CN103140214A - Oral care compositions with improved sweetness - Google Patents

Oral care compositions with improved sweetness Download PDF

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Publication number
CN103140214A
CN103140214A CN2011800473866A CN201180047386A CN103140214A CN 103140214 A CN103140214 A CN 103140214A CN 2011800473866 A CN2011800473866 A CN 2011800473866A CN 201180047386 A CN201180047386 A CN 201180047386A CN 103140214 A CN103140214 A CN 103140214A
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China
Prior art keywords
sweeting agent
agent
glycosides
sweetener
oral care
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CN2011800473866A
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CN103140214B (en
Inventor
J·C·霍特
E·施奈德曼
L·A·桑克
R·L·小斯温
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Procter and Gamble Ltd
Procter and Gamble Co
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Procter and Gamble Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/37—Halogenated sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention is directed to improved sweetener compositions and oral care compositions, especially those in the form of a toothpaste or oral/dental rinse, comprising the same. The sweetener composition comprises a combination of saccharin, sucralose and a rebaudioside, or sweeteners of similar sucrose equivalence and type, preferably in a ratio of about 1:about 1:about 2. The sweetener composition of the invention was found to significantly improve the taste profile, long lasting freshness and clean feel of oral care compositions and to deliver an in-use sweetness that was more natural and pleasant than artificial sweeteners alone.

Description

There is the oral care composition that improves sweet taste
Technical field
The present invention relates to sweetener composition, oral care composition and improve the method for oral care composition sweet taste.
Background technology
Therefore as sensation, sweet taste is generally considered to be the perception of sucrose and artificial sweetener, and described artificial sweetener has take the grade that Seq is unit.There is the compound of multiple enhancing sweet taste.Although naturally occurring carbohydrate sweetening agents, for example sucrose is the most widely used sweeting agent, and they suffer expensive, high heat content and cause the shortcoming of decayed tooth.Still they are refused by consumer owing to not having enough " sucrose sample " mouthfeels sometimes to have designed the artificial sweetener that overcomes these problems.Artificial sweetener has the sweet taste feature different from sucrose and produced by sweet perception for example the side effect that postpones and/or make us unhappy pleasant impression.
Because it causes decayed tooth, for example sucrose or high-fructose corn syrup are problematic so that excellent sweet taste characteristic to be provided in oral care composition to use natural sweetener.For reducing the decayed tooth contribution, usually use artificial sweetener so that sweet taste to be provided, but they may have the worthless mouthfeel for consumer, for example sweet taste produces and postpones; The sweet taste pleasant impression of can't get rid of; Bitterness, metallic taste or astringent taste; And/or dry flavor.For example, the sweet taste of natural and/or synthetic high-potency sweetener produces slow and continues length than the sweet taste produced by sugar, and therefore changes the mouthfeel balance of food compositions.Because these difference are used the efficiency natural sweeting agent to replace for example sugar of bulk sweetener in Foods or drinks, cause unbalanced time and/or flavor characteristic.Difference on temporal characteristics, high-potency sweetener generally also shows (i) than the low peak response of sugar, and (ii) abnormal flavour comprises bitterness, metallic taste, nice and cool flavor, astringent taste, Radix Glycyrrhizae sample mouthfeel etc., and/or the sweet taste weakened while (iii) repeatedly tasting.Those skilled in the art of food/beverage formula know the sweeting agent changed in compositions needs rebalancing flavoring agent and other sense of taste component (for example acidulant).If the mouthfeel feature of the natural and synthesizing efficient sweeting agent of correctability, to give more the mouthfeel feature as the certain desired of sugared sample, can significantly enlarge type and the kind of the compositions that thus prepared by sweeting agent.Therefore, expect the optionally mouthfeel feature of modified natural and synthesizing efficient sweeting agent.
In oral care product, the problem of the pleasant impression of artificial sweetener especially is that the composition in a lot of oral care compositions has their bad mouthfeel attributes.Although flavoring agent is used as and covers up the compensation that smell substance comprises sweeting agent, when the ether high-load is used, flavoring agent itself can be given bitterness, also require more sweeting agents to hide described flavoring agent.Final result may be too bitter, too sweet, give bad pleasant impression or the formula of high cost simply.The purpose of this invention is to provide the novel combination of the sweeting agent that overcomes aforementioned bad attribute.With comparing that any independent sweeting agent is done, this combination provides more long-acting pure and fresh, clean feel, minimizing bitterness and mouthfeel impression.
Relate to that some of combinations of sweeteners purposes are relevant openly to be comprised:
EP658340A1 disclose with glucide or glucide substitute and other sweeting agent for example the combination of thaumatin or stevioside offset the bitterness of beet alkali surface activator.Document does not instruct use wherein to reduce as described herein three recombinations of the sweeting agent of glucide application.
At US2007/0116831A1(Prakash, Dubois) in, disclose the purposes of high-potency sweetener compositions in dental composition, described high-potency sweetener compositions comprises for example for example combination of sucralose and " sweet taste improves compositions " and dentistry active substance of rebaudioside A and/or synthesizing efficient sweeting agent of efficiency natural sweeting agent.Its objective is that establishment is more as the taste of sugared sample.In US2009/0053378A1, the people such as Prakash further disclose sweetness enhancers, for example arylcarboxylic acid derivative on the basis of US2007/0116831A1.These documents are not all instructed and are used combinations of sweeteners as herein described.
US2009/0004360A1(Bingley) also pay close attention to use sweeting agent modifier (being (two) hydroxy benzoic acid in this case) and carried out modification sweeting agent feature.It is not instructed and uses multiple sweeting agent.
The people such as US2007/0178123A1(Levenson) relate to and be used for the treatment of the local flavor enhancing composition of cough with product.It discloses the combination of neotame and sucralose.
EP1869986(Schwarz, Rathjen) the so-called edible composition with cane-sugar taste feature is disclosed, but it comprises for example combination of sucralose of isomaltulose, acesulfame K and other high intensity sweetner.
WO2009/086049(Catani, Liao) sweetener composition, the combination of the pure extract that described compositions comprises sucralose and Folium Stevlae Rebaudianae (comprising Rebaudiodside A and Du Ke glycosides) disclosed.In special ratios scope at sucralose to Folium Stevlae Rebaudianae, observe the cooperative effect that increases sweet intensity.The concrete combination of the unexposed sucralose of described document and Folium Stevlae Rebaudianae and other sweeting agent.
US4,915,969(Beyts) disclosed the sweet cooperative effect of increasing of sucralose and cyclamate in beverage.
The people such as JP2002-171930(Morita) reported sugariness and the sweet taste quality from the excellence of sucralose, Folium Stevlae Rebaudianae and acesulfame K combination.
Although there is more this progress as the new sweetening agent combined aspects of sucrose sample feature in research and development, but still need to comprise oral cavity composition, especially dentifrice and the collutory of sweet taste optimal combination thing.Expectation research and development sweetener composition, described compositions makes the amount of the natural or artificial sweetener in Orally taken product reduce or optimize, and therefore reduce the abnormal flavour be associated with specified raw material in Orally taken product, but it avoids the harmful effect to local flavor.Particularly, need sweetener composition, described compositions can provide the high-sucrose identity property, and the sweet taste of the pleasant impression of the sweet perception of modification sweeting agent, sweeting agent, sweeting agent produces phase, the sweet taste peak period of sweeting agent and/or the sweet taste period of delay of sweeting agent.
