CN103169446B - The early-stage cancer suspicious lesions being applicable to endoscope checks device - Google Patents
The early-stage cancer suspicious lesions being applicable to endoscope checks device Download PDFInfo
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Abstract
Embodiments of the present invention relate to being applicable to the early-stage cancer suspicious lesions of endoscope and check device, it includes that exciting light transmits optical fiber (1), double light switching illumination apparatus (2), video separator (3), White-light image processing device (4), fluorescence image processing device (5), image compressor (6), image display (7), image and illumination lock unit (8), the present invention utilizes the fluorescence of cancerous issue and normal group to be woven with the characteristic of the biggest difference, expressed by the form to this fluorescence detection and its difference pseudo color image, easily the suspicious lesions of early-stage cancer is identified, can also accurately indicate pathological biopsy, can play an important role with accuracy rate for improving the recall rate of early-stage cancer diagnosis.
Description
Technical field
The invention belongs to medical Instrument field, relate to the inspection device of a kind of early-stage cancer suspicious lesions.
Background technology
Medical endoscope (gastroscope, intestinal mirror, bronchoscope, cystoscope, colposcope, peritoneoscope etc.) in clinical medicine inspection
Become the important tool of medical diagnosis on disease.By the observation of the morphological characteristic of lesion region being found many cancers, but right
Being difficult to be detected in the cancer early lesion not having obvious morphological characteristic, present inventive concept is in invention one can be suitably used for
The early-stage cancer suspicious lesions that mirror uses checks that device improves current existing endoscope to early-stage cancer power of test.
A large amount of medical researches show that in kenel and although normal structure does not has a notable difference to the early lesion of cancer, but cancer
Become contained fluorescent material in tissue and but there occurs change along with canceration is formed, cause the fluorescence of cancerous issue and normal group to be woven with very
Big difference.The present invention is exactly based on the fluorescence anomalous variance of detection pathological tissues and normal structure and is converted into the puppet easily identified
Coloured image realizes.
Summary of the invention
The early-stage cancer suspicious lesions being applicable to scope of present invention design checks that device is transmitted optical fiber, double light by exciting light
Switching illumination apparatus, video separator, White-light image processing device, fluorescence image processing device, image compressor, image display, figure
As combining with illumination lock unit.Its structure chart is as it is shown in figure 1, in figure, exciting light transmits optical fiber (1), the switching illumination of double light
Device (2), video separator (3), White-light image processing device (4), fluorescence image processing device (5), image compressor (6), display
(7), image is formed through being connected with illumination lock unit (8).Wherein, the input of exciting light transmission optical fiber (1) is connected to double light
On royal purple radiant delivery outlet in switching illumination apparatus (2), outfan inserts in pliers path hole of endoscope, provides royal purple for endoscope
The illumination of light.In double light switching illumination apparatus (2), white light source delivery outlet is connected to the input port of the guide-lighting fibre bundle of endoscope
On, provide white-light illuminating for endoscope.Two set light sources be respectively arranged with an electronic shutter can image with illumination lock unit (8 control under
Make the switching illumination of various different modes.The input of video separator (3) is connected in the image channel of endoscope, directly will
The video of the mixing switching illumination in endoscope is separated into white-light illuminating video and indigo plant under image controls with illumination lock unit (8)
The video of purple light illumination.White-light illuminating video entrance White-light image processing device (4) exported from image splitter (3) entangles as colour cast
Just become the video of the highest true color image send into image compressor (6) with after profile intensive treatment；From video separator
(3) royal purple optical illumination video entrance fluorescence image processing device (5) the employing dedicated module exported is to perform picture breakdown, point-to-point
Computing and process generate the video of fluorescence pseudo color image and deliver to image compressor (6).Inner respectively to sending at image compressor (6)
The video of true color image and the video of fluorescence pseudo color image that come are compressed, and finally deliver to the appointment window of display (7)
Show in Kou.About screen, respectively offer an equirotal window at two respectively on the screen of display (7) to show
Image/video, the video of the true color image of left side window display white-light illuminating, the fluorescence of right side window display royal purple optical illumination
The video of pseudo color image, screen display video image mode is also by the control of image with illumination lock unit (8).Image and illumination
Lock unit (8) also has two functional switches in addition to Synchronization Control video separation with illumination switching and carrys out the Working mould of control device
Formula.Wherein, one is white light continuous illumination mode of operation switch, and under this pattern, double light switching illumination apparatus (2) only have white light to shine
Bright output, video separator (3) only has white-light illuminating video to send, true color image under display (7) only display white-light illuminating
Video；Another is double light switching gaffer's operation mode switches, and its work process is that double light switching illumination apparatus (2) is with switching
According to mode export two kinds of light sources in endoscope, the mixing under double for scope output light switching illuminations is regarded by video separator (3)
Frequency carries out separated in synchronization, and sends two videos respectively and carry out image procossing to each autocorrelation unit, finally in display (7)
The Dual-window carrying out two videos shows.
