CN103120789A - 一种治疗偏头痛的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗偏头痛的中药组合物。中医学认为，偏头痛的病理机制关键在于不通，通则不痛、痛则不通，而不通的根源在于气滞血瘀导致脑组织的气血不能正常畅通运行，从而引起血管的痉挛收缩而头痛。为此，本发明选择中药奶浆柴胡、樟树果、十八症、细辛、滴水珠、乌药、桂枝、蝉翼藤、五灵脂、三七、莪术、紫河车、肉苁蓉、丁香、甘草，水煎成汤剂，经我院临床试验，总有效率达到97.3％，而且无毒副作用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗偏头痛的中药组合物。
背景技术
偏头痛是神经内科常见病之一，是以头部一侧或两侧反复发作的搏动性疼痛为主要表现的一种临床常见痛症；阳虚寒凝型偏头痛多因头痛日久、阳气渐虚、寒湿内生、蒙寒清窍、脑脉收引而拘挛痛甚，且遇寒加重，反复发作，经久难愈，久成痛风。目前对发病机制尚不明确，临床治疗仍以西药为主，西药治疗偏头痛症只能暂时缓解症状，难以去除病根，给患者带来一定的痛苦，目前，临床缺乏有效的治疗方法。本人经过多年的临床观察发现，利用中药治疗偏头疼具有较好的疗效。
发明内容
本发明的目的是提供一种治疗偏头痛的中药组合物。中医学认为，偏头痛的病理机制关键在于不通，通则不痛、痛则不通，而不通的根源在于气滞血瘀导致脑组织的气血不能正常畅通运行，从而引起血管的痉挛收缩而头痛。
本发明的目的是通过以下技术方案实现的，该治疗偏头痛的中药组合物由以下重量份的中药制成：奶浆柴胡7-10份、樟树果5-8份、十八症5-15份、细辛3-5份、滴水珠10-15份、乌药7-9份、桂枝5-10份、蝉翼藤15-25份、五灵脂5-9份、三七4-6份、莪术8-10份、紫河车7-15份、肉苁蓉9-11份、丁香6-8份、甘草2-4份。
优选的，奶浆柴胡9份、樟树果6份、十八症10份、细辛4份、滴水珠12份、乌药8份、桂枝7份、蝉翼藤23份、五灵脂8份、三七5份、莪术9份、紫河车14份、肉苁蓉10份、丁香7份、甘草3份。
制备方法 按传统的制备方法水煎制成汤剂。
方中：奶浆柴胡、樟树果、十八症、细辛、滴水珠祛风散寒，消瘀止痛，消肿解毒；蝉翼藤、五灵脂、三七、莪术活血化瘀，消肿止痛；乌药行气止痛，温肾散寒；桂枝发汗解肌，温通经脉，助阳化气；紫河车温肾补精，益气养血；肉苁蓉补肾阳，益精血；丁香温中降逆，散寒止痛，温肾助阳；甘草益气补中，清热解毒，缓解止痛。
临床资料
1、一般资料 所选150例患者均为2008年5月-2010年6月本院神经内科门诊的偏头痛患者，随机分为治疗组和对照组，治疗组75例，其中，男性23例，女性52例，年龄18～55岁，平均(35.2±11.5)岁，平均病程(5.8±2.1)；中度头痛60例，重度头痛15例；对照组，其中，男性25例，女性50例，年龄18～60岁，平均(37.2±13.5)岁，平均病程(6.8±8.1)；中度头痛62例，重度头痛13例；两组年龄、性别、病程、头痛程度等一般资料经统计学处理，差异均无显著性意义(P＞0.05)，具有可比性。
2、诊断标准 参照1992年国家中医药管理局脑病急症协作组制定的《头风诊断与疗效评定标准》[1]且符合阳虚寒凝型偏头痛特点：头痛欲裂或跳痛，反复发作，遇寒加重，遇热痛减，头部恶风怕冷，喜裹头，四肢发冷，小便清长，舌淡，脉沉迟。
3、治疗方法 治疗组服用本发明所述的中药组合物，即取奶浆柴胡9g、樟树果6g、十八症10g、细辛4g、滴水珠12g、乌药8g、桂枝7g、蝉翼藤23g、五灵脂8g、三七5g、莪术9g、紫河车14g、肉苁蓉10g、丁香7g、甘草3g，水煎成汤剂，每日一剂，早晚2次分服；对照组给予头痛宁胶囊3粒，每日3次口服；两组均治疗2个月。
4、疗效标准 参照《中药新药临床指导原则》制定的疼痛程度分级评分。缓解：头痛及伴随症状完全消失；显效：头痛程度减轻，伴随症状减轻或发作次数或头痛持续时间减少2/3；有效：头痛程度减轻1级，或发作时间间隔延长，或头痛持续时间减少不足1/3；无效：头痛程度未减轻，头痛持续时间缩短不足1/3或头痛加重，持续时间延长。
5、治疗结果 (1)两组治疗2个月后疗效比较，见表1。
表1 两组治疗2个月后疗效比较
与对照组比较P＜0.05
两组疗效比较，治疗组缓解率，总有效率，明显高于对照组，差异有显著性意义(P＜0.05)。
(2)两组治疗前后头痛发作次数，中医证候积分比较，见表2。
表2. 两组治疗2个月后头痛发作次数、中医证候积分比较