Summary of the invention
The present invention relates to the sweetener composition improved and the oral care composition that comprises described sweetener composition, especially with those of toothpaste or collutory/periodontal collutory form.More specifically, the oral care composition that the present invention relates to sweetener composition and comprise described sweetener composition, wherein said sweetener composition comprises sweeting agent A, sweeting agent B and sweeting agent C, wherein sweeting agent A is the artificial sweetener with 250-350 Seq, sweeting agent B is the artificial sweetener with 500-600 Seq, and sweeting agent C is the natural sweetener with 0.5-400 Seq.The preferred embodiment of sweeting agent A, B and C is respectively glucide, sucralose and Rebaudiodside A.Preferably the ratio of described sweeting agent A, B and C is (0.5-2): (0.5-2): 2.In most preferred embodiment, the combination that described sweetener composition comprises glucide, sucralose and Rebaudiodside A that ratio is about 1:1:2.
The invention still further relates to the method for the sweet taste that improves oral care composition, it comprises in oral care composition and adds sweetener composition.
The specific embodiment
Except as otherwise noted, the equal overall weighing scale by compositions of all percentage ratio used and ratio hereinafter.Except as otherwise noted, the percent of all the components that this paper mentions, ratio and content is the actual content based on this composition all, and is not included in solvent, filler or other material that can use together with these compositions in commercially available prod.Except as otherwise noted, all measurements that this paper mentions are all carried out under approximately 25 ℃ (being room temperature).
As used herein, word " approximately " refers to +/-10%.As used herein, word " comprises/comprises " and variant to be intended to be nonrestrictive, make the narration of project in list not get rid of the similar item that other also may be useful in material of the present invention, compositions, apparatus and method.
This paper " oral care composition " refers in general use procedure, is not deliberately swallowed with the interior absorption administration for particular therapeutic agent, but retain the sufficiently long time in oral cavity, or have the enough degree tactile with whip graft to experience the product of its mouthfeel.Applicable oral care composition comprises personal health care product (such as cough syrup, cough drops etc.), confection, Food & Drink (such as chewing gum, soda water etc.).Preferred oral care composition is not intended to as nutraceutical, and can various forms comprises glue, collutory, mousse, foam, mouth spraying agent, lozenge, chewable tablet, lozenge, chewing gum or denture nursing product under toothpaste or gutta-percha, gum.This oral care composition also can be blended on band or film, directly to use or to adhere to oral surfaces.In a preferred embodiment, described oral care composition comprises surfactant or for oropharynx, particularly other therapeutic active substance in oral cavity.
Except as otherwise noted, term used herein " dentifrice " comprises paste, gel or liquid preparation.As used herein, term " tooth " refers to nature tooth and artificial teeth or artificial tooth.
Can be used for active component of the present invention and other composition can classify or describe according to effect or the operational mode of its beauty treatment and/or treatment beneficial effect or its supposition.Yet should be appreciated that in some cases, can be used for beauty treatment and/or treatment beneficial effect or effect that active substance of the present invention and other composition can provide more than one, or work or move by more than one model of action.Therefore, the classification of this paper is for convenience's sake, but not is intended to composition is limited on the function or activity of listed concrete appointment.
sweeting agent
The sweeting agent that this paper mentions also comprises and relates to its salt commonly used; For example, term " glucide " comprises saccharin sodium, and " acesulfame " comprises potassium salt, acesulfame K.As usually understood ground in this area, the feature of sweeting agent can be its sucrose identity property aspect, be expressed as the ratio of sucrose weight required sweeting agent weight to transmission same amount sweet taste of sending a certain amount of sweet taste, as by expert group, the sugariness of the sugariness of sweetener soln and sucrose stock solution coupling determined.Because the sucrose identity property can be depending on the sucrose concentration mated, the Seq of this paper is 10% Seq.Therefore, if 0.1% solution of sweeting agent is sent the sugariness identical with 10% sucrose solution, this sweeting agent has 100(10/0.1) 10% Seq.
In one aspect, the present invention relates to sweetener composition, wherein said sweetener composition comprises sweeting agent A, sweeting agent B and sweeting agent C, wherein sweeting agent A is the artificial sweetener with 250 to 350 Seqs, sweeting agent B is the artificial sweetener with 500 to 600 Seqs, and sweeting agent C is the natural sweetener with 0.5 to 400 Seq.
Preferably the ratio of described sweeting agent A, B and C is (0.5-2): (0.5-2): 2.In one embodiment, the ratio of described sweeting agent A and sweeting agent B is 0.5:1 to 2:1, preferably 0.8:1 to 1.5:1.In one embodiment, the ratio of described sweeting agent A and sweeting agent C is 0.3:1 to 0.9:1, preferably 0.3:1 to 0.7:1.
Sweeting agent A is high intensity sweetner, and it is preferably selected from: glucide, alitame, aspartame, neotame, cyclamate and their mixture.These sweeting agents measure with 10% Seq of 250-350 usually.Sweeting agent A is glucide most preferably.
Sweeting agent B is high intensity sweetner, it is preferably selected from: three chloros-sucrose (sucralose), acesulfame, neohesperidin DC, thaumatin, glycyrrhizin, Momordia grosvenori aglycone IV, mogroside Ⅴ, Cyclocarya paliurus Iljinskaja glycosides I, N-[N-[3-(3-hydroxyl-4-methoxyphenyl) propyl group]-L-α-aspartyl]-L-Phe 1-methyl ester, N-[N-[3-(3-hydroxyl-4-methoxyphenyl)-3-methyl-butyl]-L-α-aspartyl]-L-Phe 1-methyl ester, N-[N-[3-(3-methoxyl group .-4-hydroxy phenyl) propyl group]-L-α-aspartyl]-L-Phe 1-methyl ester, and their mixture.These sweeting agents have than the stronger sweet taste of A type sweeting agent, and usually with 10% Seq of 500-600, measure.Sweeting agent B most preferably is sucralose.
The glucoside that sweeting agent C is natural source or polyhydric alcohol sweeting agent, it is preferably selected from: stevioside, rebaudioside A, RB, dulcoside B, Rebaudiodside A D, Rebaudiodside A E, Rebaudiodside A F, Du Ke glycosides A, Du Ke glycosides B, Rubusoside, Folium Stevlae Rebaudianae, stevioside, momordica grosvenori sweetening agent, the Simon glycosides, Monatin and salt thereof (Monatin SS, RR, RS, SR), Rhizoma Curculiginis sweet protein, monellin, mabinlin, Bradley neat because of, Holland's sucdrol (hemandulcin), leaf stripe, the root bark phenolic glycoside, phlorhizin, Trilobatin, shellfish promise glycosides (baiyanoside), Ao Silaiding, a poly-ripple glycosides (polypodoside) A, butterfly card glycosides (pterocaryoside) A, butterfly card glycosides B, if Mu Ku glycosides (mukurozioside), MISOPROSTOL glycosides (phlomisoside) I not, periandrin I, the Semen Abri Precatorii saponin A, and their mixture.In addition, sweeting agent C can be selected from one or more of following natural source resource, for example for example xylitol, erithritol, maltose alcohol, mannitol and sorbitol or L-arabinose, inulin, dextrin, Raffinose, trehalose, Tagatose or tower lattice alcohol of polyalcohols.These sweeting agents measure with 10% Seq of 0.5-400 usually.Especially, in the embodiment expected in the present invention, sweeting agent C comprises one or more the combination in rebaudioside A and RB, dulcoside B, Rebaudiodside A F, Rebaudiodside A F, stevioside, steviolbioside or Du Ke glycosides A.In the preferred embodiment of this paper, sweeting agent C comprises at least 70% rebaudioside A or xylitol.REBIANA is can be from Cargill, the trade name of the high-purity source rebaudioside A that Inc. and The Coca-Cola Company are commercially available.It is the diterpene glycoside thing of crystallization, approximately sweet 300 times than sucrose.Xylitol is the polyhydric alcohol of being manufactured by Cargill.
The sweetener composition of this paper also comprises edible carrier material to improve the flow behavior of sweetener composition.These edible carrier materials can comprise the bulk sweetener material, crystallinity sugar alcohol particularly, but it may give some sweet tastes more much lower than the sugariness of the present invention sweeting agent.In addition, can in sweetener composition, add flavour enhancer for example glucopyrone or hydroxy benzoic acid.