The work of the present invention is as follows:
The working method of the present invention is according to image and functional switch k in illumination lock unit (8)1、、K2, setting and relay
Device J1、J2The switch combination of many groups controls double light switching illumination apparatus (2) and the output of video separator (3), can make white light and shine continuously
Bright mode of operation and the selection of double light switching gaffer's operation mode.
Double light switching gaffer's operation mode: image and set in illumination lock unit (8) are at K1Pass, K2During the state opened, at figure
Relay J in 41Do not work, J2Work, this is to have J21、J22Logical, J★ 23Obstructed, and J24、J★ 12Logical (at Fig. 3).Image and photograph
The electronic shutter that lock-out pulse (28) in bright lock unit (8) is output in double light illuminator (2) in two light paths drives
Driving shutter action in device (14), (18), the pulse driving the electronic shutter of royal purple light is to carry out once through phase inverter (31)
Paraphase, so can make to be passed to white light electronic shutter driver (14) pulse when being high level, and the electronic shutter being passed to royal purple light drives
Dynamic device (18) is then low level, forces the action of two electronic shutters (13) and (17) to alternate, electronic soon at these
Under gate action, the output of white light and royal purple light is also alternately.Meanwhile, image and the mutual inversion in illumination lock unit (8)
Pulse amplitude is become 5V and is passed in video separator (3) relevant by the pulse pulse shaper in Fig. 4 (32), (33) respectively
On the electrical switch (21) of passage and (22), the 5V lock-out pulse through paraphase is not passed to the M control pole of electrical switch (21),
The N being passed to electrical switch (22) after paraphase controls extremely to go up, and thus the mixed video of switching illumination synchronously can be isolated
Come, in mixed video, white-light illuminating image walks the passage of electrical switch (21), separate before mixed image in white light 1,
3,5 ... odd number width image goes out, being output as only odd number width image through image reshaper (23) does not has even number width figure
As the white-light illuminating video formed；In mixed video, royal purple light optical illumination image walks the passage of electrical switch (22), dividing
In front mixed image the 2 of royal purple optical illumination, 4,6 ... even number width image goes out, defeated through image reshaper (24)
Go out the royal purple optical illumination video not having odd number width image to form for only even number width image.The every kind of light source lighting so exported
Video all exists can follow a width not have the image of signal after a width has signal pattern, forms the video that a kind of image is flickering
Output form, the most abnormal, bring many troubles can to image procossing below.Abnormal defeated in order to improve separation rear video
Going out, the abnormal video of light source lighting separated every kind respectively in video separator (3) is divided into two tunnels, road warp respectively
Cross respective picture delay device (25), (26) postpone, and are set to the cycle time of piece image time delay, and another road is but
Without delay, then Jiang Zhe bis-road video is separately input to respective image recombiner (27), (28) are combined, after being combined
Just the image having signal in video just can be filled a vacancy on the image of the no signal of video not having to postpone, make compound after defeated
The video gone out all becomes normal video output mode.Then, white-light illuminating video feeding White-light image processing device (4) carries out color
Correct and formed after the process of emphasizing contour the video of the clear true color image of high-resolution, more aobvious after compression of images (6) is compressed
Show on the left side window of display (7)；Royal purple optical illumination video but enters fluorescence image processing device (5) and carries out color decomposition,
Different colours picture point obtains difference to point processing, comparison, weighting, is converted into corresponding pseudo-colours according to different information size raw
The video becoming fluorescence pseudo color image enters compressor (6) and is compressed, display window on the right of the screen of display (7)
On.The J of relay under the pattern of double light switching illumination work24、J★ 11Switch be here logical, make picture delay device
(25) work in this mode of operation, and the two J in white light mode of operation repeat circuit24、J★ 11Switch for close
State, is not involved in work to meet white light continuous illumination mode of operation at white light continuous illumination pattern hypograph delayer (25)
Need.
