CN103120767A - Traditional Chinese medicine for treating diabetic retinopathy and preparation method thereof - Google Patents
Traditional Chinese medicine for treating diabetic retinopathy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating diabetic retinopathy and a preparation method thereof. The traditional Chinese medicine comprises the components of red ginseng, Chinese yam, fruit of Chinese wolfberry, dogwood, turtle shell, chrysanthemum, semen plantaginis, moutan bark, gastrodia elata, white atractylodes rhizome (fried), semen cuscutae, root of kudzu vine, earthworm, eucommia ulmoides and the like. The product disclosed by the invention selects a natural plant as a material, and the prescription accords with the theory of traditional Chinese medicine, is free of poison and harm to a human body, and convenient to use by a sufferer, and has better treatment effect on the diabetic retinopathy.
Description
Technical field
The present invention relates to Chinese medicine that a kind for the treatment of of diabetic retinopathy becomes and preparation method thereof, particularly relate to and contain Radix Ginseng Rubra, Rhizoma Dioscoreae, Fructus Lycii, Fructus Corni, Carapax Trionycis, Flos Chrysanthemi, Semen Plantaginis, Cortex Moutan, Rhizoma Gastrodiae, the Rhizoma Atractylodis Macrocephalae (stir-fry), Semen Cuscutae, Radix Puerariae, Pheretima, the Cortex Eucommiae etc. and be used for the treatment of Chinese medicine of diabetic renal papillary necrosis and preparation method thereof.
Background technology
Diabetic renal papillary necrosis is one of severe complication of diabetes.At present clinical is main mainly with controlling blood glucose and laser therapy, and curative effect is not satisfactory, thereby early diagnosis and treatment have positive meaning and clinical value.
Diabetic renal papillary necrosis, early stage patient be without obvious subjective symptoms, and pathological changes further develops or shows as blurred vision, visual deterioration when involving macular area, keeps in dark place, and the colour vision symptom such as go down is to cause blind main cause.Cause the main and retinal vessel of these pathological changes to attenuate, sclerostenosis causes the retinal ischemia anoxia that direct relation is arranged, long-term retinal ischemia anoxia, the new vessels releasing factor is discharged, new vessels generates, and pathological changes enters proliferation period, causes irreversible pathological change.Actively effectively control diabetes, make on an empty stomach and post-prandial glycemia all near normal level, glycolated hemoglobin is controlled at below 7%, be the basic measures of preventing and treating diabetic retinopathy, the quality of glycemic control is related to the weight of retinopathy.Therefore improve in early days the retinal microcirculation obstacle, improve high blood coagulation state, to retinopathy, particularly early lesion is effective method.It is considered herein that this disease should be take Replenishing QI and nourishing YIN, liver heat removing and eyesight improving, blood circulation promoting and blood stasis dispelling as method, through scientific composition, selected Chinese medicine is developed pure Chinese medicinal preparation.
Product of the present invention is through modern pharmacology and a large amount of clinical research confirmation, has the effect that improves circulation, nonenzymatic glycosylation to rat blood serum albumen and crystallin has obvious inhibitory action, can improve hemorheology index, improve microcirculation, diabetic renal papillary necrosis is had therapeutical effect preferably.
Summary of the invention
Purpose of the present inventionBe to provide Chinese medicine of a kind for the treatment of of diabetic retinopathy change and preparation method thereof.
Technical scheme of the present invention:
The Chinese medicine that a kind for the treatment of of diabetic retinopathy becomes, it comprises the component of following weight portion:
27～33 parts of Radix Ginseng Rubra, 8～12 parts of Rhizoma Dioscoreaes, 8～12 parts of Fructus Lycii, 16～24 parts of Fructus Corni, 3～7 parts of Carapax Trionycis, 3～7 parts of Flos Chrysanthemis, 3～7 parts of Semen Plantaginiss, 5～10 parts of Cortex Moutans, 12～18 parts, Rhizoma Gastrodiae, 3～7 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 2～5 parts of Semen Cuscutae, 0.8～1.2 part of Radix Puerariae, 5～12 parts of Pheretimas, 1～5 part of the Cortex Eucommiae.
