CN103105413B - Biological sensor and biometric system - Google Patents

Biological sensor and biometric system Download PDF

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Publication number
CN103105413B
CN103105413B CN201210464441.8A CN201210464441A CN103105413B CN 103105413 B CN103105413 B CN 103105413B CN 201210464441 A CN201210464441 A CN 201210464441A CN 103105413 B CN103105413 B CN 103105413B
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impedance
code
end points
biological sensor
loop
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CN103105413A (en
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邓开宗
李志鸿
程昭维
李长昇
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Delbio Inc
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Delbio Inc
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  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention discloses a kind of biological sensor, in order to sense biological specimen.This biological sensor has first code and the second code of the characteristic representing biological sensor.Biological sensor comprises substrate and conductive layer.Conductive layer is configured in the first side of substrate, and comprises the first loop, second servo loop and tertiary circuit.First loop is formed between the first end points and the second end points, and has the first impedance.Second servo loop is formed between the 3rd end points and the 4th end points, and has the second impedance.Second end points and the 3rd end points are electrically insulated each other.Tertiary circuit is formed between the 4th end points and five terminal point, and has the 3rd impedance.First impedance and second or the 3rd impedance define first code, and the first impedance and second or the 3rd impedance define second code.The present invention reduces the risk of erroneous judgement measurement result, also improves the operation ease of overall biometric system.

Description

Biological sensor and biometric system
Technical field
The present invention relates to a kind of biological sensor, particularly a kind of biological sensor with code.
Background technology
Current glucometer mostly is and utilizes the enzyme in fingertip blood and biochemistry detection test piece (strip) to carry out chemical reaction, to realize blood glucose measurement.Due to the restriction in manufacturing process, have different characteristics, such as enzyme reaction characteristic in the biochemistry detection test piece manufactured by different batches processing procedure, this will affect the measurement result of blood sugar.Therefore, in the manufacture process of every a collection of biochemistry detection test piece, manufacturer need set the code of the enzyme reaction characteristic about this batch of biochemistry detection test piece.When user uses glucometer, by these codes of the input through keyboard on glucometer, or the cipher card of these codes (codecard) burning is had to insert glucometer for reading.After glucometer obtains these codes, then can change or set the parameter of blood glucose measurement operation, with the impact making blood glucose measurement can not be subject to enzyme reaction characteristic variations.
But in practical operation, user may the code of input error, or user may forget the cipher card inserting cipher card or inserting error.These situations will cause blood glucose measurement deviation, and then delay user connects subject opportunity or takes the drug dose of deviation, be very the body life safety of harm user.
Summary of the invention
Therefore, expect to provide a kind of biological sensor being used for sensing biological specimen, it has the code of the characteristic representing biological sensor.When biological sensor connects biometric device, biometric device automatically can read the code of biological sensor, and then reduces the risk of erroneous judgement measurement result, also improves the operation ease of overall biometric system.
According to one embodiment of the invention, the invention provides a kind of biological sensor, in order to sense biological specimen.This biological sensor has first code and the second code of the characteristic representing biological sensor.Biological sensor comprises substrate and conductive layer.Conductive layer is configured in the first side of substrate, and comprises the first loop, second servo loop and tertiary circuit.First loop is formed between the first end points and the second end points, and has the first impedance.Second servo loop is formed between the 3rd end points and the 4th end points, and has the second impedance.Second end points and the 3rd end points are electrically insulated each other.Tertiary circuit is formed between the 4th end points and five terminal point, and has the 3rd impedance.First impedance and second or the 3rd impedance define first code, and the first impedance and second or the 3rd impedance define second code.
According to another embodiment of the present invention, the invention provides a kind of biometric system, in order to sense the analysis thing of biological specimen.This biometric system comprises biological sensor and biometric device.Biological sensor has first code and the second code of the characteristic representing biological sensor, and comprises substrate, biological respinse layer and a conductive layer.Substrate has the first side and second side relative with the first side.Biological respinse layer is configured in the bio-reaction zone of the first side, and has chemical reagent.Biological specimen can place bio-reaction zone.Conductive layer is configured in the second side, and comprises the first loop, second servo loop and tertiary circuit.First loop is formed between the first end points and the second end points, and has the first impedance.Second servo loop is formed between the 3rd end points and the 4th end points, and has the second impedance.First loop and second servo loop are electrically insulated each other.Tertiary circuit is formed between the 4th end points and five terminal point, and has the 3rd impedance.Biological sensor can connect biometric device.Biometric device measures the first impedance, the second impedance and the 3rd impedance, and according to the first impedance and second or the 3rd impedance calculate first code and according to the first impedance and second or the 3rd impedance calculate second code.According to first code and second code, the analysis thing to biological specimen carries out measurement operation to biometric device.
