CN103127292A - Preparation for nourishing liver and kidney, delaying senescence, removing freckles and beautifying - Google Patents
Preparation for nourishing liver and kidney, delaying senescence, removing freckles and beautifying Download PDFInfo
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Abstract
The invention discloses a preparation for nourishing liver and kidney, delaying senescence, removing freckles and beautifying. The preparation is prepared from the following materials in parts by weight: 2500-3500 parts of cherries, 90-100 parts of safflower, 40-60 parts of spina date seed, 40-60 parts of poria, 40-60 parts of longan aril, 40-60 parts of herba leonuri, 40-60 parts of chrysanthemum, 40-60 parts of panax quinquefolium, 40-60 parts of peach seed, 40-60 parts of angelica sinensis, 20-30 parts of honey and 8000-12000 parts of 50 DEG C white wine. The preparation is processed through the steps of crushing, steeping, decompressing, concentrating, centrifuging, blending, filtering, filling and the like. According to the preparation, traditional Chinese medicines with mild drug properties are selected according to a traditional Chinese medicine theory, and the preparation has the efficacies of nourishing liver and kidney, benefiting qi, nourishing blood, nourishing heart, tranquilizing mind, and moistening skin by virtue of the combined medicines, so that the purposes of nourishing liver and kidney, delaying senescence, removing freckles and beautifying are achieved.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula, be used for nourishing the liver and kidney, slow down aging and spot-eliminating beauty treatment.
Background technology
Deficiency of liver-YIN and deficiency of the kidney yin merge becomes the hepatic and renal YIN deficiency, deficiency of liver-YIN mainly causes due to deficiency of the kidney yin, deficiency of kidney-QI, and the Symptoms of the hepatic and renal YIN deficiency is mainly: hypomnesis, unhappy, self-doubt, sexual function reduction, senilism, alopecia and white hair, presenility etc.Reach with the quickening pace of modern life the increase of operating pressure, the living habit such as people's diet, sleep are more and more irregular, cause hepatic and renal YIN deficiency crowd's continuous increase.The hepatic and renal YIN deficiency can cause that body crosses presenility, is embodied in forgetful insomnia, inappetence, and skeleton and arthralgia, soreness of the waist and knees, endurance, not weak, visual deterioration, audition decay, alopecia or early whitening of beard and hair, odontoseisis Yi Luo etc.; Also presenility be can make, eye pouch, black eye are specially, the dark and gloomy tarnish of the colour of skin, skin quality is coarse, dry, wrinkle occurs, mottle, middle aged skin sore, skin lacks flexibility, and voice is gruff gradually, and female breast begins sagging, waist, abdomen athero, male's male pattern alopecia etc.These symptoms are brought very large misery to people especially women, have had a strong impact on people's orthobiosis and work, and have become a class social problem, cause that more and more people pay close attention to.The product of the nourishing the liver and kidney that occurs in the market, spot-eliminating beauty treatment, slow down aging is more, but add chemical composition more, after human body is edible, dependency is arranged, some cosmetics are owing to including the chemical composition harmful to skin, also can damage skin with of a specified duration, make the people old and feeble.Therefore, invent and a kind ofly can overcome the existing product deficiency, the product that reaches nourishing the liver and kidney, spot-eliminating beauty treatment, slow down aging purpose is significant.
Summary of the invention
Technical problem to be solved by this invention is to provide the preparation of a kind of nourishing the liver and kidney, slow down aging, spot-eliminating beauty treatment, and not only effect is remarkable, and cheap, taking convenience.