In this paper preferred embodiment, the sweetener composition of this paper comprises altogether 20% to 100%, preferably 50% to 100% sweeting agent A, B and C.
oral care composition
Another aspect of the present invention relates to oral care composition, and described compositions comprises sweetener composition of the present invention.Described oral care composition can comprise 0.001% to 4%, preferably 0.01% to 3% sweetener composition of the present invention.
Be expected to be useful in very much consumer goods clean and the nursing oral cavity and give pure and fresh and clean sensation, because this sensation provides lasting pure and fresh and clean signal to consumer.Except clean sensation, consumer expects the beneficial effect as anticalculus agent from the treatment oral care active usually, for example, by their oral care regimen.Oral care composition is usually by the constituting of component, and described component can comprise carrier material, surfactant, flavoring agent, sensory agent, stain, active substance and other additive.Yet the ability of preparation consumer acceptable oral care composition has proposed challenge because many for giving local flavor, the component of sending beneficial effect or oral care composition base component brought bad taste and/or sensation when bringing their purpose beneficial effect.Therefore, the preparation oral care composition can be the balance behavior between acceptable local flavor and acceptable beneficial effect.
the mouth care carrier material
The mouth care carrier material generally is applied to everywhere, consumption for the weighing scale 25% of pressing oral care composition to approximately 95%.Can comprise Polyethylene Glycol, propylene glycol and other edible polyhydric alcohol, ethanol or their combination that water, glycerol, sorbitol, molecular weight are less than 50,000 as the example of material of carrier material.Multiple these carrier materials also can be used as stoping the wetting agent of toothpaste drying.In these carrier materials, cause the example of some carrier materials of poor taste in oral care composition to comprise for example propylene glycol and ethanol.Usually the poor taste be associated with this class material is bitterness, pungent, astringent taste and/or Earthy Taste or stink.
surfactant
Another component of oral care composition, especially dentifrice can be surfactant.The surfactant generally comprised in oral care composition is 1% to 15%.Surfactant can be anion, non-ionic, both sexes, zwitterionic, cationic or their mixture.The water soluble salt of the sulfonation monoglyceride of the fatty acid that the anion surfactant that can be used for this paper comprises the water soluble salt of the alkylsurfuric acid that contains 8 to 20 carbon atoms in alkyl for example and contains 8 to 20 carbon atoms.The example of this analog anion surfactants is sodium lauryl sulfate (SLS) and Cortex cocois radicis monoglyceride sulfonates.Other suitable anion surfactant comprises that sarcosinate is as sodium lauroyl sarcosine, taurate, lauryl sulfoacetate sodium, lauroyl sodium isethionate, laureth carboxylic acid sodium and dodecylbenzene sodium sulfonate.Also can use the combination of anion surfactant.In various embodiments, compositions of the present invention comprises anion surfactant, and its content is 0.025% to 9%, 0.05% to 5%, or 0.1% to 1%.
This paper can with another kind of anion surfactant be alkyl phosphate.Surface activity organophosphorus ester reagent has strong affinity to enamel surfaces, and has sufficient surface combination tendency, so that the desorbing of pellicle protein, and remain adhered on enamel surfaces.That the suitable example of organophosphorus compounds comprises is single-, two-or three esters, they mean with formula hereinafter, wherein Z 1, Z 2, or Z 3can be identical or different, at least one is organic group, be selected from one embodiment straight chain with 1 to 22 carbon atom or the alkyl or alkenyl of branching, it is optionally replaced by one or more phosphate-based, alkoxylated alkyl or thiazolinyl, (many) sugar, polyhydric alcohol or polyether group.
Some other reagent comprise the alkyl or alkenyl phosphate ester by following representation:
Figure BDA00002988270700082
R wherein 1representative has 6 to 22 carbon atoms, the straight chain or branched-alkyl or the thiazolinyl that optionally by one or more phosphate esters (or salt) group, are replaced; N and m are respectively 2 to 4 separately, and a and b are respectively 0 to 20 separately; Z 2and Z 3can be identical or different, represent that separately hydrogen, alkali metal, ammonium, protonated alkylamine or protonated sense alkylamine are as alkanolamine or R 1-(OC nh 2n) a(OC mh 2m) b-group.The example of suitable reagent comprises that alkylphosphonate and (gathering) alkoxyl alkylphosphonate are as lauryl phosphate; PPG5 cetearyl polyoxyethylene ether-10 phosphate ester; Laureth-1 phosphate ester; Laureth-3 phosphate ester; Laureth-9 phosphate ester; Three laureth-4 phosphate ester; C 12-18the PEG9 phosphate ester; And dilauryl polyoxyethylene ether-10 sodium phosphate.In one embodiment, alkyl phosphate is polymerization.The example of poly-alkyl phosphate comprises that the alkoxyl that comprises repetition is as those of polymeric part, comprises specifically those of 3 or more ethyoxyl, propoxyl group, isopropoxy or butoxy.
Other suitable surfactant is sarcosinate, isethionate and taurate, particularly their alkali metal salts or ammonium salt.Its example comprises: Hamposyl L salt, Hamposyl M salt, palmitoyl sarcosine salt, Hamposyl S salt and oleoyl sarcosinates or their combination.
In these anion surfactants, cause some examples of poor taste in oral care composition to comprise for example SLS, Hamposyl L salt and/or the fatty alcohol or the acid that are associated with the surfactant of natural origin.Usually the poor taste be associated with these surfactants is soapy flavor, chemicals flavor and/or artificial taste.
This paper can with amphion or amphoteric surfactant comprise aliphatic quaternary ammonium,
Figure BDA00002988270700091
derivant with sulfonium compound, wherein said aliphatic group can be straight chain or branching, one of them aliphatic substituent group comprises 8 to 18 carbon atoms, and an aliphatic substituent group comprises the anionic water solubilizing group, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Suitable beet alkali surface activator is disclosed in the United States Patent (USP) 5,180,577 of authorizing the people such as Polefka.Typical alkyl dimethyl betaine comprises decyl betaine or 2-(N-decyl-N, the N-dimethylamino) acetas, coco betaine or 2-(N-cocoyl-N, N-dimethylamino) acetas, myristyl betanin, palmityl betaine, lauryl betaine, cetyl betaine, cetyl betaine, stearyl betaine etc.It is example that amido betaines be take cocoamidoethyl betanin, cocoamidopropyl (CADB) and lauramido propyl betaine.In these surfactants, cause some examples of poor taste in oral care composition to comprise for example cocoamidopropyl and lauryl betaine.Usually the poor taste be associated with these surfactants is soapy flavor and chemicals flavor.These surfactants that generally comprise in oral care composition are 0.5% to 5%.
For example comprise that for cationic surfactant of the present invention have the long alkyl chain derivant of quaternary ammonium compound of (comprising 8 to 18 carbon atoms) is as lauryl trimethyl ammonium chloride, hexadecylpyridinium chloride
Figure BDA00002988270700092
cetyl trimethyl ammonium bromide, cetyl are fluoridized pyridine
Figure BDA00002988270700093
or their combination.In these surfactants, cause some examples of poor taste in oral care composition to comprise for example cetylpyridinium chloride or chlorhexidine.Usually the poor taste be associated with these surfactants is chemicals flavor and/or antiseptic flavor.
