CN103110872A - Traditional prescription for preventing recurrence of infantile febrile convulsion - Google Patents
Traditional prescription for preventing recurrence of infantile febrile convulsion Download PDFInfo
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Abstract
The invention relates to the field of tradtional Chinese medical science and traditional Chinese medicines, and discloses a traditional prescription for preventing the recurrence of infantile febrile convulsion. The traditional prescription is prepared by taking radix codonopsis pilosulae, fried bighead atractylodes rhizome, poria cocos, clean licorice, astragalus mongholicus, Chinese yams, fructus alpiniae oxyphyllae, polygala tenuifolia, bile arisaema, rhizoma typhonii, scorpion and stiff silkworms as raw materials. The traditional prescription concurrently takes both symptoms and root causes into consideration, and has the effects of invigorating spleen and supplementing qi, relieving dizziness and calming the mind, eliminating phlegm and dredging collaterals. The traditional prescription has a good clinical application effect, can effectively reduce the recurrence of infantile febrile convulsion, and has no adverse reaction, and the compliance of infant patients is good, therefore, for numerous infant patients with febrile convulsion, the traditional prescription has considerable market potentials and social benefits.
Description
Technical field
The invention belongs to the Chinese medicine technical field, specifically a kind of prescription of preventing child hyperpyrexia convulsion recurrence.
Background technology
Children with high fever induced convulsions is a kind of convulsions phenomenon relevant with heating, and China's children with high fever induced convulsions sickness rate is 4.4%, becomes one of common emergency case of department of pediatrics.In general, the children with high fever induced convulsions prognosis is mostly good, does not stay sequela, does not affect growth promoter.But children with high fever induced convulsions very easily recurs, and domestic report relapse rate reaches 51.7%, wherein 2%～7% changes and is the tendency without febrile convulsion or epilepsy, and 8%～20% may cause behavior disorder or mental retardation.Therefore, the recurrence of control children with high fever induced convulsions is the problem that needs great attention.Doctor trained in Western medicine lacks special treatment means to preventing the recurrence of children with high fever induced convulsions at present.Domestic scholars recommendation Benzodiazepines and barbiturate prevent the recurrence of children with high fever induced convulsions.Because this type of medicine without therapeutical effect, also may cause the dystropy such as children's is absent minded, many moving to protopathy, cause that liver, blood system are impaired, therefore using has certain limitation.Motherland's medical science thinks that children with high fever induced convulsions belongs to the acute infantile convulsion category, the treatment of domestic most literature report take heat clearing away, eliminating phlegm, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., relieving convulsion as fundamentum, on the whole, stage of attack bring down a fever the spasmolytic effect still can, but prevention of recurrence is not had effect.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, by for many years clinical practice with from Chinese medical discrimination angle analysis research, think the easily main cause of outbreak repeatedly of children with high fever induced convulsions: children's's the liver being liable to excess, the spleen lung is not enough, the turbid interior love of expectorant.In case being invaded by exogenous pathogen, the expectorant of love in then easily touching causes stasis blocking venation, upper illiteracy thinking or transformation of fire and occurrence of wind syndrome and causes frightened.Thereby its control when from easily repeatedly the pathogenesis of outbreak set about, in the catabasis to the infant clothes take invigorating the spleen and benefiting QI and the expectorant of dispelling interior love as main decoction, the prescription that a kind of preventing child hyperpyrexia convulsion is recurred is disclosed for this reason.
The prescription of a kind of preventing child hyperpyrexia convulsion recurrence is characterized in that: it is that preparation of raw material by following weight parts forms: Radix Codonopsis 6-10; Rhizoma Atractylodis Macrocephalae preparata 6-10; Poria 6-10; Clear Radix Glycyrrhizae 3-5; Radix Astragali 6-12; Rhizomadioscoreae 6-10; Fructus Alpiniae Oxyphyllae 6-10; Radix Polygalae 6-10; Arisaema Cum Bile 2-3; Rhizoma Typhonii 6-10; Scorpio 1-2; Bombyx Batryticatus 5-9.
As preferably, the present invention's each optimum proportion of materials of filling a prescription is: Radix Codonopsis 6; Rhizoma Atractylodis Macrocephalae preparata 10; Poria 10; Clear Radix Glycyrrhizae 3; The Radix Astragali 10; Rhizomadioscoreae 10; Fructus Alpiniae Oxyphyllae 10; Radix Polygalae 6; Arisaema Cum Bile 2.5; Rhizoma Typhonii 6; Scorpio 1.5; Bombyx Batryticatus 6.