The technical solution adopted in the present invention is: adopting Fructus Pruni pseudocerasi, Flos Carthami, Semen Ziziphi Spinosae, Poria, Arillus Longan, Herba Leonuri, Flos Chrysanthemi, Radix Panacis Quinquefolii, Semen Persicae, Radix Angelicae Sinensis, Mel, Chinese liquor is primary raw material, is made by following quality proportioning: 2500～3500 parts, Fructus Pruni pseudocerasi, 90～100 parts, Flos Carthami, 40～60 parts of Semen Ziziphi Spinosaes, 40～60 parts, Poria, 40～60 parts of Arillus Longans, 40～60 parts of Herba Leonuris, 40～60 parts of Flos Chrysanthemis, 40～60 parts of Radix Panacis Quinquefoliis, 40～60 parts, Semen Persicae, 40～60 parts of Radix Angelicae Sinensis, 20～30 parts of Mel, 8000～12000 parts of 50 degree Chinese liquor; Wherein Poria, Flos Carthami, Semen Persicae, Radix Angelicae Sinensis, Radix Panacis Quinquefolii powder are broken into 24 order coarse powder, and Arillus Longan, Semen Ziziphi Spinosae, Herba Leonuri, Flos Chrysanthemi is cataclasm, is placed in rustless steel container, spend the airtight dipping of Chinese liquor 2 times with 50 respectively, use for the first time 12 times of amounts, lixiviate 7d, stir once every day, collects cooling bath; Use for the second time 10 times of amounts, lixiviate 7d, stir once every day, collect cooling bath, medicinal residues merge press liquor and twice supernatant again through squeezing, decompression (0.080～-0.085Mpa, 60 ℃) when being concentrated into relative density and being 1.05-1.10, cooling, standing 24h puts in centrifuge (4000r/min) centrifugal, collect clear liquor, namely get the medical material wine liquid; Then fresh Fructus Pruni pseudocerasi essence is picked up, clean up, smash to pieces with machinery after enucleation, put in centrifuge, centrifugal 30min, waste is collected Fructus Pruni pseudocerasi liquid; Fructus Pruni pseudocerasi liquid and medical material wine liquid are blent, added the Mel stirring and dissolving, mixing, sealing, standing 10d, with 200 mesh sieve plate-and-frame filtration, then with 0.22 μ m membrane filter fine straining, the filtrate fill, and get final product.
It is 15～30mL that preparation suggestion day of the present invention takes effective dose, divides and takes for 2 times.
The invention has the beneficial effects as follows: the present invention selects according to the Chinese medicine theory Chinese medicine that the property of medicine is gentle and have nourishing the liver and kidney, mind tranquilizing and the heart calming, antioxidation, skin care effect, wherein Fructus Pruni pseudocerasi, Semen Ziziphi Spinosae, Flos Chrysanthemi nourishing the liver and kidney, Fructus Pruni pseudocerasi, Radix Panacis Quinquefolii invigorating QI and tranquilization, Poria, Semen Ziziphi Spinosae, Flos Chrysanthemi mind tranquilizing and the heart calming, Flos Carthami, Herba Leonuri, Mel, Arillus Longan nourishing blood to tranquillize the mind, Chinese angelica blood supplementing is calmed the nerves; Semen Persicae, Flos Carthami, Herba Leonuri, Radix Angelicae Sinensis QI and blood regulating, the battalion's face of invigorating blood circulation, dissolving stasis and dispelling spots.All medicines share, and gather altogether the effect of nourishing the liver and kidney, benefiting qi and nourishing blood, mind tranquilizing and the heart calming, skin care, thereby reach the purpose of nourishing the liver and kidney, slow down aging, spot-eliminating beauty treatment.
Compound basis:
Fructus Pruni pseudocerasi, sweet in the mouth enters spleen, Liver Channel, the strengthening the spleen stomach, nourish liver and kidney has the effect of skin care life lengthening.Fructus Pruni pseudocerasi has very high nutritive value, contains the nutritional labelings such as abundant saccharide, protein, calcium, ferrum, and wherein the ferrum amount occupies first of fruit.The traditional Chinese medical science thinks, heart master blood, spleen are the source of hemopoietic, weakness of the spleen and stomach, blood failing to tonify the heart, mental derangement, therefore forgetful insomnia, the hepatic and renal YIN deficiency, can not on meet at the heart, cause deficiency-heat to disturb god, therefore vexed insomnia.The present invention is take Fructus Pruni pseudocerasi as principal agent, and the strengthening the spleen stomach is taken a tonic or nourishing food to build up one's health heart spleen, and QI invigorating rises blood, nourish liver and kidney, and heat clearing away blood, tranquilizing by nourishing the heart, thus improve sleep.Motherland's medical science is thought, the Fructus Pruni pseudocerasi strongly invigorating primordial QI is transferred blood to invigorate blood circulation, but often eaten the Fructus Pruni pseudocerasi nourishes rough skin, and beauty functions is arranged, and it is had rosy cheeks, and has good color.