Beneficial effect of the present invention is, biological sensor of the present invention, and it has the code of the characteristic representing biological sensor.When biological sensor connects biometric device, biometric device automatically can read the code of biological sensor, and then reduces the risk of erroneous judgement measurement result, also improves the operation ease of overall biometric system.
Accompanying drawing explanation
Fig. 1 represents the outboard profile of the biological sensor according to the embodiment of the present invention;
Fig. 2 represents a side of the substrate of biological sensor;
Fig. 3 A represents the another side of the substrate of biological sensor;
Fig. 3 B represents the code pattern on the side of Fig. 3 A;
Fig. 4 represents the biometric system according to the embodiment of the present invention;
Fig. 5 A and Fig. 5 B represents in biometric system, measures the schematic diagram of the electric current in each loop.
Wherein, description of reference numerals is as follows:
1 ~ biological sensor; 4 ~ biometric system
10 ~ substrate; The side of 10a, 10b ~ substrate;
11 ~ conductive layer: 12 ~ biological respinse layer;
20 ~ reaction zone; 21,22 ~ electrode;
30,31,32 ~ loop; 40 ~ biometric device;
41 ~ slot; 42 ~ display screen;
A, B, C, D, E ~ end points; GND ~ earthing potential;
I50, I51, I52 ~ electric current; V50 ~ specific voltage.
Embodiment
For making above-mentioned purpose of the present invention, feature and advantage become apparent, a preferred embodiment cited below particularly, and coordinate accompanying drawing, be described in detail below.
Fig. 1 represents the outboard profile of biological sensor according to an embodiment of the invention.Biological sensor 1 is used for sensing one of biological specimen and analyzes thing, and consult Fig. 1, biological sensor 1 has substrate 10, conductive layer 11 and biological respinse layer 12.Conductive layer 11 is configured in one of substrate 10 side 10a, and biological respinse layer 12 is configured in the another side 10b relative with the side 10a of substrate 10.
Fig. 2 represents the side 10b of aforementioned substrates 10.Consult Fig. 2, biological respinse layer 12 is configured in the bio-reaction zone 20 of side 10b.Biological respinse layer 12 has chemical reagent.When the biological specimen taking from user is instilled, sucks or is placed in bio-reaction zone 20, at least one analysis thing in biological specimen and chemical reagent carry out chemical action.For example, biological specimen can be the blood of user, and analysis thing is the glucose (blood sugar) in blood, and the chemical reagent of biological respinse layer 12 is a kind of enzymes.When the blood of user is instilled, sucks or is placed in bio-reaction zone 20, the glucose in blood and chemical reagent (enzyme) carry out chemical action.Should be noted that, in Fig. 1 and Fig. 2, biological respinse layer 12 is only an illustrative example with the size of bio-reaction zone 20.In practical application, the factors such as the amount that the size of the large I foundation biological sensor 1 of biological respinse layer 12 and bio-reaction zone 20, biological specimen sample and actual demand decide.
Fig. 3 A represents the side 10a of substrate 10.Consult Fig. 3 A, be configured with 5 terminal A, B, C, D and E at conductive layer 11 lower edge.Conductive layer 11 has code pattern, and it defines two code Code1 and the Code2 representing biological sensor 1 characteristic.In this embodiment, this two code Code1 and Code2 represents the manufacturing information of biological sensor 1, the control information etc. of the response characteristic of the such as chemical reagent of biological respinse layer 12, the manufacturing time (date or all numbers) of biological sensor 1 or biological sensor 1.This code pattern comprises and is formed in the loop between loop between terminal A and B, end points C and D and the loop between end points D and E.In order to clear display, the code pattern of conductive layer 11 is shown in Fig. 3 B.Consult Fig. 3 B, loop 30 is formed between terminal A and B, and loop 31 is formed between end points C and D, and loop 32 is formed between end points D and E.Be electrically insulated each other between terminal B and C, in other words, loop 31 and loop 32 are electrically insulated from loop 30 respectively.In the 1st with 3A figure, the size of conductive layer 11 is only an illustrative example.In practical application, as aforementioned, one of design considerations of the size of conductive layer 11 is the size of code pattern.
In embodiments of the present invention, the impedance in loop 30 and the impedance in loop 31 define code Code1, and the impedance in the impedance in loop 30 and loop 32 defines code Code2.Loop 30,31, with 32 each self-impedance by changing respective live width or length changes.For example, in loop 30,31, with in the 32 conditioned disjunction situations with roughly the same live width, loop 30,31, with 32 respective length determine respective impedance.
