CN103110904A - Traditional Chinese medicine composition for treating schizophrenia at restoration stage and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating schizophrenia at restoration stage and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating schizophrenia at a restoration stage and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components by weight: radix glehniae, radix rehmanniae recen, arisaema cum bile, radix curcumae, chrysoidine, polygala, rhizoma acori graminei, tuckahoe, fushen, radix scrophulariae, uncaria, salvia miltiorrhiza, ligusticum wallichii, raw ferrosic oxide and raw oyster shell. The traditional Chinese medicine composition has the effects of nourishing yin to clear away the lung-heat and soothing the nerves, and can be used for effectively treating the schizophrenia at the restoration stage.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of convalescent Chinese medicine composition of schizophrenia and preparation method thereof for the treatment of.
Background technology
Schizophrenia is a kind of psychiatric department disease the most serious in psychosis, because thalamus, brain dysfunction and pathological changes cause, and the basic reason of its brain dysfunction is that in brain, monoamine neurotransmitter norepinephrine (NE), dopamine (DA), 5-hydroxy tryptamine (5-HT) disequilibrium cause.Schizophrenia often has the inharmonious of many-sided obstacles such as special thinking, consciousness, emotion and behavior and ergasia and environment, and social function is subject to obvious infringement, and the course of disease is delayed more.Be 7.11 ‰ in China's city prevalence, the rural area is 4.26 ‰.Be divided into according to stadium and the prognosis of disease of living in: post-schizophrenic depression, schizophrenia in remission, schizophrenia residual period, chronic schizophrenia, Deteriorated schizophrenia.Schizophrenia convalescent period refers to be in the patient who returns to form after the acute psychosis shape obviously goes down, and some patient's mental symptoms disappear, and insight recovers, and social function is recovered; Although some patient's mental symptoms disappear substantially, can stay personality change in various degree, the more sick front reduction of working and learning ability; Might again show effect.In most cases, without active treatment, considerable Convalescent Patients with Schizophrenia recurrence is arranged, bring great misery to patient and family.Belong to the category of " demented " in theory of Chinese medical science.Its cause of disease is " healthy energy " that the interior external world " pathogen " has overwhelmed body, i.e. the invasion and attack of six climate exopathogens, and seven emotions are crossed and are injured overstrain, wound, heredity etc., so that body yin and yang 2 Qi deficiency and excess is uncomfortable, and function is disorderly, the QI and blood phlegm-fire knot of fighting, hoodwink thinking, and produce empty or real demented disease.Major lesions is at liver, gallbladder, the heart, spleen.At present, the convalescent treatment of schizophrenia is main mainly with Western medicine, to alleviating and eliminating psychotic symptoms, remarkable effect is arranged, but most of Western medicine can produce serious untoward reaction, affects patient's drug compliance.Chinese medicine has some superiority, and Chinese medicine can play the conditioning emotion, and consciousness-restoring and orifice-opening, soothing the liver clearing away phlegm, QI and blood regulating are adjusted the function of body and the effect of Yin Yang balancing.The treatment by Chinese herbs side effect is little, treating both the principal and secondary aspects of a disease and there is no dependency, and can resist the side effect of Western medicine, the health after conditioning long-term taking Western medicine, and the conditioning viscera function, vital base and primordial QI consolidating reaches the purpose of healing.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has rapid-action for treatment schizophrenia convalescent period, determined curative effect, the characteristics that have no side effect.
The present invention selects that Radix Glehniae, Radix Rehmanniae, Arisaema Cum Bile, Radix Curcumae, dried tangerine peel, Radix Polygalae, Rhizoma Acori Graminei, Poria, Poria cum Radix Pini, Radix Scrophulariae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the pig iron fall, Concha Ostreae makes up, make each efficacy of drugs produce synergism these drug regimens, make it to have nourishing YIN and clearing away lung-heat, the effect of mind tranquilizing and the heart calming, thus schizophrenia convalescent period can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Glehniae: be the dry root of samphire glehnia littoralis Glehnia littoralis Fr.Schmidt ex Miq..Nature and flavor are slightly cold, sweet, little hardship.Enter lung, spleen channel.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.
Radix Rehmanniae: be the tuber of scrophulariaceae rehmannia glutinosa plant.Nature and flavor sweetness and bitterness, cool.Enter the heart, liver, kidney channel.Effect: heat clearing away, the YIN nourishing of promoting the production of body fluid nourishes blood.The central nervous system is had obvious sedation, and its aqueous extract can suppress autonomic activities.