The preparation method of the Chinese medicine that described treatment of diabetic retinopathy becomes can adopt with lower any one:
Method for making one: the said components raw material is cleaned, pulverized 80～100 mesh sieves, mixing is made the watered pill according to powder and water quality than 1:0.4, drying, and get final product.
Method for making two: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80～100 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials decoct with water 2 times, add for the first time water and be 8～10 times of medical material amount, extract 1～2 hour, add for the second time water and be 6～8 times of medical material amount, extracted collecting decoction 0.5～1.5 hour, filter with 160～200 mesh sieves, it is 1.25～1.30g/cm that filtrate is concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Method for making three: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80～100 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials add 70% alcohol reflux 2 times, add for the first time 70% ethanol and be 8～10 times of medical material amount, reflux, extract, 1～2 hour, adding for the second time 70% ethanol is 6～8 times of medical material amounts, reflux, extract, 0.5～1.5 hour, collecting decoction filters with 160～200 mesh sieves, it is 1.25～1.30g/cm that filtrate recycling ethanol, medicinal liquid continue to be concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Beneficial effect of the present invention: the patient can directly take product of the present invention.
The Chinese medicine that treatment of diabetic retinopathy of the present invention becomes has following features:
1, convenient: use product of the present invention, the patient is easy to use, and therapeutic effect is good.
2, safety: it is raw material that product of the present invention is selected natural plant, and prescription meets theory of Chinese medical science, and is nontoxic to human body.
3, evident in efficacy: the present invention is directed to diabetic renal papillary necrosis has therapeutical effect preferably.
In Chinese medicine formula of the present invention, the effect of each crude drug is:
Radix Ginseng Rubra, Rhizoma Dioscoreae, Fructus Lycii, Fructus Corni, Carapax Trionycis are monarch, and wherein Radix Ginseng Rubra can " tonifying five ZANG-organs makes eye bright except pathogen ... " (" herbal classic "), and Rhizoma Dioscoreae, Fructus Lycii, Fructus Corni, Carapax Trionycis share with supplementing QI and nourishing YIN and make eye bright.
Make eye bright with Flos Chrysanthemi, Semen Plantaginis, Cortex Moutan purging liver-fire, the Rhizoma Gastrodiae suppressing the hyperactive liverization is turbid, and Rhizoma Atractylodis Macrocephalae QI invigorating principal drug assistance reaches the effect of Replenishing QI and nourishing YIN, liver heat removing and eyesight improving and is ministerial drug.Flos Chrysanthemi is hot, bitter, is slightly cold, and returns liver, lung meridian, wind and heat dispersing, and detoxifcation makes eye bright; The Semen Plantaginis sweet in the mouth is cold in nature, returns kidney, liver, lung meridian, and the energy liver heat removing and eyesight improving with Flos Chrysanthemi phase 5, is used for conjunctival congestion, cataract, poor vision, liver-heat conjunctival congestion and swelling pain.Cortex Moutan is bitter, hot, is slightly cold, and GUIXIN, liver, kidney channel, the energy clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, Compendium of Material Medica is called it " with blood, hemopoietic, removing heat from blood, to control the blood fire second of the three ten-day periods of the hot season, heat clearing away and restlessness relieving." Rhizoma Gastrodiae embellishes but not dry, and mainly enters Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, the merit of tool suppressing the hyperactive liver sun, clearing away liver-fire.
Semen Cuscutae is hot, sweet, and is flat, returns liver, kidney channel, has the tonifying liver function of improving eyesight, is usually used in the treating the liver kidney deficiency, poor vision.Radix Puerariae is sweet, hot, cool, returns liver, stomach warp, the energy relieving muscles diaphoresis, and analgesic promoting the production of body fluid is used for calentura excessive thirst effect rather good.Take a tonic or nourishing food to build up one's health Liver and kidney with Semen Cuscutae and make eye bright the side, and Radix Puerariae opening or cleaning gas is to make eye bright, and Pheretima is invigorated blood circulation, and Cortex Eucommiae liver and kidney tonifying is supplementary drug altogether, helps all medicines of the monarch and his subjects to reach the effect of supplementing QI and nourishing YIN, liver heat removing and eyesight improving.