White light continuous illumination mode of operation: image and position processed in illumination lock unit (8) are at K1Open, K2During the state closed, at figure
4 repeat circuit J1Work, J2Not working, this is to have J21、J22Obstructed J★ 23Logical；J24、J★ 11Obstructed (at Fig. 3).Image is same with illumination
In step device (8), lock-out pulse (29) output is put by resistance, and the signal of 12V DC source (30) passes through J★ 23Arrive double light switching illumination
In the electronic shutter driver (14) of the electronic shutter (13) of device (3), open shutter and pass through white light, and 12V signal is through extra pulse
Become after reshaper (33), on the control pole M of the electrical switch (21) that 5V level is transported to video separator (3), making split tunnel
Open.And electrical switch (22) closes that to control the upper control signal of pole N be zero to be closed, only white-light illuminating image leads to by separating
Road, the video of the image separated composition white light continuous illumination, is normal video output format, it is not necessary to pass through video separation
Picture delay device (25) in device (3) produces the image of delay and repairs the Incomplete image separated in video, and in Fig. 3
J24、J★ 11Obstructed, it is simply that to intercept the participation deferring procedure of picture delay device (24), be so still by image recombiner (27) output
The video of continuous print white light continuous illumination, then after White-light image processing (4) processes, send into image compressor (6), finally aobvious
Show that in the screen of device (7), a window shows.This mode of operation is exactly the common audit function of the most original endoscope
Pattern.
Present invention have the advantages that, switched by double optical illumination, videodataclus tearing, separate the video figure of rear two kinds of light sources
As carrying out Display on the same screen after image procossing in the display.Display video can be seen clearly by the observation of true color image
Lesion tissue morphological characteristic；In video shows by fluorescence pseudo color image, (fluorescence pseudocolour picture seems by fluoroscopic image
After processor process, generation obtains, and when generating, cancerous issue is marked by red pseudo-colours, and normal structure is but revealed as green
Colour) observation, according to the difference of color of image just can the position that exists of clear and definite canceration and scope, the most intuitively and fast make
Diagnose accurately and accurately indicate biopsy.
Accompanying drawing explanation
Fig. 1 is population structure of the present invention diagram
Double light switching mode diagrams in Fig. 2 light switching illumination apparatus (2)
Fig. 3 video separator (3) video separation structural diagrams
Fig. 4 image and illumination lock unit (8) image and illumination Synchronization Control and gaffer's operation mode management diagram
Fig. 5 display (7) screen picture display window illustrates
Label in figure:
1 for exciting light transmit optical fiber 2 be double light switching illumination apparatus 3 be White-light image processing for video separator 4
Device 5 is that fluorescence image processing device 6 for image and illuminates lock unit 9 for white light for display 8 for image compressor 7
Light source 10 light reflector cover 11 drives for electronic shutter for electronic shutter 14 for white light condenser lens 13 for heat-protecting glass 12
Dynamic device 15 be white light output port 16 be royal purple radiant
17 be electronic shutter 18 be royal purple light output end for electronic shutter driver 19 for royal purple light condenser lens 20
Mouthfuls 21 be electrical switch 22 be picture delay device for image reshaper 24 for image reshaper 25 for electrical switch 23
26 be picture delay device 27 be 12V direct current for image recombiner 29 for clock-pulse generator 30 for image recombiner 28
Power supply 31 for pulse inverter 32 for pulse shaper 33 for pulse shaper 34 for image display left window 35 is
Image shows that right window 36 is adaptive medical endoscope
Detailed description of the invention:
The most just the specific embodiment of the invention is introduced.
Assembly of the invention can adaptive all medical endoscopes.