Arisaema Cum Bile: for fine powder and cattle, sheep or the Fel Sus domestica of Rhizoma Arisaematis (processed) processes from strand, or process through fermentation for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.Nature and flavor bitter cold, little suffering, cool.Return lung, liver, spleen channel.Effect: removing heat-phlegm, dispelling wind and relieving convulsion." book on Chinese herbal medicine converge with speech ": " Rhizoma Arisaematis, forefathers with Fel Bovis seu Bubali system it, name is said Arisaema Cum Bile.Fel Bovis seu Bubali bitter cold and moistening has the relieving convulsion merit of the liver benefiting, star processed dry and make not malicious.″
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S.G.Lee et C.F.Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor are hot, bitter, cold.Return liver, the heart, lung meridian.Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Tangerine: as to be the dry outer peel of rutaceae Huazhou Fructus Citri tangerinae CitrusgrandisOsbeckvar.tomentosaHort. or Fructus Citri tangerinae CitrusreticulataBlanco and variety thereof.Nature and flavor are hot, bitter, temperature.Return lung, spleen channel.Effect: cold expelling, dampness, promoting the circulation of QI, expectorant." medicineization justice ": dried tangerine peel, suffering can be walked crosswise eliminating stagnation, and the bitter decline of keeping straight on is the promoting the circulation of QI key medicine.Lid is controlled expectorant and must be regulated the flow of vital energy, the spontaneous recovery of diarrhea due to disorder of QI expectorant, therefore with entering the lung spleen, main all expectorant are sick, merit occupies on all expectorant medicines.
Rhizoma Acori Graminei: be the rhizome of acorus gramineus araceae plant.Nature and flavor are hot, bitter, temperature.GUIXIN, stomach warp.Effect: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Rhizoma Acori Graminei has anticonvulsant action, and the volatile oil of Rhizoma Acori Graminei has the sedation of calming the nerves, the secretion of Rhizoma Acori Graminei decoct energy for oral administration facilitating digestion liquid." Chongqing hall random notes ": Rhizoma Acori Graminei, comfortable gas, the smooth mind, happy mood, beneficial will, panacea is also.Removing summer-heat medicinal it, rely that it is dirty turbid and defend city wall to eliminate the phlegm, nourish medicinal it, so as to the knot of a surname's thought and being proficient in the law of natural movement.
Radix Polygalae: be the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L..Nature and flavor are bitter, hot, tepor.GUIXIN, kidney, lung meridian.Effect: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence.The natural prerequisite medicine that contains TMCA in the Radix Polygalae water extract plays sedation.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, and are flat.GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.The Poria decoct has obvious sedation." modality ": " cure mainly the Ji Rou Shun muscle of throbbing with fear cautious, the dizziness agitation is controlled on the side.”
Poria cum Radix Pini: be the sclerotium of sleeping hole platymiscium Poria (the Poria cocos Schw.) Wolf of Polyporaceae, former species are rudimentary plant, are the funguses that colonizes on pinaster.Medicinal part is the dry sclerotia body.Nature and flavor are sweet, light flat.GUIXIN, spleen channel.Effect: mind calming, calm the nerves, diuretic.Poria cum Radix Pini has sedation." property of medicine opinion ": main infantile convulsion, tranquilizing the mind is mended tired; Main acute pain in the epigastrium is hard full, and small intestinal is unfavorable.
Radix Scrophulariae: be the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..Nature and flavor are sweet, bitter, salty; Be slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing." book on Chinese herbal medicine " says that it only enters kidney channel, and do not know that it walks lungs especially, therefore can move back the fire that unrooted swims, loose whole body expectorant stagnation of pathogenic heat carbuncle." medicine origin ": control that the regretful Nang of the heart is tired and insomnia is wild utterly confused, the stasis dysuria.
Ramulus Uncariae Cum Uncis: for dicotyledon medicine Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and belong to the buckle branch of various plants together.Nature and flavor are sweet, bitter, be slightly cold.Return liver, heart channel.Effect: heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.Ramulus Uncariae Cum Uncis agent or ethanol extract have calmness and anticonvulsant action." detailed outline ": Ramulus Uncariae Cum Uncis, hands, foot are fainted cloudy medicine also.The foot cloudy main air of fainting, the hands dizzy fortune of cloudy main fiery ， Jing Epilepsy of fainting, liver-wind diseases of fire mutually all, the logical pericardium of Ramulus Uncariae Cum Uncis is in edema with the liver involved, the quiet fire of wind puts out, all diseases oneself remove.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor are bitter, are slightly cold.Enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor are hot, temperature.Return liver, gallbladder, pericardium channel.Effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Rhizoma Chuanxiong has obvious sedation to the central nervous system.Movable inhibited to animal brain when Rhizoma Chuanxiong volatile oil is a small amount of, and medulla oblongata respiratory center, vasomotor center and spinal reflex maincenter are had excitation.