Flos Carthami, acrid in the mouth, warm in nature.GUIXIN, Liver Channel.Have blood circulation promoting and blood stasis dispelling, the tissue regeneration promoting function nourishes blood.The discussion of " consumptive disease with restlessness insomnia " is also arranged in " Medical Treasures of the Golden Chamber ".The traditional Chinese medical science thinks, Flos Carthami have invigorate blood circulation, promoting the circulation of blood, the effect that nourishes blood, nourish the blood of the heart thereby reach, the effect of mind tranquilizing and the heart calming.Pharmacological research shows, Flos Carthami has the effect that strengthens immunity, and its function of promoting blood circulation to disperse blood clots can effectively improve microcirculation, play nourishes rough skin, organismic internal environment can be kept relative stability, and enhancing body resistance against diseases and to the adaptive capacity of adverse environment reduces disease and slow down aging.Clinical research shows, treats chloasma take Semen Persicae, Flos Carthami as main decoct and has good curative effect.
Semen Ziziphi Spinosae, sour in the mouth, sweet, property is flat, returns liver, gallbladder, heart channel, has the blood that nourishes heart, the liver benefiting blood, mind calming god's effect.Can suppress the central nervous system, and prove through clinical trial, truly have the effect of Cure for insomnia.Pharmacological research shows, Semen Ziziphi Spinosae total flavonoids, total Saponin and Semen Ziziphi Spinosae oil all can obviously reduce spontaneous activity in mice, have the effect of calmness and hypnosis.And the Semen Ziziphi Spinosae oil life-time service has no toleration.Studies show that, suanzaoren decoction can significantly reduce mice autonomic activities number of times, increases sub-threshold dose pentobarbital sodium induced mice sleep number of elements, extends above threshold dosage pentobarbital sodium induced mice length of one's sleep.The researchs such as Chen Baiquan are pointed out, jujuboside is the main component of Semen Ziziphi Spinosae central inhibitory action, its high, medium and low three dosage groups all can obviously suppress the movable number of times of normal mouse, suppress the central excitation effect of amfetamine, reduce the coordination exercise of rat, shorten its downslide time, effect is strong and weak to be proportionate with the dosage size.And the jujuboside A of high dose is overexcited to CA 1 of Hippocampus inhibitory action is arranged.
Poria, property is sweet, light, flavor is flat, GUIXIN, spleen, kidney, urinary bladder channel.Has invigorating spleen and reinforcing stomach, the effects such as mind tranquilizing and the heart calming.Poria contains the Multiple components such as pachyman, pachyman, and clinical use proves, Poria not only has the effect of spleen invigorating invigorating middle warmer, and be mind calming, the calmness of calming the nerves preferably, improve the good medicine of the uniqueness of effect simply of immunity of organisms.Pharmacological research shows: the Poria water decoction has sedation to mice, with Poria and compound preparation Cure for insomnia thereof, curative effect is preferably arranged all.In addition, Poria also has the effect of promoting diuresis to eliminate damp pathogen, can regulate renal function.
Arillus Longan, sweet in the mouth, warm in nature.GUIXIN, spleen channel.Arillus Longan is rich in the compositions such as glucose, sucrose, protein, multivitamin, invigorating the heart and spleen is arranged, the effect of nourishing blood to tranquillize the mind.Be used for insufficiency of vital energy and blood, severe palpitation, the diseases such as forgetful insomnia.