Exciting light transmits optical fiber (1) and uses pliers path hole of endoscope to import to internal in the present invention, and exciting light transmits optical fiber
(1) making with the material quartz that can transmit royal purple light, core diameter is 60um-400um, has outward high intensity to prevent the PVC plastic fractureed
Casing protection, plastic outer sleeve peripheral diameter is not more than 2mm, it is ensured that the minimum dimension biopsy channel hole mouth in all of endoscope can
Using, fiber lengths is different because of different endoscopies, and the principle optical fiber that length is selected exposes 1500mm after inserting endoscope.Excite
Light transmission optical fiber (1) one end supporting stainless steel metal sleeve outside plastics pillar, metal sleeve a size of Φ 10mm ×
30mm, metal sleeve is tightly inserted on the output port (20) of the royal purple light in double light switching illumination apparatus (2).The optical fiber other end is carried out
Special handling, or hacking makes light be output as the form of dispersing, and increases the illumination zone of light；Or dissipate at fiber port gluing glazing
Micro lens, increase optical illumination angle, it is possible to be illuminated on a large scale, in order to image viewing.
The exciting light of the present invention transmits optical fiber (1) and is when Olympus endoscope for upper digestive tract uses, and optical fiber core diameter selects
Being set to 200um, fiber lengths is chosen to be 3000mm.
In double light switching illumination apparatus (2), white light source (9) uses the spherical xenon lamp of 300W, is placed on Jiao of spheric reflection cover (10)
In point, improve light source output efficiency, then use focal length be the aspheric condenser lens of 40mm (12) by this light-resource fousing to white light
On output port (15).An electronic shutter (13), electronic shutter is placed between condenser lens (12) and white light delivery outlet (15)
Clear aperture is not less than 20mm, and is placed on the place close proximity to white light output port (15), electronic shutter (13) and electricity
In dynamic shutter driver (14) connection.Rear temperature lighted by 300W xenon lamp is the highest, in order to reduce the heat of light output, at light
Illumination in reflective membrane that shaped reflector (10) is plated be infrared, reduce ultrared reflection；But also at optically focused
Mirror (12) front placement heat-protecting glass (11) stops that infrared ray passes through so that it is output meets the requirement of endoscope's cold light illumination.Double
Royal purple radiant (16) in light switching illumination apparatus (2) can be chosen in 350nm-440nm spectral band, and the present invention uses
The semiconductor laser of 375nm is not less than 150mW as royal purple radiant, 375nm semiconductor laser power, because quasiconductor swashs
The output facula of light is rectangular strip, it is necessary to use short focus non-spherical lens to be exported by such a laser efficiently
It is coupled in optical fiber, the non-spherical lens selecting focal length to be 6mm, Φ 5mm for this royal purple light condenser lens (19), the coupling efficiency of light
Can reach 80-90%, royal purple light condenser lens (19) and royal purple optical output port (20) are installed together the focusing adjusting laser
Point strictly overlaps with optic fibre input end.Electronic shutter (17) be arranged on royal purple radiant (16) and royal purple light condenser lens (19) it
Between, and connect upper electronic shutter driver (18).Owing to laser quasi is straightforward good, light beam is little, and electronic shutter clear aperture is permissible
The least, typically between 8mm-10mm with obtaining.Two electronic shutters in double light switching illumination apparatus (2) can be by image and illumination
The control of lock unit (8), the suitable light source needed of output.
Converting as one, in double light switching illumination apparatus (2), royal purple radiant (16) can also be by 350nm-440nm wave band
In other laser instrument such as 405nm laser instrument, 355nm laser instrument etc. replaces, it would however also be possible to employ in this 350nm-440nm wave band
Go out the LED light source of light, or use the mercury lamp equipped with royal purple light light filter, xenon lamp.
Converting as one, electronic shutter (13) in double light switching illumination apparatus (2), (17) can be with motors or watch
Take driven by motor one the fan plate that is in the light to swing back and forth at certain angle and replace.
The effect of image splitter (3) is that the obtained white-light illuminating under the switching illumination of double light endoscope exported is with blue
The video of the mixed image composition that purple light illumination is alternate, is separated into video and the video of pure blue violet optical illumination of pure white optical illumination.