In one embodiment, loop 30,31, arrange on the substrate 10 with screen printing techniques with 32.When loop 30,31, print with different slurries from 32 time, even if in roughly the same live width and length condition, loop 30,31, also may have different impedances from 32.
Fig. 4 represents the biometric system according to the embodiment of the present invention.Consult Fig. 4, biometric system 4 comprises biological sensor 1 and the biometric device 40 of Fig. 1.In one embodiment, biometric system 4 is a blood sugar measuring system.Below will illustrate as example with blood sugar measuring system.When user is for measuring the concentration of glucose in blood, needs first biological sensor 1 to be inserted in the slot 41 of biometric device 40, afterwards blood being instilled, sucks or be placed on bio-reaction zone 20.Consult Fig. 2 and Fig. 4, the side 10b of substrate 10 is also provided with electrode 21 and 22, it connects biological respinse layer 12.When the glucose in blood and chemical reagent (enzyme) carry out electrochemical reaction, biometric device 40 obtains the electric signal caused by above-mentioned electrochemical reaction by electrode 21 and 22, to carry out measurement operation to the concentration of glucose in blood.
In addition, when biological sensor 1 is inserted into the slot 41 of biometric device 40, biometric device 40 go back measuring circuit 30,31, with 32 each self-impedance.When biometric device 40 learn loop 30,31, with each self-impedance of 32 after, biometric device 40 calculates the code Code1 of biological sensor 1 according to the impedance in the impedance in loop 30 and loop 31, and calculates the code Code2 of biological sensor 1 according to the impedance in loop 30 and the impedance in loop 32.Then, biometric device 40 carrys out at least one parameter of setting measurement operation according to code Code1 and Code2, makes biometric device 40 can carry out measurement operation according to this parameter to the concentration of glucose of blood.With measure glucose concentration for example, according to two code Code1 and Code2 of biological sensor 1 and at least one parameter set, in biological respinse layer 12 as the enzyme of chemical reagent response characteristic relevant.Thus, even if use the biological sensor 1 manufactured by different batches processing procedure, biometric device 40 still can measure the concentration of glucose in user's blood exactly.Measurement result can not be subject to the differential responses characteristic that different batches processing procedure causes to be affected, and improves and measures precision.
Measure the concentration of glucose in blood when biometric device 40 after, measurement result can be shown on a display screen 42 of biometric device 40, read for user or healthcare givers.
Below by illustrate biometric device 40 how by measuring circuit 30,31, with 32 each self-impedance calculate code Code1 and the Code2 of biological sensor 1.
Consult Fig. 5 A, when biological sensor 1 is inserted into the slot 41 of biometric device 40, biometric device 40 is by an end points in loop 30, and such as terminal B, is coupled to earthing potential GND.Meanwhile, biometric device 40 provides a specific voltage V50 to terminal A.Now, according to impedance and the above-mentioned specific voltage V50 in loop 30, loop 30 causes the electric current I 50 being flowed to terminal B by terminal A.Biometric device 40 measures electric current I 50 in terminal A.
Consult Fig. 5 B, when biological sensor 1 is inserted into the slot 41 of biometric device 40, biometric device 40, by end points D, is coupled to earthing potential GND.Now, biometric device 40 provides specific voltage V50 to end points C.Now, according to impedance and the above-mentioned specific voltage V50 in loop 31, loop 31 causes the electric current I 51 being flowed to end points D by end points C.Biometric device 40 measures electric current I 51 on end points C.In addition, biometric device 40 also provides specific voltage V50 to end points E.Now, according to impedance and the above-mentioned specific voltage V50 in loop 32, loop 32 causes the electric current I 52 being flowed to end points D by end points E.Biometric device 40 measures electric current I 52 on end points E.
Those skilled in the art are known according to Ohm law (Ohm's Law), and for a conductor, the impedance of the electric current and this conductor that flow through a conductor is inversely proportional to.Therefore, biometric device 40 calculate obtain electric current I 50, I51, the impedance in loop 30, the impedance in loop 31, the impedance in loop 32 can be represented respectively with I52.In other words, biometric device 40 is by measuring electric current I 50, I51, the impedance distinguishing measuring circuit 30 with I52, the impedance in loop 31, the impedance in loop 32.Acquisition electric current I 50, I51, with I52 after, biometric device 40 obtains the code Code1 of biological sensor 1 according to formula (1) and/or formula (2), and obtains the code Code2 of biological sensor 1 according to formula (1) and/or formula (2).Such as, in one embodiment, biometric device 40 obtains the code Code1 of biological sensor 1 according to formula (1), and obtains the code Code2 of biological sensor 1 according to formula (2).