Prescription analysis: the present invention is comprised of Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, Poria, clear Radix Glycyrrhizae, the Radix Astragali, Rhizomadioscoreae, Fructus Alpiniae Oxyphyllae, Radix Polygalae, Arisaema Cum Bile, Rhizoma Typhonii, Scorpio, Bombyx Batryticatus 12 flavor medicines.Ancient times and modern pharmacological research show:
The Radix Codonopsis invigorating the spleen and replenishing QI can strengthen the phagocytic function of reticuloendothelial system, improves body immunity;
Rhizoma Atractylodis Macrocephalae preparata replenishing QI to invigorate the spleen, dampness diuretic, strengthening superficial resistance to stop perspiration can promote cellular immune function, and strong effect is arranged;
Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming have to strengthen immunologic function and calm effect;
Clear Radix Glycyrrhizae invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription eliminate the phlegm, the effects such as antibiotic, antiviral, antiinflammatory;
Radix Astragali air making-up and spleen enlivening, benefit are defended consolidating superficial resistance, can increase and regulate body's immunity, and interferon system is had facilitation, can improve the premunition of body, and cytopathy has slight inhibitory action due to the multiple virus such as infected by influenza, and more widely antibacterial action is arranged;
The Rhizomadioscoreae supplementing QI and nourishing YIN, spleen reinforcing lung kidney has preventive and therapeutic action to the experimental rat model of spleen deficiency, and mouse cell immunologic function and humoral immunization are had stronger facilitation;
Saliva is taken the photograph in Fructus Alpiniae Oxyphyllae warming the kidney controlling nocturnal emission with astringent drugs reducing urination, warming the spleen appetizing; Radix Polygalae calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm and have one's ideas straightened out, calmness, hypnosis and anticonvulsant action are arranged;
Arisaema Cum Bile has the effect of removing heat-phlegm, dispelling wind and relieving convulsion;
Rhizoma Typhonii has drying dampness to eliminate phlegm, expellings wind and relieving convulsion;
Scorpio endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain have obvious epilepsy, convulsion effect;
Bombyx Batryticatus endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses have hypnosis, anticonvulsant action.
Quan Fanghe and use it, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, Poria, clear Radix Glycyrrhizae invigorating the spleen and benefiting QI in the side, the Radix Astragali, Rhizomadioscoreae invigorating the spleen and replenishing QI, the Rhizoma Typhonii relieving convulsion that reduces phlegm, Arisaema Cum Bile, Bombyx Batryticatus, Scorpio wind-transformation expectorant, open and stop up knot, endogenous wind stopping relieving convulsion, Radix Polygalae, Fructus Alpiniae Oxyphyllae mind tranquilizing and the heart calming, full side's compatibility giving consideration to both the incidental and fundamental has invigorating the spleen and benefiting QI, an effect of the mind calming that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., the collateral dredging that eliminates the phlegm.
Characteristics of the present invention are:
1, be deficiency in origin and excess in superficiality from the traditional Chinese medical science to the main cause that this sick dialectical analysis proposes the children with high fever induced convulsions recurrence, it shows three aspects: (1), children's's body characteristics, the pure sun of children's's natural disposition, flesh are gathered weakness, again " the liver being liable to excess ", so climate change, cold temperature is not normal, and it is evil to be easy to sense, after the sense heresy, the high Sheng of pathogen, or control untimelyly then is easy to fire-transformation, gives birth to expectorant, gives birth to wind and faint from fear; (2), the turbid interior love of expectorant, though infantile convulsion is flat, love in expectorant is normal, make it children's's " the spleen tending to insufficiency usually ", be easy to lose strong and help damp-phlegm, so if multiple sense and the expectorant of volt in moving causes wind-phlegm to be won mutually hinders in the network key to fall into convulsions; (3), the spleen lung is not enough, if meet with repeatly exopathogen, it is not enough and can not consolidating superficial resistance to cause lung, spleen is strong and can not semen deposition.More than 3 reciprocal causations.
