CN103156913A - Pharmaceutical combination of traditional Chinese medicines used for dispersing exterior pathogen, clearing heat and resolving dampness - Google Patents
Pharmaceutical combination of traditional Chinese medicines used for dispersing exterior pathogen, clearing heat and resolving dampness Download PDFInfo
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- CN103156913A CN103156913A CN2011104160006A CN201110416000A CN103156913A CN 103156913 A CN103156913 A CN 103156913A CN 2011104160006 A CN2011104160006 A CN 2011104160006A CN 201110416000 A CN201110416000 A CN 201110416000A CN 103156913 A CN103156913 A CN 103156913A
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Abstract
The present invention discloses a pharmaceutical combination of traditional Chinese medicines used for dispersing exterior pathogen, clearing heat and resolving dampness, and a preparation method thereof. A dispersible tablet contains the following ingredients, by weight: 40 parts of agastache, and 60 parts of pig gall powder. The dispersible tablet of the present invention is a pure herbal pharmaceutical combination oral solid dosage form. The dispersible tablet of the invention is prepared based on compatibility principles of traditional Chinese medicine formulations, has the efficacies of resolving turbidity with aroma, relieving the stuffy nose, eliminating liver and gallbladder fire, and eliminating or easing nasal congestion caused by thick snivel and headaches, and can be used for sinusitis and rhinitis. The dispersible tablet of the present invention has advantages of small in dosage, convenient for taking, fast in absorption, high in bioavailability, portable, accurate in dosing, stable in quality, etc.
Description
Technical field
The invention belongs to field of pharmaceutical technology, particularly a kind of Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof.
Background technology
" sinusitis with purulent discharge " has another name called nasal sinusitis, and the long stream of the turbid tears of yellow fluid causes Naohu empty endlessly dizzy.Sinusitis, rhinitis are a kind of common sinus mucosa chronic inflammatory diseases, the Chang Fanfu outbreak, and touching difficulty is more.Adopted western medicines, but effect is dissatisfied more in the past.
Summary of the invention
Purpose of the present invention aims to provide a kind of Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof, it has the merit of removing dampness by means of aromatics, dispelling exopathogens from superficies of the body, be applicable to the headache due to turbid damp internal resistance, clear YANG failing to ascend, the disease of the turbid tears of stream, Fel Sus domestica unguentum has the merit of removing heat from the lung and dissipating phlegm, detoxifcation, to the nasal obstruction of violating the lung key on strongly fragrant in wind-heat invading the lung, pathogenic heat, dampness-heat in the liver and gallbladder, flow turbid tears, decreased sense of smell has effect preferably.
Technical scheme of the present invention is: design a kind of Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 40 parts of Herba Pogostemoniss, 60 part of 2 flavor medicine of Pulvis Fellis Suis are the oral solid formulation of effective ingredient; 2 flavor medicines are made dried cream powder in the present invention, and dried cream powder and supplementary material weight proportion thereof are: 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of micropowder silica gel, 50 parts of ethanol.
Above-mentioned this Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof is characterized in that it comprises the following steps:
1) by following weight ratio weighting raw materials: 40 parts of Herba Pogostemoniss, 60 parts of Pulvis Fellis Suiss;
2) with above-mentioned Herba Pogostemonis, pulverize, divide dipping 2 times with 10 times of amount 65% ethanol, flooded 48 hours at every turn, the merging leachate, filtration, it is 1.2～1.3 clear paste that filtrate decompression is concentrated into relative density;
3) above-mentioned clear paste, add Pulvis Fellis Suis, mix homogeneously, and 50 ℃ of drying under reduced pressure were pulverized 80 mesh sieves, became dried cream powder standby;
4) accurately take by dried cream powder and ratio of adjuvant in (1), cross 60 mesh sieves;
5) above-mentioned dried cream powder is pressed 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of mix homogeneously of micropowder silica gel, with 50 parts of soft materials processed of ethanol.
6) 14 mesh sieves are granulated, 50-60 ℃ of forced air drying;
7) 14 mesh sieve granulate, add the residue adjuvant, mix homogeneously;
8) tabletting gets final product.
Characteristics of the present invention are: it is according to present prescription combination principle, the redesign prescription, adopt advanced process route to make dispersible tablet, this Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof, have that taking dose is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, the advantage such as steady quality.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
This Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness of embodiment and preparation method thereof is characterized in that it comprises the following steps:
1) by following weight ratio weighting raw materials: 40 parts of Herba Pogostemoniss, 60 parts of Pulvis Fellis Suiss;
2) with above-mentioned Herba Pogostemonis, pulverize, divide dipping 2 times with 10 times of amount 65% ethanol, flooded 48 hours at every turn, the merging leachate, filtration, it is 1.2～1.3 clear paste that filtrate decompression is concentrated into relative density;
3) above-mentioned clear paste, add Pulvis Fellis Suis, mix homogeneously, and 50 ℃ of drying under reduced pressure were pulverized 80 mesh sieves, became dried cream powder standby;
4) accurately take by dried cream powder and ratio of adjuvant in (1), cross 60 mesh sieves;
5) above-mentioned dried cream powder is pressed 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of mix homogeneously of micropowder silica gel, with 50 parts of soft materials processed of ethanol.