The pig iron falls: for the pig iron is calcined to red redly, hammered into shape the iron filings that fall during outer oxide.Nature and flavor are hot, cool.Return liver, heart channel.Effect: checking hyperfunction of the liver for relieving convulsion.The hot cool matter of this product is heavy, is good at suppressing the hyperactive liver, and the flat fire of wood falls, thus say the therapeutic method to keep the adverse QI flowing downwards quickly, gas be fire also.The merit of this product checking hyperfunction of the liver for relieving convulsion is usually used in the card that the mania characterized by being susceptible to rage sun of stagnation of liver-QI fire Sheng is fainted, and the available pig iron falls to frying in shallow oil simply drink, i.e. decoction of Iron Scale (" Plain Questions "); If control the mania syndrome of disturbing on phlegm-fire, can be equal to use with Radix Polygalae, Rhizoma Acori Graminei, Arisaema Cum Bile, as decoction of Iron Scale (" Medicine Comprehended ").Compendium of Material Medica: " suppressing the hyperactive liver goes timid, controls susceptible to get angry and goes mad.”
Concha Ostreae: be the shell of the long Concha Ostreae Ostrea of Ostreidae animal gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.Nature and flavor are salty, be slightly cold.Return liver, gallbladder, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.Concha Ostreae has convergence, calmness, detoxifcation, analgesic effect.
Medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope: Radix Glehniae 13-23 part, Radix Rehmanniae 35-45 part, Arisaema Cum Bile 7-17 part, Radix Curcumae 10-20 part, tangerine 7-17 part, Radix Polygalae 20-28 part, Rhizoma Acori Graminei 15-25 part, Poria 10-20 part, Poria cum Radix Pini 13-23 part, Radix Scrophulariae 10-20 part, Ramulus Uncariae Cum Uncis 15-25 part, Radix Salviae Miltiorrhizae 25-35 part, Rhizoma Chuanxiong 7-17 part, the pig iron fall 25-35 part, Concha Ostreae 25-35 part.
Wherein be preferably: 18 parts of Radix Glehniaes, 40 parts of Radix Rehmanniae, 12 parts of Arisaema Cum Bile, 15 parts of Radix Curcumaes, tangerine 12 parts, 24 parts of Radix Polygalaes, 20 parts of Rhizoma Acori Graminei, 15 parts, Poria, 18 parts of Poria cum Radix Pinis, 15 parts of Radix Scrophulariaes, 20 parts of Ramulus Uncariae Cum Uncis, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of Rhizoma Chuanxiongs, the pig iron fall 30 parts of 30 parts, Concha Ostreae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into decoction.
Step 1, at first first put into container according to weight proportion weighing Concha Ostreae and boiled 20 minutes;
Step 2, then put off to fry in shallow oil again in the step 1 container according to weight proportion weighing Radix Glehniae, Radix Rehmanniae, Arisaema Cum Bile, Radix Curcumae, dried tangerine peel, Radix Polygalae, Rhizoma Acori Graminei, Poria, Poria cum Radix Pini, Radix Scrophulariae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the pig iron and got final product in 25-30 minute.
Medicine of the present invention has nourishing YIN and clearing away lung-heat, effects such as mind tranquilizing and the heart calming, and rapid-action, and determined curative effect has no side effect, and according to clinical 30 routine patients are observed statistics, uses 85%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 95%.
The specific embodiment
Embodiment one, 13 parts of Radix Glehniaes, 35 parts of Radix Rehmanniae, 7 parts of Arisaema Cum Bile, 10 parts of Radix Curcumaes, tangerine 7 parts, 20 parts of Radix Polygalaes, 15 parts of Rhizoma Acori Graminei, 10 parts, Poria, 13 parts of Poria cum Radix Pinis, 10 parts of Radix Scrophulariaes, 15 parts of Ramulus Uncariae Cum Uncis, 25 parts of Radix Salviae Miltiorrhizaes, 7 parts of Rhizoma Chuanxiongs, the pig iron fall 25 parts of 25 parts, Concha Ostreae.
Embodiment two, 18 parts of Radix Glehniaes, 40 parts of Radix Rehmanniae, 12 parts of Arisaema Cum Bile, 15 parts of Radix Curcumaes, tangerine 12 parts, 24 parts of Radix Polygalaes, 20 parts of Rhizoma Acori Graminei, 15 parts, Poria, 18 parts of Poria cum Radix Pinis, 15 parts of Radix Scrophulariaes, 20 parts of Ramulus Uncariae Cum Uncis, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of Rhizoma Chuanxiongs, the pig iron fall 30 parts of 30 parts, Concha Ostreae.