2, the pathogenesis that easily repeatedly shows effect from children with high fever induced convulsions is set about, and has established this double rule of controlling of table, gives positive Chinese medicine medical treatment in this sick stage of stable development, and according to these sick characteristics, has established one month medical treatment phase.
3, according to the etiology and pathogenesis of children with high fever induced convulsions, established the medical treatment rule, set up the prescription of invigorating the spleen and benefiting QI consolidating superficial resistance, mind tranquilizing and the heart calming, eleminating phlegm and freeing channels with 12 flavor Chinese medicines.In taking process, untoward reaction does not appear.And it is basic that the party not only can planning slowly and carefully, effectively prevents and treats the children with high fever induced convulsions recurrence, can also improve infant body constitution, improves its resistance against diseases.Its curative effect is obvious, has no side effect, and the infant compliance is good, and reasonable price alleviates patient's cost burden, and its popularizing application prospect is wide, can become effectively " Traditional Chinese Medicine Anti is fainted from fear and recurred preparation ".
Compared with prior art, the present invention has following beneficial effect: in taking process, untoward reaction do not occur.And it is basic that the party not only can planning slowly and carefully, effectively prevents and treats the children with high fever induced convulsions recurrence, can also improve infant body constitution, improves its resistance against diseases.Its curative effect is obvious, has no side effect, and the infant compliance is good, and reasonable price alleviates patient's cost burden, and its popularizing application prospect is wide, can become effectively " Traditional Chinese Medicine Anti is fainted from fear and recurred preparation ".
The specific embodiment
Take by weighing raw material by following proportioning:
Prescription: Radix Codonopsis 6g; Rhizoma Atractylodis Macrocephalae preparata 10g; Poria 10g; Clear Radix Glycyrrhizae 3g; Radix Astragali 10g; Rhizomadioscoreae 10g; Fructus Alpiniae Oxyphyllae 10g; Radix Polygalae 6g; Arisaema Cum Bile 2.5g; Rhizoma Typhonii 6g; Scorpio 1.5g; Bombyx Batryticatus 6g.
Manufacturing process of the present invention is: above-mentioned dried medical material prepared in proportion, removed impurity, be decocted in water for oral dose, and 1 dose of every day, decocting 20 minutes, day takes 200 milliliters, divides and takes for 2-3 time, and 30 days is a course for the treatment of.
Clinical data
1, diagnostic criteria
Mainly formulate about the suggestion of hyperpyrexia convulsion diagnosis and treatment with reference to the neural academic conference symposium of nineteen eighty-three whole nation children's, require to possess following 4 points:
1. hyperpyrexia convulsion medical history person was once arranged; 2. the age was at 1～6 years old; 3. after convulsions stops, without upper respiratory tract and digestive tract infection person; 4. without intracranial infection and other organic or metabolic disturbance diseases persons.
2, Standards of Chinese Medical Syndrome Differentiation
1. the hyperpyrexia convulsion medical history was once arranged; 2. the empty susceptible of body usually, the asthenia hyperhidrosis; 3. Na Gu is not good; 4. lustreless complexion; 5. thin white fur of tongue or thin greasy.
Therapeutic Method
1, administrated method
Present embodiment forms 1 dose of every day, decocting 20 minutes by Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, Poria, clear Radix Glycyrrhizae, the Radix Astragali, Rhizomadioscoreae, Fructus Alpiniae Oxyphyllae, Radix Polygalae, Arisaema Cum Bile, Rhizoma Typhonii, Scorpio, Bombyx Batryticatus 12 flavor medicines according to the above ratio, day takes 200 milliliters, divide and take for 3 times, 30 days is a course for the treatment of, and drug withdrawal was followed up a case by regular visits to 1 year.
2, observational technique
Carry out Effect of follow-up visit by telephone once to infant every month, and whether each itemized record infant recurs hyperpyrexia convulsion and other clinical symptoms.During this time infant 6 months and each outpatient service further consultation in 1 year once detects the health giving quality index at every turn, and whether observe in detail and record infant has recurrence hyperpyrexia convulsion and other symptom and signs.
3, observation index
Safety indexes: general physical examination (comprising untoward reaction); Hematuria excrement three is large conventional; Liver, renal function.Treatment before measurement 1 time if having unusually, is regularly rechecked.