Herba Leonuri, bitter in the mouth, property suffering are slightly cold.Return liver, pericardium channel, promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Modern medicine study proves, Herba Leonuri contains the materials such as leonurine, stachydrine.This Alkaloid has physiologically active, and skin is had the competent cell tissue, and the beautification function such as enhance metabolism and brighten.Also contain various trace elements, trace element is moist skin, the beauty treatment of beneficial face, the material base of health care.Wherein selenium has the generation that strengthens the immunocyte vigor, relaxes atherosclerosis and improves the effect that body is defendd the function of diseases system; Manganese energy antioxidation, anti-aging, resisting fatigue reach and improve sleep, improve function of human body comprehensively.
Flos Chrysanthemi, sweet in the mouth, hardship, cold nature.Return lung, Liver Channel.The Flos Chrysanthemi clearing heat and relieving fidgetness, mind tranquilizing and the heart calming is used for hyperactivity of fire caused by deficiency of YIN, liver-yang disturbance type insomnia.Flos Chrysanthemi benefit blood profit is held, and has the beautification function of skin care.
Radix Panacis Quinquefolii, sweet in the mouth, little hardship, cool in nature.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Be used for the deficiency of vital energy thanks to cloudy, interior-heat, cough with asthma expectorant blood, the tired tired disease of waiting of deficiency-heat.Radix Panacis Quinquefolii contains the compositions such as ginsenoside, quintessence oil, starch, saccharide, and the effect of tranquillizing and allaying excitement is arranged.
Semen Persicae, bitter in the mouth, sweet, property is flat.GUIXIN, liver, large intestine channel.Activating blood circulation and dissipating phlegm, loosening bowel to relieve constipation.The Semen Persicae heat clearing away is eliminated the phlegm, and mind tranquilizing and the heart calming is used for the type of phlegm-heat attacking internally insomnia.The Semen Persicae blood circulation promoting and blood stasis dispelling can improve microcirculation, and endocrine regulation plays the effect of skin care.
Radix Angelicae Sinensis, sweet in the mouth, suffering, warm in nature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, the diseases such as amenorrhea dysmenorrhea.Radix Angelicae Sinensis contains the organic principles such as multiple organic acid, lipid, sugar, several amino acids, trace element.Pharmacological research shows, Chinese Angelica blood replonishing is calmed the nerves, and deficiency of YIN-blood institute induced insomnia is improved effect.Contained provitamin A, vitamin B
12Deng the nutrients such as aminoacid of multivitamin and needed by human, can strengthen human body metabolism and endocrine function, make skin gloss fine and smooth.
The Mel sweet in the mouth, property is flat, returns lung, spleen, large intestine channel, can help the intestines and stomach digestion, and peace is supported spirit.Be rich in glucose and fructose in Mel, also contain multivitamin, aminoacid, protein, various trace elements, can directly be digested and absorb by human body, be the best of human foods.The traditional Chinese medical science is thought " discomfort in the stomach is night restlessness ".Take Mel, can promote human body to digest and assimilate, appetite stimulator, calming soporific is grown the lung QI invigorating, improves body immunity.Clinical proof, Mel have the effect of nourishing skin moistening, tranquilizing soporific.
Efficacy effect:
1, nourishing the liver and kidney, slow down aging
The contained Chinese medicine ingredients of preparation of the present invention can be alleviated the symptoms such as hypomnesis due to the hepatic and renal YIN deficiency, unhappy, self-doubt, sexual function reduction, senilism by nourishing the liver and kidney.Can remove human free radical, reduce the damage of radical pair cell, slow down aging.
2, postpone climacteric, alleviate menopause syndrome
The contained functional component of preparation of the present invention can endocrine regulation, provides nutrient to ovary, repairs and promotes the estrogenic function of ovarian secretion, thereby reaching the elimination menopause syndrome, postpones involutional purpose.