Embodiment three, 23 parts of Radix Glehniaes, 45 parts of Radix Rehmanniae, 17 parts of Arisaema Cum Bile, 20 parts of Radix Curcumaes, tangerine 17 parts, 28 parts of Radix Polygalaes, 25 parts of Rhizoma Acori Graminei, 20 parts, Poria, 23 parts of Poria cum Radix Pinis, 20 parts of Radix Scrophulariaes, 25 parts of Ramulus Uncariae Cum Uncis, 35 parts of Radix Salviae Miltiorrhizaes, 17 parts of Rhizoma Chuanxiongs, the pig iron fall 35 parts of 35 parts, Concha Ostreae.
The below is the clinical statistics data that the patient uses medicine of the present invention:
One, physical data
Accept patient's totally 30 examples for medical treatment, male's 8 examples wherein, women's 22 examples, M-F 0.4: 1,26 years old mean age.
Two, tcm diagnosis standard
1, spiritedness is depressed, suspiciously worry too much, or anxious timid, speak to oneself less moving, or sad strongly fragrant kind crying, the undesired performance such as stupid sigh.
2, how in love will stimulates, and is intended to the risk factors such as unsuccessful, or family history is arranged.
3, get rid of the medicine reason person of causing.
4, should differentiate with strongly fragrant disease, hysteria.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue services once sooner or later, and 60 is a course for the treatment of.
Four, efficacy assessment standard
Recovery from illness: language, manner are normal, and look stable, can the normal process routine matter, and the BPRS total points subtracts a minute rate 〉=80%.
Take a turn for the better: look stable, speech, manner normal or be improved, and the BPRS total points subtracts minute rate 30～79%.
Do not heal: spirit, language, behave strangely and can not control, the BPRS total points subtracts a minute rate＜30%.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+improvement rate
Model case and curative effect:
Case one, Liu, female, 19 years old age.Schizophrenia is suffered from patient's readme the year before, and mental symptom is controlled now, but study still can not be wholwe-hearted, and interest is unable to lift in the activity of school organization, always likes a people to stay at home.Employing is taken Chinese medicine of the present invention after course for the treatment of, transference cure, after do not follow up a case by regular visits to recurrence.
Case two, Chen, female, patient age 28 years old.Mother accompanies to examine and states daughter and suffered from schizophrenia 3 years, and mental symptom is controlled now, but always thinks to eat food more, always repeats when pondering a problem and simple, often says simple naivety, and self-care ability is also relatively poor, do things unordered, and the dependence father and mother.After the patient adopted and to take treatment by Chinese herbs of the present invention two courses for the treatment of, symptom was clearly better.
Case three, appoint certain, the man, 26 years old age, got schizophrenia in the time of 24 years old, nowadays disease is maintained, but the mental status or bad panesthesia tire out, and anything does not want to do very slack.After the patient adopted and to take treatment by Chinese herbs of the present invention two courses for the treatment of, symptom was obviously improved, and takes a turn for the better.
Claims (3)
1. treat the convalescent Chinese medicine composition of schizophrenia for one kind, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Glehniae 13-23 part, Radix Rehmanniae 35-45 part, Arisaema Cum Bile 7-17 part, Radix Curcumae 10-20 part, tangerine 7-17 part, Radix Polygalae 20-28 part, Rhizoma Acori Graminei 15-25 part, Poria 10-20 part, Poria cum Radix Pini 13-23 part, Radix Scrophulariae 10-20 part, Ramulus Uncariae Cum Uncis 15-25 part, Radix Salviae Miltiorrhizae 25-35 part, Rhizoma Chuanxiong 7-17 part, the pig iron fall 25-35 part, Concha Ostreae 25-35 part.
2. the convalescent Chinese medicine composition for the treatment of schizophrenia described according to claims 1, it is characterized in that, by the ingredients of following weight portion: 18 parts of Radix Glehniaes, 40 parts of Radix Rehmanniae, 12 parts of Arisaema Cum Bile, 15 parts of Radix Curcumaes, tangerine 12 parts, 24 parts of Radix Polygalaes, 20 parts of Rhizoma Acori Graminei, 15 parts, Poria, 18 parts of Poria cum Radix Pinis, 15 parts of Radix Scrophulariaes, 20 parts of Ramulus Uncariae Cum Uncis, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of Rhizoma Chuanxiongs, the pig iron fall 30 parts of 30 parts, Concha Ostreae.
3. according to the preparation method of claims 1 or the 2 convalescent Chinese medicine compositions of described treatment schizophrenia, it is characterized in that:
Step 1, at first first put into container according to weight proportion weighing Concha Ostreae and boiled 20 minutes;
Step 2, then put off to fry in shallow oil again in the step 1 container according to weight proportion weighing Radix Glehniae, Radix Rehmanniae, Arisaema Cum Bile, Radix Curcumae, dried tangerine peel, Radix Polygalae, Rhizoma Acori Graminei, Poria, Poria cum Radix Pini, Radix Scrophulariae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the pig iron and got final product in 25-30 minute.
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Cited By (1)
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Application publication date: 20130522 |