TRUNC ((i50/i51)-0.26) * 10/1.28+1) formula (1)
TRUNC ((i50/i52)-0.35) * 10/1.6+1) formula (2)
Wherein i50 represents the value of electric current I 50, and i51 represents the value of electric current I 51, and i52 represents the value of electric current I 52.TRUNC () function the numerical value containing decimal is converted to integer (part namely after unconditional fractions omitted point).
Below illustrate, consult table 1, its represent electric current I 50, I51, with numerical value i50, the i51 of I52, an illustrative example with i52, the code Code1 of biological sensor 1 and the code Code2 of biological sensor 1, wherein table 1 lists code Code1 and Code2 and all calculates with previously described formula (1) and obtain.
Table 1
i51 i50 Code1 i52 Code2
2099 7811 1 7809 1
2123 6718 1 6733 1
2175 5746 1 5748 1
2195 5116 2 5111 2
2353 4605 2 4596 2
2256 4199 3 4192 2
2171 3823 3 3816 3
2188 3571 3 3573 3
2162 3349 4 3347 4
2229 3121 4 3116 4
2251 2936 4 2929 4
2297 2762 5 2760 5
2269 2579 5 2575 5
2167 2421 5 2416 6
2275 2343 6 2347 6
2299 2258 6 2251 6
2269 2116 7 2114 7
2264 2036 7 2034 7
2301 1853 8 1851 8
2253 1684 9 1680 8
2303 1634 9 1632 9
2123 1556 9 1554 9
2256 1590 10 1588 10
Below an example is lifted again, consult table 2, its represent electric current I 50, I51, with numerical value i50, the i51 of I52, another illustrative example with i52, the code Code1 of biological sensor 1 and the code Code2 of biological sensor 1, wherein table 1 lists code Code1 and code Code2 and all calculates with previously described formula (2) and obtain.
Table 2
i51 i50 Code1 i52 Code2
5583 15348 1 15348 1
5624 13779 1 12984 1
5661 12069 1 11297 1
5792 10819 2 10278 2
5885 10010 2 9889 2
5742 8802 2 8585 2
5833 7994 3 7541 3
5816 7422 3 7334 3
5850 6844 4 6955 4
5820 6450 4 6476 4
5857 5996 4 6394 4
5977 5648 5 5835 5
5900 5318 5 5552 5
5755 4994 6 4988 6
6005 4816 6 4733 6
5950 4559 6 4549 6
5855 4229 7 4431 7
5824 4033 7 4196 7
5601 3712 8 3810 8
5672 3555 8 3644 8
5566 3366 9 3386 9
5687 3216 9 3271 9
5714 3051 10 3070 10
According to above-mentioned, biological sensor 1 of the present invention have three loops 30,31, with 32, be used for defining two code Code1 and the Code2 representing biological sensor 1 characteristic.When user is for measuring by the analysis thing of biometric device 40 to a biological specimen, biological sensor 1 is inserted into the slot 41 of biometric device 40 by user.Now, biometric device 40 can measure simultaneously three loops 30,31, with 32 impedance, obtain code Code1 and Code2 by this.Biometric device 40 carrys out at least one parameter of setting measurement operation according to code Code1 and Code2, makes biometric device 40 can carry out measurement operation according to this parameter to the glucose of blood.Thus, user does not need will to represent that biometric device 40 keyed in by the code of biological sensor 1 characteristic in input.In addition, because loop is arranged on a side of biological sensor 1, therefore, user does not need to perform the operation of cipher card being inserted biometric device 40, and the situation avoiding inserting error cipher card occurs.
Though the present invention discloses as above with preferred embodiment; so itself and be not used to limit scope of the present invention; any person of ordinary skill in the field; without departing from the spirit and scope of the present invention; when doing a little change and retouching, therefore protection scope of the present invention is when being as the criterion depending on the claim person of defining.

Claims (19)

1. a biological sensor, in order to sense a biological specimen, and has a first code and a second code of the characteristic representing this biological sensor, comprising:
One substrate;
One conductive layer, is configured in the first side of this substrate, and wherein, this conductive layer comprises:
One first loop, is formed between one first end points and one second end points, and has one first impedance;
One second servo loop, is formed between one the 3rd end points and one the 4th end points, and has one second impedance, and wherein, this second end points and the 3rd end points are electrically insulated each other; And
One tertiary circuit, is formed between the 4th end points and a five terminal point, and has one the 3rd impedance;
Wherein, this first impedance and this second or the 3rd impedance define this first code, and this first impedance and this second or the 3rd impedance define this second code; And
One biological responding layer, is configured in a bio-reaction zone of one second side of this substrate, and has a chemical reagent,
Wherein, this biological specimen is positioned over this bio-reaction zone; And
Wherein, this second side is relative to this first side.