3, QI and blood regulating, dissolving stasis and dispelling spots
Preparation of the present invention can strengthen metabolism and the endocrine function of human body, QI and blood regulating, invigorate blood circulation battalion's face, skin care, thus reach the purpose of spot-eliminating beauty treatment.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
The invention will be further described below in conjunction with embodiment:
Embodiment 1: the preparation of a kind of nourishing the liver and kidney, slow down aging, spot-eliminating beauty treatment, adopt Fructus Pruni pseudocerasi 3000g, Flos Carthami 96g, Semen Ziziphi Spinosae 48g, Poria 48g, Arillus Longan 48g, Herba Leonuri 48g, Flos Chrysanthemi 48g, Radix Panacis Quinquefolii 48g, Semen Persicae 48g, Radix Angelicae Sinensis 48g, Mel 24g, Chinese liquor 10560ml through pulverizing, lixiviate, the technique such as concentrated, centrifugal are made medicated wine.
Embodiment 2: the preparation of a kind of nourishing the liver and kidney, slow down aging, spot-eliminating beauty treatment, adopt Fructus Pruni pseudocerasi 2500g, Flos Carthami 100g, Semen Ziziphi Spinosae 60g, Poria 60g, Arillus Longan 60g, Herba Leonuri 60g, Flos Chrysanthemi 60g, Radix Panacis Quinquefolii 60g, Semen Persicae 60g, Radix Angelicae Sinensis 60g, Mel 30g, Chinese liquor 8000ml through pulverizing, lixiviate, the technique such as concentrated, centrifugal are made medicated wine.
Embodiment 3: the preparation of a kind of nourishing the liver and kidney, slow down aging, spot-eliminating beauty treatment, adopt Fructus Pruni pseudocerasi 3500g, Flos Carthami 90g, Semen Ziziphi Spinosae 40g, Poria 40g, Arillus Longan 40g, Herba Leonuri 40g, Flos Chrysanthemi 40g, Radix Panacis Quinquefolii 40g, Semen Persicae 40g, Radix Angelicae Sinensis 40g, Mel 20g, Chinese liquor 12000ml through pulverizing, lixiviate, the technique such as concentrated, centrifugal are made medicated wine.
Embodiment 4: human feeding trial 1
Use the preparation of the present invention of preparation in embodiment 1, the effect of functions of removing chloasma of the present invention is tested.
1 object and method
1.1 study subject: adopt two kinds of control design between self and group, select the 100 simple patients that suffer from for a long time the insomnia of example, the age between 18～60 years old,
1.2 experimental design and grouping: be divided at random test-meal group and matched group according to the symptom weight, every group of 50 examples, the test-meal group is taken preparation of the present invention, and matched group eats placebo, and placebo outward appearance, color and luster, weight, instructions of taking are identical with the present invention.Consider to affect as far as possible the principal element of observed result, as age, sex, the course of disease etc., carry out the harmony check, to guarantee having comparability between two groups.The experimenter takes 2 everyone every day, each 10mL.The duration of test normal diet does not change original dietary habit, and medicine and the health product of the insomnia of inactive other treatment, and viewing duration is 30d.
2 symptom integral are observed: the weight situation scores accumulated (serious symptom 3 minutes, moderate 2 minutes, slight 1 minute) of pressing insomnia.
3 experimental results
Before test-meal, the situation of test-meal group and matched group sees Table 1.
Data as table 1 test-meal is last
After test-meal, the situation of test-meal group and matched group sees Table 2.
Table 2 clinical symptoms integral contrast
Relatively, compare P＜0.01 between P＜0.01 ## group before * and test-meal
Result shows, self relatively reaches between the matched group group before and after the test-meal of test-meal group and compares, and clinical symptoms obviously reduces (P＜0.01), and test-meal group crowd sleep quality obviously improves, and without other side effect, so the present invention is improved the function of sleep.
Test-meal test 2:
1 object and method
1.1 study subject: press the principle of voluntariness and select 22-45 year, have chloasma experimenter 100 examples.
1.1.1 diagnostic criteria: the visible brown spot of Head And Face perusal is mainly in and locates in cheekbone, cheek, volume, nose, lip week etc., without symptoms such as sufferings.
1.1.2 the person's of including in standard: all volunteers that chloasma is arranged, all can carry out test-meal through medical fitness and observe.