4, health giving quality index
Electroencephalogram; Serum immune globulin IgA, IgG, IgM; Myocardium enzyme.Treatment before measurement 1 time was respectively surveyed once in after this 6 months and 1 year again.
Clinical recovery: clinical symptom disappearance, to follow up a case by regular visits to after the drug withdrawal 1 year or four high heat nothing convulsions, electroencephalogram is normal.
Take a turn for the better: clinical symptoms is obviously improved, and follows up a case by regular visits to after the drug withdrawal that 1 year or four times are high pines for generations of once fainting from fear, and electroencephalogram normally or mile abnormality.
Invalid: clinical symptoms is improved not obvious, meets the still outbreak of sense heating convulsions.
5, prescription therapeutic effect of the present invention
Table 1 basic condition relatively
Continued 1
Total effects, traditional Chinese medical science disease curative effect are relatively after the table 2 liang group treatment
6, the present invention prevents and treats children with high fever induced convulsions recurrence interpretation of result
Clinical research shows, consolidate the relapse rate that anti-frightened soup effectively reduces children with high fever induced convulsions, relapse rate was down to 20.3% in 1 year, tcm syndrome curative effect 92.8%, than relapse rate 47.8% and the tcm syndrome curative effect 61.9% of matched group, illustrate consolidate anti-frightened soup for control FC recurrence and improve that the empty susceptible of infant body, asthenia hyperhidrosis, Na Gu are not good, the effect of lustreless complexion and tongue fur body of the tongue all obviously is better than west, ground companion.Before the treatment, the electroencephalogram, immunologic function of rear 6 months for the treatment of and rear 1 year treatment group for the treatment of relatively, difference has extremely significantly statistical significance (P＜0.01), illustrate to consolidate to prevent shying soup the improvement of electroencephalogram, immunologic function is all had obvious effect.Consolidate and prevent that frightened soup group is treated rear 1 year electroencephalogram, immunologic function is compared with matched group, difference has significance (P＜0.05), illustrates to consolidate to prevent that the effect that frightened soup improves infant electroencephalogram and immunologic function is better than diazepam.The relation analysis of infant basic condition and total effects, the effective percentage that consolidates anti-frightened soup control FC recurrence and onset age, the traditional Chinese medical science state of an illness, family history, body temperature, electroencephalogram, myocardium enzyme, immunologic function all have certain relation when previously twitching number of times, the persistent period of twitching, children with high fever induced convulsions typing, convulsions in 24 hours when attack times and onset.Consolidate the recurrence of anti-frightened soup control children with high fever induced convulsions, its curative effect in years curative effect with infant between 1～4 years old is higher, the traditional Chinese medical science state of an illness is lighter, previously attack times less, the tic number of times less in 24 hours, the persistent period of twitching is shorter, when fainting from fear higher, the electroencephalogram of body temperature, myocardium enzyme and immunologic function to detect the better infant curative effect of index more remarkable, for the impact of sex, the statistics no significant difference.
Claims (2)
1. the prescription of preventing child hyperpyrexia convulsion recurrence is characterized in that: it is that preparation of raw material by following weight parts forms: Radix Codonopsis 6-10; Rhizoma Atractylodis Macrocephalae preparata 6-10; Poria 6-10; Clear Radix Glycyrrhizae 3-5; Radix Astragali 6-12; Rhizomadioscoreae 6-10; Fructus Alpiniae Oxyphyllae 6-10; Radix Polygalae 6-10; Arisaema Cum Bile 2-3; Rhizoma Typhonii 6-10; Scorpio 1-2; Bombyx Batryticatus 5-9.
2. the prescription of a kind of preventing child hyperpyrexia convulsion recurrence according to claim 1, it is characterized in that: each raw material weight proportioning is: Radix Codonopsis 6; Rhizoma Atractylodis Macrocephalae preparata 10; Poria 10; Clear Radix Glycyrrhizae 3; The Radix Astragali 10; Rhizomadioscoreae 10; Fructus Alpiniae Oxyphyllae 10; Radix Polygalae 6; Arisaema Cum Bile 2.5; Rhizoma Typhonii 6; Scorpio 1.5; Bombyx Batryticatus 6.
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| CN104524303A (en) * | 2015-01-09 | 2015-04-22 | 单既利 | Traditional Chinese medicine particles for treating infantile convulsion and preparation method thereof |
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Application publication date: 20130522 |