The ionic surfactant pack can be used in the present composition is drawn together the compound for example produced with the organic hydrophobic compound condensation that itself can be aliphatic series or alkyl aromatic by alkylidene oxide group (itself is hydrophilic).The example of suitable non-ionic surface active agent comprises the polyethylene oxide condensation compound of poloxamer, alkyl phenol, derived from the mixture of ethylene oxide condensate, long chain tertiary amine oxide, long chain tertiary phosphine oxide, long-chain dialkyl sulphoxide and these materials of the product of the condensation of the product of oxirane and expoxy propane and ethylenediamine, aliphatic alcohol.
flavoring agent
The another kind of component that can be an oral care composition part comprises flavoring agent.Flavoring agent generally exists with the amount of 0.4 % by weight to 3 % by weight of described oral care composition.For the example of some flavoring agent of oral care composition and flavor components be Oleum menthae, wintergreen oil, clove bud oil, Cortex cinnamomi japonici (Ramulus Cinnamomi), Salvia japonica Thunb., parsley oil, origanum, Fructus Citri Limoniae, orange, methylol anethole, heliotropin, 4-cis-heptenal, diacetyl, p-tert-butyl-phenyl methyl acetate, methyl salicylate, ethyl salicylate, acetic acid 1-menthyl ester,
Figure BDA00002988270700101
alkane ketone, α-ionone, methyl cinnamate, ethyl cinnamate, butyl cinnamate, ethyl n-butyrate., ethyl acetate, methyl 2-aminobenzoate, isoamyl acetate, isoamyl butyrate, allyl hexanoate, acetaminol, eucalyptole, thymol, cinnamyl alcohol, capryl alcohol, octanal, decanol, capraldehyde, phenethanol, benzylalcohol, α-terpinol, linalool, limonene, neral, citral, geranial, the geraniol nerol, maltol, ethyl maltol, anethole, dihydroanethole, carvone, menthone, dorinone, ionone, γ-decalactone, nonyl lactone, peach aldehyde, or their combination.In general, suitable flavor components is the compound that architectural feature and functional group are less inclined to redox reaction.These comprise derivant saturated or that comprise the flavor compounds of stablizing aromatic ring or ester group.In these flavoring agent, cause some examples of poor taste in oral care composition to comprise citral, geranial, cineole, thymol and acetaminol.Usually the poor taste be associated with these flavoring agent is tart flavour, chemicals flavor, bitterness, pungent and/or astringent taste.
sensory agent
The another kind of component that can be an oral care composition part is sensory agent.Sensory agent is used for sending signal to consumer as refrigerant, warm and tingling reagent.The general consumption of sensory agent is oral care composition 0.001% to 0.8%.The cooling sensation immunomodulator compounds that people know the most is menthol, l-menthol especially, its natural being present in Oleum menthae.The menthol of high-load can cause bitterness and sometimes be associated with offending records such as being described as Earthy Taste, Camphora flavor, musty.
In synthetic cool agent, many is derivants of menthol or to relevant on the menthol structure, comprises the cyclohexane extraction part and is that functional group is derivative, and described functional group comprises carboxylic acid amides, ketal, ester, ether and alcohol.Example comprises menthane carbosamided compound as N-ethyl-p-terpane-3-Methanamide.On structure, with the example of the incoherent synthetic carboxylic acid amides cool agent of menthol, be WS-23.Additional exemplary synthetic cool agent comprises 01 derivatives example 3-1-methoxy propane-1,2-glycol, isopulegol, to terpane-3,8-glycol; MGA; Menthyl ester is menthyl acetate, acetoacetic ester menthyl ester, menthyl lactate and mono succinate menthyl ester for example.
On structure, but additive reagent that by report had similar physiological cooling effect irrelevant to menthol comprises and is described in United States Patent (USP) 6,592, α-one base enamine derivates in 884, comprise 3-methyl-2-(1-pyrrolidinyl)-2-cyclopentene-1-one (3-MPC), 5-methyl-2-(1-pyrrolidinyl)-2-cyclopentene-1-one (5-MPC); 2,5-dimethyl-4-(1-pyrrolidinyl)-3 (2H)-furanones (DMPF); Be described in the people's such as Wei J.Pharm.Pharmacol.(1983), the icilin(in 35:110-112 is also referred to as AG-3-5, chemical name 1-[2-hydroxy phenyl]-the 4-2[nitrobenzophenone]-1,2,3, the 6-tetrahydropyrimidin-2-ones).
In these cooling sensation agent, cause some examples of poor taste in oral care composition to comprise for example menthol and menthone.Usually the poor taste be associated with these cooling sensation agent comprises pungent, chemicals flavor and/or flavour of a drug.
The example of some warm sensory agents comprises ethanol; Nicotinate, for example pyridine-.beta.-carboxylic acid benzyl ester; Polyhydric alcohol; Pelargonyl group Rhizoma et radix valerianae amide; N-nonanoic acid Rhizoma et radix valerianae ether; Rhizoma et radix valerianae alkyl ether derivative, for example Rhizoma et radix valerianae ether, Rhizoma et radix valerianae butyl ether, Rhizoma et radix valerianae amyl ether and Rhizoma et radix valerianae hexyl ether; Different cephrol alkyl ether; Ethyl cephrol alkyl ether; The veratryl alcohol derivant; The benzylalcohol derivative replaced; The benzylalcohol alkyl ether replaced; The vanillin propylene glycol acetal; The ethyl vanillin propylene glycol acetal; Rhizoma Zingiberis Recens extract; Oil of Rhizoma Zingiberis Recens; Zingiberol; (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone; Or their combination.The content of the warm sensory agent generally comprised in oral care composition is 0.05% to 2%.
Some tingling feels that the example of agent comprises capsaicin; Homotype capsaicin, Herba Cancriniae lasiocarpae oleoresin, Pericarpium Zanthoxyli (Zanthoxylum peperitum), numb-taste component of zanthoxylum-I, numb-taste component of zanthoxylum II, sanshoamide, piperine, piperidines, spilanthol, 4-(1-methoxyl methyl)-2-phenyl-1,3-dioxolane or their combination.The tingling generally comprised in oral care composition feels that the content of agent is 0.0005% to 1%.In these tinglings are felt agent, in oral care composition, provide some examples of bad taste to comprise, for example Herba Cancriniae lasiocarpae oleoresin and numb-taste component of zanthoxylum.Usually feel that with these tinglings the poor taste that agent is associated comprises Fructus Piperis flavor, bitterness and/or metallic taste.
sweeting agent
The sweeting agent that this paper mentions also comprises and relates to its salt commonly used; For example, term " glucide " comprises saccharin sodium, and " acesulfame " comprises potassium salt, acesulfame K.As usually understood in this area, the feature of sweeting agent can be its sucrose identity property aspect, be expressed as send a certain amount of sweet taste sucrose weight to sending the ratio of the required sweeting agent weight of same amount sweet taste, as by expert group, the sugariness of the sugariness of sweetener soln and sucrose stock solution coupling determined.Because the sucrose identity property can be depending on the sucrose concentration mated, the Seq of this paper is 10% Seq.Therefore, if 0.1% solution of sweeting agent is sent the sugariness identical with 10% sucrose solution, this sweeting agent has 100(10/0.1) 10% Seq.
In one aspect, the present invention relates to sweetener composition, wherein said sweetener composition by sweeting agent A, sweeting agent B and sweeting agent C with (0.5-1): (0.5-1): (1-3) ratio forms, wherein sweeting agent A is the artificial sweetener with 250 to 350 Seqs, sweeting agent B is the artificial sweetener with 500 to 600 Seqs, and sweeting agent C is the natural sweetener with 0.5 to 400 Seq.
Sweeting agent A is high intensity sweetner, and it is preferably selected from: glucide, alitame, aspartame, neotame, cyclamate and their mixture.These sweeting agents measure with 10% Seq of 250-350 usually.Sweeting agent A is glucide most preferably.