Above most medicine such as Fructus Lycii, Flos Chrysanthemi, Cortex Moutan, Rhizoma Gastrodiae, Radix Puerariae etc. all contain isoflavonoid, through modern pharmacology and a large amount of clinical research confirmation, have the effect that improves circulation, in the side, all medicine mutual reinforcements between are use, the merit of playing altogether supplementing QI and nourishing YIN, liver heat removing and eyesight improving.Can be used for quenching one's thirst with the passing of time, the eye part disease due to the cloudy consumption wound of gas, flaming up of liver-fire, disease is seen the muddy illiteracy of binocular, blurring of vision, attention.
Adopt treatment of diabetic retinopathy of the present invention to become the clinical treatment standard as follows:
More than produce effects (1) vision progress 3 row.(2) optical fundus change to show that the retina microangioma number reduces to (++) by (+++), or reduces to (+) by (++), or by (+) to disappearance; The retinal hemorrhage amount reduces to (+) by (+++), or by (++) to disappearing, seepage discharge reduces (++) by (+++), or reduces to (+) by (++), or by (+) to disappearance; Microangioma, hemorrhage, ooze out to change and have 2 above indexs to reach requirement.(1) and (2) satisfy simultaneously and be produce effects.
Effectively more than (1) vision progress 2 row.(2) optical fundus change to show that the retina microangioma number reduces to (++) by (+++), or reduce to (+) by (++), or by (+) to disappearing, the retinal hemorrhage amount reduces to (+) by (+++), or by (++) to disappearing, seepage discharge by (+++) to (++), or by (++) to (+), or by (+) to disappearing; Microangioma, hemorrhage, ooze out to change and have 1 above index to reach requirement.(1) and (2) satisfy simultaneously for effectively.
Invalid indices is substantially unchanged.
Worsen vision and regress more than 2 row, or the fluoroscopic visualization lesions showed there is new progress.
Every patient gives conventional blood sugar lowering, and blood pressure lowering and blood lipid-lowering medicine treatment make glycolated hemoglobin＜7%, and controlling of blood pressure is below 130/85mmHg, and it is normal or lower that blood fat reaches.Treatment group is taken product 4.5～9g of the present invention every day, and minute morning and evening one twice-daily is oral.The control group calcium dobesilate is oral, and a 0.5g 2 times on the one, withdrew for 1 week after often taking continuously for 3 weeks.3 months is 1 course for the treatment of, and be a curative effect cycle 3 courses for the treatment of.
Concurrent patient with retinopathy 116 examples of type 2 diabetes mellitus, the eye pathological changes is diagnosed as diabetic renal papillary necrosis through fluoroscopic visualization and optical fundus.The patient is divided into two groups at random, each 58 people of product treatment group of the present invention and anticoagulant matched group.Treatment group: male 35 examples, female's 23 examples; Matched group: male 33 examples, female's 25 examples.
Two groups of general curative effects of result see Table 1.
Table 1 a liang group general curative effect is observed table (P＜0.05)
Two groups of vision situations of change see Table 2.
Table 2 a liang group vision situation of change sees Table
Two groups of fluoroscopic visualization situations of change see Table 3.
Table 3 liang group fluoroscopic visualization situation of change
Model case:
The king * *, the man 67 years old, uses product of the present invention after 3 courses for the treatment of, more than vision progress 3 row.The optical fundus change to show that the retina microangioma number reduces to (++) by (+++), and is hemorrhage, ooze out and change index and reach requirement.
* *, the female 62 years old, uses product of the present invention after 3 courses for the treatment of, more than vision progress 3 row.The optical fundus change to show that the retina microangioma number reduces to (++) by (+++), and microangioma, hemorrhage index reach requirement.
Poplar * *, the man, 60 years old, diabetic history 4 years used product of the present invention after 3 courses for the treatment of, more than vision progress 3 row.The optical fundus change to show that the retina microangioma number reduces to (++) by (+++), microangioma, oozes out and changes 2 indexs and reach requirement.
