cave iodine of claim 1, it is characterized in that: povidone iodine 20%; Hydroxyethyl-cellulose 1%; Nonoxynolum-10 1% water for injection 78%.
5. the preparation method of the tripartite compound sterilizing disinfectant of the described poly-dimension cave of claim 2 iodine is as follows: preparation procedure is formulated as example with 100 kilograms, and concrete operations are as follows:
The first step is opened the hand hole cover of 100L Agitation Tank, takes by weighing during injection water 25kg adds jar, closes hand hole cover; Open the stirring power supply, rotating speed is transferred to 50r/min, begin to stir; Take by weighing povidone iodine 11kg and put into povidone iodine special stainless steel bucket, slowly join in the Agitation Tank by hopper, pick up counting and stirred 1-1.5 hour;
Second step, take by weighing hydroxyethyl-cellulose 0.1kg and put into the beaker of 5000ml, taking by weighing injection water 25kg again adds in the hydroxyethyl-cellulose special stainless steel bucket, with agitator the injection water in the hydroxyethyl-cellulose special stainless steel bucket is stirred (rotating speed transfers to 1450r/min gradually), regularly 25-30 minute, slowly add hydroxyethyl-cellulose in the injection water, stir after 25-35 minute, close agitator, the solution that stirs is poured in the 250L Agitation Tank, open and stir power supply, the adjusting rotating speed is 50r/min, pick up counting, stir and stop after 3-5 hour stirring, left standstill again 7-9 hour;
The 3rd step took by weighing the beaker that nonoxynolum-10 0.2kg puts into 5000ml, stirred into uniform milky with Glass rod; The injection water that takes by weighing 2kg then adds in the beaker of 5000ml, and continuing to be stirred to solution is uniform state; Seal standby with preservative film;
The 4th step was added to above-mentioned second step and the 3rd solution that goes on foot in the Agitation Tank of the first step, added about 36.7kg injection water again to the graduation mark of Agitation Tank 100kg, restir 20-30 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101188935A CN103191147A (en) | 2013-04-06 | 2013-04-06 | Povidone-iodine three-component compound sterilizing-disinfecting agent |
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| CN2013101188935A CN103191147A (en) | 2013-04-06 | 2013-04-06 | Povidone-iodine three-component compound sterilizing-disinfecting agent |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872026A (en) * | 2005-05-30 | 2006-12-06 | 张东军 | New medicinal preparation for vagina |
| CN101491470A (en) * | 2009-03-13 | 2009-07-29 | 王祥西 | Contraceptive sheath (cap) capable of releasing microbe and HIV eradicator |
| CN101642467A (en) * | 2008-08-06 | 2010-02-10 | 吴天祥 | Long-acting disinfection paste |
| CN101810639A (en) * | 2010-04-19 | 2010-08-25 | 江苏省健尔康医用敷料有限公司 | Broad-spectrum touch-out medical bactericide and preparation method thereof |
-
2013
- 2013-04-06 CN CN2013101188935A patent/CN103191147A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872026A (en) * | 2005-05-30 | 2006-12-06 | 张东军 | New medicinal preparation for vagina |
| CN101642467A (en) * | 2008-08-06 | 2010-02-10 | 吴天祥 | Long-acting disinfection paste |
| CN101491470A (en) * | 2009-03-13 | 2009-07-29 | 王祥西 | Contraceptive sheath (cap) capable of releasing microbe and HIV eradicator |
| CN101810639A (en) * | 2010-04-19 | 2010-08-25 | 江苏省健尔康医用敷料有限公司 | Broad-spectrum touch-out medical bactericide and preparation method thereof |
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Application publication date: 20130710 |
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