It is to be formed by connecting with the electronic integrated circuit of the related functioning components in Fig. 3 structure chart.Image splitter (3) is at image and photograph
Under bright lock unit (8) synchronizing signal controls, make what endoscope sent here odd number width be white-light illuminating image and even number width is royal purple
The mixed video of optical illumination image composition walks different passage output, and wherein white-light illuminating (odd number width) image walks out electrical switch
(21) export through image shaper (23) after passage；Royal purple optical illumination (even number width) image walks out the passage of electrical switch (22)
By image shaper (24) export, video just by separated in synchronization, but after this separation output in, regarding of white-light illuminating
Only taking several width in Pin by force and do not have the image of even number width, in the video of royal purple optical illumination, only even number width does not has the image of odd number width,
It is all the video showing as the flickering output of a kind of image, is not video NORMAL output mode.In order to improve this video
Output mode, the white-light illuminating video of the improper video output mode after separating in video separator (3) is divided into two tunnels,
One tunnel carries out postponing piece image cycle time through picture delay device (25), the most again with another road through regarding of postponing
Frequency is combined at image recombiner (27), the nothing letter not having to postpone of will being filled a vacancy to by the image that have signal in video after being combined
Number image on, becoming the most every width has the normal video output mode of picture signal.Same in image splitter (3)
In also will separate after the royal purple optical illumination video of improper video frequency output be divided into two tunnels, a road is prolonged at picture delay device (26)
Late, the video after then postponing is not combined, also the carrying out of image recombiner (28) through the video of delay with another road
Equally can be by the pattern that video is normal video frequency output of the royal purple optical illumination of improper output.
It is white flat that White-light image processing device (4) uses Olympus image VC-185 image processor to carry out White-light image
Weigh the pattern colour deflection correction regulated, and image outline emphasizes to improve the definition of image, the true color figure that output definition is high
The video of picture.
The effect of fluorescence image processing device (5) is that the image of the video by the royal purple optical illumination of input carries out color decomposition,
Blusher color image decomposition obtained and green coloured image carry out the point-to-point computing of pixel, then with in tissue illumination mechanism
Pathological characters contrasts and weights, and therefrom finds difference, and is converted into corresponding pseudo-colours picture point according to difference size, generates
The video of the fluorescence pseudo color image that early-stage cancer suspicious lesions exists can be indicated.The present invention is to use Shanghai to contain jade-like stone Optoelectronics Technology
The SY-1404 Computer Vision module of company limited makees the process of royal purple light image.
Converting as one, fluorescence image processing device (5) can also decompose and image pixel with having video image color
Other Computer Vision module of point-to-point computing and comparing function is replaced.
Image compressor (6) is to use software MPEG-4 compression engine respectively to from White-light image processing device in computer
(4) video of the image of the true color transmitted and the image of fluorescence pseudo-colours that transmits from royal purple light image processor (5)
Video is compressed.It is passed to display (7) each specified window after compression show.
Display (7) arranges two stationary windows, shows different videos respectively.Display (7) can be by image and photograph
Bright lock unit (8) controls, and the video making different modes shows, the screen of display (7) is the 16 of 19 cun-26 cun that computer uses
: the display screen of 9.
It is by clock-pulse generator (29), 12V DC source (30), pulse paraphase to image with illuminating lock unit (8)
Device (31), two functional switch K1、K2And relay J1、J2Formed.Wherein clock-pulse generator (29) is that use can generation side
The integrated circuit of wave impulse makes, in order to ensure that light source lighting switches on the synchronization of image output, the pulse of square wave in video
Width to adjust through accurate, and the present invention is the PAL video type system handle side according to the endoscopic video output used in China
Ripple pulse-width adjustment is the cycle time of piece image under 40ms, 40ms PAL video formats just.2V DC source (30) uses 1A
Switching Power Supply.Pulse inverter (31) uses the NAND gate circuit of digital integrated block to make.K1、K2Use 1 × 1 single-pole single-throw(SPST electricity
Son switch.J1Use the 12V relay of 1 × 2 (a cutter two-way switch), J2Adopt the 12V relay getting rid of 4 × 2 (4 cutter two-way switch),
Wherein lower footnote the 1st bit digital of relay J represents which relay, lower footnote the 2nd bit digital represent which of relay
Knife-like switch.The upper footnote of relay J i.e. represent relay on off state, the relay that upper footnote represents without ★ symbol, its
Switch contact is connected on normally opened upper (it is obstructed for being equivalent to switch when relay does not works), such as the J in figure21、J22、J24Expression；
Upper footnote is the relay of ★ symbol, and its switch contact is connected on and normally closed closes that (it is logical for being equivalent to switch when relay does not works
), such as the J in figure★ 11、J★ 23Expression.The above device can be achieved with image by its institute's connection of connected mode in the example shown
Synchronize and the control of different light source switching working mode from illumination.
