CN103127436B - Traditional Chinese medicine composition for treating acute radioactive skin injury - Google Patents
Traditional Chinese medicine composition for treating acute radioactive skin injury Download PDFInfo
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- CN103127436B CN103127436B CN201310054102.7A CN201310054102A CN103127436B CN 103127436 B CN103127436 B CN 103127436B CN 201310054102 A CN201310054102 A CN 201310054102A CN 103127436 B CN103127436 B CN 103127436B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating acute radioactive skin injury. The traditional Chinese medicine composition comprises fine powders which are grinded through senecio scandens, paris polyphylla, fructus galangae, blumea balsamifera, herba aristolochiae, folium photiniae, tangerine seeds, bletilla and red peony roots. The drug is sieved through 100-mesh sieve and added with appropriate honey to be manufactured to be paste, irradiation field area skin is carried out on a treatment of topical application of the drug, and a control group adopts a method of a conventional radioactive skin treatment. A clinical test is proved, skin reaction occurrence rates of the treatment group in the fifth day, the tenth day and the fifteenth day of the drug using are respectively 32.9%, 43.4% and 44.7%; skin reaction occurrence rates the control group in the fifth day, the tenth day and the fifteenth day are respectively 55.5%, 71.1% and 87.0%. Through observation, the traditional Chinese medicine composition is thought to have an obvious curative effect on prevention and treatment of cervical cancer radiation patient acute radioactive skin injury. By the adoption of a method of continuous topical application of the drug, the time of skin contacting the drug is long, absorption is easy, and cost is low. The traditional Chinese medicine composition is worthy to be popularized.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of acute radiation skin injury.
Background technology
Radiotherapy is one of primary treatment means of malignant tumor, is all inevitably irradiated to some normal structures or organ in treatment clinical course.Nearly all patient skin mucosa and subcutaneous tissue are all accepted extra exposure dose; Cervical cancer is modal gynecologic malignant tumor.Previously II above stage middle-advanced cervical carcinoma of b phase adopts radiotherapy in principle, radiotherapy is except easily causing radiation rectitis, radiocystitis, radiation skin injury also causes doctor and patient's concern just gradually, if radiation injury prevents not in time and treats, can produce impact greatly to completing smoothly with patients ' life quality of radiotherapy planning.At present, desirable Therapeutic Method without comparison also.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of acute radiation skin injury.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment acute radiation skin injury is made by the Chinese medicine of following weight portion: Herba Senecionis Scandentis 10-30 part, Rhizoma Paridis 5-20 part, Fructus Galangae 15-30 part, Herba Blumeae Balsamiferae 3-13 part, Herba Aristolochiae 5-20 part, Folium Photiniae (Folium Photiniae serrulatae) 10-25 part, Semen Citri Reticulatae 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-25 part, Radix Paeoniae Rubra 10-30 part.
Preferably, 20 parts of Herba Senecionis Scandentiss, 12 parts of Rhizoma Paridis, 23 parts of Fructus Galangaes, 8 parts of Herba Blumeae Balsamiferaes, 12 parts of Herba Aristolochiaes, 17 parts of Folium Photiniae (Folium Photiniae serrulatae), 12 parts of Semen Citri Reticulataes, 17 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Radix Paeoniae Rubra.
Herba Senecionis Scandentis, Rhizoma Paridis heat-clearing and toxic substances removing in side, cool the blood dissipate blood stasis; Fructus Galangae, Herba Blumeae Balsamiferae heat clearing and damp drying, promoting blood circulation and detoxication; Herba Aristolochiae promoting flow of QI and blood, inducing diuresis to remove edema; Folium Photiniae (Folium Photiniae serrulatae) dispelling wind and removing obstruction in the collateral; The pain relieving of Radix Paeoniae Rubra clots absorbing, removing heat from blood detumescence; Semen Citri Reticulatae is regulated the flow of vital energy, eliminating stagnation, pain relieving; Pseudobulbus Bletillae (Rhizoma Bletillae) hemostasia and detumescence, promoting tissue regeneration and ulcer healing.All medicines share, and play altogether heat-clearing and toxic substances removing, and circulation of qi promoting dissipating blood stasis is turbid except humidifying, the merit of cutting poison bundle poison.
Preparation method: above-mentioned Chinese medicine is ground into carefully not, crosses 100 mesh sieves, get proper honey furnishing pasty state during use standby.