1.1.3 eliminator's standard:
1.1.3.1 the age, gestation or women breast-feeding their children were to preparation allergy sufferers of the present invention under-18s or over-65s person.
1.1.3.2 be associated with the serious primary disease such as conscience kidney and hemopoietic system, the psychotic.
1.1.3.3 do not meet inclusive criteria, do not use in accordance with regulations tested material, can't judge effect or data not umbra sound effect or safety judgement person.
1.2 experimental design and grouping: adopt two kinds of forms of contrast between self cross-reference and group.100 experimenters are divided into experimental group and matched group at random, and experimental group is taken tested material, and matched group is blank.
1.3 taking dose and time: every day 2 times, each 10mL, continuous 30d, the experimenter cuts out medicine or other health product and the cosmetics of relevant face-beautifying and spot-removing at experimental session.
2 observation index:
Before and after following observation index experiment, each checks once.
2.1 effect observation:
2.1.1 ordinary circumstance:
Detailed medical history-taking is understood experimenter's diet situation, observes the clinical symptoms such as feeling of fatigue, agitation, sleep, constipation.
2.1.2 the Head And Face chloasma detects:
2.1.2.1 size changes: with major diameter and the wide footpath of the same chloasma in the tested front and back of tape measure, reference area (cm
2).
2.1.2.2 shade changes:
According to Institute of Geography, Academia Sinica's development and design, brown (Y+M+Bk i.e. yellow+pinkish red+black folded color) colour atla in " practical standard colour atla " (front page) that Mapping Press published in 1992 is the criterion of chloasma shade: I degree (15,20,5), II degree (30,40,10), III degree (40,60,15).Calculate integration according to colourity, colour atla I degree, II degree, III degree were counted respectively 1 minute, 2 minutes, 3 minutes.
2.2 safety is observed:
2.2.1 just routine examination of blood and routine urinalysis:
Red blood cell count(RBC), hemoglobin, numeration of leukocyte is urinated ten, just conventional sense.
2.2.2 Biochemical Indexes:
Serum albumin ALB, total protein TP, hepatic and renal function (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT, blood urea nitrogen UREA, inosine CRE), blood glucose GLU, blood fat (T-CHOL TC, triglyceride TG).
2.2.3 Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest (checking once before on-test).
3 spot-removal functions are judged:
Effectively: chloasma color decline I degree, area reduces greater than 10%, does not produce new chloasma.
Invalid: chloasma color and area are without significant change.
4 results are judged:
Test-meal group area of chloasma decreased average, and more than or equal to 10%, the color integration obviously descends, and relatively reaches before and after self with matched group to compare, and difference all has significance, and does not produce new chloasma, can judge that this given the test agent has the effect of chloasma-dispelling function.
5 experimental results:
5.1 general status:
Observe altogether chloasma experimenter 100 examples, be the women, be divided at random experimental group and matched group, every group of 50 examples.Average 34 ± 5 years old of experimental group age.Average 34 ± 5 years old of matched group age.
5.2 the chloasma shade changes:
Before and after table 3. experimenter test-meal preparation of the present invention, chloasma color integration changes
* self relatively compares P＜0.01 between P＜0.01 ## group
By as seen from Table 3, before and after experimenter's test-meal preparation of the present invention, chloasma color integration descends, and changing has significant difference; After test-meal, test-meal group and matched group relatively have significant difference.
5.3 area of chloasma size variation:
Area of chloasma size variation before and after table 4. experimenter test-meal preparation of the present invention
* self relatively compares P＜0.01 between P＜0.01 ## group
By as seen from Table 4, area of chloasma all reduces before and after experimenter's test-meal preparation of the present invention and before and after the matched group test, and changing all has significant difference; After test-meal, test-meal group and matched group relatively have significant difference.
5.4 effect is judged:
Effect result of determination after table 5. experimenter test-meal preparation of the present invention
**P＜0.01
By as seen from Table 5, after test-meal group test-meal preparation of the present invention, comparing total effective rate with matched group has significant difference.