Sweeting agent B is high intensity sweetner, it is preferably selected from: three chloros-sucrose (sucralose), acesulfame, neohesperidin DC, thaumatin, glycyrrhizin, Momordia grosvenori aglycone IV, mogroside Ⅴ, Cyclocarya paliurus Iljinskaja glycosides I, N-[N-[3-(3-hydroxyl-4-methoxyphenyl) propyl group]-L-α-aspartyl]-L-Phe 1-methyl ester, N-[N-[3-(3-hydroxyl-4-methoxyphenyl)-3-methyl-butyl]-L-α-aspartyl]-L-Phe 1-methyl ester, N-[N-[3-(3-methoxyl group-4-hydroxy phenyl) propyl group]-L-α-aspartyl]-L-Phe 1-methyl ester, and their mixture.These sweeting agents have than the stronger sweet taste of A type sweeting agent, and usually with 10% Seq of 500-600, measure.Sweeting agent B most preferably is sucralose.
The glucoside sweeting agent that sweeting agent C is natural source, it is preferably selected from: stevioside, rebaudioside A, RB, dulcoside B, Rebaudiodside A D, Rebaudiodside A E, Rebaudiodside A F, Du Ke glycosides A, Du Ke glycosides B, Rubusoside, Folium Stevlae Rebaudianae, stevioside, momordica grosvenori sweetening agent, the Simon glycosides, Monatin and salt thereof (Monatin SS, RR, RS, SR), Rhizoma Curculiginis sweet protein, monellin, mabinlin, Bradley neat because of, Holland's sucdrol, leaf stripe, the root bark phenolic glycoside, phlorhizin, Trilobatin, shellfish promise glycosides, Ao Silaiding, a poly-ripple glycosides A, butterfly card glycosides A, butterfly card glycosides B, if Mu Ku glycosides, MISOPROSTOL glycosides I not, periandrin I, the Semen Abri Precatorii saponin A, and their mixture.These sweeting agents measure with 10% Seq of 0.5-400 usually.Especially, in the embodiment expected in the present invention, sweeting agent C comprises one or more the combination in rebaudioside A and RB, dulcoside B, Rebaudiodside A F, Rebaudiodside A F, stevioside, steviolbioside or Du Ke glycosides A or polyhydric alcohol xylitol.Sweeting agent C most preferably is rebaudioside A or xylitol.REBIANA is can be from Cargill, the trade name of the high-purity source rebaudioside A that Inc. and The Coca-Cola Company are commercially available.It is the diterpene glycoside thing of crystallization, approximately sweet 300 times than sucrose.Xylitol is naturally occurring sugar alcohol and is also provided by Cargill.
In addition, can in sweetener composition, add for example glucopyrone of flavour enhancer.
stain
In addition, stain can form the part of oral care composition.Stain generally exists with the amount of 0.001 % by weight to 0.5 % by weight of described oral care composition.Some stain examples for oral care composition comprise D& C yellow No. 10, FD& C blue No. 1, FD& C red No. 40, D& C red No. 33 and their combination.The content of stain can be in 0.0001% to 0.1% scope.In one embodiment, the amount of stain is the weighing scale 0.001% to 0.01% by described oral care composition.In these stains, cause some stain examples of poor taste in oral care composition to comprise for example D& Red No. 33 of C.Usually the poor taste be associated with these stains is metallic taste and/or chemicals flavor.
active substance
A kind of annexing ingredient that can comprise in oral care composition comprises oral care active.Oral care active generally exists with 0.0001% to 8% amount.Some examples of oral care active comprise caries preventive agent, antimicrobial, anticalculus agent, halitosis inhibitor and bleach.The consumption of caries preventive agent is generally 0.01% to 3.0%.Usually there are enough fluorides in dentifrice and other oral cavity composition, thereby the fluoride ion concentration of 0.0025 % by weight to 5.0 % by weight is provided in described compositions, so that anticaries efficacy to be provided.In one embodiment, fluoride concentration is by weight 0.005% to 2.0%.The material of multiple generation fluorion can be used as soluble fluoride source suitable in the present composition and method.The suitable examples of materials that produces fluoride ion is found in the United States Patent (USP) 3,535,421 of authorizing the people such as Briner and authorizes in the people's such as Widder United States Patent (USP) 3,678,154.Representational fluoride ion source comprises: stannous fluoride, sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, indium, amine fluoride be Olaflur etc. for example.In one embodiment, described caries preventive agent comprises approximately the stannous fluoride of 0.454% amount.In another embodiment, described caries preventive agent comprises approximately the sodium fluoride of 0.243% amount.In these caries preventive agents, cause some caries preventive agent examples of poor taste to comprise for example stannous fluoride and potassium fluoride.Usually the poor taste be associated with these caries preventive agents comprises Earthy Taste, stink and/or metallic taste.
Another kind of oral care active is antimicrobial.An example of antimicrobial is quaternary ammonium compound.Comprise following those for those quaternary ammonium reagent of this paper: wherein the substituent carbon chain lengths of one or two on quaternary nitrogen (being generally alkyl) is 8 to 20, typically is 10 to 18 carbon atoms, remain substituent group (being generally alkyl or benzyl) simultaneously and there is lower carbon number as 1 to 7 carbon atom, be generally methyl or ethyl.Typical quaternary ammonium antibacterial embodiment is Dodecyl trimethyl ammonium chloride, TPC, brominated phenododecinium bromide, chlorination N-myristyl-4-ethylpyridine, dodecyl dimethyl (2-benzene oxygen ethyl) ammonium bromide, benzyl dimethyl stearyl chlorination ammonium, cetylpyridinium chloride, quaternized 5-amino-1, two (2-the ethylhexyl)-5-methyl hexahydropyrimidines of 3-, benzalkonium chloride, benzethonium chloride and methyl benzethonium chloride.Other compound comprises two [4-(R-amino)-1-pyridines
Figure BDA00002988270700141
] alkane, it is disclosed in United States Patent (USP) 4,206,215, and this patent is authorized Bailey on June 3rd, 1980.Other quaternary ammonium compound comprises pyridine
Figure BDA00002988270700142
compound.Pyridine the example of quaternary ammonium compound comprises cetyl pyridinium and myristyl pyridine halogen (that is, villaumite, bromine salt, villiaumite and iodine salt).The content of the quaternary ammonium antimicrobial that can comprise is at least 0.035%.In other embodiments, it is included with the weighing scale 0.045% to 1.0% by described oral care composition or 0.05% to 0.10%.
The present invention also can comprise other antimicrobial, comprise the non-cationic antimicrobial, as halogenated diphenyl ethers, oxybenzene compound (comprising phenol and homologue thereof), an alkyl and many halogenated alkyls phenol and halogenated aromatic phenol, resorcinol and derivant thereof, xylitol, bisphenol compound and halo salicylamide, benzoate and halo carbanilide.Also available antimicrobial is enzyme, comprises endo-glycosidase, papain, glucanase, mutant enzyme and their combination.This type of reagent is disclosed in the United States Patent (USP) 2,946,725 of authorizing the people such as Norris July 26 nineteen sixty and authorizes in the people's such as Gieske United States Patent (USP) 4,051,234.The example of other antimicrobial comprises that chlorhexidine, triclosan, triclosan monophosphate and flavor oil are as thymol.Triclosan and this type of other reagent are disclosed in Parran, the people's such as Jr. United States Patent (USP) 5,015,466 and authorizing in the people's such as Nabi United States Patent (USP) 4,894,220.The content of these reagent counts 0.01% to 1.5% by the weight of described Dentrifice composition.In antimicrobial above, cause some examples of poor taste to comprise for example chlorhexidine, triclosan and thymol.Usually the poor taste be associated with these antimicrobials comprises bitterness, stink, Earthy Taste, tart flavour and/or astringent taste.