Clinical data
1, this group of physical data case 152 examples, wherein age minimum is 25 years old, and maximum 75 years old, 51 years old mean age.All cases is diagnosed as cervical cancer through pathology, scale cancer 138 examples wherein, adenocarcinoma 10 examples, adenosquamous carcinoma 4 examples, syphilis (+) 6 examples, HCV (+) 2 examples.Press FIGO by stages: IIb phases 58 example, IIIb phases 94 example.At random 152 routine cases are divided into treatment group and matched group.
2, radiation therapy method extracorporeal six field radiation all adopts the external exposure of linear accelerator 6MV-X line.According to pelvic lymph node characteristic distributions, adopt the large wild full pelvic irradiation in pelvic cavity front and back, the pelvic cavity vast expanse of open ground to irradiate.Under analog machine, locate, the upper bound is equivalent to 4th～5 lumbar vertebra levels; Lower bound is 4～5cm under superior margin of pubic symphysis; Circle, left and right is femoral head center line.This irradiation field comprises that ilium is total, in ilium, outer, the closed pore of ilium and sacrum ALN group, large wild exposure dose DT26Gy～30Gy; After change the pelvic cavity vast expanse of open ground into and irradiate, launched field boundary is constant only at full pelvic field center stop 3～4cm wide (length is with former launched field) lead.Pelvic cavity vast expanse of open ground exposure dose DT20Gy-24Gy; After the large wild irradiation 20Gy of pelvic cavity, start the row intracavitary afterloading therapy same period, adopt 192Ir afterloading unit intracavitary radiotherapy, A point 6Gy/ time, 1 time/week, accumulated dose 36～42Gy/6～7 time.
3, radiation skin injury is pressed 0 grade of RTOG grade scale: unchanged; 1 grade: slight atrophy, pigmentation, division header falling out; 2 grades: lamellar atrophy, moderate telangiectasis, all alopecia; 3 grades: obviously atrophy, intercrossing telangiectasis; 4 grades: ulcer.
4, Therapeutic Method treatment group: get Herba Senecionis Scandentis 200g, Rhizoma Paridis 120g, Fructus Galangae 230g, Herba Blumeae Balsamiferae 80g, Herba Aristolochiae 120g, Folium Photiniae (Folium Photiniae serrulatae) 170g, Semen Citri Reticulatae 120g, Pseudobulbus Bletillae (Rhizoma Bletillae) 170g, Radix Paeoniae Rubra 200g, be ground into carefully not, cross 100 mesh sieves, during use, get appropriate with Mel furnishing pasty state, in 2 weeks (irradiating 10 times) exposure doses of radiotherapy, reaching 20GY starts to contrast coverage field skin and carries out the drug of topical application, finish to radiotherapy, treatment group adds Mel furnishing pasty state by JINHUANG SAN and spreads on the wild district of abdominal irradiation outward, drug of topical application scope is greater than irradiation field scope 2-3cm, thick 0.5cm, with one-time treatment towel, praise outward, in case medicine moisture evaporates and lessens the curative effect, replacing in 24 hours (is once to wash away medicine before radiotherapy every day, the drug of topical application after radiotherapy), during each replacing, with continuous label, dip in normal saline clean local.
Conventional planning skin nursing method for matched group, the course for the treatment of same treatment group.
5, method for estimating curative effect starts at every turn, by with 1 charge nurse's drug of topical application and dermoreaction is assessed, every day 1 time, to record time, exposure dose, symptom classification and duration of symptoms that dermoreaction occurs from medication.
6, the incidence rate of therapeutic outcome cervical cancer radical radiation therapy radioactive skin reaction relatively sees the following form.
The incidence rate comparison of cervical cancer radical radiation therapy radioactive skin reaction
Two groups of radiation skin injury incidence rates comparison: treatment group radiation skin injury incidence rate is than the obvious minimizing of matched group, and two groups relatively have statistical significance (P < 0.01).
The specific embodiment
Embodiment mono-: get Herba Senecionis Scandentis 200g, Rhizoma Paridis 120g, Fructus Galangae 230g, Herba Blumeae Balsamiferae 80g, Herba Aristolochiae 120g, Folium Photiniae (Folium Photiniae serrulatae) 170g, Semen Citri Reticulatae 120g, Pseudobulbus Bletillae (Rhizoma Bletillae) 170g, Radix Paeoniae Rubra 200g, be ground into carefully not, cross 100 mesh sieves, during use, get appropriate standby with Mel furnishing pasty state.