2. biological sensor as claimed in claim 1, wherein, this first code and this second code represent the response characteristic of this chemical reagent.
3. biological sensor as claimed in claim 1, wherein this biological sensor senses the glucose of this biological specimen.
4. biological sensor as claimed in claim 1, wherein, this first loop, this second servo loop and this tertiary circuit have identical live width, and the respective length of this first loop, this second servo loop and this tertiary circuit determines this first impedance, this second impedance and the 3rd impedance respectively.
5. biological sensor as claimed in claim 1, wherein, this first code and this second code represent the manufacturing information of this biological sensor.
6. biological sensor as claimed in claim 1, wherein, this first loop of this conductive layer, this second servo loop and this tertiary circuit are arranged on this substrate with screen printing techniques.
7. biological sensor as claimed in claim 1, wherein, this biological sensor is a blood sugar sensor.
8. biological sensor as claimed in claim 1, wherein, this first impedance and this second impedance define this first code, and this first impedance and the 3rd impedance define this second code.
9. a biometric system, in order to sense a biological specimen one analyzes thing, comprising:
One biological sensor, has a first code and a second code of the characteristic representing this biological sensor, and comprises:
One substrate, has one first side and one second side relative with this first side;
One biological responding layer, is configured in a bio-reaction zone of this first side, and has a chemical reagent, and wherein, this biological specimen is positioned over this bio-reaction zone;
One conductive layer, is configured in this second side, and wherein, this conductive layer comprises:
One first loop, is formed between one first end points and one second end points, and has one first impedance;
One second servo loop, is formed between one the 3rd end points and one the 4th end points, and has one second impedance, and wherein, this first loop and this second servo loop are electrically insulated each other; And
One tertiary circuit, is formed between the 4th end points and a five terminal point, and has one the 3rd impedance; And
One biometric device, wherein, this biological sensor connects this biometric device;
Wherein, this biometric device measures this first impedance, this second impedance and the 3rd impedance, and according to this first impedance and this second or the 3rd impedance calculate this first code and according to this first impedance and this second or the 3rd impedance calculate this second code; And
Wherein, this biometric device carries out a measurement operation according to this first code and this second code to one of this biological specimen analysis thing.
10. biometric system as claimed in claim 9, wherein, this first code and this second code represent the response characteristic of this chemical reagent.
11. biometric system as claimed in claim 9, wherein this biological sensor senses the glucose of this biological specimen.
12. biometric system as claimed in claim 9, wherein, this first loop, this second servo loop and this tertiary circuit have identical live width, and the respective length of this first loop, this second servo loop and this tertiary circuit determines this first impedance, this second impedance and the 3rd impedance respectively.
13. biometric system as claimed in claim 9, wherein, this first code and this second code represent the manufacturing information of this biological sensor.
14. biometric system as claimed in claim 9, wherein, this first loop of this conductive layer, this second servo loop and this tertiary circuit are arranged on this substrate with screen printing techniques.
15. biometric system as claimed in claim 9,
Wherein, when this second end points is coupled an earthing potential and provides a specific voltage to this first end points by this biometric device, this biometric device measures one first electric current on this first end points to represent this first impedance;
Wherein, when the 4th end points is coupled this earthing potential and provides this specific voltage to the 3rd end points by this biometric device, this biometric device measures one second electric current on the 3rd end points to represent this second impedance; And
Wherein, when the 4th end points is coupled this earthing potential and provides this specific voltage to this five terminal point by this biometric device, this biometric device measures one the 3rd electric current on this five terminal point to represent the 3rd impedance.
16. biometric system as claimed in claim 9, wherein, when this biological sensor connects this biometric device, this biometric device sets at least one parameter of this bio-measurement operation to measure this analysis thing according to this first code and this second code.
17. biometric system as claimed in claim 9, wherein, this biometric device has a display screen, in order to display, this analysis thing is carried out to the measurement result of this measurement operation.
18. biometric system as claimed in claim 9, wherein, this biometric system is a blood sugar measuring system.
19. biometric system as claimed in claim 9, wherein, this biometric device calculates this first code according to this first impedance and this second impedance and calculates this second code according to this first impedance and the 3rd impedance.
CN201210464441.8A 2011-11-15 2012-11-15 Biological sensor and biometric system Expired - Fee Related CN103105413B (en)

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CN109781989A (en) * 2017-11-10 2019-05-21 上海瀚联医疗技术股份有限公司 The method and biosensor of blood sugar test

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