Double light switching gaffer's operation mode:
Image and position processed in illumination lock unit (8) are at K1Pass, K2During the state opened, relay J in the diagram1Do not work, J2
Work, this is to have J21、J22Logical, J★ 23Obstructed, and J24、J★ 12Logical (at Fig. 3).Image and lock-out pulse in illumination lock unit (8)
(28) the electronic shutter driver (14), (18) the middle driving shutter that are output in double light illuminator (2) in two light paths move
Make, make the action of two electronic shutters (12) and (17) alternate, white light and royal purple light under a little electronic shutter effects
Output be also alternately.The pulse amplitude of the most this switching is that the synchronizing signal of 5V also can be passed in video separator (3)
The electrical switch (21) of relevant passage and the M of (22) control pole and N controls extremely to go up, and synchronize to open respective channel and separate,
The white-light illuminating video of the only odd number width image after separation is divided into two tunnels, and a road is through J24、J★ 11Switch to delayer
(25) postponing, be set to the cycle time of piece image time delay, the video after delay is with another road is without delay
It is combined at image recombiner (27), becomes normal white-light illuminating video frequency output.Then white-light illuminating video is sent into white
Light image processor (4) carries out the video that color is corrected and formed high-resolution true color image after the process of emphasizing contour, then through pressure
After after contracting device (6) compression, display is on the left side window of display (7)；Equally, the royal purple of only even number width image is separated
Optical illumination video is divided into two tunnels too, and a road enters picture delay device (26) and postpones, and postpones another road of heel not through prolonging
Slow video is combined in image recombiner (28), obtains normal royal purple optical illumination video frequency output, subsequently into fluorescence
Image processor (5) carries out color decomposition, and different colours picture point obtains difference to point processing, comparison, weighting, and according to difference
Information size is converted into video entrance compressor (6) of corresponding pseudo-colours generation fluorescence pseudo color image and is compressed, display
On window on the right of the screen of display (7).
White light continuous illumination mode of operation:
Image and position processed in illumination lock unit (8) are at K1Open, K2During the state closed, relay J in the diagram1Work, J2No
Work, this is to have J21、J22Obstructed J★ 23Logical；J24、J★ 11Obstructed (at Fig. 3).Image and lock-out pulse in illumination lock unit (8)
(29) output is put by resistance, and the signal of 12V DC source (30) passes through J★ 23Arrive the electronic shutter of double light switching illumination apparatus (3)
(13), in electronic shutter driver (14), open shutter and pass through white light, and 12V signal becomes after pulse shaper (33)
On the control pole M of the electrical switch (21) that 5V level is transported to video separator (3), split tunnel is made to open.And electrical switch
(22) closing that to control the upper control signal of pole N be zero to be closed, only white-light illuminating image is by split tunnel, the image separated
The video of composition white light continuous illumination, at this moment J24、J★ 11It is obstructed, it is simply that to intercept the participation deferring procedure of picture delay device (24),
It is still the video of continuous print white light continuous illumination by image recombiner (27) output, then send after White-light image processing (4) processes
Entering image compressor (6), finally in the screen of display (7), a window shows.This mode of operation is exactly suitable
The common audit function pattern of original endoscope.