6) 14 mesh sieves are granulated, 50-60 ℃ of forced air drying;
7) 14 mesh sieve granulate, add the residue adjuvant, mix homogeneously;
8) tabletting gets final product.
The below is the embodiment of the present inventionThis Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness
The dispersible tablet that thing is made (hereinafter to be referred as dispersible tablet) treatment chronic maxillary sinusitis clinical case is observed
The inventor adopts self-control embodiment of the present invention dispersible tablets of Chinese medicine to be combined with Western medicine 168 routine chronic maxillary sinusitis is treated observation, and compares with simple western medicine treatment group 72 examples, the evaluation curative effect, and its principle is inquired into.The Comprehensive Treatment result, Chinese medicine and western medicine is respectively 78.57% and 100% in conjunction with group cure rate, total effective rate, and simple western medical treatment group cure rate, total effective rate are respectively 44.44% and 97.22%.Chinese Herbs is lasting, and the therapy of combining Chinese and Western medicine chronic maxillary sinusitis is evident in efficacy, is worthy to be popularized.We are to eliminating the nasal cavity inflammatory edema, and minimizing is oozed out, and improving the BITONG airway dysfunction all has better curative effect.
Dispersible tablet of the present invention is comprised of Herba Pogostemonis, Pulvis Fellis Suis, has the evacuation pathogenic factor in the exterior, the effect of clearing away heat and eliminating dampness, and experiment confirm has obvious anti-inflammation detumescence, reduces capillary permeability, improves the sensitization territory and strengthens immune function.Chinese medicine combination taking dose of the present invention is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, the advantage such as steady quality.Conventional equipment can be completed production, is worth further research.
Claims (2)
1. one kind is used for Chinese medicine combination of evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 40 parts of Herba Pogostemoniss, 60 part of 2 flavor medicine of Pulvis Fellis Suis are the oral solid formulation of effective ingredient; 2 flavor medicines are made dried cream powder in the present invention, and dried cream powder and supplementary material weight proportion thereof are: 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of micropowder silica gel, 50 parts of ethanol.
2. above-mentioned this Chinese medicine combination for evacuating the pathogenic factor in the exterior clearing away heat and eliminating dampness and preparation method thereof is characterized in that it comprises the following steps:
1) by following weight ratio weighting raw materials: 40 parts of Herba Pogostemoniss, 60 parts of Pulvis Fellis Suiss;
2) with above-mentioned Herba Pogostemonis, pulverize, divide dipping 2 times with 10 times of amount 65% ethanol, flooded 48 hours at every turn, the merging leachate, filtration, it is 1.2～1.3 clear paste that filtrate decompression is concentrated into relative density;
3) above-mentioned clear paste, add Pulvis Fellis Suis, mix homogeneously, and 50 ℃ of drying under reduced pressure were pulverized 80 mesh sieves, became dried cream powder standby;
4) accurately take by dried cream powder and ratio of adjuvant in (1), cross 60 mesh sieves;
5) above-mentioned dried cream powder is pressed 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of mix homogeneously of micropowder silica gel, with 50 parts of soft materials processed of ethanol;
6) 14 mesh sieves are granulated, 50-60 ℃ of forced air drying;
7) 14 mesh sieve granulate, add the residue adjuvant, mix homogeneously;
8) tabletting gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104160006A CN103156913A (en) | 2011-12-14 | 2011-12-14 | Pharmaceutical combination of traditional Chinese medicines used for dispersing exterior pathogen, clearing heat and resolving dampness |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104160006A CN103156913A (en) | 2011-12-14 | 2011-12-14 | Pharmaceutical combination of traditional Chinese medicines used for dispersing exterior pathogen, clearing heat and resolving dampness |
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| CN103156913A true CN103156913A (en) | 2013-06-19 |
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| CN2011104160006A Pending CN103156913A (en) | 2011-12-14 | 2011-12-14 | Pharmaceutical combination of traditional Chinese medicines used for dispersing exterior pathogen, clearing heat and resolving dampness |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705581A (en) * | 2013-12-30 | 2014-04-09 | 长沙理工大学 | Compound Huodan dispersible tablet and preparation method and application thereof |
| CN109288891A (en) * | 2018-10-26 | 2019-02-01 | 禹州市中医院 | A kind of Chinese medicine composition and preparation method thereof for treating chronic nasosinusitis |
-
2011
- 2011-12-14 CN CN2011104160006A patent/CN103156913A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705581A (en) * | 2013-12-30 | 2014-04-09 | 长沙理工大学 | Compound Huodan dispersible tablet and preparation method and application thereof |
| CN103705581B (en) * | 2013-12-30 | 2016-01-13 | 长沙理工大学 | Compound Huodan dispersible tablet and its preparation method and application |
| CN109288891A (en) * | 2018-10-26 | 2019-02-01 | 禹州市中医院 | A kind of Chinese medicine composition and preparation method thereof for treating chronic nasosinusitis |
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Application publication date: 20130619 |