5.5 safety indexes detects:
Safety indexes assay before and after table 6. examination trencherman's test-meal preparation of the present invention
By as seen from Table 6, every biochemical indicator before and after test-meal, urine, just routine is all in normal range.
5.6 the pretest inspection Abdominal B type ultrasonography, electrocardiogram, the x-ray fluoroscopy of chest is all in normal range.
6 conclusions:
6.1100 routine chloasma experimenter is divided into test-meal group and matched group at random, after the test-meal group was taken preparation 30d of the present invention on request, area of chloasma on average dwindled 6.51 ± 3.57cm
2(P＜0.01), area decreased average are 18.66%; Color shoals, and colour atla on average reduces by 0.78 ± 0.68 (P＜0.01); Effective 32 examples wherein, total effective rate 64.00%.Before and after test-meal group self relatively, with the matched group group between comparison color integration and the area difference in change is different that statistical meaning all arranged, do not produce new chloasma during test-meal, illustrate that preparation of the present invention has the functions of removing chloasma effect.
6.2 before and after preparation test-meal of the present invention, routine blood test, urine, just routine and blood biochemistry index all in normal range, illustrate that preparation of the present invention has no adverse effects to the experimenter is healthy.And have no irritated and other untoward reaction during test-meal.
Embodiment 5: human feeding trial 2:
1. experimenter's inclusive criteria: the age, physical condition was good at 45～65 years old, and without obviously brain, the heart, liver, lung, kidney, Hematological Diseases, without the Long-term taking medicine history, the crowd men and women who volunteer tested assurance cooperation all can; The voluntary participation clinical experiment is also signed informed consent person.
2. experimenter's exclusion standard: the age is below 45 years old or the over-65s person; Gestation or women breast-feeding their children are to preparation allergy sufferers of the present invention; Be associated with the serious general disease such as cardiovascular, liver, kidney and hemopoietic system, the psychotic; Take in a short time the article relevant with tested function, have influence on the judgement person to result; Do not meet inclusive criteria, do not use in accordance with regulations given the test agent, can't judge effect or data not umbra sound effect or safety judgement person.
3. experimental design and grouping: select 100 experimenters, the experimenter is divided into test-meal group and matched group at random by MDA, SOD, GSH-Px level, consider as far as possible affect the principal element of result such as age, sex, Diet lifestyle etc., carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 50 examples.
4. test method
Adopt two kinds of control design between self and group.The test-meal group is taken preparation of the present invention, and matched group is taken placebo, and everyone each 10mL, keeps original life and dietary habit constant at every day 2 times during test-meal.Be 90d observing time.
5. observation index
The effect observation: each tests once indices when test-meal begins and finish.
5.1 safety is observed
5.1.1 the general status sign comprises spirit, sleep, diet, defecation, blood pressure etc.
5.1.2 blood, excrement, routine urianlysis.
5.1.3 liver, kidney function test.
5.1.4 Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection
5.2 effect index
5.2.1 variation and the MDA decline percentage rate of MDA before and after the LPO viewing test.
5.2.2 variation and the SOD rising percentage rate of SOD before and after the superoxide dismutase viewing test.
5.2.3 variation and the GSH-Px rising percentage rate of GSH-Px before and after the glutathion peroxidase viewing test.
6. result
6.1 physical data
6.1.1 front two groups of ages of test-meal, sex, diet situation are relatively
By as seen from Table 7, front two groups of ages of test-meal, sex, MDA, SOD, there are no significant for the GSH-Px level difference (P＞0.05), has comparability.
As table 7 test-meal is last, data relatively
6.1.2 experimenter's defecation during test-meal, blood pressure are without extremely, spirit is normal, and diet situation is consistent with diet, and sleep is without abnormal performance, and Chest X-rays before test-meal, Abdominal B type ultrasonography, electrocardiogram are all extremely existing.
6.2 efficiency index
MDA, SOD, the horizontal situation of change of GSH-Px before and after test-meal
The horizontal situation of change of MDA before and after experimenter's test-meal, self compare after the test-meal of test-meal group with before test-meal as seen from Table 8, and difference has highly significant (p＜0.01); And between the matched group group, relatively, difference has highly significant (P＜0.01).