Claims (11)
1. the early-stage cancer suspicious lesions being applicable to endoscope checks device, it is characterised in that include that exciting light transmits light
Fine (1), double light switching illumination apparatus (2), video separator (3), White-light image processing device (4), fluorescence image processing device (5), figure
As compressor (6), image display (7), image and illumination lock unit (8), wherein,
Exciting light transmits the input of optical fiber (1) and is connected on the royal purple optical output port (20) in double light switching illumination apparatus (2),
Exciting light transmits the outfan of optical fiber (1) and inserts in pliers path hole of endoscope, provides royal purple optical illumination for endoscope；
In double light switching illumination apparatus (2), white light output port (15) is connected on the input port of light-conductive optic fibre bundle of endoscope, for
Endoscope provides white-light illuminating, and wherein royal purple radiant and white light source are respectively arranged with an electronic shutter, with same with illumination at image
Step device (8) makees the switching illumination of various different modes under controlling；
The input of video separator (3) is connected in the image channel of endoscope, and directly switching in endoscope illuminated is mixed
The video of the image closed is separated into white-light illuminating image by video separator (3) under image controls with illumination lock unit (8)
Video and the video of royal purple optical illumination image, the video of the white-light illuminating image wherein exported from video separator (3) enters
White-light image processing device (4) becomes the video feeding figure of the true color image of high-resolution after making colour cast correction and profile intensive treatment
As compressor (6), and video entrance fluorescence image processing device (5) of the royal purple optical illumination image exported from video separator (3),
Using dedicated module to perform picture breakdown, point-to-point computing and process, the video generating fluorescence pseudo color image delivers to image
Compressor (6), wherein video separator (3) is under image controls with illumination lock unit (8) synchronizing signal, makes endoscope send here
Odd number width is that white-light illuminating image and mixed video that even number width is royal purple optical illumination image are from different passages outputs, wherein white light
Illumination image exports from the passage of an electrical switch, and royal purple optical illumination image exports from the passage of another electrical switch,
The video of the white light source so separated and the illumination of royal purple radiant be all a kind of only odd number width do not have even number width or
Only even number width does not has the video of odd number width image, from but the flickering video of a kind of image, be not that video normally exports
Pattern；
Respectively the video of the true color image sent here and the video of fluorescence pseudo color image are pressed image compressor (6) is inner
Contracting, finally delivers to show in the specified window of image display (7).
Inspection device the most according to claim 1, it is characterised in that in exciting light transmission optical fiber (1), optical fiber is with passing
The material quartz sending royal purple light is made, and core diameter is 60 μm-400 μm, has outward the PVC plastic casing protection that high intensity prevents fractureing, moulds
Material sleeve pipe peripheral diameter is not more than 2mm, it is ensured that in endoscope, minimum dimension biopsy channel hole mouth can use, and fiber lengths is because of in difference
Sight glass and different, the selected principle of length is that to insert protruded length after endoscope be 1500mm to optical fiber, and wherein, exciting light transmits light
One end of optical fiber supporting stainless steel metal sleeve outside plastic bushing in fine (1), metal sleeve a size of Φ 10mm ×
30mm, metal sleeve is tightly inserted on the royal purple optical output port (20) in double light switching illumination apparatus (2), and the optical fiber other end enters
Row special handling, or hacking makes light be output as the form of dispersing, and increases the illumination zone of light, or sends out at fiber port gluing glazing
The micro lens dissipated, increases optical illumination angle, it is possible to be illuminated on a large scale.
Inspection device the most according to claim 1, it is characterised in that
Between white light condenser lens (12) and the white light output port (15) of the white light source (9) in double light switching illumination apparatus (2)
Place the clear aperture the first electronic shutter (13) not less than 20mm；
It is arranged between royal purple radiant (16) and royal purple light condenser lens (19) in double light switching illumination apparatus (2) and light admission port is installed
Footpath is second electronic shutter (17) of 8mm-10mm；
The first electronic shutter in double light switching illumination apparatus (2) and the second electronic shutter by image with illuminate the same of lock unit (8)
The control of step signal, makes double light switching illumination apparatus (2) can export the illumination of various different switching mode.
4. according to the inspection device according to any one of claim 1-3, it is characterised in that white in double light switching illumination apparatus (2)
Radiant (9) uses the spherical xenon lamp of 300W, is placed in the focus of spheric reflection cover (10), plates red at spheric reflection cover (10)
External reflectance film, and use heat-protecting glass (11) to reduce the temperature in the output beam of light source, wherein, white light condenser lens (12)
Using focal length is that the aspheric lens of 40mm are by light-resource fousing to white light output port (15).
5. according to the inspection device according to any one of claim 1-3, it is characterised in that blue in double light switching illumination apparatus (2)
Purple light light source (16) uses the laser instrument in 350nm-440nm wave band, or uses the LED going out light at 350nm-440nm wave band
Light source, or use the mercury lamp equipped with royal purple light light filter, xenon lamp.