Another kind of oral care active agents comprises anticalculus agent.An example of anticalculus agent is the pyrophosphate as the pyrophosphate ion source.The pyrophosphate can be used in the present composition comprises for example pyrophosphoric acid one alkali metal salt, two alkali metal salts and four alkali metal salts and their combination.It is the Sodium Acid Pyrophosphate (Na of hydrated form and hydrated form not 2h 2p 2o 7), sodium acid pyrophosphate, tetrasodium pyrophosphate (Na 4p 2o 7) and tetrapotassium pyrophosphate (K 4p 2o 7) be other material.In compositions of the present invention, pyrophosphate can exist with the one in three kinds of modes: basically dissolve, basically do not dissolve or the combination of dissolving and undissolved pyrophosphate.The pyrophosphate amount that can be used for preparing these compositionss is that any tartar is controlled effective dose.In various embodiments, the amount of pyrophosphate is the weighing scale 1.5% to 15%, 2% to 10% or 3% to 8% by described oral care composition.
The additional examples of oral care active is the bleach for tooth-whitening.The example of bleach comprises peroxide, perborate, percarbonate, peroxy acid, persulfate and their combination.Suitable peroxide comprises hydrogen peroxide, urea peroxide, calper calcium peroxide, sodium peroxide, zinc peroxide or their combination.An example of percarbonate is SODIUM PERCARBONATE.An example of persulfate comprises potassium hydrogen persulfate.Following amount represents the amount of peroxide raw material, although peroxide source also can comprise the composition outside the peroxide raw material.For example, peroxide source can be the solution of peroxide raw material and carrier material.In general, compositions of the present invention can comprise 0.01% to 30% peroxide raw material.In other embodiments, the peroxide raw material is the weighing scale 0.1% to 10% or 0.5% to 5% by described oral care composition.In these bleachs, cause some bleach examples of poor taste in oral care composition to comprise for example peroxide and percarbonate.Usually the poor taste be associated with these bleachs comprises stink, chemicals flavor and/or tart flavour.
Another kind of oral care active is the halitosis inhibitor.The example of halitosis remover comprises mantoquita and carbonyl compound, for example ascorbic acid [the ancient Lip river of 3-oxo-L-furan lactone]; Cis-jasmone [3-methyl-2-(pentenyl-2-cyclopentenone]; 2,5-dimethyl-4-hydroxyl-3 (2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2 (5H)-furanone; Vanillin [3-methoxy-4-hydroxybenzaldehyde]; Ethyl vanillin, anisaldehyde [4-methoxybenzaldehyde]; 3,4-methylene dioxo benzaldehyde; Veratraldehyde; The 4-hydroxy benzaldehyde; Benzaldehyde,2-methoxy; Benzaldehyde; Cinnamic aldehyde [3-phenyl-2-acrylic aldehyde]; Jasminolene; α-methylcinnamaldehyde; O-methoxycinnamic aldehyde; Or their combination.Be not bound by theory, it is believed that some halitosis inhibitor are as " trapping thing ", play a role by reacting with mercaptan or sulfide and forming the weak product of abnormal smells from the patient.In these halitosis inhibitor, provide the example of poor taste in oral care composition to comprise for example anisaldehyde.Usually the poor taste be associated with these halitosis inhibitor comprises chemicals flavor, plastics flavor, bitterness and/or tart flavour.
slaine
Another kind in oral care composition may component be slaine.The slaine function is extensive, from antimicrobial to sensitivity agent and/or buffer.In one embodiment, slaine comprises zinc salt, tin salt, potassium salt, mantoquita or their combination.In another embodiment, zinc salt is selected from: zinc fluoride, zinc chloride, zinc iodide, chlorofluorination zinc, zinc acetate, hexafluoro close zirconic acid zinc, zinc sulfate, zinc lactate, zinc tartrate, zinc gluconate, zinc citrate, malic acid zinc, zinc glycinate, zinc pyrophosphate, Metaphosphoric acid zinc, zinc oxalate, zinc phosphate, zinc carbonate and their combination.In another embodiment, zinc salt comprises zinc chloride, zinc citrate, zinc gluconate, zinc lactate, zinc oxide or their combination.
In another embodiment, potassium salt is selected from: potassium nitrate, potassium citrate, potassium oxalate, potassium bicarbonate, potassium acetate, potassium chloride and their combination.In another embodiment, potassium salt comprises potassium nitrate, potassium citrate, potassium chloride or their combination.In another embodiment, mantoquita is selected from: copper fluoride, copper chloride, Copper diiodide, chlorofluorination copper, copper acetate, hexafluoro close zirconic acid copper, copper sulfate, Cupric Lactate., cupric tartrate, copper gluconate, copper citrate, malic acid copper, cupric glycinate, Copper pyrophosphate., Metaphosphoric acid copper, cupric oxalate, cupric phosphate, curpic carbonate and their combination.In another embodiment, mantoquita comprises copper gluconate, copper acetate, cupric glycinate or their combination.
In another embodiment, tin salt is selected from: stannous fluoride, stannous chloride, Tin diiodide., the inferior stannum of chlorofluorination, stannous acetate, hexafluoro close the inferior stannum of zirconic acid, stannous sulfate, the inferior stannum of lactic acid, stannous tartrate, the inferior stannum of gluconic acid, stannous citrate, stannous malate, the inferior stannum of glycine, ditin diphosphate, the inferior stannum of Metaphosphoric acid, stannous oxalate, phosphoric acid stannous chloride, the inferior stannum of carbonic acid, the inferior stannum of gluconic acid and their combination.In another embodiment, tin salt comprises stannous fluoride, stannous chloride, two hydrated stannous chlorides, stannous fluoride, the inferior stannum of lactic acid, the inferior stannum of gluconic acid, stannous sulfate or their combination.
In another embodiment, strontium salt can be selected from: strontium chloride, strontium citrate, strontium lactate, gluconic acid strontium, strontium fluoride, strontium bromide, strontium nitrate, strontium oxalate, strontium carbonate, strontium iodide, strontium sulfate, Strontium hydrate. and strontium acetate.
The dentifrice that comprises tin salt (especially stannous fluoride and stannous chloride) is described in the United States Patent (USP) 5,004,597 of authorizing the people such as Majeti.Other description of tin salt is found in the United States Patent (USP) 5,578,293 of authorizing the people such as Prencipe and authorizes in the people's such as Lukacovic United States Patent (USP) 5,281,410.Except stannous ion source, also can comprise and stablize other required composition of inferior stannum, as described compositions of people such as the people such as Majeti and Prencipe.
Provide some examples of the slaine of poor taste to comprise zinc chloride, zinc citrate, copper gluconate, zinc gluconate or their combination.The poor taste be associated with these types of metals salt is stink, dry flavor, Earthy Taste, metallic taste, tart flavour, bitterness and astringent taste.
In one embodiment, slaine exists with the amount of 0.05 % by weight to 11 % by weight of described oral care composition.In other embodiments, slaine exists with 0.5% to 7% or 1% to 5% amount.In additional embodiment, tin salt exists with 0.1 % by weight to 7 % by weight of described oral care composition or the amount of 1 % by weight to 5 % by weight or 1.5 % by weight to 3 % by weight.In a particular embodiment, can be in 0.01 to 5% scope for the amount of zinc salt of the present invention or mantoquita.In other embodiments, the amount of zinc salt or mantoquita is 0.05 to 4% or 0.1 to 3.0%.
Therefore, in one embodiment, the present invention relates to for improving the method for oral care composition mouthfeel, described method comprises provides oral care composition, and described compositions comprises alkyl phosphate, beet alkali surface activator, hexadecylpyridinium chloride
Figure BDA00002988270700171
, phosphate, polymer, slaine, potassium salt, peroxide or their compositions, and the Rebaudiodside A that is 0.05% to 0.4% to the weighing scale content added in described oral care composition by described oral care composition, the glucide that is 0.05% to 0.4% by the weighing scale content of described oral care composition, by the weighing scale content of described oral care composition, be 0.05% to 0.4% sucralose.In one embodiment, slaine comprises zinc salt, tin salt, potassium salt, mantoquita or their combination.In another embodiment, peroxide is selected from: hydrogen peroxide, urea peroxide, calper calcium peroxide, sodium peroxide and their combination.In another embodiment, potassium salt comprises potassium nitrate, and its amount with 0.01 % by weight to 5.0 % by weight of described oral care composition exists.In another embodiment, zinc salt comprises zinc citrate, and its amount with 0.05 % by weight to 5.0 % by weight of described oral care composition exists.In another embodiment, hydrogen peroxide exists with the amount of 0.001 % by weight to 5.0 % by weight of described oral care composition.
example
consumer tests I
For sweetener composition being shown on reducing the impact of the effect of alkyl phosphate abnormal flavour in dentifrice, the following formula of preparation is also tested in 10 people groups.The mouthfeel attributes of the following formula of described group's evaluation.Report 10 group members during brushing teeth until the brushing teeth meansigma methods of each evaluation of 30 minutes.