与本组治疗前后比较，①P＜0.05；与对照组治疗后比较，②P＜0.05
两组治疗后头痛发作次数、中医证候积分平均明显减少，与治疗前比较，差异均有显著性意义(P＜0.05)，两组治疗后组间比较，差异也有显著性意义(P＜0.05)。
(3)两组治疗前后头痛持续时间比较，见表3。
表3 两组治疗前后头痛持续时间比较
与本组治疗前后比较，①P＜0.05；一对照组同期比较，②P＜0.05。
两组治疗2个月后头痛持续时间均明显减少，与治疗前比较，差异均有显著性意义P＜0.05)；两组治疗2个月后组间比较，差异也有显著性意义P＜0.05)。
6、不良反应 对照组患者在治疗期间偶然出现恶心、口干、腹部不适，头晕困倦、体重增加等不良反应，但在治疗过程中不良反应逐渐消失；治疗组患者在治疗期间没有出现不良反应。
具体实施方式
实施例一：称取奶浆柴胡9g、樟树果6g、十八症10g、细辛4g、滴水珠12g、乌药8g、桂枝7g、蝉翼藤23g、五灵脂8g、三七5g、莪术9g、紫河车14g、肉苁蓉10g、丁香7g、甘草3g。按传统的制备方法水煎制成汤剂。
实施例二：称取奶浆柴胡7g、樟树果5g、十八症5g、细辛3g、滴水珠15g、乌药9g、桂枝5g、蝉翼藤15g、五灵脂9g、三七4g、莪术10g、紫河车7g、肉苁蓉11g、丁香6g、甘草4g。按传统的制备方法水煎制成汤剂。
实施例三：称取奶浆柴胡10g、樟树果8g、十八症15g、细辛5g、滴水珠10g、乌药7g、桂枝10g、蝉翼藤25g、五灵脂5g、三七6g、莪术8g、紫河车15g、肉苁蓉9g、丁香8g、甘草2g。按传统的制备方法水煎制成汤剂。
Claims (2)
1.一种治疗偏头痛的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：奶浆柴胡7-10份、樟树果5-8份、十八症5-15份、细辛3-5份、滴水珠10-15份、乌药7-9份、桂枝5-10份、蝉翼藤15-25份、五灵脂5-9份、三七4-6份、莪术8-10份、紫河车7-15份、肉苁蓉9-11份、丁香6-8份、甘草2-4份。
2.根据权利要求1所述的一种治疗偏头痛的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：奶浆柴胡9份、樟树果6份、十八症10份、细辛4份、滴水珠12份、乌药8份、桂枝7份、蝉翼藤23份、五灵脂8份、三七5份、莪术9份、紫河车14份、肉苁蓉10份、丁香7份、甘草3份。
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| CN103585417A (zh) * | 2013-11-20 | 2014-02-19 | 张霞 | 一种治疗原发性三叉神经痛的药剂 |
| CN104784501A (zh) * | 2015-05-12 | 2015-07-22 | 潘连香 | 一种治疗偏头痛的药剂 |
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| CN102784280A (zh) * | 2012-08-25 | 2012-11-21 | 孙玲 | 一种治疗偏头痛的中药熏洗液 |
| CN102872421A (zh) * | 2012-10-05 | 2013-01-16 | 程海波 | 一种治疗颅外伤后遗症的中药化瘀合剂 |
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| CN1101277A (zh) * | 1994-04-18 | 1995-04-12 | 鲍淑芬 | 正斜散药及其制备方法 |
| CN102784280A (zh) * | 2012-08-25 | 2012-11-21 | 孙玲 | 一种治疗偏头痛的中药熏洗液 |
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| CN103585417A (zh) * | 2013-11-20 | 2014-02-19 | 张霞 | 一种治疗原发性三叉神经痛的药剂 |
| CN103585417B (zh) * | 2013-11-20 | 2015-05-13 | 张霞 | 一种治疗原发性三叉神经痛的药剂 |
| CN104784501A (zh) * | 2015-05-12 | 2015-07-22 | 潘连香 | 一种治疗偏头痛的药剂 |
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