The week * *, the man, 51 years old, diabetic history 3 years used product of the present invention after 3 courses for the treatment of, more than vision progress 3 row.The optical fundus change to show that the retina microangioma number reduces to (++) by (+++), microangioma, hemorrhage, ooze out and change index and reach requirement.
The specific embodiment
Embodiment 1
The Chinese medicine that a kind for the treatment of of diabetic retinopathy becomes comprises the component of following weight portion:
33 parts of Radix Ginseng Rubra, 8 parts of Rhizoma Dioscoreaes, 12 parts of Fructus Lycii, 16 parts of Fructus Corni, 7 parts of Carapax Trionycis, 3 parts of Flos Chrysanthemis, 7 parts of Semen Plantaginiss, 5 parts of Cortex Moutans, 18 parts, Rhizoma Gastrodiae, 3 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 5 parts of Semen Cuscutae, 0.8 part of Radix Puerariae, 12 parts of Pheretimas, 1 part of the Cortex Eucommiae.
The present embodiment Chinese medicine can adopt following preparation method:
Method for making one: the said components raw material is cleaned, pulverized 100 mesh sieves, mixing is made the watered pill, drying, and get final product.
Method for making two: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 100 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials decoct with water 2 times, add for the first time water and be 10 times of medical material amount, extract 2 hours, add for the second time water and be 8 times of medical material amount, extract 1.5 hours, and collecting decoction filters with 200 mesh sieves, and it is 1.30g/cm that filtrate is concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Method for making three: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 100 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials add 70% alcohol reflux 2 times, add for the first time 70% ethanol and be 10 times of medical material amount, reflux, extract, 2 hours, adding for the second time 70% ethanol is 8 times of medical material amounts, reflux, extract, 1.5 hours, collecting decoction filters with 200 mesh sieves, it is 1.30g/cm that filtrate recycling ethanol, medicinal liquid continue to be concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Embodiment 2
The Chinese medicine that a kind for the treatment of of diabetic retinopathy becomes comprises the component of following weight portion:
By weight ratio raw materials used:
27 parts of Radix Ginseng Rubra, 12 parts of Rhizoma Dioscoreaes, 8 parts of Fructus Lycii, 24 parts of Fructus Corni, 3 parts of Carapax Trionycis, 7 parts of Flos Chrysanthemis, 3 parts of Semen Plantaginiss, 10 parts of Cortex Moutans, 12 parts, Rhizoma Gastrodiae, 7 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 2 parts of Semen Cuscutae, 1.2 parts of Radix Puerariaes, 5 parts of Pheretimas, 5 parts of the Cortexs Eucommiae.
The present embodiment Chinese medicine can adopt following preparation method:
Method for making one: the said components raw material is cleaned, pulverized 80 mesh sieves, mixing is made the watered pill, drying, and get final product.
Method for making two: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials decoct with water 2 times, add for the first time water and be 8 times of medical material amount, extract 1 hour, add for the second time water and be 6 times of medical material amount, extract 0.5 hour, and collecting decoction filters with 160 mesh sieves, and it is 1.25g/cm that filtrate is concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Method for making three: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials add 70% alcohol reflux 2 times, add for the first time 70% ethanol and be 8 times of medical material amount, reflux, extract, 1 hour, adding for the second time 70% ethanol is 6 times of medical material amounts, reflux, extract, 0.5 hour, collecting decoction, filter with 160 mesh sieves, it is 1.25g/cm that filtrate recycling ethanol, medicinal liquid continue to be concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Embodiment 3
The Chinese medicine that a kind for the treatment of of diabetic retinopathy becomes comprises the component of following weight portion:
By weight ratio raw materials used:
30 parts of Radix Ginseng Rubra, 9 parts of Rhizoma Dioscoreaes, 9 parts of Fructus Lycii, 21 parts of Fructus Corni, 6 parts of Carapax Trionycis, 5 parts of Flos Chrysanthemis, 5 parts of Semen Plantaginiss, 8 parts of Cortex Moutans, 15 parts, Rhizoma Gastrodiae, 5 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 4 parts of Semen Cuscutae, Radix Puerariae 1,5～12 parts of Pheretimas, 3 parts of the Cortexs Eucommiae.