6. according to the inspection device according to any one of claim 1-3, it is characterised in that in double light switching illumination apparatus (2)
Royal purple radiant (16) uses the semiconductor laser of 375nm as royal purple radiant, and 375nm semiconductor laser power is the least
In 150mW, wherein, the non-spherical lens that royal purple light condenser lens (19) selects focal length to be 6mm, Φ 5mm, non-spherical lens and royal purple
Optical output port (20) is installed together.
7. according to the inspection device according to any one of claim 1-3, it is characterised in that in double light switching illumination apparatus (2)
Electronic shutter (13), (17) are for driving the fan plate that is in the light to swing back and forth at certain angle with motor or servomotor.
Inspection device the most according to claim 1, it is characterised in that fluorescence image processing device (5) is by the royal purple light of input
In illumination video, image carries out color decomposition, and the blusher color image then decomposition obtained and green coloured image carry out pixel pair
The computing of point, and contrast with the pathological characters in tissue illumination mechanism and weight, thus find difference.
Inspection device the most according to claim 1, it is characterised in that fluorescence image processing device (5) is for having color of image
Decompose and the point-to-point computing of image pixel and the Computer Vision module of comparing function.
Inspection device the most according to claim 1, it is characterised in that the screen in image display (7) is computer
The display screen of the 16: 9 of 19 cun-26 cun, arranges the window of two fixing display video images, and two windows are placed side by side layout and are full of
Whole screen, wherein window shows and can be controlled with illumination lock unit (8) by image, and the image making single window or Dual-window shows.
11. inspection devices according to claim 1, it is characterised in that image includes lock-out pulse with illumination lock unit (8)
Generator (29), 12V DC source (30), pulse inverter (31), two functional switch K1、K2And relay J1、J2, wherein
Clock-pulse generator (29) makes, in order to ensure light source light transform and image of the integrated circuit that can produce square-wave pulse
The synchronization of output, the pulse width of square wave to adjust through accurate, and defeated according to the endoscopic images video used in China
The PAL formula requirement gone out, is adjusted to 40ms the square wave pulse width of lock-out pulse；12V DC source (30) uses 1A Switching Power Supply；
Pulse inverter (31) uses the NAND gate circuit of digital integrated block to make；K1、K2Use 1 × 1 single-pole single-throw(SPST electrical switch；J1
Use the 12V relay of a cutter two-way switch, J2Adopt the 12V relay getting rid of 4 cutter two-way switch.
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| US20170181636A1 (en) * | 2014-05-23 | 2017-06-29 | Covidien Lp | Systems for imaging of blood flow in laparoscopy |
| CN104939794B (en) * | 2015-07-15 | 2016-06-01 | 吉林大学第一医院 | Alimentary tract disease scope locating device |
| CN107550450A (en) * | 2017-09-14 | 2018-01-09 | 中国科学院高能物理研究所 | A kind of fluorescence endoscopy system for bronchial disease early diagnosis |
| CN112603240A (en) * | 2020-12-16 | 2021-04-06 | 刘奇为 | Medical endoscope system capable of realizing intelligent image processing |
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| CN1341003A (en) * | 1999-01-26 | 2002-03-20 | 牛顿实验室公司 | Autofluorescence imaging system for endoscopy |
| CN101125075A (en) * | 2007-09-26 | 2008-02-20 | 叶衍铭 | Fluoroscopic image early cancer diagnosis equipment |
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| KR100411631B1 (en) * | 2001-10-18 | 2003-12-18 | 주식회사 메디미르 | Fluorescence endoscope apparatus and a method for imaging tissue within a body using the same |
| FR2842407B1 (en) * | 2002-07-18 | 2005-05-06 | Mauna Kea Technologies | "METHOD AND APPARATUS OF FIBROUS CONFOCAL FLUORESCENCE IMAGING" |
| JP4139276B2 (en) * | 2003-06-17 | 2008-08-27 | オリンパス株式会社 | Electronic endoscope apparatus and signal processing apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1341003A (en) * | 1999-01-26 | 2002-03-20 | 牛顿实验室公司 | Autofluorescence imaging system for endoscopy |
| CN101125075A (en) * | 2007-09-26 | 2008-02-20 | 叶衍铭 | Fluoroscopic image early cancer diagnosis equipment |
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