MDA situation of change before and after table 8 test-meal
Annotate: * and matched group be P＜0.01 relatively
The horizontal situation of change of SOD before and after experimenter's test-meal, self compare after the test-meal of test-meal group with before test-meal as seen from Table 9, and difference has highly significant (p＜0.01); And between the matched group group, relatively, difference has highly significant (P＜0.01).
SOD situation of change before and after table 9 test-meal
Annotate: * and matched group be P＜0.01 relatively
The horizontal situation of change of GSH-Px before and after experimenter's test-meal, self compare after the test-meal of test-meal group with before test-meal as seen from Table 10, and difference has highly significant (p＜0.01); And between the matched group group, relatively, difference has highly significant (P＜0.01).
GSH-Px situation of change before and after table 10 test-meal
Annotate: * and matched group be P＜0.01 relatively
7. brief summary
Result shows: preparation of the present invention can obviously reduce the content (P＜0.01) of MDA in serum, and the obvious content (P＜0.01) of increased SOD and GSH-Px.Blood, urine, just conventional before and after test-meal, every detection indexs such as liver, kidney merit, blood glucose is all in normal range, and do not find any toxic and side effects, has the function of good slow down aging.
Claims (2)
1. the preparation of a nourishing the liver and kidney, slow down aging, spot-eliminating beauty treatment adopts 8000～12000 parts, 2500～3500 parts, Fructus Pruni pseudocerasi, 90～100 parts, Flos Carthami, 40～60 parts of Semen Ziziphi Spinosaes, 40～60 parts, Poria, 40～60 parts of Arillus Longans, 40～60 parts of Herba Leonuris, 40～60 parts of Flos Chrysanthemis, 40～60 parts of Radix Panacis Quinquefoliis, 40～60 parts, Semen Persicae, 40～60 parts of Radix Angelicae Sinensis, 20～30 parts of Mel, 50 degree Chinese liquor to make medicated wine; Its concrete preparation method is: Poria, Flos Carthami, Semen Persicae, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, be ground into 24 order coarse powder, Arillus Longan, Semen Ziziphi Spinosae, Herba Leonuri, Flos Chrysanthemi is cataclasm, be placed in rustless steel container, spend the airtight dipping of Chinese liquor 2 times with 50 respectively, use for the first time 12 times of amounts, lixiviate 7d, stir once every day, collects cooling bath; Use for the second time 10 times of amounts, lixiviate 7d, stir once every day, collect cooling bath, medicinal residues merge press liquor and twice supernatant again through squeezing, decompression (0.080～-0.085Mpa, 60 ℃) to be concentrated into relative density be 1.05～1.10h, cooling, standing 24h puts in centrifuge (4000r/min) centrifugal, collect clear liquor, namely get the medical material wine liquid; Then fresh Fructus Pruni pseudocerasi essence is picked up, clean up, smash to pieces with machinery after enucleation, put in centrifuge, centrifugal 30min, waste is collected Fructus Pruni pseudocerasi liquid; Fructus Pruni pseudocerasi liquid and medical material wine liquid are blent, added the Mel stirring and dissolving, mixing, sealing, standing 10d, with 200 mesh sieve plate-and-frame filtration, then with 0.22 μ m membrane filter fine straining, the filtrate fill, and get final product.
2. the preparation of a kind of nourishing the liver and kidney according to claim 1, slow down aging, spot-eliminating beauty treatment, it is 15～30mL that its day takes effective dose, takes minutes for 2 times.
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| CN101015618A (en) * | 2007-02-28 | 2007-08-15 | 西安中科生物有限公司 | Health-care wine with sleeping improving and beauty functions and its preparing process |
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| CN101015618A (en) * | 2007-02-28 | 2007-08-15 | 西安中科生物有限公司 | Health-care wine with sleeping improving and beauty functions and its preparing process |
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Application publication date: 20130605 |