Embodiment bis-: get Herba Senecionis Scandentis 100g, Rhizoma Paridis 200g, Fructus Galangae 150g, Herba Blumeae Balsamiferae 30g, Herba Aristolochiae 200g, Folium Photiniae (Folium Photiniae serrulatae) 100g, Semen Citri Reticulatae 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Paeoniae Rubra 300g, be ground into carefully not, cross 100 mesh sieves, during use, get appropriate standby with Mel furnishing pasty state.
Embodiment tri-: get Herba Senecionis Scandentis 300g, Rhizoma Paridis 50g, Fructus Galangae 300g, Herba Blumeae Balsamiferae 130g, Herba Aristolochiae 50g, Folium Photiniae (Folium Photiniae serrulatae) 250g, Semen Citri Reticulatae 200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 250g, Radix Paeoniae Rubra 100g, be ground into carefully not, cross 100 mesh sieves, during use, get appropriate standby with Mel furnishing pasty state.
Embodiment tetra-: get Herba Senecionis Scandentis 130g, Rhizoma Paridis 170g, Fructus Galangae 200g, Herba Blumeae Balsamiferae 90g, Herba Aristolochiae 80g, Folium Photiniae (Folium Photiniae serrulatae) 150g, Semen Citri Reticulatae 70g, Pseudobulbus Bletillae (Rhizoma Bletillae) 200g, Radix Paeoniae Rubra 160g, be ground into carefully not, cross 100 mesh sieves, during use, get appropriate standby with Mel furnishing pasty state.
Claims (1)
1. treat a Chinese medicine composition for acute radiation skin injury, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight: Herba Senecionis Scandentis 200g, Rhizoma Paridis 120g, Fructus Galangae 230g, Herba Blumeae Balsamiferae 80g, Herba Aristolochiae 120g, Folium Photiniae (Folium Photiniae serrulatae) 170g, Semen Citri Reticulatae 120g, Pseudobulbus Bletillae (Rhizoma Bletillae) 170g, Radix Paeoniae Rubra 200g.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103920031B (en) * | 2014-04-10 | 2018-06-01 | 威海市妇女儿童医院 | A kind of skin reactions intervene drug and preparation method thereof |
| CN105920119A (en) * | 2016-04-29 | 2016-09-07 | 丽水市人民医院 | Traditional She medicine for treating skin injury and application method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245707A (en) * | 1999-08-12 | 2000-03-01 | 黄英秀 | Chinese medicine for curing AIDS and carcinomatosis |
| CN101926935B (en) * | 2010-08-05 | 2012-05-23 | 韩必芝 | Wound anti-inflammation irrigant and preparation method thereof |
| CN102580033A (en) * | 2012-03-13 | 2012-07-18 | 广西梧州三鹤药业有限公司 | Medicinal composition for treating skin injury and quality detection method |
| CN102579772A (en) * | 2012-02-27 | 2012-07-18 | 单淑香 | Preparation method of Chinese medicinal lotion for treating chronic ulcer of shank with phlegm turbidity and obstruction syndrome |
| CN102836369A (en) * | 2012-09-27 | 2012-12-26 | 景义 | Traditional Chinese medicine decoction for treating middle-late lung cancers |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245707A (en) * | 1999-08-12 | 2000-03-01 | 黄英秀 | Chinese medicine for curing AIDS and carcinomatosis |
| CN101926935B (en) * | 2010-08-05 | 2012-05-23 | 韩必芝 | Wound anti-inflammation irrigant and preparation method thereof |
| CN102579772A (en) * | 2012-02-27 | 2012-07-18 | 单淑香 | Preparation method of Chinese medicinal lotion for treating chronic ulcer of shank with phlegm turbidity and obstruction syndrome |
| CN102580033A (en) * | 2012-03-13 | 2012-07-18 | 广西梧州三鹤药业有限公司 | Medicinal composition for treating skin injury and quality detection method |
| CN102836369A (en) * | 2012-09-27 | 2012-12-26 | 景义 | Traditional Chinese medicine decoction for treating middle-late lung cancers |
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