Figure BDA00002988270700181
Figure BDA00002988270700191
1the laureth sodium phosphate provided by Rhodia
Formula I f with following combinations of sweeteners:
Sample: If-1 If-2 If-3 If-4 If-5 If-6 If-7 If-8 If-9
Glucide 0.2 0.1 0.05 0.2 0.2 0.2 0.1 0.1 0.1
Sucralose - - - - - - - - -
REBIANA - - - 0.2 0.1 0.05 0.2 0.1 0.05
Sample: If-10 If-11 If-12 If-13 If-14 If-15 If-16 If-17 If-18
Glucide 0.05 0.05 0.05 0.1 0.1 0.1 0.05 0.05 0.05
Sucralose - - - 0.1 0.1 0.1 0.01 0.01 0.01
REBIANA 0.2 0.1 0.05 0.2 0.1 0.05 0.1 0.1 0.1
NHDC - - - - - - 0.1 0.05 0.05
Monellin - - - - - - - 0.05 0.05
Sample: If-19 If-20 If-21 If-22 If-23 If-24 If-25 If-26 If-27 If-28
Glucide 0.4 0.2 - - - - - - - -
Sucralose - 0.2 - - - - - - - 0.4
REBIANA - - - - - 0.4 - - - -
NHDC - - - - - - 0.2 - - -
Monellin - - - - - - - - 0.2 -
Acesulfame K - - 0.8 - - - - - - -
Aspartame - - - 0.21 - - - - - -
Neotame - - - - 0.5 - - - - -
Mai Litian - - - - - - - 0.02 - -
Sample I f-1 to 1 f-28 data are shown in hereinafter:
Figure BDA00002988270700201
Figure BDA00002988270700202
Figure BDA00002988270700211
Figure BDA00002988270700221
Figure BDA00002988270700231
Data illustrate product 13(glucide: sucralose: the ratio of Rebaudiodside A is 1:1:2) be better than all other combinations, comprise glucide: sucralose combination (product 20), and be better than independent glucide (product 1-3 and 19).
the dentifrice that example product I I-comprises slaine
The dentifrice hereinafter illustrated is used conventional method preparation; Content means with percentage by weight (%).
Composition IIA IIB IIC IID IIE
Calcium carbonate ? ? ? 40.00 ?
Binding agent 1.00 1.8 1.00 1.00 0.20
Thickening agent 2.00 1.00 1.25 0.4 0.8
Colourant solution (1%) 0.05 0.05 ? ? 0.175
Calcium phosphate dibasic dihydrate ? ? 35.00 ? ?
Flavoring agent 1 1.00 1.00 1.00 1.00 1.00
Cool agent 0.03 0.24 0.20 0.50 0.58
VBE 0.01 0.01 0.01 0.01 0.01
Glycerol USP 16.489 ? 15.00 ? ?
Poloxamer188, NF ? ? ? ? 0.20
Orthophosphoric acid list sodium ? ? ? ? ?
Potassium nitrate 5.00 ? ? ? ?
Saccharin sodium USP 0.47 0.25 0.30 0.300 0.58
Silica abrasive 24.00 12.50 ? ? 17.00
Sodium lauryl sulfate (27.9% solution) 7.50 7.00 5.50 7.00 4.00
50%NaOH solution ? 1.00 ? ? ?
Sodium monofluorophosphate 0.76 ? 0.76 0.76 0.76
Sodium fluoride ? 0.32 ? ? ?
Gluconic acid sodium salt ? 1.00 ? ? ?
Stannous chloride dihydrate ? 1.00 ? ? ?
Zinc citrate ? 0.50 ? ? ?
Tertiary sodium phosphate 3.20 ? ? ? ?
Wetting agent 10.50 33.00 12.00 14.00 57.00
Anhydrous tetrasodium pyrophosphate ? ? 0.50 0.50 3.85
Sodium acid pyrophosphate ? ? ? ? 1.00
Titanium dioxide 0.50 0.50 ? ? 0.25
Water, purification, USP In right amount In right amount In right amount In right amount In right amount
Composition IIF IIG IIH II IIK
Calcium carbonate ? ? ? 40.00 ?
Binding agent 1.00 1.8 1.00 1.00 0.20
Thickening agent 0.5 1.00 1.25 0.4 0.8
Colourant solution (1%) 0.05 0.05 ? ? 0.175
Calcium phosphate dibasic dihydrate ? ? 35.00 ? ?
Flavoring agent 1 1.5 1.0 0.8 1.00 0.8
Cool agent 0.5 0.2 ? 0.08 ?
Glycerol USP 16.489 ? 15.00 ? 0.10
Potassium nitrate 5.00 ? ? ? ?
Combinations of sweeteners 0.47 0.25 0.30 0.300 0.58
Silica abrasive 24.00 12.50 ? ? 17.00
Sodium lauryl sulfate (27.9% solution) 7.50 7.00 5.50 7.00 4.00
50%NaOH solution ? 1.00 ? ? ?
Sodium monofluorophosphate 0.76 ? 0.76 0.76 0.76
Sodium fluoride ? 0.32 ? ? ?
Gluconic acid sodium salt ? 1.00 ? ? ?
Stannous chloride dihydrate ? 1.00 ? ? ?
Zinc citrate ? 0.50 ? ? ?
Tertiary sodium phosphate 3.20 ? ? ? ?
Wetting agent 12.00 33.00 12.00 14.00 57.00
Anhydrous tetrasodium pyrophosphate ? ? 0.50 0.50 3.85
Sodium acid pyrophosphate ? ? ? ? 1.00
Titanium dioxide 0.50 0.50 ? ? 0.25
Water, purification, USP In right amount In right amount In right amount In right amount In right amount
1 flavoring agent comprises approximately 31.3% menthol, and the menthol of about 500ppm is provided.
example product I II-collutory compositions
Prepared by conventional method by the collutory compositions, and group component is shown in hereinafter with percentage by weight (%).
Composition IIIA IIIB IIIC
Ethanol, the USP190 degree 15.000 15.000 15.000
Glycerol 7.500 7.500 7.500
Polysorbate 80, NF 0.120 0.120 0.120
Flavoring agent 0.160 0.160 0.160
Combinations of sweeteners 0.1 0.1 0.060
Colourant solution 0.040 0.040 0.040
Cetylpyridinium chloride 0.045 0.045 0.045
Benzoic acid 0.005 0.005 0.005
Sodium benzoate 0.054 0.054 0.054
Water In right amount In right amount In right amount
example product I V-peroxide collutory compositions
Hereinafter show the collutory compositions that comprises peroxide, group component means with percentage by weight (%).These compositionss are used the conventional method preparation.They provide Herba Menthae taste and the significant long-acting pure and fresh implication of pleasant efficient during use.
Figure BDA00002988270700261
example product V-tartar is controlled Dentrifice composition
The dentifrice hereinafter illustrated is used conventional method preparation; Content means with percentage by weight (%).
Composition VA VB VC VD VE
Calper calcium peroxide FCC ? ? 0.10 ? ?
Thickening agent 5.0 2.5 4.5 0.80 5.0
Binding agent 0.60 0.75 0.40 0.45 0.70
Polymer ? ? 0.20 ? ?