The present embodiment Chinese medicine can adopt following preparation method:
Method for making one: the said components raw material is cleaned, pulverized 80 mesh sieves, mixing is made the watered pill, drying, and get final product.
Method for making two: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials decoct with water 2 times, add for the first time water and be 10 times of medical material amount, extract 1.5 hours, add for the second time water and be 8 times of medical material amount, extract 1 hour, and collecting decoction filters with 180 mesh sieves, and it is 1.28g/cm that filtrate is concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Method for making three: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials add 70% alcohol reflux 2 times, add for the first time 70% ethanol and be 10 times of medical material amount, reflux, extract, 1.5 hours, adding for the second time 70% ethanol is 8 times of medical material amounts, reflux, extract, 1 hour, collecting decoction filters with 180 mesh sieves, it is 1.28g/cm that filtrate recycling ethanol, medicinal liquid continue to be concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
Claims (2)
1. the Chinese medicine that becomes of a treatment of diabetic retinopathy is characterized in that comprising the component of following weight portion:
27～33 parts of Radix Ginseng Rubra, 8～12 parts of Rhizoma Dioscoreaes, 8～12 parts of Fructus Lycii, 16～24 parts of Fructus Corni, 3～7 parts of Carapax Trionycis, 3～7 parts of Flos Chrysanthemis, 3～7 parts of Semen Plantaginiss, 5～10 parts of Cortex Moutans, 12～18 parts, Rhizoma Gastrodiae, 3～7 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 2～5 parts of Semen Cuscutae, 0.8～1.2 part of Radix Puerariae, 5～12 parts of Pheretimas, 1～5 part of the Cortex Eucommiae.
2. the preparation method of the described Chinese medicine of claim 1 is characterized in that adopting any one in following method:
Method for making one: each component raw material is cleaned, pulverized 80～100 mesh sieves, mixing is made the watered pill, drying, and get final product;
Method for making two: each component raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80～100 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials decoct with water 2 times, add for the first time water and be 8～10 times of medical material amount, extract 1～2 hour, add for the second time water and be 6～8 times of medical material amount, extracted collecting decoction 0.5～1.5 hour, filter with 160～200 mesh sieves, it is 1.25～1.30g/cm that filtrate is concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product;
Method for making three: the said components raw material is cleaned, and wherein Radix Ginseng Rubra, Rhizoma Dioscoreae, Radix Puerariae were pulverized 80～100 mesh sieves, and mix homogeneously gets the medical material fine powder; All the other medical materials add 70% alcohol reflux 2 times, add for the first time 70% ethanol and be 8～10 times of medical material amount, reflux, extract, 1～2 hour, adding for the second time 70% ethanol is 6～8 times of medical material amounts, reflux, extract, 0.5～1.5 hour, merge extractive liquid, filters with 160～200 mesh sieves, it is 1.25～1.30g/cm that filtrate recycling ethanol, medicinal liquid continue to be concentrated into density
3Clear paste, with above-mentioned medical material fine powder mixing, make the watered pill, drying, and get final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966349A (en) * | 2019-05-16 | 2019-07-05 | 谭大国 | A kind of Chinese medicine composition and preparation method thereof for preventing and treating diabetic retinopathy |
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2013
- 2013-03-21 CN CN2013100919454A patent/CN103120767A/en active Pending
Non-Patent Citations (2)
| Title |
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| 章瑾: "中西医结合治疗糖尿病视网膜病变96例", 《中国中医药科技》 * |
| 陈学铭 等: "糖尿病诊疗规律综述", 《全国首届中青年中医眼科学术研讨会资料汇编》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966349A (en) * | 2019-05-16 | 2019-07-05 | 谭大国 | A kind of Chinese medicine composition and preparation method thereof for preventing and treating diabetic retinopathy |
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Application publication date: 20130529 |