Colourant solution (1%) 0.05 0.05 0.50 0.75 0.175
Flavoring agent ? ? ? ? 0.15
Coolant ? ? 0.02 0.05 0.02
Glycerol USP99.7% 9.00 11.85 33.164 9.00 ?
Poloxamer188, NF ? ? 1.00 ? 0.20
Tetrapotassium pyrophosphate (60% solution) 6.38 ? ? ? ?
Propylene glycol USP Crest ? ? 10.00 ? ?
Combinations of sweeteners 0.46 0.50 0.45 0.40 0.58
Sodium acid pyrophosphate 2.10 ? ? 4.00 1.00
Silica abrasive 22.00 31.00 20.00 21.00 17.00
Multiviscosisty silicon dioxide ? ? 2.00 ? ?
Sodium bicarbonate USP ? 1.50 9.00 ? ?
Natrium carbonicum calcinatum NF ? 0.50 ? ? ?
Sodium hydroxide, 50% solution ? ? 1.74 2.20 ?
Sodium lauryl sulfate (27.9% solution) 4.00 5.00 3.00 4.00 4.00
Sodium monofluorophosphate 0.76 0.76 0.76 0.76 0.76
Sorbitol solution USP 24.28 24.54 3.985 44.686 56.885
Anhydrous tetrasodium pyrophosphate 2.05 5.045 3.85 ? 3.85
Titanium dioxide 0.50 ? 1.00 ? 0.25
Titanium dioxide/Carlow bar Wax particles ? 0.60 ? 0.30 ?
Water, purification, USP In right amount In right amount In right amount In right amount In right amount
example-consumer tests 2
Data in following table, from 146 people groups, are wherein sent product in dentifrice as prepared as example V.Choose at random seven products and surpass and estimated in one week in single continuously mode by the group member.The experimenter brushes teeth twice (morning, an afternoon) and then fill in the computerization questionnaire of self management every day.Brush teeth at every turn and use about 1.0 gram products.Dentifrice (d) is contained in the sweeting agent of product same ratio in consumer tests 1.
Figure BDA00002988270700271
Figure BDA00002988270700281
Overall evaluation preference, Herba Menthae taste, flavor intensity, sweet taste sensation and higher value and the quality that all other dentifrices-provide are higher significantly is provided dentifrice in test (d).
Dimension disclosed herein and value are not appreciated that and are strictly limited to quoted exact value.On the contrary, except as otherwise noted, each such dimension all is intended to both mean quoted value, also means the scope be equal on the function of this value.For example, the dimension that is disclosed as " 40mm " is intended to mean " about 40mm ".
Unless clearly get rid of or in other words restriction to some extent, each document of quoting herein, comprise any cross reference or Patents or patent application, all is incorporated in full this paper with way of reference accordingly.The quoting of any document is not it as disclosed herein or be subject to the prior art of any invention of claims protection; perhaps its individually or with any combination of any other list of references, or with reference to, propose, suggestion or disclose the approval of any this type of invention.In addition, if in this document, any implication of term or definition are with any implication of same term in the document be incorporated to way of reference or define and conflict mutually, will be as the criterion with implication or the definition of giving that term in this document.
Although illustrate and described specific embodiment of the present invention, it should be apparent to those skilled in the art that in the situation that do not break away from the spirit and scope of the invention and can make many other change and modification.Therefore, claims are intended to contain all these changes and the modification in the scope of the invention.

Claims (15)

1. a sweetener composition, the mixture that comprises sweeting agent A, sweeting agent B and sweeting agent C,
Wherein
A) sweeting agent A is the artificial sweetener with 250 to 350 Seqs;
B) sweeting agent B is the artificial sweetener with 500 to 600 Seqs; And
C) sweeting agent C is the natural sweetener with 100 to 400 Seqs.
2. sweetener composition according to claim 1, the mixture that comprises sweeting agent A, sweeting agent B and sweeting agent C, wherein
A) sweeting agent A is selected from: glucide, alitame, aspartame, neotame, cyclamate and their mixture;
B) sweeting agent B is selected from: three chloros-sucrose (sucralose), acesulfame, neohesperidin DC, thaumatin, glycyrrhizin, Momordia grosvenori aglycone IV, mogroside Ⅴ, Cyclocarya paliurus Iljinskaja glycosides I, N-[N-[3-(3-hydroxyl-4-methoxyphenyl) propyl group]-L-α-aspartyl]-L-Phe 1-methyl ester, N-[N-[3-(3-hydroxyl-4-methoxyphenyl)-3-methyl-butyl]-L-α-aspartyl]-L-Phe 1-methyl ester, N-[N-[3-(3-methoxyl group-4-hydroxy phenyl) propyl group]-L-α-aspartyl]-L-Phe 1-methyl ester, and their mixture, and
C) sweeting agent C is selected from: stevioside, rebaudioside A, RB, dulcoside B, Rebaudiodside A D, Rebaudiodside A E, Rebaudiodside A F, Du Ke glycosides A, Du Ke glycosides B, Rubusoside, Folium Stevlae Rebaudianae, stevioside, momordica grosvenori sweetening agent, the Simon glycosides, Monatin and salt thereof (Monatin SS, RR, RS, SR), Rhizoma Curculiginis sweet protein, monellin, mabinlin, Bradley neat because of, Holland's sucdrol (hemandulcin), leaf stripe, the root bark phenolic glycoside, phlorhizin, Trilobatin, shellfish promise glycosides (baiyanoside), Ao Silaiding, a poly-ripple glycosides (polypodoside) A, butterfly card glycosides (pterocaryoside) A, butterfly card glycosides B, if Mu Ku glycosides (mukurozioside), MISOPROSTOL glycosides (phlomisoside) I not, periandrin I, the Semen Abri Precatorii saponin A, and their mixture.
3. according to claim 1 or sweetener composition claimed in claim 2, the ratio of wherein said sweeting agent A, B and C is (0.5-2): (0.5-2): 2.
4. sweetener composition according to claim 2, the ratio of wherein said sweeting agent A and sweeting agent B is 0.5:1 to 2:1.
5. sweetener composition according to claim 2, the ratio of wherein said sweeting agent A and sweeting agent C is 0.3:1 to 0.9:1.
6. sweetener composition according to claim 2, the ratio of wherein said sweeting agent A and sweeting agent C is 0.3:1 to 0.7:1.
7. according to sweetener composition in any one of the preceding claims wherein, wherein sweeting agent A is glucide, and sweeting agent B is sucralose, and sweeting agent C comprises rebaudioside A.
8. sweetener composition according to claim 2, the combination of its glucide that is about 1:1:2 by ratio, sucralose and Rebaudiodside A forms.
9. an oral cavity composition comprises:
A) sweetener composition of claim 2, the preferably sweetener composition of 0.01% to 1% claim 2; With
B) one or more oral cavity acceptable carrier materials.
10. oral cavity composition according to claim 9, comprise alkylphosphonic or alkyl sulfate surfactant.
11. according to the described oral cavity composition of claim 9 or 10, comprise and be selected from following oral care active: caries preventive agent, antimicrobial, anticalculus agent, halitosis remover, bleach and their mixture.
12. according to claim 9,10 or 11 described oral cavity compositions, comprise and be selected from following slaine: zinc salt, tin salt, potassium salt, mantoquita, strontium salt and their mixture preferably comprise and are selected from following slaine: zinc salt, tin salt, mantoquita and their mixture.
13. oral cavity composition according to claim 9, comprise aminoacid, preferably comprises and be selected from following aminoacid: arginine, lysine, ornithine, citrulline and their mixture.
14. oral cavity composition according to claim 9, comprise bleach.
15. oral cavity composition according to claim 9 comprises and is selected from following sensory agent: cool agent, warm dose, numb agent and their mixture of stinging.
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